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Potentially Deadly Drug Interactions Found Mining FDA Complaint Bin (arstechnica.com)

Thousands of people are sent to the hospital each year from adverse drug-drug interactions that are difficult to predict and even trickier to track. To get around the problem, a team of researchers (working with the journalists at The Chicago Tribune) created a computer model to create side-effect profiles for prescription drugs. Then, they mined a massive database of drug-reaction complaints sent to the Food and Drug Administration, as well as 380,000 electronic health records. The results of the analysis so far suggest that four drug combinations "including the combination of the common antibiotic, ceftriaxone, with the over-the-counter heartburn medication, Prevacid (lansoprazole) may cause a potentially fatal heart rhythm.

55 comments

  1. AARRGGH by Moblaster · · Score: 3, Funny

    First po.... urg... heart attack!

  2. A link by NEDHead · · Score: 1

    to an article might be useful

    1. Re:A link by Anonymous Coward · · Score: 0

      Or even just a list of the "potentially fatal drug combinations."

    2. Re:A link by Anonymous Coward · · Score: 0

      You're supposed to click on the "arstechnica" link to the right of the title. It's obviously a sponsored story.

    3. Re:A link by llamahunter · · Score: 5, Informative

      http://arstechnica.com/science... "The results of the analysis so far suggest that four drug combinations—including the combination of the common antibiotic, ceftriaxone, with the over-the-counter heartburn medication, Prevacid (lansoprazole)—may cause a potentially fatal heart rhythm." "The other problematic drug combinations that the data flagged as possibly producing the same heart problem are: cefazolin, an antibiotic, and meperidine, a pain medicine; meperidine and vancomycin, another antibiotic; and metoprolol, a blood pressure medication, and fosphenytoin, a seizure medication." Paywalled original story: http://www.chicagotribune.com/...

    4. Re:A link by Anonymous Coward · · Score: 0

      "It's a GREAT high, but you can only do it once."

    5. Re:A link by Trax3001BBS · · Score: 1

      http://arstechnica.com/science...

      "The other problematic drug combinations that the data flagged as possibly producing the same heart problem are: cefazolin, an antibiotic, and meperidine, a pain medicine; meperidine and vancomycin, another antibiotic; and metoprolol, a blood pressure medication, and fosphenytoin, a seizure medication."

      Son of a Bit@# /. might of saved my life, at the least added to it; till this article I took Metoprolol.

    6. Re: A link by Anonymous Coward · · Score: 1

      Dude, don't stop the metoprolol... just avoid combining it with its evil twin. If you rely on /. for medical advice, all I can say is Darwin.

    7. Re:A link by Anonymous Coward · · Score: 0

      I also take Metoprolol so this is very good to know.

    8. Re: A link by Trax3001BBS · · Score: 1

      Dude, don't stop the metoprolol... just avoid combining it with its evil twin. If you rely on /. for medical advice, all I can say is Darwin.

      If one follows the links further in, it shows Metoprolol alone increases the QT level in 13% of the patients, 22% when comboded.
      http://www.chicagotribune.com/...

      A lengthened QT interval is a marker for the potential of ventricular tachyarrhythmias like torsades de pointes and a risk factor for sudden death.
      https://en.wikipedia.org/wiki/...

      Metoprolol isn't manufactured as a QT adjuster https://en.wikipedia.org/wiki/... in fact advised against it's use for that condition http://circep.ahajournals.org/... (very long read just search for Metoprolol).

      Odd or better without, and there are substitutes.

    9. Re: A link by Anonymous Coward · · Score: 0

      There are a fuck ton of drugs that increase the QT interval. To stop taking metoprolol based off of this article is beyond fucking retarded. Metoprolol is a very good drug. Speak with your cardiologist before being a fucking retard. -dr

    10. Re: A link by Trax3001BBS · · Score: 1

      There are a fuck ton of drugs that increase the QT interval. To stop taking metoprolol based off of this article is beyond fucking retarded. Metoprolol is a very good drug. Speak with your cardiologist before being a fucking retard. -dr

      Ah heck, I have an appt this week it's been scheduled for awhile now, even used the website the Hospital set up to send a message to my Dr. Give me a break, you don't know of the secondaries.

      As for the "There are a fuck ton of drugs that increase the QT interval."

      I would think so after that article, it's that sudden death that has my attention. And yes I'm aware that in 2013 Metoprolol was the 19th most prescribed drug in the US.

  3. Link to article? by Anonymous Coward · · Score: 0

    Where is the link to the article? Which drugs? What method did they use?

  4. Linky? by Saeed+al-Sahaf · · Score: 1

    A linky might be nice...

