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Stress Found to Accelerate Chromosome Aging

th3d0ct0r writes "Various sources report that according to the findings of a science team led by Elissa Epel at the University of California, SF, stress can cause accelerated aging of cells. The mecanism seems to be linked to oxidative stress at cellular level, that keeps the enzyme telomerase from regenerating the chromosomial telomere caps which shorten a bit during each replication cycle. Telomere caps are known to be a very important factor determining the replication capacity of every cell. Once these caps are gone,a cell goes to a state of senescence, and ultimately dies. People exposed to prolonged periods of stress have been shown to have significantly shorter telomere caps on the chromosomes of their white blood cells."

43 comments

  1. I wonder... by alexjohns · · Score: 1, Interesting
    I wonder if this is the root cause of depravity among the ruling class. Our elected leaders usually only last 4-6 years. But those kings of old that ruled for decades, maybe the body realized it was under stress and looked for outlets that relieved that stress.

    Could explain all that debauchery and inbreeding and stuff. Or maybe it's just because they had absolute power and could do whatever they wanted with impugnity. I bet a good defense lawyer could use it in court.

    "I submit that my client, Caligula, committed these atrocities as stress relief. He didn't really want to do all these things the prosecution alleges. His body was just looking to alleviate all the stress he's been under in running the Roman empire. He's a victim of stress, nothing more. A good man with too much pressure on him."

    It could happen.

    Obquote: "It's good to be the king."

    1. Re:I wonder... by alexjohns · · Score: 1

      Ha! Frist post! It's probably been 5 years since my last one. Heh.

    2. Re:I wonder... by Jazu · · Score: 1

      Wow, you're Bill Frist? I didn't know there were any senators on /.

      --
      My joke got modded as Insightful and my insight got modded as Funny.
    3. Re:I wonder... by Anonymous Coward · · Score: 0

      This makes me sick.
      How can a comment's ONLY moderation be "overrated?"

      Boo!

  2. Unsupported method exception by orthogonal · · Score: 0

    stress can cause accelerated aging of cells.

    Aha!

    When I said doing those dumbass Java Server Pages and pretending that was real OOP was killing me, I had no idea how literal I was being.

    1. Re:Unsupported method exception by KwaiChangLee · · Score: 0

      It could have been worse... it could have been *Struts*. (shudder)

  3. Stress the managing of stress by Staplerh · · Score: 2, Interesting

    Further evidence that stress has real, actual impact on the human body and that stress management programmes should be accorded respect. I don't know any statistics on the subject, but for every workplace that has a stress programme there are certainly many that do not.

    Just as asbestos is a workplace hazard, stress should be considered in the similar vein. While people may chuckle at the mental image of a bunch of cubicle workers doing tai-chi or some other stress exercise, it may be the right move to deal with a signifigant health hazard.

    Perhaps somebody should do a study of those EA workers and if their health was impacted by the long periods of stressful work?

    --
    "There's no success like failure, and failure's no success at all."
    - Bob Dylan
    1. Re:Stress the managing of stress by nomel · · Score: 2, Interesting

      I wonder if caffeine accelerates aging since it puts the body in the same state as if it were in stress.

  4. So.... by tansey · · Score: 2, Interesting

    Does this mean IT people will start getting hazard pay?

    1. Re:So.... by superpulpsicle · · Score: 1

      Aaaaahhh... that explains why all the upper-management folks always look so young. All that golf stress during the 9 to 5 do them no good.

  5. Bollocks by brunes69 · · Score: 1

    Stress has as much to do with psychology as your environment. Stress is created by your brain - the threshold of what you perceive as stressful and what I perceive as stressful are likely totally different, as I am a pretty easy-going guy. Some people just flip out over nothing, others can smile and laugh while their world comes crashing down upon them. And you can do tai-chi till you're blue in the face and it won't change any of that, all it will result in is the people who can't cope with their situations properly will be wasting their whole days doing tiger-crane.

