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An anonymous reader quotes a report from NPR: A study by researchers at Johns Hopkins Medicine says medical errors should rank as the third-leading cause of death in the United States -- and highlights how shortcomings in tracking vital statistics may hinder research and keep the problem out of the public eye. The authors, led by Johns Hopkins surgeon Dr. Martin Makary, call for changes in death certificates to better tabulate fatal lapses in care. In an open letter, they urge the Centers for Disease Control and Prevention to immediately add medical errors to its annual list reporting the top causes of death. Based on an analysis of prior research, the Johns Hopkins study estimates that more than 250,000 Americans die each year from medical errors. On the CDC's official list, that would rank just behind heart disease and cancer, which each took about 600,000 lives in 2014, and in front of respiratory disease, which caused about 150,000 deaths. Medical mistakes that can lead to death range from surgical complications that go unrecognized to mix-ups with the doses or types of medications patients receive. The study was published Tuesday in The BMJ, formerly the British Medical Journal.

An anonymous reader writes: Cardiologists from Johns Hopkins have published an analysis of exercise data that strongly links a patient's performance on a treadmill to their risk of dying. Using data from stress tests of over 58,000 people, they report: "[A]mong people of the same age and gender, fitness level as measured by METs and peak heart rate reached during exercise were the greatest indicators of death risk. Fitness level was the single most powerful predictor of death and survival, even after researchers accounted for other important variables such as diabetes and family history of premature death — a finding that underscores the profound importance of heart and lung fitness, the investigators say." The scoring system is from -200 to +200. People scoring between -100 and 0 face an 11% risk of dying in the next decade. People scoring between -200 and -100 face a 38% risk of death within the next decade. People scoring above zero face only a 3% chance or less.

stemceller passed us a link to the official site for Johns Hopkins, which is reporting on some research into cognition. Generally, doctors have understood our best learning to be done at a young age, when the brain has a 'robust flexibility'. As we get older, our brain cells become 'hard-wired' along certain paths and don't move much - if at all. Or, at least, that was the understanding. Research headed by the hospital's Dr. Linden has taken advantage of 'two-photon microscopy', a new technique, to get a new picture inside a mouse's head. "They examined neurons that extend fibers (called axons) to send signals to a brain region called the cerebellum, which helps coordinate movements and sensory information. Like a growing tree, these axons have a primary trunk that runs upward and several smaller branches that sprout out to the sides. But while the main trunk was firmly connected to other target neurons in the cerebellum, stationary as adult axons are generally thought to be, 'the side branches swayed like kite tails in the wind,' says Linden. Over the course of a few hours, individual side branches would elongate, retract and morph in a highly dynamic fashion. These side branches also failed to make conventional connections, or synapses, with adjacent neurons. Furthermore, when a drug was given that produced strong electrical currents in the axons, the motion of the side branches stalled.'"