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Some Tumors Are Responding to A New Cancer Therapy (bloomberg.com)

A new cancer therapy in an early-stage trial by the U.S. National Cancer Institute "continued to be safe and show durable responses against solid tumors for some patients," reports Bloomberg. "In a trial of 14 patients who received different doses, three patients' cancers have shrunk partially, according to a study presented Sunday... The researchers had presented initial positive data in November, and the updated study shows that the three partial responses were durable, with one cervical cancer patient's response continuing at 15 months." Kite Pharma Inc. licensed the therapy, and by the end of the year will file an "investigational new drug" application with the FDA to begin the next round of testing. The therapy involves genetically engineered T cells, targeted to the solid tumors using the MAGE-A3 protein as a unique marker expressed in up to 30 percent of cancers.

53 comments

  1. Ah so its about gm tech by Ubi_NL · · Score: 4, Insightful

    This just takes the price for least informative summary ever. So a new cancer drug has effects. Ok great, every day we see these trials and most have at least some effect. Only in the last sentence is desribed why this particular trial is worth mentioning.

    --

    If an experiment works, something has gone wrong.
    1. Re:Ah so its about gm tech by umafuckit · · Score: 4, Informative

      This just takes the price for least informative summary ever. So a new cancer drug has effects. Ok great, every day we see these trials and most have at least some effect. Only in the last sentence is desribed why this particular trial is worth mentioning.

      The summary says "The therapy involves genetically engineered T cells, targeted to the solid tumors using the MAGE-A3 protein as a unique marker expressed in up to 30 percent of cancers." Seems pretty informative to me.

    2. Re:Ah so its about gm tech by Anonymous Coward · · Score: 0

      genetically engineered T cells

      Kite Pharma Inc

      Umbrella Turned Delta Kite

      Coincidence? I think not.

    3. Re:Ah so its about gm tech by dgatwood · · Score: 1

      The summary says "The therapy involves genetically engineered T cells, targeted to the solid tumors using the MAGE-A3 protein as a unique marker expressed in up to 30 percent of cancers." Seems pretty informative to me.

      In journalism, they call that "burying the lede". That bit should have been in the very first sentence, or at the very latest, the second sentence. Instead, it is at the very end of the story, where it is almost guaranteed to get chopped off in the future by some well-meaning editor trying to save column inches.

      --

      Check out my sci-fi/humor trilogy at PatriotsBooks.

    4. Re:Ah so its about gm tech by rs79 · · Score: 1

      Nah it's pretty mundane and only tells you about their stuff, how it does something complicated and patentable with something expressed by 30% of cancers. Big deal.

      In 2007, Potter, Burke et al found CYP1B1 in nearly 100% of cancers.

      Fitst they found Resveratrol ("red wine") killed cells with these markers (which turn the Resveratrol into potential which kills only that cell) but it wasn't strong enough to work on humans. Next they found the Salvestrol family of molecules.

      Have a look for yourself how well that panned out.

      --
      Need Mercedes parts ?
    5. Re:Ah so its about gm tech by Big+Hairy+Ian · · Score: 1

      My eye's glazed over at Bloomberg

      --

      Build a Man a Fire, and He'll Be Warm for a Day. Set a Man on Fire, and He'll Be Warm for the Rest of His Life.

    6. Re:Ah so its about gm tech by Anonymous Coward · · Score: 0

      Pretty sure the word 'humans' was used in the summary, not 'labs'.

    7. Re: Ah so its about gm tech by Anonymous Coward · · Score: 0

      Lol resident evil

    8. Re:Ah so its about gm tech by Anonymous Coward · · Score: 0

      Sorry that you have to read 5 full pages of fluff to get to that.

    9. Re:Ah so its about gm tech by Anonymous Coward · · Score: 0

      This just takes the price for least informative summary ever. So a new cancer drug has effects. Ok great, every day we see these trials and most have at least some effect. Only in the last sentence is desribed why this particular trial is worth mentioning.

      I, also, immediately thought it was weird the actual news bit is tucked away in the last sentence.

    10. Re:Ah so its about gm tech by Ubi_NL · · Score: 1

      yes in the last sentence, this is what i mentioned.

      --

      If an experiment works, something has gone wrong.
  2. Coming soon by Dunbal · · Score: 4, Insightful

    For only $500,000 per dose.

    --
    Seven puppies were harmed during the making of this post.
    1. Re:Coming soon by Anonymous Coward · · Score: 0

      Who cares how much it costs if it can safe your life?