    What *really* should be happening is that people who are likely to be put into high-stress situations should be screened beforehand to avoid breakdowns and other health problems.

    The military can do it, why not the private sector? Sure, there would likely be legal challenges at first under equal rights, but really, I don't see what the difference is between a programming company giving a psyche profile and an insurance company asking you to fill out a health form.

    1. Re:Bollocks by DaoudaW · · Score: 1

      The military can do it, why not the private sector?

      Yeah right! That would be why over a hundred thousand veterans of Gulf War I are registered as suffering from Gulf War Syndrome. Or maybe that's why Vietnam vets have such a pristine record regarding murders, suicides and mental illness. Come to think of it, many WWII vets came home with what was called at the time "shell shock." I knew a man like that once. We called him "Tarz" short for Tarzan. He wandered the streets of the small town where I grew up and little children laughed at him.

      Oh yeah, the military is real good at screening people who are likely to be put into high-stress situations ... beforehand to avoid breakdowns and other health problems.

    2. Re:Bollocks by th3d0ct0r · · Score: 1

      Everybody is sensitive to stress, you just may deal with it differently. Just as some people react differently to a painfull stimulus.
      You may not show that you are stressed, or maybe not consciously perceive it that way, but subconsciously it can very well have a strong impact.
      Just think of all the bruxers in the US!

      --
      pass me those sparticles will ya?!
  6. I am curious by Murphy+Murph · · Score: 3, Insightful

    I am curious what how this relates to the effect of stress on the immune system.

    Is the immune system weakened somehow by this?
    Are a weakened immune system and this shortening of the telomeres both symptoms of another problem?
    Are the telomeres shortened in these white blood cells because the immune system has been running it's self to rags due to stress?
    Or is the fact they found this shortening in white blood cells a red herring?

    Then again, this was a study of 58 women. Not a very large sample, and I'm male - so I'm safe.

    (I always was jealous of my sisters as a child. I found it unfair that sharks were man-eaters.)

    --
    I dub thee... Sir Phobos, Knight of Mars, Beater of Ass.
  7. But... by Anonymous Coward · · Score: 0

    Only in Korea.

  8. Can you really minimize stress by Drunken_Jackass · · Score: 2, Insightful

    I mean, at some level, don't you as a thinking human, start stressing out about something? Aren't we all at a basic level stressed that we don't have enough to eat, that we won't have a place to live and that we won't pass along our genes to future generations?

    Or are they referring to "Modern Stress" - something that only afflicts the "Modern World"?

    --
    There are 01 types of people in this world. Those that understand binary, and me.
    1. Re:Can you really minimize stress by sjames · · Score: 1

      I mean, at some level, don't you as a thinking human, start stressing out about something?

      I suspect they mean "Modern Stress". Unlike the first ones you cite, modern stress focuses on things we tend to feel powerless to do anything about.

  9. Correlation/Causation by Anonymous Coward · · Score: 2, Insightful

    To study the effect of stress on the cell, Epel and her colleagues looked at the chromosomes in the white blood cells of 58 mothers, two-thirds of whom had chronically ill children. The other women had healthy children so may be expected to suffer less stress.

    Perhaps they have merely discovered that people with shortened telomeres are more likely to have chronically ill children.

    1. Re:Correlation/Causation by Anonymous Coward · · Score: 0

      when my kids are sick, they shut the hell up, and I get more than 4 hours of sleep for once.

  10. I guess this is why... by psyconaut · · Score: 1

    I'm 32 going on 50!

    -psy

  11. Would this affect their children? by code+addict · · Score: 1

    Forgive me, but my biology is failing me...

    Does the state of one's telomeres at the time they conceive a child have any effect on the state of a child's telomeres at birth? Or do children start with a clean slate in that regard?

    1. Re:Would this affect their children? by code+addict · · Score: 1

      Never mind... RTFA... RTFA... yes yes...

