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Aphid's Color Comes From a Fungus Gene

Iron Nose writes with an account from Byte Size Biology of horizontal gene transfer from a fungus to an insect. The author suspects that we will see lots more of this as we sequence more genomes. "The pea aphid is known for having two different colors, green and red, but until now it was not clear how the aphids got their color. Aphids feed on sap, and sap does not contain carotenoids, a common pigment synthesized by plants, fungi, and microbes, but not by animals. Carotenoids in the diet gives many animals, from insects to flamingos, their exterior color after they ingest it, but aphids do not seem to eat carotenoid-containing food. Nancy Moran and Tyler Jarvik from the University of Arizona looked at the recently sequenced genome of the pea aphid. They were surprised to find genes for synthesizing carotenoids; this is the first time carotenoid synthesizing genes have been found in animals. When the researchers looked for the most similar genes to the aphid carotenoid synthesizing genes, they found that they came from fungi, which means they somehow jumped between fungi and aphids, in a process known as horizontal gene transfer."

132 comments

  1. wiki by hh4m · · Score: 1, Informative
    1. Re:wiki by mrmeval · · Score: 0, Redundant

      They state with authority the gene came from a fungi but they have not shown where they have observed this happening. The fact that the genes are identical does not mean they're of the same origin.

      --
      I'd go on a Vegan diet but the delivery time from Vega is too long. --brownkitty
    2. Re:wiki by Thanshin · · Score: 1

      The fact that the genes are identical does not mean they're of the same origin.

      I've got little knowledge on the topic but I'd guess it's a matter of numbers.

      The larger the identical combination, the more probable is their common origin.

    3. Re:wiki by masterwit · · Score: 2, Informative

      Carotenoids are colored compounds produced by plants, fungi, and microorganisms and are required in the diet of most animals for oxidation control or light detection. Pea aphids display a red-green color polymorphism, which influences their susceptibility to natural enemies, and the carotenoid torulene occurs only in red individuals. Unexpectedly, we found that the aphid genome itself encodes multiple enzymes for carotenoid biosynthesis. Phylogenetic analyses show that these aphid genes are derived from fungal genes, which have been integrated into the genome and duplicated. Red individuals have a 30-kilobase region, encoding a single carotenoid desaturase that is absent from green individuals. A mutation causing an amino acid replacement in this desaturase results in loss of torulene and of red body color. Thus, aphids are animals that make their own carotenoids.

      That's the abstract from the in-text link, whatever a Phylogenetic analyses is...my guess:

      Phase 1: Found genes......Phase 2: ???......Phase 3: Science! (good point mrmeval)

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    4. Re:wiki by Anonymous Coward · · Score: 2, Informative

      ...they have not shown where they have observed this happening.

      It's like paternity tests: you can't exactly get in a time machine and go observe it happening but when you calculate the probabilities based on reasonable assumptions they can come out pretty high.

    5. Re:wiki by morty_vikka · · Score: 4, Informative

      The fact that the genes are identical does not mean they're of the same origin.

      Actually, if the genes are identical in terms of nucleotide sequence then it is absolutely irrefutable that they are of the same origin. Even genes that are evolutionarily conserved vary in sequence between members of the same genus, let alone organisms from completely different kingdoms of life.

    6. Re:wiki by Anonymous Coward · · Score: 0

      Or it's evidence some mold got into the tissue sample that was being stored for sequencing :)

    7. Re:wiki by Anonymous Coward · · Score: 0

      They state with authority the gene came from a fungi but they have not shown where they have observed this happening. The fact that the genes are identical does not mean they're of the same origin.

      Can I use the same argument when denying partenity of my future children?

    8. Re:wiki by Stooshie · · Score: 1

      What? and inserted itself into the genes in a place where it could naturally be processed? Also, in every sample! Puh-lease!

      --
      America, Home of the Brave. ... .and the Squaw.
    9. Re:wiki by Anonymous Coward · · Score: 0
    10. Re:wiki by Anonymous Coward · · Score: 0

      Humans accrue roughly 40 new single-point mutations every time they reproduce. And we've got really stable genomes. If two organisms actually have the same sequence for the same gene in nucleotide sequence and not just amino acid sequence (there's a big difference, remember, and actually homology analyses are only conducted using the latter), then they're probably near relatives, not just of the same species.

    11. Re:wiki by Anonymous Coward · · Score: 2, Informative

      Well, they can't publish their entire paper in the abstract - the details cost you money, unfortunately. However, it's likely that the method they followed involved statistical comparisons of the nucleotide sequence for similarity. Initially, this seems to be pseudo-scientific, but there are a number of factors to consider: Eukaryotes(animals and fungi + others) make several modifications to the "raw" sequence before translation machinery can code protein from an mRNA template(exons, for example: http://en.wikipedia.org/wiki/Exon). Now, if the coding (post-splice) sequence bears sufficient similarity, you can with fair confidence say that the genes probably have a recent common origin (on the scale of geological time.)
      Phylogenetic analysis is basically doing this for a wide array of organisms, essentially looking for the most similar gene in terms of 1:1 exon similarity, then using that data to state with high confidence that this gene in aphids is more related to that gene in fungi than any other potential candidate for the source of this gene.

    12. Re:wiki by smellsofbikes · · Score: 1

      The fact that the genes are identical does not mean they're of the same origin.

      Actually, if the genes are identical in terms of nucleotide sequence then it is absolutely irrefutable that they are of the same origin.

      It's indicative that they're the same, but not absolutely irrefutable. Any given sequence of DNA will be 25% identical to any other sequence, just because there are only four bases, while on the other end of the spectrum, even the DNA coding for something highly conserved, like cytochrome C, that exists in just about every eukaryote on the planet, isn't 100% identical across all eukaryotes.

      As such, if you have a gene that's only a couple dozen bases long, it's fairly likely that if you find exactly the same sequence in another genome, they're either related or there's been horizontal gene transfer -- but only fairly likely, because a sequence of 30 bases could easily show up twice just by chance. But really massively long DNA sequences, even if they show very slight differences within them, are extremely likely to indicate ancestral relationships. For instance, while the general function of eyes has evolved 30 or 40 different times (or more, according to Ernest Mayr) the genes coding for the proteins that detect light, enabling vision, generally called opsins have probably only evolved twice, one for bacteria and once for all eukaryotes. But even then, the two gene groups are amazingly similar for having different ancestries.

      My point being: extremely strong indicator, yes. But nothing in science is absolutely irrefutable, and gene similarity is significantly less irrefutable than many scientific theories, because gene content is constantly changing.

      --
      Nostalgia's not what it used to be.
    13. Re:wiki by Follis · · Score: 1

      Your math is way off on the 25% figure. Any sequence with 4 letters in the alphabet and of length x will have probability 1/4^x of being identical to any other randomly chosen sequence of length x.

    14. Re:wiki by smellsofbikes · · Score: 1

      I didn't pay much attention in math class... but would you be willing to explain this a little more? It seems to me that if you have four letters, in a string, any two random strings you look at should have about 25% of their letters match between them. The chances that there will be any *sequences* that match drop as an exponential function of the number of letters in the matching sequence, right? but, for example, caggtcatgactaa and gattacagattaca, have a roughly 20% identical sequence, insofar as they have three points in the sequence with matching bases.

      --
      Nostalgia's not what it used to be.
    15. Re:wiki by Anonymous Coward · · Score: 0

      The chances that there will be any *sequences* that match drop as an exponential function of the number of letters in the matching sequence, right?

      I'm not the GP, but that's probably what he's talking about. The fact that there are 4 bases and "25% of letters will match" is at best misleading, but more like totally irrelevant. Since what we're talking about IS sequences matching, not a few random single-character matches here and there.

      Even short sequences have very low probability of appearing randomly even WITHOUT considering the genetic reasons a sequence would or wouldn't evolve.

    16. Re:wiki by swsbai · · Score: 1

      Impression births brought in big bad determine along one'study, body of http://www.watches21.com/>replica watcheswork and animation.inward reality,impression dissembles not lone unmatchable heed only in addition to hullos body. Those with life-threatening low level impotent to keep their crop or carry extinct rule bodily function* of imprint. The symptoms mainly let in flavours from sorrowfulness, hopelessness, not wanting nutrient http://www.watches21.com/>replica watchesand ail dormant.Besides, depressive disorder costs linked to more former diseases, care heart disease, What's worse, deprssion is one of the main courses of people's suicide.

  2. Horizontal gene transfer?? by Anonymous Coward · · Score: 5, Funny

    Well fuck me sideways.

    1. Re:Horizontal gene transfer?? by pieisgood · · Score: 1

      *slow clap*

      I commend your creativity.

      --
      Eat sleep die
    2. Re:Horizontal gene transfer?? by SETIGuy · · Score: 1

      It's too bad scores are limited to 5.

  3. fungi by Anonymous Coward · · Score: 0

    fungi grow out of insects all the time.

    1. Re:fungi by masterwit · · Score: 0

      fungi grow out of insects all the time.

      Read the article, this is not about fungi growing on insects as it is about gene transfer.

      An article published today in Science shows the first case of animals synthesizing carotenoids.

      Indeed, when they looked for the most similar genes to the aphid carotenoid synthesizing genes they found that they came from fungi, which means they somehow jumped between fungi and aphids, in a process known as horizontal gene transfer. Horizontal gene transfer is not unheard-of in animals, and is actually quite common in plants (yeah, fungi are not plants, I know that), but this is the first time someone has shown a jump from fungi to animals, and that the trait that this gene conveys — color — became embedded and functional in the genome.

