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US Scientists Successfully 'Switch Off' Cancer Cells
iONiUM sends news that Mayo Clinic cancer researchers have developed a technique to reprogram cancer cells in a lab, essentially "turning off" their excessive cell growth.
That code was unraveled by the discovery that adhesion proteins — the glue that keeps cells together — interact with the microprocessor, a key player in the production of molecules called microRNAs (miRNAs). The miRNAs orchestrate whole cellular programs by simultaneously regulating expression of a group of genes (abstract). The investigators found that when normal cells come in contact with each other, a specific subset of miRNAs suppresses genes that promote cell growth. However, when adhesion is disrupted in cancer cells, these miRNAs are misregulated and cells grow out of control. The investigators showed, in laboratory experiments, that restoring the normal miRNA levels in cancer cells can reverse that aberrant cell growth.
When I see it in practice with proven real world results.
Too often these promising studies generate all kinds of hype and then disappear shortly thereafter.
Political correctness is really just herd psychology pushed by insecure people who desperately seek social conformity.
yadda yadda https://xkcd.com/1217/
There isn't much to say here. Let's hope that this time it works.
Just take my money already! Cure me dammit!
While the title is misleading click-bait, there is potential to this discovery. Here's a rundown:
We already knew that miRNA (which is a regulator/anti-virus peptide working on DNA) was silencing tumour-suppressing genes, this is very old stuff.
We already knew that re-introducing tumour suppressing proteins into cells that lack them would remove the carcinogenic behaviour.
We did not know that adhesive proteins (a part of the external cell stuff that is commonly called Extra-Cellular Matrix (ECM)) regulated miRNA in proximal cells. This is very interesting stuff, and leads to several intriguing possibilities. What if you flood a cancer site with adhesive proteins attached to a membrane connecting peptide? Will that upregulate tumour-suppressing proteins? What happens when you do this to healthy cells? If the response in heathy cells is low, this could be a universal "low-risk, unknown reward" medication for multiple cancer types, something cancer treatment has long lacked (all non-crazy-person treatments are dangerous to healthy tissue now).
So, while not the panacea the title suggests, it's certainly an intriguing discovery.
do I drink more coffee or less coffee or the same coffee? Do I take the Angelina Jolie course and cut it all off and out or the Christina Applegate course and just off?
"It took a few years," the wise one continued, "but once they polished a cure up, the clamor for smoking in public places built gloriously until a few years later, when those pollies removed the laws. They knew what side their bread was buttered on, which was the only reason they changed it in the first place."
"What a bizarre little period that was," we stated.
"Yes. It was."
"What did the fussbudgettry turn their attentions to, then?"
"Oh, I don't know. Anti 3D printed sex slave robots or something. They didn't have mouths genetically engineered growing outta their taints to give the what-for to their own junk, as guaranted by International Rights today, back in those days."
"Craaaaazy!"
(-1: Post disagrees with my already-settled worldview) is not a valid mod option.
As a researcher whos grant money is majority funded by federal dollars, I can assure you we face much more stringent requirements in the lab than the private sector. At the end of the day we're in charge of switching off lights, computers, machinery--basically everything. For about 10 years now our benefactors have decided thats not enough, and have insisted we start switching off things like the mitochondria lest it waste energy. Switching off things like centrifugal force, strong and weak forces, and even electromagnetism (where applicable) has saved many countless grant dollars. So when we're researching cancer, its only logical we'd switch that off at the end of the day as well.
In fact, ill let you in on a little secret. The heat death of the universe is billions of years away not because of some natural phenomenon, but because the research into the expansion of the universe is constrained by a mandate to make sure we put up all the timespace in the locked cabinet near doris' office at the end of the day.
Good people go to bed earlier.
Now we're all gonna die from Alzheimer's!
The shepherds did so well protecting the flock that the sheep no longer believed that wolves existed.
can somebody please put some of that in a vial and give it to President Carter?
THX!!
... last year, after my wife had thankfully survived breast cancer, my wife's oncologist told us rather plainly that barring of some kind of unprecedented breakthrough, which he apparently did not consider to be likely anytime soon, it was not going to be possible. He suggested that the best anyone can realistically hope for is earlier detection, to the point that it may be more easily treatable, even potentially entirely noninvasively, but basically he suggested that hoping for any kind of actual cure in the future, or "turning off" cancer somehow was not being realistic.
File under 'M' for 'Manic ranting'
Microprocessors and regular expression, you sure this is biotech?
"WE Scientists Successfully 'Switch Off' Cancer Cells" ... C'mon, Slashdot editors!
Dark Reflection
Really US? As if your flagrant disregard for personal liberties wasn't enough, now you're pushing forced sterilization programs on certain subsets of cells you consider genetically "defective" by some arbitrary privileged criteria? Way to underscore your blatant classism. Seriously. Get your shit together.
Morphology has always been at the heart of Cancer.
That the answer might lie in the Extracellular Matrix is no surprise.
Only due to the forced over focus on grants and defunding of basic science have we literally been forced to turn a blind eye to it.
It's exactly like saying "Your Fat because you Eat too much!" Well duh.. but you have to be able to make fat in the first place.
If cancer cells can be "contained" by expressing or treating them with something that supresses their growth and reproduction.. they become a long term managable disease.. cellular surgery might be decades away.. or death by natural causes.. but the end result would be the same.. you don't die from Cancer.
I hope someone funds the follow up.. if its not.. it may take another generation or two for some indepedently wealthy researcher to come up with the medication.. until til then.. people will keep dying of ignorance.