    2. Re:Would this affect their children? by WolfWithoutAClause · · Score: 1

      The telomeres of the child have to start at full length. AFAIK it's not known how that works.

      --

      -WolfWithoutAClause

      "Gravity is only a theory, not a fact!"
    3. Re:Would this affect their children? by PsiPsiStar · · Score: 1

      Non differentiated cells are immortal.
      Differentiated cells are not.

      --

      ___
      It's the end of my comment as I know it and I feel fine.
  12. Does this mean by lowmagnet · · Score: 1

    That Cannabis will lengthen one's lifespan? Hmmmmmm....

    --
    Heute die Welt, morgen das Sonnensystem!
  13. Caligula's Lawyer by handy_vandal · · Score: 1

    "I submit that my client, Caligula, committed these atrocities as stress relief. He didn't really want to do all these things the prosecution alleges. His body was just looking to alleviate all the stress he's been under in running the Roman empire. He's a victim of stress, nothing more. A good man with too much pressure on him."

    Result:

    Caligula goes free. He orders the lawyer to commit suicide. The lawyer draws a hot bath, drinks a cup of wine, opens his veins. Caligula feels much better afterward: "Why, that must have added a year to my life!"

    -kgj

    --
    -kgj
  14. I knew I wasn't crazy by Oriumpor · · Score: 2, Interesting

    I remember seeing Clinton before he was elected, and then pictures of him at the end of his term. He got old FAST.

    1992
    2000

    1. Re:I knew I wasn't crazy by Spoing · · Score: 1
      1. He got old FAST.

      In Korea ... nevermind.

      --
      A firewall can not protect you from yourself. Turn off what you do not need. Do not use the firewall to do your work.
  15. But "psychological stress" is crap... by CodeWanker · · Score: 2, Interesting

    because all the impacts they should measure are physiological. They ought to measure the relative frequency that the fight or flight response gets triggered without a satisfactory response (the body can neither fight nor flee,) the average amount of sleep, the average amount of aerobic exercise, the relative frequency of overeating and drinking to self-medicate a negative emotional state, and other things we can quantify. "Sick kids worry parents to death" is not a scientific premise or conclusion. And I speak as a parent who would worry himself to death if his daughter had a serious illness.

    --


    "Wow. Now THAT'S a lot of angry Indians." - Lt. Col. George Armstrong Custer
    1. Re:But "psychological stress" is crap... by foobsr · · Score: 1

      They ought to measure ... the relative frequency of overeating and drinking to self-medicate a negative emotional state, ...

      ... erm ... and what kind of non-psychological device do you use to assess "a negative emotional state" ??

      CC.

      --
      TaijiQuan (Huang, 5 loosenings)
    2. Re:But "psychological stress" is crap... by CodeWanker · · Score: 1

      Um... An emotional state that induces self-medication. If you're self-medicating, that's the non-psychological device.

      --


      "Wow. Now THAT'S a lot of angry Indians." - Lt. Col. George Armstrong Custer
  16. Beer. by msimm · · Score: 1

    Then...beer saves lives?

    --
    Quack, quack.
  17. it seems then that.. by Ghouki · · Score: 0

    I just don't even to have the time to stress ...

    --

    insert witty comment here
  18. I guess... by cuteseal · · Score: 1

    ... we've just found scientific proof that stress will kill you faster! That's it, I'm off to the Bahamas.

  19. stress != oxidative stress by RedLaggedTeut · · Score: 1

    It says oxidative stress, which is put on by oxidation. Anti-oxidants are very high on the list of stuff that is good for you, very prominent are metformin, turmeric and the tannins in tea. Actually it seems lots of vegetables contain anti-oxidants.

    Stress also has effects on the immune system, but that is an issue in general unrelated to this article about the telomers. But of course, everything is connected to everything, two.