    --
    "Who are in control, they are not in control of anything - they don't even control themselves!" - Glen Beck
    1. Re:Linky? by whipslash · · Score: 0

      Coming right up

    2. Re:Linky? by Anonymous Coward · · Score: 0

      It's that silly change that puts the reference link in the article title bar. The thing saying "(arstechnica.com)" after the title.

    3. Re:Linky? by Anonymous Coward · · Score: 0

      No, if there was a link, people could actually read the article to find facts. Best without a link...headlines and someone's summary are sufficient to start an argument.

      And isn't that all the new Slashdot needs?

    4. Re:Linky? by whipslash · · Score: 1

      There was a link but it wasn't showing on mobile. Now it is. Everyone remain calm on this fine Saturday

    5. Re:Linky? by Sarten-X · · Score: 1

      Look, we warned you when you arrived...

      Slashdotters are a bunch of cranky old farts who can't handle anything moving around on them, even if it looks exactly the same and only moved 15 pixels to the left. I expect there's at least one of us who reads the site on a VT100.

      Now that I said that, I realize I have a brand-new VT220 in a box in my closet, and I have a Raspberry Pi that needs a new job... Slashdotters are a bunch of mad engineers...

      --
      You do not have a moral or legal right to do absolutely anything you want.
    6. Re:Linky? by Saeed+al-Sahaf · · Score: 1

      I'm not on mobile. I'm a luddite. I have an "old-man" flip phone. Now get off my lawn.

      --
      "Who are in control, they are not in control of anything - they don't even control themselves!" - Glen Beck
    7. Re:Linky? by whipslash · · Score: 1

      Fair enough.

    8. Re:Linky? by whipslash · · Score: 1

      Yeah I'm aware. No place I'd rather spend my Saturday

    9. Re:Linky? by Anonymous Coward · · Score: 0

      Well done, Mr. W.

    10. Re:Linky? by Anonymous Coward · · Score: 0

      cranky old farts who can't handle anything moving around on them, even if it looks exactly the same and only moved 15 pixels to the left

      Um, sure the link is just moved a bit when read on a laptop, but on a tablet those fancy title bar links are nowhere to be found.
      But hey, it works for you, right?

      Sincerely,
      A. -cranky old fart- Coward

    11. Re:Linky? by Fencepost · · Score: 1

      So how does the site look on Opera Mini?

      --
      fencepost
      just a little off
    12. Re: Linky? by Anonymous Coward · · Score: 0

      Just like it does on Chrome, but with a different skin.

  5. RTFA? by Anonymous Coward · · Score: 0

    The most deadly thing in the world and you're eating it for breakfast! Just follow this link... right..... ah frack guys! common!

  6. Where's TFA? by Anonymous Coward · · Score: 0

    Second front-page history without a link, just this week. WTF?

  7. Give the man some rope! - Some Russian guy... by Saeed+al-Sahaf · · Score: 1

    Slashdot "editor" - and I use that term loosely - BeauHD is new here. Thus we must cut him a limited amount of slack which to hang himself with...

    --
    "Who are in control, they are not in control of anything - they don't even control themselves!" - Glen Beck
  8. Didn't RTFA by Anonymous Coward · · Score: 0

    Didn't RTFA, because there wasn’t one.

    1. Re:Didn't RTFA by Anonymous Coward · · Score: 0

      Yeah, me too! That's totally why I didn't read the article, not because I never do! RAH!

  9. And the 4 combinations are... by Anonymous Coward · · Score: 0

    "The results suggest that four common drug combinations may cause a potentially fatal heart rhythm." ... Um, which are? May be important in here.

    1. Re:And the 4 combinations are... by ColdWetDog · · Score: 2

      "The results suggest that four common drug combinations may cause a potentially fatal heart rhythm." ... Um, which are? May be important in here.

      I wouldn't get your panties in a twist just yet. Even though the methodology is interesting there is ** NO ** statistical analysis of the data so I'm presuming that non exists and this is one of those many, many "associative" studies that don't pan out in practice. To their credit, they try to correlate the drugs with some sort of plausible biochemical pathway but without any sort of kinetic data, it is impossible to determine if these things actually do happen and if they do, to what frequency.

      The combination of ceftriaxone (an antibiotic) and lanzaprole (a Prilosec clone for acid reduction) is extremely common in a hospitalized setting. If there was any reasonable clinical correlation we would likely have seen something by now.

      It is food for thought, good for a bunch of grants but I'd still buckle my seatbelt and stay away from errant meteors.