      :)

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    2. Re:fungi by MichaelSmith · · Score: 1

      through what mechanism, I ask you..

      DNA strands move between organisms all the time.

    3. Re:fungi by Cassius+Corodes · · Score: 0, Redundant

      To completely blow your mind - did you know we have virus DNA in our DNA? Some of which has even been adapted for our internal use.

      --
      Control is an illusion, order our comforting lie. From chaos, through chaos, into chaos we fly
  4. I knew it! by masterwit · · Score: 4, Informative

    As an aside, many of our pseudogenes and other contents of “junk DNA” are thought to have been acquired by horizontal gene transfer.

    The guy behind the genetically mutated guido, look at his hand. (I'm sorry you cannot un-see that)

    On a more serious note, my roommate, a biology/pre-med major, found this article very interesting and said thanks.

    Apparently horizontal gene transfer (or at least inserting useless bits of DNA) is not very hard to do in a lab environment and is very common in bacteria, viruses, and other single celled organisms. Here is another link I found from 08 that talks about bacteria (E.coli) if anyone wants a read http://genomebiology.com/2008/9/1/R4 (full text). Whatever I'm no expert in this field, but I like this type of stuff.

    --
    We should start a new Slashdot and return control to the geeks. It actually wouldn't be that hard to get some users to
  5. Movies by Thanshin · · Score: 2, Funny

    I wonder how soon I'll see this used in a movie.

    My bet is: Man becomes werewolf after eating many wolves.

    1. Re:Movies by Anonymous Coward · · Score: 0

      Awesome! I'm gonna be a dorito!

      This news also brings up a disturbing image of why some people are such assholes.....

      Captcha:abutters (That's weird.)

    2. Re:Movies by Thanshin · · Score: 2, Funny

      Awesome! I'm gonna be a dorito!

      Nonono. You didn't get it.

      You only get some genes, so you'll just be crispier. Or have a better taste.

      Careful in your next visit to the zoo.

    3. Re:Movies by celibate+for+life · · Score: 4, Funny

      Or have a better taste.

      You have never eaten Doritos, obviously.

    4. Re:Movies by Thanshin · · Score: 2, Insightful

      Or have a better taste.

      You have never eaten Doritos, obviously.

      Or I don't share your fondness for human flesh.

    5. Re:Movies by ZeroExistenZ · · Score: 1

      I wonder how soon I'll see this used in a movie.

      District 9: African leader wants to eat a human mutating into an alien to gain his mutant-properties.
      The way this works isn't explained, yet it's implied it's a voodoo-belief.

      --
      I think we can keep recursing like this until someone returns 1
    6. Re:Movies by foniksonik · · Score: 1

      No that's classic cannabalism. Eat your enemies to gain their power. See the movie Ravenous or wikipedia cannabalism.

      --
      A fool throws a stone into a well and a thousand sages can not remove it.
    7. Re:Movies by Clueless+Nick · · Score: 1

      Is this the very first instance of the noun wikipedia being used as a verb, or is it the very first time I have seen it?

      By the way, and movies aside, read The Ancestor's Tale by Richard Dawkins. It has a brilliant explanation of the various evolutionary genetic processes.

      --
      Chat with other atheists http://secularchat.org
    8. Re:Movies by Idiomatick · · Score: 1

      I've seen 'wiki it' a few times before.... And does Ancestor's tale go into detail about horizontal gene transfer methods? Or just touch on them?

    9. Re:Movies by camperdave · · Score: 1

      ... or turn orange.

      --
      When our name is on the back of your car, we're behind you all the way!
    10. Re:Movies by rcuhljr · · Score: 1

      First time you've seen it, you've heard of googling something I hope?

    11. Re:Movies by Anonymous Coward · · Score: 0

      Bleach the anime?

    12. Re:Movies by riggah · · Score: 1

      You have never eaten MSG, obviously.

      There, fixed that for ya.

  6. Betsey Dexter Dyer on color by CuteSteveJobs · · Score: 4, Interesting

    According to this hottie (see link) black and brown are natural colors produced by pigments; usually red, oranges and yellows are the carotenoids which animals get from foods, and blues and greens (in birds) come from microstructure rather than actual color. (Obviously a green caterpillar gets the color from the diet. A bit different for animals, since I've never seen a green cow.)

    http://www.learnoutloud.com/Catalog/Science/Biology/Basics-of-Genetics/31316

    She also says that horizontal gene transfer is very common, and that 90% of our DNA is viral. The viruses we hear about are the ones that make us sick. The ones that have no ill effects we don't notice so much; these are also called viruses or jumping genes.

    http://wheatoncollege.edu/quarterly/q2003fall/bacteria.html

    1. Re:Betsey Dexter Dyer on color by MichaelSmith · · Score: 4, Interesting

      90% of our DNA is viral. The viruses we hear about are the ones that make us sick. The ones that have no ill effects we don't notice so much; these are also called viruses or jumping genes

      This is why I wonder about sexual behaviour which doesn't lead to reproduction. Could our genes have found ways to propagate themselves without reproduction?

    2. Re:Betsey Dexter Dyer on color by WindBourne · · Score: 1

      It is only a matter of time before our genes make their way back to other species due to virus. Likely it will be short lived species that is in constant contact with us and mosquito's. I would suggest that Canine evolution is still on-going with dogs getting brighter and brighter possibly due to our genes being slowly transferred to them

      --
      I prefer the "u" in honour as it seems to be missing these days.
    3. Re:Betsey Dexter Dyer on color by osgeek · · Score: 1

      According to this hottie (see link)

      Yes, that static-like sound you hear is the cacophony of Slashdotters furiously mashing mouse buttons all over the planet.

    4. Re:Betsey Dexter Dyer on color by Xtravar · · Score: 1

      I would suggest that Canine evolution is still on-going with dogs getting brighter and brighter possibly due to our genes being slowly transferred to them

      lol really? Domesticated dogs smarter than wolves?

      --
      Buckle your ROFL belt, we're in for some LOLs.
    5. Re:Betsey Dexter Dyer on color by mutube · · Score: 1

      In order for genetic material to persist it has to get into the germline cells - that is, sperm or egg - of the host. It's highly unlikely that 'just being around' humans would allow this to happen at all. Bacteria/fungal transfer is possible because, as an infecting pathogen, it can presumably get to where it is in close association with these germline cells - including, and probably limited to, the sexual orifices. So no, I seriously doubt dogs are getting smarter because they're picking up our genes.

      Saying that, if you have found some other way of getting your DNA into your dogs semen, I wish you the best of luck. I suspect you'll need it.

    6. Re:Betsey Dexter Dyer on color by Judinous · · Score: 1

      I'm not sure that I buy that 90% number. The percentage of our DNA that is composed of endogenous retroviral material is around 5-8%. ERVs are horizontal gene transfers that occur in germ-line cells, such as sperm, ova, and all of the cells in their ancestry back to the original zygote for that individual. Genetic changes to these cells (and only these cells) will be passed down to future generations.

      Now, it's true that ERVs are not the only type of viral DNA that an individual may have in their cells. Any infection of a somatic (non-germ-line) cell by the appropriate type of virus since the individual's conception will lead to chimeric DNA in some part of the body. For example, well over 90% of American adults have had some form of herpes infection during their lives, such as chicken pox or herpes simplex. This becomes a permanent addition to the DNA in the infected portions of the body, but it is NOT passed down to offspring.

      The reason that your 90% figure doesn't pass the sniff test is because it would mean that more than 80% of the DNA in an individual's body would be acquired AFTER birth. If this were true, then wouldn't we expect to see huge, obvious differences between individuals throughout the entire genome? This is definitely not what we see when we sequence DNA. After all, which diseases an individual contracts, when they contract them, and in what order is essentially never the same. Hell, the difference between a human and a chimpanzee's genome is only about 4%. The difference between individual humans is far smaller than that, so it seems likely that only a small (probably 1%) percentage of an individuals genome is made up of viral material obtained since birth. This passes the sniff test as well; you'd expect the genetic insertions that have accumulated over millions upon millions of years in germ-line cells to far outweigh the horizontal gene transfers that happen within a single individual's lifetime.

    7. Re:Betsey Dexter Dyer on color by WindBourne · · Score: 1

      So, you do not think that virus work their way back into germ cells? Hmmm. What exactly do you think feeds those? Do not think that blood is involved? Something new? And by what mechanism are virus blocked from entering germ cells?

      Now, if you have solutions for those (a different form of circulation other than bood and lymphatic that isolates the germ cells; and a means of blocking all virus from germ cells), then please share with the world, since you will win an INSTANT nobel prize.

      BTW, back in 77-81, I was used to taking hits by my profs. Back then, I was arguing that DNA/RNA HAD to do work (like a protein). Why? Because Life assumes the lowest level of energy possible. It will excise an extra RNA/DNA that is not needed. Carrying that around is VERY expensive. Yet, it does carry it around. Interestingly, Tom Czech got a nobel prize for paying attention. This is the exact same thing.

      --
      I prefer the "u" in honour as it seems to be missing these days.
    8. Re:Betsey Dexter Dyer on color by mutube · · Score: 1

      To be honest I missed the part in your post about the viral vector - I thought you were suggesting some direct gene transfer human-dog which was bizarre.