    2. Re:Coming soon by St.Creed · · Score: 3, Interesting

      Let's assume it does cost that much. Suppose I'm a minister of a health department, and I have 10 million to spend on medication for 10.000 patients. I can treat them all with vaccines, antibiotics, and set broken bones for that amount, or I can provide therapy for one patient... I'm afraid that one patient will have to go elsewhere.

      As long as the medical companies are racking up profits to the tune of 1000% on medication, there will NEVER be a budget that can buy all the medication a population needs. Since each company will charge "what the market will bear" the combined effect is more than the market can actually bear. And thus people die.

      --
      Therefore, by the (faulty) logic you're using, you're just a cow with a keyboard - osu-neko (2604)
    3. Re:Coming soon by newcastlejon · · Score: 5, Insightful

      Who cares how much it costs if it can safe your life?

      People who can't afford it.

      --
      If God forks the Universe every time you roll a die, he'd better have a damned good memory.
    4. Re:Coming soon by Dunbal · · Score: 1

      OK I'll remind you of that when you're bitching about how your health insurance premiums have gone up. Again.

      --
      Seven puppies were harmed during the making of this post.
    5. Re:Coming soon by ShanghaiBill · · Score: 2

      For only $500,000 per dose.

      But only $20 in Canada.

    6. Re:Coming soon by Anonymous Coward · · Score: 0

      That is why it is best no to have this kind of cure. All it does is mess up the actuary tables for Social Security.

    7. Re: Coming soon by Anonymous Coward · · Score: 0

      This is a good example of why intellectual property rights suck. It possibly helps innovation but at the expense of everyone who actually benefits from that innovation. $500,000 isn't a good price though, you want something just high enough that the insurance companies will accept and actually pay for.

    8. Re:Coming soon by tlambert · · Score: 1

      That is why it is best no to have this kind of cure. All it does is mess up the actuary tables for Social Security.

      This is a good point.

      Because it is our reason for existing to make actuaries happy because...

      OK, I can't hold out any longer: FUCK THEM.

      "Oh my holy hell, you sank my business model!"

      "And?"

      "But it's MY business model!"

      "And?"

      "But .. but .. but ..."

      "And?"

      Not really caring about some "bro" and his business model.

    9. Re:Coming soon by dgatwood · · Score: 1

      For only $500,000 per dose.

      For now.

      Historically, T-cell therapy has been specific to a single person, because it had to be constructed using that person's own T cells. However, some teams are working on custom T cells that are modified to avoid expressing the genes that would normally cause them to attack unknown cells, thus allowing generic, off-the-shelf T cells to be introduced into anyone. Assuming it is possible to do that with CD4 cells, and assuming the immune system doesn't immediately attack and destroy those CD4 cells, it might be possible to build an off-the-shelf T-cell therapy based on what these folks are doing, in which case the cost will eventually be much, much lower.

      --

      Check out my sci-fi/humor trilogy at PatriotsBooks.

    10. Re:Coming soon by Anonymous Coward · · Score: 0

      Who cares how much it costs if it can safe your life?

      You can't possibly be that stupid. Can you?

    11. Re:Coming soon by maxm · · Score: 1

      If you think that a viable and functioning treatment will keep staying expensive then you have very little imagination. Immune therapy is a hot topic these days, and seem to be very suitable for automation. It actually seem to be best suited for automation. So my best guess is that prices will plummet if it becomes standard.

      --
      Max M - IT's Mad Science
    12. Re:Coming soon by slashrio · · Score: 1

      If you don't have the money, it won't save your life at all.

      --
      "Trump!!", the new Godwin.
    13. Re:Coming soon by Anonymous Coward · · Score: 0

      That's why you need the 2nd amendment. Haven't you seen the movie where the hero captures the scientist with access, drags him back to the highly secure laboratory in the middle of the night guarded by a single Barney Fife and forces the scientist to give him the cure/antidote/whatever? I think it was called Die Hard Tumors.

    14. Re:Coming soon by lsatenstein · · Score: 1

      Let's assume it does cost that much. Suppose I'm a minister of a health department, and I have 10 million to spend on medication for 10.000 patients. I can treat them all with vaccines, antibiotics, and set broken bones for that amount, or I can provide therapy for one patient... I'm afraid that one patient will have to go elsewhere.