      --
      Faster! Faster! Faster would be better!
  10. Re: Expect the republicans by Anonymous Coward · · Score: 0

    They already blocked the link! Blocked the link!

  11. Re: Expect the republicans by Anonymous Coward · · Score: 0

    The repukianz that rule this site are already keeping us from reading more.

  12. Re: Expect the republicans by Anonymous Coward · · Score: 0

    Expect to? No, they already did.

  13. Re: Expect the republicans by Anonymous Coward · · Score: 0

    Republicans hate knowledge. That is why their kind refuses to provide a link.

  14. Can I be a Slashdot editor now? by RDW · · Score: 1
  15. Re:Expect the republicans by Anonymous Coward · · Score: 0

    to block this since it helps the people.

    Expect to? No, they already blocked it. This site has become so conservative since the recent buy-out.

    I did some research, and here is an article about this topic that the management of /. decided to block:

    http://arstechnica.com/science/2016/02/potentially-deadly-drug-interactions-found-mining-fda-complaint-bin/

  16. Link doesn't show on mobile by Anonymous Coward · · Score: 0

    Apparently the desktop version has a link to arstechnica, but it does not show on mobile.

    1. Re:Link doesn't show on mobile by whipslash · · Score: 1

      It's in there now

  17. Re: Expect the republicans by Anonymous Coward · · Score: 0

    I don't see any reason why those Tepublicans went so far in trying to censor that. The article is a poorly written mess with no facts. It looks like those pukianz would support it.

  18. Re: Expect the republicans by Anonymous Coward · · Score: 0

    This BeauDufus seems to love ignorance and hate knowledge. That is solid evidence he is a Republican.

  19. Link to ARS Article (courtesy of Google) by Anonymous Coward · · Score: 1

    http://arstechnica.com/science/2016/02/potentially-deadly-drug-interactions-found-mining-fda-complaint-bin/

  20. So where is the missing reference? by Anonymous Coward · · Score: 0

    It's more of a "color commentary" story than a solid content story, but this appears to be the missing link:

    http://www.chicagotribune.com/news/watchdog/druginteractions/ct-drug-interactions-signal-detection-met-20160209-story.html

  21. FDA Complaint by PPH · · Score: 2

    Dear FDA,

    I have been prescribed this combination of drugs which I believe to be .... [Eeep! Aaack! Gurgle ........ Thud!]

    --
    Have gnu, will travel.
    1. Re: FDA Complaint by sirlatrom · · Score: 2

      I wonder did he write that himself, or was he dictating it?

  22. When questioned... by Chris+Mattern · · Score: 1

    ...the interactions claimed they thought some of the complaints might have been for them.

  23. The more drugs, the more issues. by Anonymous Coward · · Score: 0

    I think a more general assumption should be. If you take more drugs, you risk more side effects, some severe. I personally think doctors over treat people in general.
    Some physical problem do not always require a prescription. I think you need to weigh the side effects of drugs over the severity of the condition. I am a diabetic and I finally cut down on medication and focused on diet because the drugs caused their own set of issues.

  24. Use the (real) source, Dude by Terman · · Score: 1

    The original scientific paper can be found at http://link.springer.com/artic...
    and the supplementary material can be found at http://static-content.springer...

  25. Bigger heart issues out there by Anonymous Coward · · Score: 0

    Thousands of people are sent to the hospital each year from adverse drug-drug interactions that are difficult to predict and even trickier to track. ... The results of the analysis so far suggest that four drug combinations .. may cause a potentially fatal heart rhythm.

    There are bigger heart issues out there.

    Long term stress, for example, has been shown to increase the rate of plaque formation and heart attacks in mice (Roth, 2015, Chronic intermittent mental stress promotes atherosclerotic plaque vulnerability, myocardial infarction and sudden death in mice).

    Of course, this is not a huge surprise, the fact that long term stress can lead to health issues has been known since the 1950's.

    Given how many entities out there (businesses, government, lawyers, and so forth) are creating extended periods of stress for people, this is doubtless a much more significant problem (though even more "difficult to predict and even trickier to track").

    Whether it's shipping companies giving one the run-around when trying to get insurance payment for a damaged shipment, or bank refusing to admit that an account created in one's name is fraudulent (to describe a few that I've personally experienced), there are lots of businesses out there doing irresponsible stuff that creates a lot of stress for people. Let's get businesses in general to be ethical and responsible with respect to how they interact with the public, before we worry about obscure drug interactions.

    If we could get even just the lawyers to be ethical, that would be a huge step forward from a societal health perspective. Instead of aiding and abetting politicians in doing stuff that steps on people, they could serve as another badly-needed check and balance on the government.