      It still seems a stretch to suggest that horizontal transfer from human to virus, then virus to dog could occur on anywhere the level required to produce an observable effect on canine intelligence. The vast majority of viruses are species-locked or species-limited and even if the virus can infect a host, the virus is further limited in which cells in the body it is capable to infect - not just by access (blood supply - there is actually a testis-blood barrier, similar to the brain to prevent autoimmunity, but I'll admit to being unsure of it's role in preventing infection) but by receptor specificity. The only canine viral zoonose I know if is rabies (please feel free to correct me), and I can't find any evidence of that infecting germline cells - it's neurotropic. Bacteria and parasites are probably a better bet, but not by much.

      Apologies for missing the point of your OP, but I still have a hard time buying it.

    9. Re:Betsey Dexter Dyer on color by TheLink · · Score: 1

      > For example, well over 90% of American adults have had some form of herpes infection during their lives, such as chicken pox or herpes simplex.
      > This becomes a permanent addition to the DNA in the infected portions of the body, but it is NOT passed down to offspring.

      In most cases no. But in other cases see this: http://www.redorbit.com/news/science/1833268/herpes_virus_can_integrate_its_dna_into_human_chromosomes/index.html

      Quote: "The USF team also confirmed preliminary results by other investigators that, a long time ago, the virus inserted its DNA into the DNA of human sperm and egg cells. As a result, some people (about 1 percent of people in the U.S.) are born with the virus's DNA in every cell in their body. Indeed, HHV-6 is the first functional virus of any type reported to be passed through the human germ line."

      As for other sorts of DNA transfer, I wouldn't say "never", after all an aphid can somehow get a fungus gene...

      > Hell, the difference between a human and a chimpanzee's genome is only about 4%. The difference between individual humans is far smaller than that,

      A bit offtopic, but since this keeps coming up, I find it strange that scientists can say that sort of stuff and also say there are no racial differences in humans.

      If http://www.healthfinder.gov/news/newsstory.aspx?docid=638412

      Plenty of other examples.

      Even the ability to digest milk, and process alcohol differs significantly. And the ability to run 100 metres really fast ;).

      To me it's silly to not think there's a human significant[2] difference between a 7 foot tall "West African" human breed and a Mbenga pygmy human breed. Maybe dogs can even smell the difference between those two breeds.

      [1] This "big difference" is of course relative, to some alien creature made of "dark matter and dark energy", all the stuff on the Earth could look pretty much the same to them - and rather strange (we're the abnormal ones since most of the universe is apparently made of something else ;) ).

      [2] Significant for human stuff, at a human level.

      --
    10. Re:Betsey Dexter Dyer on color by TheLink · · Score: 1

      (Sorry reposting with corrections - lost a chunk due to forgetting how slashdot processes "plain old text")

      > For example, well over 90% of American adults have had some form of herpes infection during their lives, such as chicken pox or herpes simplex.
      > This becomes a permanent addition to the DNA in the infected portions of the body, but it is NOT passed down to offspring.

      In most cases no. But in other cases see this: http://www.redorbit.com/news/science/1833268/herpes_virus_can_integrate_its_dna_into_human_chromosomes/index.html

      Quote: "The USF team also confirmed preliminary results by other investigators that, a long time ago, the virus inserted its DNA into the DNA of human sperm and egg cells. As a result, some people (about 1 percent of people in the U.S.) are born with the virus's DNA in every cell in their body. Indeed, HHV-6 is the first functional virus of any type reported to be passed through the human germ line."

      As for other sorts of DNA transfer, I wouldn't say "never", after all an aphid can somehow get a fungus gene...

      > Hell, the difference between a human and a chimpanzee's genome is only about 4%. The difference between individual humans is far smaller than that,

      A bit offtopic, but since this keeps coming up, I find it strange that scientists can say that sort of stuff and also say there are no racial differences in humans.

      If 4% can make such a big[1] difference between chimpanzees and humans, it seems foolishness to say that humans are all the same (and also DNA fingerprint humans ;) ). Yes, race is very imprecise term, but there are certainly breeds of humans. They're not as clearly distinct as say dog breeds, but there are differences.

      Lots of diseases affect different breeds of humans differently: http://www.healthfinder.gov/news/newsstory.aspx?docid=638412

      Plenty of other examples. Even the ability to digest milk, and process alcohol differs significantly. And the ability to run 100 metres really fast ;).

      So to me it's silly to not think there's a human significant[2] difference between a 7 foot tall "West African" human breed and a Mbenga pygmy human breed. Maybe dogs can even smell the difference between those two breeds.

      [1] This "big difference" is of course relative, to some alien creature made of "dark matter and dark energy", all the stuff on the Earth could look pretty much the same to them - and rather strange (we're the abnormal ones since most of the universe is apparently made of something else ;) ).

      [2] Significant for human stuff, at a human level.

      --
    11. Re:Betsey Dexter Dyer on color by WindBourne · · Score: 1

      Hmmm. HIV? Swine and Avian Influenza? Swine and Avian comes to mind REAL quick. But that is simply because they cause a large amount of symptoms in multiple species. Likewise, HIV is certainly interesting to me, Personally. The reason is that I worked for CDC in 1980-81. I got to see ground zero of 'the homosexual disease' (and have to say that it played a major part in my switching careers to CS. 'The band played on' as well as the current written history, miss so many important thing from those early days). The reason why we know about certain virus/bacteria/parasites is because we went looking for things causing symptoms. We do not go simply trying to isolate virus. And these days we do not do that. Heck, look in on the history of the duodenal ulcers and H. pyroli (spelling?).

      Once we start exploring for asymptomatic virus, like we used to do for bacteria, then we will see a whole new and surprising world. I believe that we will re-write out understanding of evolution. Hopefully, somebody will be bright enough to realize the importance of species diversity and the fact that we need a large number of species to be close to us.

      --
      I prefer the "u" in honour as it seems to be missing these days.
    12. Re:Betsey Dexter Dyer on color by mutube · · Score: 1

      HIV and influenza can cross species barriers - but neither infects dogs! They are also severely limited on which host cells they can infect and neither makes it into the germline. But, the point you make about asymptomatic viruses is an interesting one - the potential there is certainly underinvestigated - purely because of the large signpost screaming 'infection!' that usually gets the attention. The other side is interesting too - endemic infections that, aside from their obvious pathology, aren't investigated as 'if everyone has it, it must be harmless' - H. pylori fits the bit exactly. A personal favourite on this front is the EBV (glandular fever/infectious mononucleosis) link to multiple sclerosis (there were studies on the Faroes where the disease should be high (due to low UV/Vit-D, another risk factor) but basically only appeared following UK occupation during WWII).

      So in that sense, I agree with you. I still find the original premise with the dogs to be a bit far fetched, but I guess stranger things have happened.

    13. Re:Betsey Dexter Dyer on color by Xtravar · · Score: 1

      Interesting! Thanks for the links.

      --
      Buckle your ROFL belt, we're in for some LOLs.
    14. Re:Betsey Dexter Dyer on color by WindBourne · · Score: 1

      The problem that we have is multi-fold. America used to be the PREMIER RD country. Sadly, reagan destroyed all that (what a crime). But that was followed by the drug companies realizing that they made more money by treating symptoms than the diseases. There is a good example of this: Psoriasis. Right now, drug companies are running around screaming that it is genetic (just like the ulcers). Yet, if you look at the incident rate, it is growing leaps and bounds inside of America. It is growing much faster than genetics would explain it. Yet, all of the treatments are for the SYMPTOMS. BTW, my bet is that this is a bacteria, not a virus. I wish that some RD bacteriologist would focus on this. I could even provide a simple set of tests to show it.

      If we are going to find solutions for things like Psoriasis or even a good understanding of our genetic evolution, we have to get back to fundamental RD. My understanding is that Obama has bumped it up, but even here, I have yet to have heard what happened with DARPA. It used to do loads of fundamental RD, but W/Cheney forced them to drop that and focus on giving money to corporations (very short term goals) rather than the universities (long term fundamental goals). And even finding virus that are carrying genes is an easy, though long term issue. Basically, create 4,6,8 clone dogs, freeze several of the embryo's, and have them be around the same person(s) for the rest of their lives. At end of life of the dogs, start up again with another 2 clones. Finally, check for the difference in the DNA. It is highly likely that several (or more ) of the differences were caused by virus that were transmitted either between the dogs, OR between humans/dogs. Well, if the same sequence is in 1 or both of the first dogs, show up in the next set of dogs, then almost certainly, they were exposed to the same item. Easy, and relatively cheap to do. Of course, it will be a long experiment, but that is needed now to figure out what crosses. Do note that we could try the same with other species such as cats, mice, etc. Of course, the longer the species lifetime, the better the chance of getting multiple transfers.

      --
      I prefer the "u" in honour as it seems to be missing these days.
    15. Re:Betsey Dexter Dyer on color by Anonymous Coward · · Score: 0

      I LOL'ed!

  7. Correlation fallacy, much? by Rogerborg · · Score: 0, Redundant

    From the source paper:

    Phylogenetic analyses show that these aphid genes are derived from fungal genes, which have been integrated into the genome and duplicated.

    Until you observe the process happening, all you've got is correlation. Even if it is gene transfer, how do you know the transfer wasn't the other direction? I call XKCD on that.

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    1. Re:Correlation fallacy, much? by Clueless+Nick · · Score: 0, Troll

      By looking at other aphids.

