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Domain: aacrjournals.org

Stories and comments across the archive that link to aacrjournals.org.

Stories · 2

  1. Training an Immune System To Kill Cancer: a Universal Strategy

    Science · Biotech · · posted by Soulskill · from the fighting-fire-with-napalm dept. · 201 comments
    New submitter Guppy writes "A previous story reported widely in the media, and appearing both on Slashdot and XKCD, described a novel cancer treatment, in which a patient's own T-cells were modified using an HIV-derived vector to recognize and kill leukemia cells. In a follow-up publication (PDF), a further development is described which allows for a nearly unlimited choice of target antigens, broadening the types of malignancies potentially treatable with the technique (abstract)."

  2. Common Diabetic Drug Fights Cancer Stem Cells

    Science · · posted by kdawson · from the getting-at-the-root-or-at-least-the-stem dept. · 149 comments
    SubtleGuest writes "In the latest issue of Cancer Research, a breakthrough study shows that Metformin, a cheap and common diabetic medicine, kills cancer stem cells — the cells postulated to be responsible for tumor resistance and recurrence after chemotherapy (research abstract here). It has been known that diabetics taking Metformin experience lower cancer rates, and now it is apparent why that may be and how it may apply to non-diabetics as well. When combined with Doxorubicin to kill non-stem cancer cells, the results are nothing short of astonishing: total remission in a mouse xenograft model. The results are achieved at levels below the dosage needed for diabetic control, opening many new avenues in cancer treatment and prevention."