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Computing a Cure For HIV
aarondubrow writes: The tendency of HIV to mutate and resist drugs has made it particularly difficult to eradicate. But in the last decade scientists have begun using a new weapon in the fight against HIV: supercomputers. Using some of the nation's most powerful supercomputers, teams of researchers are pushing the limits of what we know about HIV and how we can treat it. The Huffington Post describes how supercomputers are helping scientists understand and treat the disease.
Imagen if all that computer power was put to use such as finding the cure of HIV.... We would be done by lunch time.
GIGO and the general inability to clean code.
With or without computer involvement.
Just saying.
Just coming back from an HIV meeting in D.C. at the NIH... Dude, you made my day! Thank $DIVINITY, they keep shrinking Science funding, so nobody is going to keep with these scams you so cleverly discovered.
Because we don't get out much.
This is not the sig you're looking for.
The 'meh, it's just homos and drug addicts' theory of epidemiology often leads to some...fascinating...discoveries concerning unexpected transmission paths between the filthy expendables and the good, decent, people who we assumed were safe.
As a social experiment, it's actually pretty interesting. not so much with the 'advisable'; but interesting.
Computational drug design and bitcoin miners have in common that both run best on custom hardware. The crux is, that both require very different types of hardware. As an example, please refer to Anton, designed by DE Shaw Research exactly for molecular dynamics (MD) codes.
Bitcoin mining is classified as a so called embarrassingly parallel algorithm, while MD is a tightly coupled problem. Hence an efficient parallelization for MD codes is much harder to speed up: communication gets in the way, and communication is essentially always bound by the speed of light.
ps: fun fact: bitcoin mining and MD can be carried out (at least somewhat) efficiently on GPUs.
Computer simulation made easy -- LibGeoDecomp
Mod parent funny. If the infected idiots would keep it in their pants and NOT FUCK then we wouldn't have this problem.
Humans have never found a "cure" for a virus. We've been able to find cures for bacterial infections, and we've been able to find immunizations for SOME viruses (NOT a cure, just a stimulation of the body's own immune capabilities) but NEVER a cure for a virus. The now 30-year old lie that we're going to cure HIV/AIDS "any day now" if only we throw many more $BILLIONS at the problem, has mislead many people to think they could go-on living dangerous and dysfunctional lifestyles, refusing to even moderate their activities, while millions of people died from the disease. Oh, and when the death toll is mentioned, "Blame Bush" or "Blame Reagan" is the fall-back idiocy.
Will there EVER be a cure? Hopefully, yes. I sincerely hope people eventually develop a full understanding of viruses and the ability to easily cure ANY of them... but there is currently NO proof this is even possible - no proof we CAN find a cure, and no proof we can administer such a "cure" without killing the patient. I hate articles like this one because they seem specifically-designed to mislead the general public into bad decisions and bad policies based on false promises by unaccountable people who are often pushing political agendas without regard for the human wreckage that results when people take them seriously and are then harmed by believing this stuff.
(To those who voted this to -1) This idiotic thinking needs to be addressed.
If you think the disease should run its socially useful course, then check out what happened to the Chimpanzee population when SIV struck them (I think it was 250,000 years ago). Something like 98% of the population died out, and the survivors were either SIV-immune, or SIV-resistant.
Now, what would happen if 98% of humanity died out? For a start, the bulk of the corpses would rot in public. You'd die from related diseases. Of couse, the natural world would prosper without humans to chop or burn it all down. Shame about the nuclear reactors that would have nobody to watch over them.
Of course, there are many people out there who contracted HIV because of others. For example, in New Zealand a while ago, a woman was deliberately infected by her partner (he was regularly injecting her with his blood until she caught it just so she would have sex with him again and wouldn't leave). How many people have caught HIV from blood transfusions?
Their suffering is fine, because it suits your eugenic beliefs?
You should head back to the 30s, I'm pretty sure at least one country shared your views.
Hasn't this already pretty much been cured?
I'm pretty damn sure there were extremely successful trials of a new treatment that actually resulted in curing the people since there hasn't been any remission of any HIV since the medication was stopped.
It was based on a very smart researcher saying "Well, wait, why aren't these people getting HIV?" and they figured out the difference and supposedly found a trivially simple way to target something common to all forms.
Or does it still need to go through that "trial phase" before we can officially say "yayifications we gotta cure!"?
