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Domain: genengnews.com
Stories and comments across the archive that link to genengnews.com.
Stories · 2
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Researchers Genetically Modify Common Houseplant To Remove Air of Hazardous Compounds (genengnews.com)
An anonymous reader quotes a report from Genetic Engineering & Biotechnology News: Now, researchers at the University of Washington (UW) have genetically modified a common houseplant -- pothos ivy or devil's ivy -- to remove chloroform and benzene from the air around it. The modified plants express a mammalian protein, called 2E1, that transforms these compounds into molecules that the plants can then use to support their own growth. Small molecules like chloroform, which is present in small amounts in chlorinated water, or benzene, which is a component of gasoline, build up in our homes when we shower or boil water, or when we store cars or lawn mowers in attached garages. These compounds are too small to be captured by even HEPA air filters and exposure to each has been linked to cancer. Findings from the new study were published recently in Environmental Science & Technology. -
CRISPR Eliminates HIV In Live Animals (genengnews.com)
Researchers from the Lewis Katz School of Medicine at Temple University and the University of Pittsburgh show that HIV-1 infections can be eliminated from the genomes of living animals. Findings from the study have been published in the journal Molecular Therapy. Genetic Engineering and Biotechnology News reports: This is the first study to demonstrate that HIV-1 replication can be completely shut down and the virus eliminated from infected cells in animals with a powerful gene-editing technology known as CRISPR/Cas9. The new work builds on a previous proof-of-concept study that the team published in 2016, in which they used transgenic rat and mouse models with HIV-1 DNA incorporated into the genome of every tissue of the animals' bodies. They demonstrated that their strategy could delete the targeted fragments of HIV-1 from the genome in most tissues in the experimental animals. In this new study, the LKSOM team genetically inactivated HIV-1 in transgenic mice, reducing the RNA expression of viral genes by roughly 60% to 95% -- confirming their earlier findings. They then tested their system in mice acutely infected with EcoHIV, the mouse equivalent of human HIV-1. In the third animal model, a latent HIV-1 infection was recapitulated in humanized mice engrafted with human immune cells, including T cells, followed by HIV-1 infection. "These animals carry latent HIV in the genomes of human T cells, where the virus can escape detection," Dr. Hu explained. Amazingly, after a single treatment with CRISPR/Cas9, viral fragments were successfully excised from latently infected human cells embedded in mouse tissues and organs.