      As long as the medical companies are racking up profits to the tune of 1000% on medication, there will NEVER be a budget that can buy all the medication a population needs. Since each company will charge "what the market will bear" the combined effect is more than the market can actually bear. And thus people die.

      I guess you would have to get affordble treatment outsideof the USA (Europe,Israel, Russia, Canada, etc)

      --
      Leslie Satenstein Montreal Quebec Canada
    15. Re:Coming soon by St.Creed · · Score: 1

      I live in Europe, in The Netherlands. I just quoted the discussion that is currently running in the papers and the media. I live in a rich country, but the budget for healthcare is still limited. Cheaper than the US, but paying a lot of money for three months more life? Nope.

      Since I wrote my previous comment, we got some news related to this. An acquaintance of my wife lived in China. Last week he suicided. He had cancer, and if had lived on, his daughter would have had to take on a lot of debt to pay for his treatment just to live a bit longer. Basically, she'd have had to sell herself. To avoid that, he suicided.

      --
      Therefore, by the (faulty) logic you're using, you're just a cow with a keyboard - osu-neko (2604)
    16. Re:Coming soon by slashrio · · Score: 1

      Eligium is another example :)

      --
      "Trump!!", the new Godwin.
  3. What? by Anonymous Coward · · Score: 0, Insightful

    How is this news? Honestly guys, I've never considered doing quitting Slashdot before, but what is this?

    1. Re:What? by Anonymous Coward · · Score: 0

      but what is this?

      A slashvertisement for Kite Pharma Inc., wasn't that completely obvious from the summary?

  4. MEATBAGS! by jeffb+(2.718) · · Score: 2

    It's Slashdot's dirty little secret: many posters are actually meatbags. Sometimes some of them forget to pretend that they aren't interested in meatbag-only news, like meatbag debugging techniques.

    If you're (understandably) grossed out by meatbag-related news, yeah, you might want to consider relocating.

    1. Re:MEATBAGS! by Anonymous Coward · · Score: 0

      Actually, we are ugly bags of mostly water...

    2. Re: MEATBAGS! by Anonymous Coward · · Score: 0

      And meat is mostly water, or at least it is after my local supermarket wraps it up and puts it on a shelf.

  5. Re:Uncurable? by Anonymous Coward · · Score: 0

    Funnily enough, the medical establishment actually sells drugs that went through trials which proven that they do, in fact, have a positive effect on cancer. I'd love to see some results of medical trials done with alternative therapies.

  6. Re:But of course those Republicans... by Anonymous Coward · · Score: 0

    have outlawed further research into this.

    But what happens when Republicans get cancer?

  7. For the last time by thinkwaitfast · · Score: 3, Funny

    It's not a tumor.

  8. Re:Uncurable? by sjames · · Score: 1

    You might be surprised how little effect in some cases.

  9. Some tumors are by Anonymous Coward · · Score: 0

    And some aren't.

    Thanks for reading!

  10. Re:Uncurable? by Megol · · Score: 5, Informative

    Nice blurb. Of course it mentions FDA aproval otherwise it would be verboten.

    Now if you or someone you know is sick with Cancer or another one of those "incurable" diseases my advice is: do not be afraid to search for a cure yourself.

    They should - many of the so-called "cures" are dangerous in many ways. Some of them directly (as injecting poisons isn't healthy) and some indirectly (reducing effects of medical treatment). Some are "harmless", assuming the patient doesn't think they should replace real, proven effective treatment with whatever snake-oil they choose. Those in the third category can even have positive effects just as any other placebo.

    The very idea of a cancer cure is idiotic as it is a wide spectrum of different kinds of cellular malfunction. That's the reason there are a lot of different drugs and treatments as something effective for one of the cancers will not be effective for another kind.

    Yes, a cure. I'm sure it's a crazy concept for many people stuck with approved science but until you have direct, personal experience with an option you can't dismiss it anymore than you can dismiss mainstream-approved chemoterapy and radiotherapy, which by the way are bigger killers than the cancer itself.

    And that's bullshit spread by ignorant fools and people wanting to make money on peoples fears and hopes. How do I know? Science, medical science.
    Yes there are people that dies of the cancer treatment, most commonly by a fragile body overdosing on painkillers. It isn't talked about much but is a reality. But how should those deaths be avoided? Many terminal cancer cases are extremely painful and not giving them large amounts of painkillers would be torture of people not (even if they'd want to) capable of ending their own lives, even with the Hippocratic ideals in mind allowing the patients to be tortured by their own decaying bodies for a few extra days of "life" in agony isn't a realistic choice.