    --
    I'm still trying to figure out what people mean by 'social skills' here.
  20. Whale saved! by RedLaggedTeut · · Score: 1
    I remember seeing Clinton before he was elected, and then pictures of him at the end of his term. He got old FAST.

    Maybe there is another reason:
    I heard one whale was saved by recycling all the make-up that the president used during his campaign.

    --
    I'm still trying to figure out what people mean by 'social skills' here.
  21. grad students by flyingsquid · · Score: 1
    I can think of a couple 30- year old PhD students I knew who had hair streaked through with silver. Personally, I make an effort to enjoy video games, drinking, travel, and a romantic life... but most of all, my studies. Doing stuff that interests me (instead of dreadful stuff that I think other people might like) has made work seem like play again. Plus, I play a lot when I should be working (and vice versa). I figure I ought to enjoy it- if I'm going to be miserable doing work I should head to Wall Street and at least get paid well.

    The "work smarter" thing has a lot of truth to it. I used to work like crazy to get nothing done. These days I work less, but on problems that are vastly more interesting, which hopefully will benefit my career, and I'm more productive than I ever was before, since I focus on what I put out of my work, and not what I put in. The other thing is thinking long term. I figure an academic career spans decades, and you have to pace yourself so you don't get burned out.

  22. I was talking about special ops by brunes69 · · Score: 1

    The military doe snot screen general enlistments for stress sensitivity very much.

    But they sure as hell do for special ops people. You don't want a Seal who is going to be out of radio contact for 14 days to fail his mission and be killed because he got "stressed out".

    1. Re:I was talking about special ops by Muad'Dave · · Score: 1

      The military doe snot screen general...

      Let me get this straight: the military has a general that is in charge "doe snot screening"? Or do they have a general in charge of something called a "doe snot screen?" What in the world would they use a screen like that for, and why must they put a general in charge of it? It must be a new secret weapon.

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
  23. May I be the first to call BS? by TapeCutter · · Score: 1
    "There was no difference in the telomere length of the two groups, but women in both groups who reported the most stress also had the shortest telomeres."
    My hypothosis[sic] didn't work out, so I will "mine" the data and look for another relationship. I think if they found anything at all it was this...
    "People with the shortest telomeres report the most stress regardless of the amount of perceived stress by others"
    ... they do kinda say that further down in the article. What they don't say is that the measure is subjective, they did not do any physiological measures other than telomere length. When that didn't work they "found" the same anecdotal evidence that we all have about stress and longevity. Having said that I still think she is right about the "further study" thing, but get someone who can set up a more creative, cruelty free and robust experiment.
    "I believe that how we perceive the world can matter more than our objective reality."-Must be a big Matrix fan.
    --
    And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  24. Ah-Ha! now it all makes sense by museumpeace · · Score: 1

    here we have proof that getting stressed ages you.
    and here we have proof that pain ages your brain.
    and here we have proof that a drink or two keeps you alive longer
    and even sites that aim to scare you into Tea-total abstinance admit that "...Alcohol ís a depressant. Many people use alcohol as a means to produce feelings of relaxation..."
    Uh...um.....I forgot where I was going with all this....I need a drink. Being a 90 year old wino has its drawbacks but I can never remember what they are.
    There must be good stress and bad stress because strenuous exercise on a regular basis churns up a lot of free radicals that are supposed to do the same things to you as the telomere damage cited in the art. but instead that is "exercise" and it does you good. Until somebody makes sense out of that littel dicotomy, I am not paying too much attention to these reports. a good Port is better than a good report?

    --
    SLASHDOT: news for people who can't concentrate on work or have no life at all and got tired of yelling back at the TV.
  25. mnb Re:stress != oxidative stress by Anonymous Coward · · Score: 0

    Reread the article, heck reread the summary.

    The study is about stress - and they are guessing that the mech. of damage is oxidative stress. The parent to your post asked a very good and valid question - and you showed little but ignorance in your reply.