Either that or it was AIDS, but it don't think it was that, AIDS is far more complicated than a virus. (and isn't only caused by HIV)
Very much confused.
We bothered about HIV for decades while we just had to run supercomputers to get rid of it. I wonder why nobody thought about it before.
killfuckers? Y/n
> Y
fuckers killed
There ye go. When nobody fucks anymore, the problem solves itself. Even better: all human problems solve themselves. Because we'll all die of old age (the only fucking happening in the basement involves a palm and xhamster) and have no children to continue our folly.
Condoms. Cheap, plentiful, and 99% effective.
invention of supercomputer: 1980
discovery of HIV virus: 1980
coincidence?
then again maybe HIV was a mutation of a harmless virus living on the bikini atoll -or- was brought back from the moon?
In the Fall of 1990, two medical researchers, Drs.William Lyman and Steven Kaali, working at Albert Einstein College of Medicine in New York City made an important discovery. They found that they could inactivate the HIV virus by applying a low voltage direct current electrical potential with an extremely small current flow to AIDS infected blood in a test tube. Initially, they discovered this in the lab by inserting two platinum electrodes into a glass tube filled with HIV-1 (type 1) infected blood. They applied a direct current to the electrodes and found that a current flow in the range of 50-100 microamperes (uA) produced the most effective results. Practically all of the HIV viral particles were adversely affected while normal blood cells remained unharmed. The viral particles were not directly destroyed by the electric current, but rather the outer protein coating of the virus was affected in such a way as to prevent the virus from producing reverse transcriptase, a necessary enzyme needed by the virus to invade human cells. Reverse transcriptase allows the virus to enter a human T cell line (called CEM-SS) and commandeer the DNA reproduction machinery. After using the host cell to reproduce itself into thousands of new virii, the swollen host cell (now called syncytia or giant cell) will burst and spew the contents into the bloodstream or lymph system. This is how the virus spreads, but lacking reverse transcriptase, the HIV virus can't invade the host cell and it becomes vulnerable to destruction by the body's immune system. (The details of this experiment can be read from Kaali's patent application.)
Getting the Word Out?
A brief announcement of this discovery appeared in The Houston Post (Mar 20, 1991), then in Science News (Mar. 30, 1991 pg. 207) and later in Longevitymagazine: (Dec.1992 pg. 14). Following their work in the Fall of 1990, Kaali and Lyman presented their findings at the First International Symposium on Combination Therapies (an AIDS conference) in Washington DC on March 14th, 1991. Kaali outlined two methods for treating an AIDS patient with this new therapy: One method involved removing a small amount of blood, electrifying it and then returning it to the patient's body. The second method involved sewing a miniature electrifying power supply along with two tiny electrodes directly into the lumen of an artery. For long term treatment, the mini electrifying unit needed to be removed and relocated to a new artery site after 30-45 days since scar tissue and calcification forming around the implant unit would lead to artery blockage. Kaali (along with co-inventorPeter Schwolsky) filed for a patent on this implantable electrifying device on Nov 16, 1990 and nine months later was granted patent #5,139,684 on August 18, 1992. It's interesting to note two things here:
1. In order to obtain a patent from the United States Patent Office, Kaali and Schwolsky had to prove that the device works as claimed. Lacking solid proof, US patents are simply not granted.
2. Very often it takes years to obtain a patent, yet this patent was granted in only nine months; a further indication to me of the strength of their demonstrated claims
It's also interesting to note that other than the 3 publications mentioned above and the March '91 AIDS conference, nothing again appeared in print, radio, or TV about this important discovery as a potential treatment and cure for AIDS from Kaali and company. Most knowledgeable observers feel that Kaali and Lyman's discovery was intentionally suppressed following the March '91 AIDS conference presentation. If AIDS research was on the level and not the sham that it actually is, this should have made front page news around the world. (Around 1999, I was contacted by a woman with AIDS who had managed to reach Dr. William Lyman over the phone. She asked him about his experiments with Kaali regarding blood electrification and if she could obtain the treatment through them. Lyman denied any knowledge of any AIDS treatment or cure. He said he never heard of Dr. Kaali and he had no idea what she was talking about concerning blood electrification and then hung up on her. What does that tell about the power of the people behind the suppression of this discovery?