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    2. Re:Correlation fallacy, much? by brusk · · Score: 5, Informative

      Most knowledge about evolutionary biology is based on evidence like this, and there are lots of ways to be pretty confident about such conclusions, even if there's no way to 100% rule out chance. If this gene and/or others like it are widespread in fungi, that's a hint that it developed in fungi--and under some conditions you might be able to show that the gene evolved in fungi before aphids even existed. Conversely, if no other aphids or related species have anything like this gene, it's a good bet that it came from outside. If the gene evolved suddenly in one lineage of aphids and transferred to a fungus, you would expect only a limited range of fungi, and only those that evolved after aphids did, to have the gene.

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    3. Re:Correlation fallacy, much? by Anonymous Coward · · Score: 5, Informative

      The transfer definitely did not go in the other direction, as the genes for the carotenoids would have had to travel back up the phylogenetic tree and down its other branches to all the other organisms containing carotenoids. The argument that the aphids evolved genes to express carotenoids in parallel to the part of the phylogenetic tree containing them does not fit into the current model for evolution, as a gene only evolves once, and any other organism containing that gene is descended from the organism that originally mutated to express that gene (this uses statistics and probabilities too!).

      Anyway, in almost every science nothing is solidly proven, there are merely theories. Everyone objecting to the validity of this article has been doing too much statistics and not enough biology. You can rest assured the article went under much more intense scrutiny than comparison to a webcomic to get published in Science (no matter how awesome that webcomic is).

    4. Re:Correlation fallacy, much? by Anonymous Coward · · Score: 0

      http://xkcd.com/386/

    5. Re:Correlation fallacy, much? by Anonymous Coward · · Score: 0

      there is an error in DNA replication once in every ~10,000 times, factor in the 30,000 base pairs that need to be changed to the right base (1/4), and that they need to not be selected against (interrupting a vital gene, intermediate evolutionary forms becoming detrimental, etc.), be associated with the right promoters (shine-delgarno sequences), i would guess off the top of my head that the odds of aphids evolving the gene for carotenoids is 1 in 10^100,000,000 at least.

    6. Re:Correlation fallacy, much? by Hurricane78 · · Score: 0, Offtopic

      I had to be reminded yesterday, that we can never ever directly observe causation anyway. All that we can observe, is correlation with as much other variables removed as possible. This is because physics at least demands the spacetime volumes to be different for two different (fermion-based) objects. (Pauli exclusion principle)

      So observation alone still is not worth much more. Example: When I observe rain, I also observe that less people are outside. But that does not mean that people cause sunshine. :))

      By the way: Have you also read the mousover text on that xkcd comic?

      --
      Any sufficiently advanced intelligence is indistinguishable from stupidity.
    7. Re:Correlation fallacy, much? by Anonymous Coward · · Score: 0

      But maybe it's all God's fault?

    8. Re:Correlation fallacy, much? by Paltin · · Score: 1
      So, correlation does not imply causation.

      But, that's not what is happening here. The systems of genetic transfer and mutation are very well understood. There are extremely robust models that explain this exact process and how to detect that have withstood the test of time.

      For an example, here's one from wikipedia:

      B causes A (reverse causation)

      The more firemen fighting a fire, the bigger the fire is going to be. Therefore firemen cause fire.

      The above example is simple and easy to understand. The strong correlation between the number of firemen at a scene and the size of the fire that is present does not imply that the firemen cause the fire. Firemen are sent according to the severity of the fire and if there is a large fire, a greater number of firemen are sent; therefore it is rather that fire causes firemen to arrive at the scene.

      In that example, the absurdity is that we know that larger fires are responded to by firemen, and more come when there is a fire. You're arguing that unless we actually saw the fire growing THIS time, we can only say there is correlation. That's stupid. We have a model of fire growth and fireman response then has been developed through empirical observation. We have a model of evolutionary change and of horizontal gene transfer that has been tested and validated through many, many studies. You need to present an alternative that is more likely in order to explain this away, not just wave your hands, close your eyes, and go "Nyah nyah nyah!"

    9. Re:Correlation fallacy, much? by Clueless+Nick · · Score: 1

      I know this is bad etiquette, but 'looking at other aphids' means genome sequencing of other aphid species, which can clarify if the same gene / allele appears in other species' genome.

      It would be a very very rare chance by which a highly similar gene / allele mutates and evolves independently in a fungus as well as an aphid.

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    10. Re:Correlation fallacy, much? by telomerewhythere · · Score: 1

      Fahrenheit 451 was wrong? Say it ain't so.

    11. Re:Correlation fallacy, much? by Anonymous Coward · · Score: 0

      Most knowledge about evolutionary biology is based on evidence like this, and there are lots of ways to be pretty confident about such conclusions, even if there's no way to 100% rule out chance. If this gene and/or others like it are widespread in fungi, that's a hint that it developed in fungi--and under some conditions you might be able to show that the gene evolved in fungi before aphids even existed. Conversely, if no other aphids or related species have anything like this gene, it's a good bet that it came from outside. If the gene evolved suddenly in one lineage of aphids and transferred to a fungus, you would expect only a limited range of fungi, and only those that evolved after aphids did, to have the gene.

      Indeed. Also, there's no way to prove that your post is actually as Informative as the moderation implies, and not just the product of an bunch of monkeys who got loose and started banging on keyboards in an Internet cafe. (In fact, the quality of most Slashdot posts would seem to suggest it.)

  8. More proof you Darwinist fools have it all wrong! by Anonymous Coward · · Score: 1, Funny

    Find something your precious "evolution" can't explain and suddenly it's "horizontal evolution"? Can't you see the facts as clear as day? This is the Intelligent Designer porting features from one creature to another!

  9. Re:More proof you Darwinist fools have it all wron by MichaelSmith · · Score: 1

    Well he's doing a shit job. Probably using ClearCase.

  10. Kinda like mother nature doing dna tie dyes by Bob_Who · · Score: 3, Funny

    Deadhead Aphids always like their fungus for the visual effect.

  11. Just wait until... by Errol+backfiring · · Score: 3, Insightful

    Individuals are sued by Monsanto for being polluted by their patented genes.

    --
    Nae king! Nae laird! Nae yurrupiean pressedent! We willna be fooled again!
    1. Re:Just wait until... by Anonymous Coward · · Score: 0

      Individuals are sued by Monsanto for being polluted by their patented genes.

      FDA hearing, 2234:"Monsanto wishes to add mammalian submissiveness genes to corn. Granted. Nothing worse than unruly vegetables."

  12. Nature's own GMO by mspohr · · Score: 2, Insightful
    This is an example of why I don't worry about man-made genetically modified organisms. It you have studied biology, you realize that nature is constantly shuffling DNA from one organism to another across species, genera, phyla and here across kingdoms.

    Nature is constantly performing billions of genetic engineering experiments, most of which don't work out. Sometimes there is a small evolutionary advantage. I don't worry about the "frankenfoods" taking over the world. Nature is constantly performing these experiments and the result is the the current highly optimized system we call "life on earth". Anything man creates just goes into the universal gene pool and has to compete with an already highly evolved system.

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    1. Re:Nature's own GMO by biryokumaru · · Score: 4, Insightful

      To play devil's advocate here, a tiger represents millions of years of predatory evolution, yet we can still hunt it to extinction. Just because nature's been doing this a lot longer then we have doesn't mean its aims are the same as ours.

      When you're talking about evolution on the scale of millions of years, there's a selective pressure not to kill everything else around you. GE crops have no such incentive, and could quite possibly be extremely hard on the soil. Planting crops without regard to the needs of the soil is what led to the dust bowl.

      Of course, it's more than likely anything we create will be able to perform its intended function fairly well, but be utterly unable to cope with any other situation and quickly die out. I don't imagine we'd create anything highly adaptable, that's nature's thing.

      --
      When you're afraid to download music illegally in your own home, then the terrorists have won!
    2. Re:Nature's own GMO by mspohr · · Score: 1
      Large animals are relatively easy to hunt to extinction. (The disappearance of woolly mammoths and saber tooth tigers, among others, corresponds clearly with the "rise" of humans). However, genes are nearly impossible to get rid of... the genes of extinct animals live on in their relatives.

      I would argue that "selective pressure" is a competition designed to get rid of "less fit" genes, not to encourage them. However, as in the case of large animals, even "unfit" genes have a way of hanging around forever as a small reservoir of "inactive" or "junk" DNA that lies in wait for external conditions to favor its return... kind of like a government in exile.

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    3. Re:Nature's own GMO by ChromeAeonium · · Score: 2, Interesting

      AMEN. As one planning on going into this area, I think about genetic engineering a lot, and that was the first thing that came to my mind too. I love how the anti-GE guys out there rail against the 'dangers' of foreign DNA being inserted into plants yet are blissfully unaware that species get foreign DNA all the time. Humans are 3-8% viral DNA depending on who you ask, and we're more genetically similar to chimps than two unrelated types of corn are to each other. My worry is that, in typical crank fashion, they'll take something like this and say 'See, we were right, inserted genes can jump to other plants, nya, nya, nya!' and totally miss the fact that it could happen with anything, especially in plants. But this won't stop them from parading their ignorance any more than facts stopped anti-vacationists or any other denialist group. They're right, and damn it, any science that proves them wrong, no matter how overwhelming, is clearly part of a plot by Monsanto to make them sick (cause killing your customers is a great business model), and therefore it to be dismissed or misused. A few million years of accumulated random mutations and horizontal gene transfer and a little human selection is fine and dandy, but add one gene in a controlled setting in a precise manner, and suddenly you've gone too far and no amount of testing well catch any problems all because scientists are either arrogant ebil B-movie villains or unethical, bribed off conspirators. Riiiiight.

    4. Re:Nature's own GMO by V+for+Vendetta · · Score: 1

      I love how the anti-GE guys out there rail against the 'dangers' of foreign DNA being inserted into plants yet are blissfully unaware that species get foreign DNA all the time.

      Yes. Perhaps with the little insicnificant difference that nature tests its "genetic engineering" thouroughly a couple of million years before releasing it to the public ...

    5. Re:Nature's own GMO by osgeek · · Score: 2, Informative

      I don't imagine we'd create anything highly adaptable, that's nature's thing.

      Genetic tinkerers don't create anything in the "from scratch" sense. They copy complex and fully-formed genes from one life form to another.

      It's like using a well-debugged library in a new application.

    6. Re:Nature's own GMO by ChromeAeonium · · Score: 1

      You must be joking. Tell that to to people who are allergic to peanuts, or have celiac's and can't eat wheat, or had a drug interaction with a grapefruit, or died from eating a starfruit. Don't anthropomorphize nature. It doesn't care of how things turn out, it doesn't care if you have an anaphylactic reaction to kiwis or whatever, it just is. It just goes, and while it does so fantastically, it doesn't care what effects any given mutation will have. Giving it any traits beyond that is just magical thinking.

    7. Re:Nature's own GMO by snowgirl · · Score: 1

      To play devil's advocate here, a tiger represents millions of years of predatory evolution, yet we can still hunt it to extinction. Just because nature's been doing this a lot longer then we have doesn't mean its aims are the same as ours.

      When you're talking about evolution on the scale of millions of years, there's a selective pressure not to kill everything else around you. GE crops have no such incentive, and could quite possibly be extremely hard on the soil. Planting crops without regard to the needs of the soil is what led to the dust bowl.

      Of course, it's more than likely anything we create will be able to perform its intended function fairly well, but be utterly unable to cope with any other situation and quickly die out. I don't imagine we'd create anything highly adaptable, that's nature's thing.

      Like Corn/Maize... which can't propagate without human intervention. If we disappeared, the first generation of corn would overseed the soil, and each kernel would compete against all the others to grow, and result in each one starving out.

      We don't need GMO to make plants that are "utterly unable to cope with any other situation".

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    8. Re:Nature's own GMO by biryokumaru · · Score: 1

      Like Corn/Maize... which can't propagate without human intervention.

      I've always felt that artificial selection should be considered genetic engineering. I don't know why it isn't.

      --
      When you're afraid to download music illegally in your own home, then the terrorists have won!
    9. Re:Nature's own GMO by Anonymous Coward · · Score: 0

      Because people, in general, are not very well educated?

    10. Re:Nature's own GMO by Urkki · · Score: 1

      This is an example of why I don't worry about man-made genetically modified organisms. It you have studied biology, you realize that nature is constantly shuffling DNA from one organism to another across species, genera, phyla and here across kingdoms.

      Nature is constantly performing billions of genetic engineering experiments, most of which don't work out. Sometimes there is a small evolutionary advantage. I don't worry about the "frankenfoods" taking over the world. Nature is constantly performing these experiments and the result is the the current highly optimized system we call "life on earth". Anything man creates just goes into the universal gene pool and has to compete with an already highly evolved system.

      Yes, but if this "natural experimentation" hits something extraordinary, it may be a disaster for the current ecosystem. It doesn't happen much in nature, in fact it's very rare on human time-scales. But when we start to do it, it suddenly happens much more frequently, and therefore also changes that may ravage ecosystems happen much more frequently. Also, in nature, every change is "out there", even if they actually do nothing. Humans purposefully design changes that do something, and only "working" changes are released into the nature. So humans are much more, let's say, efficient than nature at messing with ecosystem gene pools.

      It's pretty much the same argument as this: Since animals shit in the nature, it's ok for humans dump their sewage into the nature as well, just like has happened throughout the history. Clearly a wrong conclusion, if you're worried about well-being of people.

    11. Re:Nature's own GMO by Urkki · · Score: 1

      Like Corn/Maize... which can't propagate without human intervention.

      I've always felt that artificial selection should be considered genetic engineering. I don't know why it isn't.

      Because genetic engineering means manipulating the genes directly. Artificial selection doesn't do that, it let's the "normal" natural processes to do al the actual gene manipulation. I guess the borderline case is analyzing the DNA and performing artificial selection based on genotype. On the "traditional" side of that is artifical selection based on phenotype, and on the genetic engineering side is manipulating the genome directly (as opposed to let any DNA altering things happen in the "natural" way).

      Or to put it the other way, "genetic engineering" means engineering based on genes. If you're not dealing with genes directly (be it just sequencing or actively altering), you're not doing genetic engineering.

      If artificial selection is like an illiterate selecting books from a pile somebody else carried out of the library (of the Congress) based on how nice they look, genetic engineering is like actually going into the library and opening and reading books it before selecting, and making footnotes, and actually replaceing pieces of text and (eventually) writing entire new chapters, even writing new books (even farther into the future).

      So if you want to call plain old artificial selection "genetic engineering", then "genetic engineering" needs a new name.

    12. Re:Nature's own GMO by ChromeAeonium · · Score: 1

      It isn't because there is a technical difference (randomly mixing thousands genes via controlled pollination vs. inserting one gene precisely) even if the end product is similar, indeed, I don't see how any GMO trait could not be achieved with sufficient time and breeding (although we might be talking on an evolutionary timescale here), but let's call a spade a spade, the reason so many people act like there's such a huge difference is mostly because genetic engineering is new and creepy and they don't understand it, and a dash of scientific illiteracy doesn't help either. Breeding is something kindly old folks do in tune with nature in the bright warm orchard, genetic engineering is something arrogant crazy haired wild eyed mad scientists cook up in some creepy lab. But at the end of the day, they both result in plants that have had their genetic make-up altered to suit humans.

      People act as if there is a rift between genetic engineering and breeding techniques. There's not, they're just different tools for different situations, and each have their uses. You wouldn't try to saw a board with a level or pound in a nail with a wrench, yet these anti-GE people expect all plant advances to come through breeding, and that's just not going to happen. Why should it, that's just silly. We need both. Theoretically GE can replace breeding entirely one day but that day will not come for a long time, so in the mean time, we need both types of genetic manipulation. I think everything commercially grown should be genetically modified, plenty of benefits and no known negatives, but thanks to all the baloney floating around the net about GMOs, that seems like an extremist, radically pro-science position any more.

      I can't imagine the reaction we'd be getting today of things like breeding and grafting were invented today. I'm reminded of a story about people who went to Africa to teach people in Cameroon about grafting and breeding and they were met with skepticism over the 'white man's magic,' but they soon came to realize the benefits. If they had access to people propagating misinformation and spreading FUD I wonder if their situation would have become similar to the one the developed world now faces with GMOs.

      Personally, my two biggest horticultural interests are improving agricultural biodiversity by improving underutilized fruit crops, like pawpaw, goumi, jaboticaba, zabala, dragon fruit, ect., through breeding (because we presently really can't use genetic engineering to manipulate flavor; there are too many genes involved there and it is too complex for us right now) and improving other traits like hardiness or virus/pest resistance through genetic engineering, and I think it is a darned shame so many asshole groups have used misinformation and scare tactics to get the public so scared over something we should be embracing with open arms.

    13. Re:Nature's own GMO by snowgirl · · Score: 1

      Civil engineers on occasion still dig trenches. (in German, I'd say "let a trench be dug," and it sounds fine, but in English it sounds like I'm being a pompous bitch.)

      Just because it's not the "high brow" version, or bleeding edge version, doesn't mean it doesn't qualify.

      Artificial selection is simply a tool of genetic engineering. And considering the differences between Maize and its closest cousin Teosintes; round-up ready crops are insignificantly different.

      --
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    14. Re:Nature's own GMO by ChromeAeonium · · Score: 1

      It isn't because there is a technical difference

      It IS because there is a technical difference.

    15. Re:Nature's own GMO by Urkki · · Score: 1

      Civil engineers on occasion still dig trenches. (in German, I'd say "let a trench be dug," and it sounds fine, but in English it sounds like I'm being a pompous bitch.)

      Just because it's not the "high brow" version, or bleeding edge version, doesn't mean it doesn't qualify.

      Artificial selection is simply a tool of genetic engineering. And considering the differences between Maize and its closest cousin Teosintes; round-up ready crops are insignificantly different.

      The results don't really matter, what matters is the methodology. Without the idea of genes and knowledge that genotype and phenotype are different, there can be no genetic engineering. Even with that knowledge, it won't be genetic engineering unless the knowledge is actively applied.

      So I'll give you that genetic engineering pre-dates discovery of DNA. In Europe I guess genetic engineering was first practised when Mendelian genetics was applied into practical breeding. But I bet most artificial selection (if you count 3rd world and hobbyist breeding) even today isn't genetic engineering, because it's not based on genes, but on phenotype alone. And artificial selection pre-dates genetics by many millennia...

      Or, digging with a shovel can be used in civil engineering, but more often it's used in gardening.

    16. Re:Nature's own GMO by snowgirl · · Score: 1

      While I understand that genotype and phenotype can be different, on a large statistical scale those phenotypical features that are governed by genotype become apparent, and can be selectively applied.