Kaali and Lyman presented their findings at the First International Symposium on Combination Therapies (an AIDS conference) in Washington DC on March 14th, 1991. Kaali outlined two methods for treating an AIDS patient with this new therapy: One method involved removing a small amount of blood, electrifying it and then returning it to the patient's body. The second method involved sewing a miniature electrifying power supply along with two tiny electrodes directly into the lumen of an artery. For long term treatment, the mini electrifying unit needed to be removed and relocated to a new artery site after 30-45 days since scar tissue and calcification forming around the implant unit would lead to artery blockage. Kaali (along with co-inventorPeter Schwolsky) filed for a patent on this implantable electrifying device on Nov 16, 1990 and nine months later was granted patent #5,139,684 on August 18, 1992.
The 'meh, it's just homos and drug addicts' theory of epidemiology often leads to some...fascinating...discoveries concerning unexpected transmission paths between the filthy expendables and the good, decent, people who we assumed were safe.
As a social experiment, it's actually pretty interesting. not so much with the 'advisable'; but interesting.
It is interesting Because the people who we assumed were pretty much safe, I.e. non-promiscuous, turned out to be pretty much safe. HIV is not a threat to any reasonably intelligent and educated person because it is extremely difficult to transmit
Yes your idiotic thinking needs to be addressed:
1. Monkeys didn't know they had aids.
2. If 98% of aids victims died of their illness so would the disease. That is what run it's course means.
3. All people get aids from other people. Nobody injects themselves with the aids virus. You are a dope.
I don't want you to die of aids. That is why I also don't want you to be a homo. But it's not up to me. Like Ãll liberals you want me to pay for your really stupid choices. Fuck off.
Females are equipped with a sense of smell which detects the immune system state of any potential mate. This allows them to create progeny with two different immune systems, evolving defenses against pathogens evolving (mutating) to evade our immune defenses. The use of oral contraceptives causes the mating choices of the females using them to be opposite to the usual mating choices, and the females mate with males with similar immune systems, depriving their progeny of the enhanced protection. Nature protects the species from being at risk from this by making some of these progeny effectively sterile e.g. homosexual. This prevents the behavior from being passed on. This protection evolved against eugenic practices by religious and political organizations. The widespread use of oral contraceptives has overwhelmed the natural defenses provided by nature and led to an upping of natures protection of our species - HIV.
"non-promiscuous, turned out to be pretty much safe"
Some how I bet this kid wouldn't agree with you:
http://en.wikipedia.org/wiki/R...
It's not that specialized. It's just plenty of DSPs strapped together on a torus.
Actually Anton uses ASICS, their cores are specially geared at MD codes. This goes way beyond just "strapping together DSPs". They have IIRC ~70 hardware engineers on site. (Source: I've been to DE Shaw Research last year).
Unlike what wikipedia claims, you could probably achieve comparable performance using a more classical and general-purpose supercomputer setup with GPU or Xeon Phi accelerators, provided the network topology is well tuned to address this sort of communication scheme
No, you can't, and here is why: Anton is built for strong scaling of smallish, long running simulations. If you ran the same simulations on a "x86 + accelerator" system (think ORNL's Titan) then you'd observe two effects:
(most recent supercomputers don't use tori)
Let's take a look at the current Top 500:
So, torus networks are the predominant topology for current supercomputers.
Computer simulation made easy -- LibGeoDecomp
Um, actually the syndrome is defined specifically as a white cell count below a certain level in someone infected with the virus. How is that circular? I know that you are denying the premise that the virus is the cause of the syndrome (go infect yourself, then!), but your assertion that what you don't accept doesn't even make logical sense seems entirely baseless. To put it in perspective, I could imagine a hypothetical universe in which the influenza virus existed but something else actually caused the flu, and yet the statement "the flu is a disease characterized by fever, chills, and coughing, and it is caused by the influenza virus" would remain logically self-consistent and non-circularly defined but (in this hypothetical universe) false.
Your shaky grasp of logic doesn't exactly lend credence to your claim that the entire scientific community is wrong.
IÃ(TM)m Mercy Tebogo, IÃ(TM)m from South-Africa, I was tested HIV positive, Dr. Ozalla cured me from HIV, so I will advise you people that have it too, to contact him now, so that you will be cured by him okay.. Contact him via his email on ozalla.the.great.healer@gmail.com