      The idea that until we had Mendelian genetics we didn't practice "genetic engineering" in artificial selection is, in my opinion, a dim view; the same that purposes that people simply forgot that the Earth was round after the Greeks proved it.

      They may not have understood the actual mechanism, but they still understood descent with modification. When Darwin proposed the Origin of Species there was no question as to his premise of "decent with modification"... it is perhaps the single greatest known fact of evolution.

      I suppose it is all about where one chooses to draw the semantic lines. I don't see an actual knowledge of the mechanisms as absolutely necessary to the process of genetic engineering... mechanical and electrical engineers did a lot of work without understanding what they were really working with.

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    17. Re:Nature's own GMO by Urkki · · Score: 1

      People act as if there is a rift between genetic engineering and breeding techniques. There's not, they're just different tools for different situations, and each have their uses.

      I'd say the difference is pretty much like the difference between traditional windmill and an atomic power plant. There certainly is a rift, one has vastly more potential to do damage to the environment. (Of course, if you take into account population growth and all that, relying on old "safe" methods, may indirectly end up doing more damage than using newer, potentially more dangerous but otherwise superior methods, but that's beside the point when assessing the direct damage potential.)

      The key thing with genetic engineering, as with all changes in environment, is how fast it can change the environment. And genetic engineering taken to the extreme can change it very rapidly, changing ecological niches of species very rapidly (because of acquired genes that give competitive advantages). And a very rapid change pretty much equates mass extinctions, when natural mechanisms of evolution can't keep up with the change.

      If there were no restrictions on use of genetically engineered plants, probably thousands or millions of new genes would be brought to the market (engineered into plants and animals), then to the field, and unavoidably some of them would get horizontally transferred into wild species. And some of millions is quite a lot. And it's not even restricted to plants. If non-neutered genetically engineered pets were legal (I don't know if they are), it takes just one escaping or getting lost to potentially get that gene into the feral/wild population. Also, there (almost by definition) can't be any genetic "failsafe" that a mutation can't disable (either mutation in that failsafe gene, or mutation in other gene making the failsafe ineffective). I'd be especially worried about genetically engineered pet rodents getting those novelty genes into the wild. For example imagine a seemingly benign set of genes allowing different diet than normal, nice for pet owner and/or for the pet's health, but probably also nice for vermin control businesses profits after a few generations of recombining in wild vermin population.

      Would you dare to make a claim, that ubiquitous use of genetic engineering does not lead to spreading of new genes (especially between plants) orders of magnitude faster than occurs naturally? Or would you deny that this inflow of new genes will change ecosystems radically? Or would you deny that radical changes in ecosystems won't be any problem?

    18. Re:Nature's own GMO by SEE · · Score: 1

      Selective breeding techniques for plants used most of the last hundred years involve breaking up chromosomes with radiation to create new and completely untested genes, then taking any of the mutants that seem to have benefited from this and spreading their randomly-created genes far and wide throughout the species.

      Genetic engineering takes long-existing genes of known function and carefully inserts them into a species to create a predictable effect.

      And yet people who do the second are the ones who get portrayed as having "vastly more potential to do damage to the environment".

      The fact is, we know to a fairly high probability what, say, a Vitamin A producing gene spliced into rice from a bacterium could do if accidentally spread; it would, no matter where it wound up, create Vitamin A. That might have an accidental secondary effect if some species has a Vitamin A-bound process, of course. On the other hand, we do not know, to any degree of significance, what a new, radiation-created gene that seemed to increase maize yield will do in the wild. Yet it is the former, not the latter, which we have all the regulatory control upon, which the European Union bans, and you are comparing to atomic power plants.

      Would you dare to make a claim, that ubiquitous use of genetic engineering does not lead to spreading of new genes (especially between plants) orders of magnitude faster than occurs naturally?

      I thought we were comparing genetic engineering to selective breeding techniques in common use, not nature. It's provably true that genetic engineering does not spread new genes any faster than the methods of mutation and selective breeding used during the bulk of the last century. All that changes with genetic engineering is we can select existing genes of known function deliberately instead of creating new genes of unknown effects randomly.

    19. Re:Nature's own GMO by Urkki · · Score: 1

      Selective breeding techniques for plants used most of the last hundred years involve breaking up chromosomes with radiation to create new and completely untested genes, then taking any of the mutants that seem to have benefited from this and spreading their randomly-created genes far and wide throughout the species.

      Genetic engineering takes long-existing genes of known function and carefully inserts them into a species to create a predictable effect.

      The crucial difference can be read between the lines even in your text. Speed. Being able to engineer the genetic changes allows churning out new, functional genetic variations at far faster pace. I'd expect our capability to double per two years or so (as calculated in man-years to engineer a new genetic functionality, or amount of functional changes engineered per generation, or number of interacting genes possible to handle, or whatever is relevant to the field).

      Also our ability to put these rapidly developed functionalities out as products will grow fast. I'm talking about stuff like every kennel and stable having cheap artificial-insemination-with-gene-splicing capability, initially needing an off-site lab, eventually using something like a semi-automatic on-site device.

      And also, creating changes randomly will likely create changes that interoperate with other genes of the same species, and are less likely to be efficient or even work on different species. Individual genes introduced by genetic engineering are by necessity independent and work well on different species, and thus always have high potential to get fixed in a "contaminated" wild population.

      And yet people who do the second are the ones who get portrayed as having "vastly more potential to do damage to the environment".

      Well, indeed it does. For a less hyperbolic example than the nuclear power plant one, compare a shovel and a backhoe (digging machine). They do pretty much the same thing in principle, yet power outages are rarely caused by shovels, regularly by backhoes.

      The fact is, we know to a fairly high probability what, say, a Vitamin A producing gene spliced into rice from a bacterium could do if accidentally spread; it would, no matter where it wound up, create Vitamin A. That might have an accidental secondary effect if some species has a Vitamin A-bound process, of course. On the other hand, we do not know, to any degree of significance, what a new, radiation-created gene that seemed to increase maize yield will do in the wild. Yet it is the former, not the latter, which we have all the regulatory control upon, which the European Union bans, and you are comparing to atomic power plants.

      Indeed, and as far as I can see, there are good technical reasons for it. They are different thing. One is known, one is unknown. Though the EU ban was on political level of course mostly based on irrational fear and protectionism, not technical details, but IMHO in this case they lead to the same conclusion.

      And then there's the whole intellectual property mess (farmers getting sued, gene patenting in general, question of responsibility in case of economic or ecological damage caused by patented genes leaking into the wild or into the neighbouring farm), but let's not go there.

      Would you dare to make a claim, that ubiquitous use of genetic engineering does not lead to spreading of new genes (especially between plants) orders of magnitude faster than occurs naturally?

      I thought we were comparing genetic engineering to selective breeding techniques in common use, not nature. It's provably true that genetic engineering does not spread new genes any faster than the methods of mutation and selective breeding used during the bulk of the last century. All that changes with genetic engineering is we can select existing genes of known function deliberately instead of creating new genes of unknown effects r

    20. Re:Nature's own GMO by BlargIAmDead · · Score: 1

      I don't have a problem with us adding genes to plants. Hell, start adding genes to people! Put computer chips in someone else's brain first...then I'll jump in! Let the furries live their dreams!

      Where I have a problem is when Monsanto comes in after the fact and says "Well, well, well...awfully good looking crops ya have there. Be a shame is something were to happen to them. Like say our dominant gene with a kill switch enabled in it were to cross pollinate with your current crop....a reeeeaaaal shame. Guess we have no choice BUT to sue you. You're in cahoots with Mother Nature to steal our IP after all. Oh and your barn looks flammable too."

    21. Re:Nature's own GMO by V+for+Vendetta · · Score: 1

      You must be joking.

      Sure, I'm joking. And while I was at it, I made up Superbugs and Superweed as well. And let's not forget Monsanto's activities on that matter. A layman would think that if all's so good and well, a company like this wouldn't need all that lobbying and lawsuits.

  13. The reason is simple by WindBourne · · Score: 1

    There are a LOT more virus running around and we have very little appreciation for what they (and the lowly mosquito) do. Basically, as biologists continue to explore and some more get a bit of logic, they will realize that the vast majority of virus are asymptomatic (at least in a short term). Oddly, it will take time for ppl to accept the fact that virus do the majority of gene transfer (iow, it is not from mutation). Several interesting implications for this is that bio-diversity is conferred by bird/mosquito's/virus vectors moving from one SPECIES to another.Most will be in the same area, though some will travel. So, what this means is that as we wipe species, we will lose OUR evolution. In addition, as we grow larger and larger in density, then it is only a matter of time before we see another species acquire intelligence. We will credit it to Darwinian evolution, when in fact, it will be simply that virus carrying OUR genes, took enough snippets to enable it.

    IOW, Virus is the 3'rd major form of genetics (sex/mutation) that does more introducing new genes into a species than another other form.

    --
    I prefer the "u" in honour as it seems to be missing these days.
  14. Wow by Niubi · · Score: 0

    interesting news like this is why I love slashdot almost as much as dubli!

  15. Re:More proof you Darwinist fools have it all wron by Anonymous Coward · · Score: 0

    U know, there are probably idiots around the USA, and likely on this site, that buy into that garbage.

  16. meh, wotz up doc? by MrKaos · · Score: 1

    Carotenoids in the diet gives many animals, from insects to flamingos, their exterior color after they ingest it

    Doesn't explain why WW2 night fighter pilots didn't turn orange.

    --
    My ism, it's full of beliefs.
    1. Re:meh, wotz up doc? by telomerewhythere · · Score: 1

      http://healthmad.com/health/carrot-addicts-may-turn-orange/

      On a related but different thought: I thought I could find it, but I remember a story where scientists modified beta carotene and it produced modified eyesight in some animals or humans. Can anyone help? I'd love to read that again, or was I just dreaming?

    2. Re:meh, wotz up doc? by Anonymous Coward · · Score: 0

      Carotenoids in the diet gives many animals, from insects to flamingos, their exterior color after they ingest it

      Doesn't explain why WW2 night fighter pilots didn't turn orange.

      Because the carrot/RAF pilot night vision connection was propaganda? Telling the world they'd improved their radar considerably and that's why their pilots were so good at night would've been handing the Germans a weak spot on a silver platter. It's not like it was impossible for Axis to get their hands on carrots - had carrots really been that amazing, their pilots would've improved to similar levels quickly.

    3. Re:meh, wotz up doc? by MrKaos · · Score: 1

      Because the carrot/RAF pilot night vision connection was propaganda?

      Whooooooooooooooooooosh!

      --
      My ism, it's full of beliefs.
  17. Exhibit A by srussia · · Score: 1

    Carrot Top!

    --
    Set your phasers on "funky"!
  18. The "tanning" gene ! by Taco+Cowboy · · Score: 1

    Since the caratenoid gene can make things as red as cooked lobsters, why don't scientists find a way to transfer that gene into those tanning-philes?

    One treatment and you got free tanning for life !

    --
    Muchas Gracias, Señor Edward Snowden !
    1. Re:The "tanning" gene ! by arisvega · · Score: 2, Funny

      Imagine of all those green people posing as magenta people.

      --
      The three laws of thermodynamics:(1) You can't win. (2) You can't break even. (3) You can't even quit.
  19. Gov't Money by windcask · · Score: 0, Flamebait

    Your tax dollars at work: Finding out why nearly-microscopic bugs are colored.

  20. It adds a whole new meaning to .... by Anonymous Coward · · Score: 0

    This adds a whole new meaning to the phrase: "You are what you eat" ....

  21. Re:More proof you Darwinist fools have it all wron by Anonymous Coward · · Score: 0

    Like Echolocation?
    the mosquito bit a bat, then bit a dolphin!!! ftw!!!

  22. Re:More proof you Darwinist fools have it all wron by Anonymous Coward · · Score: 0

    He can't be all that intelligent, considering fungi aren't creatures. ...Or are they?

  23. Re:Nature's own GMO-- NOT! by Will.Woodhull · · Score: 1

    This is an example of why I don't worry about man-made genetically modified organisms. It you have studied biology, you realize that nature is constantly shuffling DNA from one organism to another across species, genera, phyla and here across kingdoms.

    And the above statement is precisely why I have begun to worry about genetically modified organisms.

    The whole concept of safety in GMO is defined in terms of species and genus, and that these abstract categories humans use to think about biology are somehow intrinsic in reality. That genes can migrate so easily across these categories shows this is not the case. Species, genus, phylum, and kingdom turn out to be convenient fictions, like centrifugal force. These fictions are an inadequate framework for working with GMO concepts in a safe manner.

    We need a much better understanding of really basic biological principals to replace the rigid classification hierarchy with a way of thinking about the flows of information, materials, and energy that are an ecosystem. Until we have that more realistic framework and can use it to guide research and applications, I find the concept of using GMO in the field rather disturbing. At a very basic level, scientists and engineers involved in GMO research and applications don't know what the f*ck they are doing.

    That disturbs me.

    --
    Will
  24. Myrmecos talks about this... by antdude · · Score: 1

    ... in his Science Blog.

    --
    Ant(Dude) @ Quality Foraged Links (AQFL.net) & The Ant Farm (antfarm.ma.cx / antfarm.home.dhs.org).
  25. Re:Nature's own GMO-- NOT! by ChromeAeonium · · Score: 1

    The whole concept of safety in GMO is defined in terms of species and genus

    Safety is assessed based on if it can be shown to cause health effects, even if it produces a new chemical that could cause those effects. The evidence to indicate that the vast majority of GMOs possess these health concerns is hugely underwhelming. I don't know where you get that taxonomy plays into it.

    We need a much better understanding of really basic biological principals to replace the rigid classification hierarchy with a way of thinking about the flows of information, materials, and energy that are an ecosystem. Until we have that more realistic framework and can use it to guide research and applications, I find the concept of using GMO in the field rather disturbing. At a very basic level, scientists and engineers involved in GMO research and applications don't know what the f*ck they are doing.

    And when will that be? What amount of knowledge will be sufficient to safely work with individual genes instead of mixing thousands of genes like we've been doing with selective breeding? Think about it, where else have we heard this appeal to ignorance with claims that the experts don't know what they're doing and moving the goalpost every time more info comes in? Oh yeah, the guys who brought back measles said the same thing about vaccinations. Same argument, same tactics, different topic, and it makes about as much sense. The science is there, and while GMOs certainty have the potential for doing bad things, the evidence to indicate that they are/will become dangerous is scant indeed.

  26. Re:Nature's own GMO-- NOT! by ChromeAeonium · · Score: 1

    Ack, forgot a part: Safety assessment for environmental damage- again, nothing hugely great to indicate that there's much worry there, although I have heard reports of cross pollination in wild populations of corn (by which I assume they mean corn relatives). Not sure just how prevalent it is or how accurate those reports were, but either way, the issue here isn't so much what harm they cause to the environment as the net harm. Farming is very bad for the environment, especially with our large population, so it isn't if GMOs cause harm, but if their use is a net reduction in damage, which it appears to be.

  27. Another challenge to dogma by dorpus · · Score: 1

    Not so long ago, transposons (jumping genes) were thought to happen only in "lower" animals, not in humans. We now know that transposons are common in humans. They also said the same of copy number variations, or of DNA letters different from A/C/G/T.

    The current dogma of genetics says that DNA homology between species is caused solely by evolutionary relationships. How long before we realize that this isn't true either?

    I'm not an evolution denialist, but I do think the current scientific understanding of evolution has a religious zeal.

    1. Re:Another challenge to dogma by CorporateSuit · · Score: 1

      I'm not an evolution denialist, but I do think the current scientific understanding of evolution has a religious zeal.

      The fact that this type of finding actually refutes most current hypotheses of evolution, yet people are attempting to use evolution to explain it, and the article is tagged "evolution", I would say that you made a bit of an understatement.

      --
      I am the richest astronaut ever to win the superbowl.
    2. Re:Another challenge to dogma by Shipud · · Score: 1

      Actually, it does not refute anything. HGT has been known to exist for a long time in all of life's kingdoms, and has no impact on the Theory of Evolution. It is yet another genetic variety generating mechanism, on top of sex. The authors provide a very plausible mechanism to explain how the gene got fixed in the population. BTW, if you don't believe in evolution, how can you on the one hand accept their inference of HGT which is based on evolutionary considerations (sequence similarity and homology), but on the other hand claim that the conclusion from that inference is that evolution is wrong. that's like saying that You calculate the area of a circle using Pi=3.14, and then claim that Pi=3.5. Doesn't make sense.

      --
      /sdrawkcab si gis siht
    3. Re:Another challenge to dogma by JoshuaZ · · Score: 1

      The current dogma of genetics says that DNA homology between species is caused solely by evolutionary relationships. How long before we realize that this isn't true either? I'm not an evolution denialist, but I do think the current scientific understanding of evolution has a religious zeal.

      Frankly, I don't think you understand what you are talking about. The linked to article is an example where DNA homology isn't due to an "evolutionary relationship" (that is, recent common ancestry) but rather horizontal gene transfer. And this isn't the only example of this. We have many other examples of horizontal gene transfer by viruses for example. See http://en.wikipedia.org/wiki/Endogenous_retrovirus. However, we do know that the vast majority of similarities in DNA are due to evolutionary relationships because the genetic sequences when one graphs them by how different they are from each other form a tree, exactly as evolution would expect. You can't just say that we'll "realize" something if you don't have a different mechanism to propose. Disregarding such comments isn't dogma, it is simply not willing to listen to someone shout "Your wrong!" when they aren't going to propose an alternate model. Propose a different explanation for the DNA similarities that we see and then people might be willing to listen. But please don't make nebulous claims about religious zeal.

    4. Re:Another challenge to dogma by dorpus · · Score: 1

      "However, we do know that the vast majority of similarities in DNA are due to evolutionary relationships because the genetic sequences when one graphs them by how different they are from each other form a tree, exactly as evolution would expect."

      Actually, no. DNA homology has re-drawn the "evolution tree" considerably, as species that were thought to be related turned out not to be, while other "unrelated" species turned out to be related. After re-drawing the tree, scientists now say this "proves" that DNA homologies are due to evolutionary relationships. Sounds like circular logic to me.

    5. Re:Another challenge to dogma by CorporateSuit · · Score: 1

      Poor analogy. It's more like saying that cars clearly run off a combustion of air and gasoline, then finding out that 20% of cars can run underwater indefinitely. It doesn't compliment the hypothesis, it refutes it. If the "air/gas combustion" was a theory, it would be reduced back to the drawing board. It shows that there are deep, underlying complexities involved that your air/gas cumbustion theory was drawn independent from -- not just that "Cars will run on air/gas except for some that run on water instead."

      Or, to use your analogy, if you've geared your entire geometric science around pi=3, and just ignore the .14+ trailing it, then not only will all your future equations based on circles be wrong, but you're missing out on some very interesting maths. When someone introduces a big circle that has a measurable difference "Hey, we're like 20 meters off! Who calculated this?" "Oh, pi only equals 3 for smaller circles. As the circle increases in size, pi approaches 3.2"

      Then tell all the haters that they just don't understand the exponential beauty of circular geometric ratios, because they're too dumb. :)

      --
      I am the richest astronaut ever to win the superbowl.
    6. Re:Another challenge to dogma by JoshuaZ · · Score: 1

      That's simply not true. We've had a lot of redrawing of minor aspects. But the overall tree looks almost identical to it did 30 or 40 years ago. The great apes for example look about what they should look like. As do mammals as a whole. Most of the redrawing that has occurred has been when we have a handful of species and we were wrong about the precise order they broke off from each other. It shouldn't be surprising that morphological data isn't always perfectly interpreted. The sort of thing that would seriously undermine evolution (say rabbits being more closely related to snakes than humans or something like that) simply hasn't happened.

    7. Re:Another challenge to dogma by dorpus · · Score: 1

      30 to 40 years ago, the tree of evolution was missing an entire kingdom of archaea. When I took high school biology, they told us that archaea are "extremely rare bacteria" that only live in hot springs. We now know this is not true; archaea are ubiquitous, only scientists didn't know where to look. Biology teachers like to show microscope pictures as "proof" of whatever theory they teach, though it's interesting they spent hundreds of years unable to find archaea that live all over the place.

      We are no longer descended from sponges, according to this article -- it's the opposite of what they taught us.

      http://www.sciencedaily.com/releases/2009/04/090402124316.htm

      They still claim that humans descended from African apes. However, humans share more DNA similarity to Asian orangutans.

      http://www.sciencedaily.com/releases/2009/06/090618084304.htm

      And when I was in high school, they claimed that HIV was a new mutant virus that appeared in Africa in the 1950s or 60s. However, we now know that HIV has been around as long as mammals have walked the Earth.

      http://www.sciencedaily.com/releases/2009/09/090927145354.htm

      So yes, there seem to be giant gaps in our understanding of life's origins. It will be interesting to see how different the theory of evolution will be in the future; maybe by then, "evolution" will be a dirty word and scientific zealots will demand that nobody mention it.

    8. Re:Another challenge to dogma by JoshuaZ · · Score: 1
      I have to wonder if you're actually reading what you've linked to. There was a lot of controversy over where animals and sponges stood in relation to each other. That's discussed in the article in question. Genetic data settled that issue. The second one I'm very sure you didn't read at all since it is talking about a group of scientists arguing based on physical evidence that humans are more closely related to orangutans than chimps. They are making that argument despite the DNA evidence showing the reverse as the article says "the researchers reject as "problematic" the popular suggestion, based on DNA analysis, that humans are most closely related to chimpanzees, which they maintain is not supported by fossil evidence." How you got that to become what you've said where you claim that "humans share more DNA similarity to Asian orangutans" is beyond me. Similarly, the last example shows a lack of understanding of what you were taught in school (unless you got taught something very garbled). HIV is relatively new. What is old are precursor viruses such as SIV (the version for apes) and FIV (the version for cats). That article is talking about HIV's ancestors, not HIV. Moreover, what you think that has to do with the general theory of evolution is beyond me.

      So yes, there seem to be giant gaps in our understanding of life's origins. It will be interesting to see how different the theory of evolution will be in the future; maybe by then, "evolution" will be a dirty word and scientific zealots will demand that nobody mention it.

      The only gaps seem to be your reading comprehension and understanding of biology. Yes, it will be interesting to see how things change as we get more data. That's part of the amazing nature of science, we don't have "zealots" but rather change opinion when the evidence presents itself. In the meantime, instead of vague claims about "zealots" and "dogma" it might help if you actually read the articles you've linked to and maybe brushed up on a little general biology.

    9. Re:Another challenge to dogma by dorpus · · Score: 1

      Are chimps that similar to humans? Scientists have measured only mitochondrial DNA before to claim "99.9% similarity" between organisms, and that because this is DNA, it is indisputable truth. But then, if we apply the same standard to Y chromosomes, then chimps and humans are only about 50-66% similar, depending on the metric used.

      http://www.wi.mit.edu/news/archives/2010/dp_0113.html

      And as MIT says, the chimpanzee is only the second Y chromosome to be comprehensively analyzed. Are you going to say for sure that orangutans are less related?

      "HIV is relatively new. What is old are precursor viruses such as SIV (the version for apes) and FIV (the version for cats)."

      But then, SIV and FIV were discovered only after HIV. I remember back then when scientists used to say that only primates can catch AIDS.

    10. Re:Another challenge to dogma by JoshuaZ · · Score: 1

      Dorpus, I really think it would help if you maybe brushed up on your level of biological knowledge. To be blunt, you seem to be repeatedly misunderstanding statements. In your post previous to this one, you completely confused what the article in question was saying about chimpanzees and orangutans and had other problems. Your recent comment above. Since I have finite amount of time, I'll only note four of them: First, you are confusing HIV with AIDS. What scientists would have said is that only primates could get HIV (even then that's not strictly true). Second, SIV was discovered in 1985, only 4 years after the discovery of HIV. Regarding the comparison of the Y chromosome, there's been heavy selective pressure on that chromosome (apparently). That chromosome is however tiny (indeed, there are good evolutionary reasons for expecting the Y chromosome to be tiny). There are only around a hundred genes on the Y chromosome and it is about 2% of all the genetic material in a human male. So trying to make comparisons based on it for the general similarity as a whole. Fourth, electrophoresis is one of the main methods we've determined the high genetic similarity beteween humans, chimpanzees and orangutans. This particular data point is thus chemistry with no assumptions from evolution. If it turned out that when we examined the individuals genes and other DNA in the entire genome in detail that they were all much farther apart, that wouldn't just be a problem for evolution that would be a problem for basic chemistry.

    11. Re:Another challenge to dogma by Urkki · · Score: 1

      The fact that this type of finding actually refutes most current hypotheses of evolution,

      Could you be more specific? Ie. which part of the theory of evolution does this refute?

      Or you want a more specific question, in the context of the Theory of Evolution, how is getting new genes by horizontal gene transfer different from getting new genes by mutation?

      It's more like horizontal gene transfer mechanisms save theory of evolution in the face of genes shared by different families. If eg. aphids and fungus had same gene, but horizontal gene transfer can be disproved, then it means that they got the same gene independently. That is so mind-bogglingly unlikely it couldn't happen by chance. So if a gene didn't appear by mutation, and didn't come via horizontal gene transfer, what have you left?

      For example, transfer of same gene in two separate occasions sounds pretty unlikely. Not totally impossible, as if a virus acquired that gene and then transferred it to the same species, the same virus could have transferred it to several species, at least if they're related. But if same gene is shared by three or more otherwise "unrelated" (ie. very distantly related, as everything is related if you go back far enough) species, where it's very unlikely that same virus could infect them all, probability of natural transfer starts to go down fast.

      Creationists and ID proponents should be fighting any research into horizontal gene transfer, and try to maintain that it doesn't take place. But I guess that would require they'd actually understood the concept, which they rarely do, as understanding tends to lead to acceptance of evolution (and possibly belief in theistic evolution or some such thing).

    12. Re:Another challenge to dogma by Anonymous Coward · · Score: 0

      No, the central dogma of genetics is that the germ line genes are sufficient to generate an organism's descendants.

      Altering the germline genes alters the organism's descendants, no matter what the mechanism of alteration is.

      Mixing in two or more partial germline gene sets also alter the descendants, no matter what the mechanism of alteration is. (In this case it's usually sexual reproduction, and usually with two haploid donors. A third-to-nth-party donor of a partial set happens, including when the nth party is from another species or kingdom altogether).

      The question of whether nuclear DNA (in eukaryotes) is the whole of the germline gene set is under study, but horizontal gene transfer is not really an issue here -- the assumption is right there in "gene" that the agent incorporated into the parent is heritable and thus part of the germline gene set.

      The central dogma of genetics is not really all that closely coupled with the theory of evolution. The latter says that environmental pressures influence the reproduction rate of organisms and that a single metric -- the number of viable offspring produced -- is sufficient to describe the fitness of an organism in a particular environment. Evolutionary biology is the study of the fitness of an organism and its descendants in an environment which changes over time. Changes in the descendants of an organism are considered adaptations, no matter how those changes have occurred, and whether or not they are heritable (most adaptations reduce the number of viable non-sterile offspring reduced to zero, and thus it does not really matter whether they were heritable or not, from a fitness perspective).

      Evolution treats heritability retrospectively -- a given adaptation in the past and inherited by an offspring's descendants can be seen to have influenced the fitness of that organism and its descendants. In this case, the mechanisms of heritability are interesting enough to be subjects of study, however there is no reason to constrain the mechanism to nuclear DNA (for example) especially since many organisms that manifest adaptations have no nuclear DNA at all. (Indeed some things that strongly appear to show adaptations and whose populations wax and wane in the face of environmental change (i.e., they can have their fitness calculated) are arguably not even organisms at all, yet still evolve).