    Mind you I'm not saying there aren't charlatans out for desperate people.There are a lot... in the medical establishment as well as outside of it. Caveat emptor.

    I can count 6 people I know of (having read their sites, articles etc.) that thought they knew a cure for cancer. They all died of the cancer they were sure to be cured. Some of them just "knew" the cure(s), some of them left a huge pile of robbed corpses.

    There are people that claim to have been cured by something, the thing in common is that they either was self-diagnosed or diagnosed by quacks.

    If someone told me or anybody else I know that I/he/she have terminal cancer I'd seek a second opinion (not expecting any better news) and then just accept palliative care trying to make my/his/her last days as comfortable as possible.

    I'll end by noting that you didn't say what any of the "cures" are.

  11. Obligatory xkcd by GuB-42 · · Score: 4, Interesting

    Genetically modified T-cells to treat cancer, reminds me of this.
    https://xkcd.com/938/

  12. New? by Anonymous Coward · · Score: 0

    Jut use the old, proven cures:
    http://topdocumentaryfilms.com...

  13. Cancer - A Different approach Non Linear Editing by Anonymous Coward · · Score: 0

    Seems to me we don't work on the obvious attack vector.

    Cancer affects organs and tissues.

    DNA is a script for "Life" from cradle to grave.

    Why not re-write the script to "temporarily" edit out that tissue or organ.. say surgery without surgery.. so now your clear of cancer.. those cells basically "Deleted" themselves.

    Then re-edit the script "grow a new organ" or tissue.. using stem cells.. or simply inform the extracellular matrix.. time to grow a new organ.. or regenerate that tissue.

    You could cure HIV and other retrovirus infect cells the same way..

    The only problem would be "making up" for the temporarily missing organ.. or tissue.. temporarily.. many organs are semi-redundant.. or could offload some of the other responsibilities.

    Brain recycling though might be a little tough.. you would want to "download" the mermories.. or save them off in some fashion while the brain was being replaced. The upload them later.

  14. Re:But of course those Republicans... by Applehu+Akbar · · Score: 2

    have outlawed further research into this.

    Read the article. It's a GMO technology, so only Republicans will use it.

  15. Re:Uncurable? by Anonymous Coward · · Score: 0

    If you want to put your lives in the hands of an industry that makes trillions as long as you stay sick, that's up to you.

    I didn't mention any specific cures because I don't want to be seen as shilling for a particular cause. Anyone who is interested can pick a search engine and start digging.
    I'll say this - The more effective cures are very likely the ones that got banned. Also search for books burned by the FDA - when the government burns books it's usually a good endorsement of the work.

  16. Re:Uncurable? by TheRaven64 · · Score: 1

    The very idea of a cancer cure is idiotic as it is a wide spectrum of different kinds of cellular malfunction

    The treatment in TFA (assuming that TFA is about the same treatment that was in the news a couple of days ago) works by allowing the body's natural defences against cancer to work properly. Cells become cancerous all of the time but they're almost always killed immediately by your autoimmune response. Some mutate in a way that prevents the immune system recognising them as broken and can then spread quite quickly. This treatment allows the immune system to recognise the cancer cells, so is likely to work on most, if not all, forms of cancer. The catch is that it requires a specific implementation for each patient.

    --
    I am TheRaven on Soylent News
  17. Re:But of course those Republicans... by pslytely+psycho · · Score: 1

    Don't worry, they gave the research to the Umbrella Corporation to secretly develop in an underground lab in Raccoon City.....

    --
    Donald Trump, on a crusade to make Nixon look respectable
  18. Tiny sample size by Anonymous Coward · · Score: 0

    Three responders out of fourteen. Wake me when there's been a real clinical trial that's properly powered. And the only endpoint that really matters is survival.

  19. Translation by Thelasko · · Score: 1

    Immunotherapy has been applied to another type of cancer, and the results look promising.

    For those that don't know, immunotherapy was a big breakthrough in cancer research in 2010. It's very expensive, as it has to be tailor made to the patient and the specific form of cancer. Many times it involves genetically modifying the patient's immune system to recognize the cancer cells as an infection.

    --
    One of our competitors trademarked the term "hypothesis". From now on, we will call them "boneheaded ideas".
  20. Re:Uncurable? by Anonymous Coward · · Score: 0

    Nice blurb. Of course it mentions FDA aproval otherwise it would be verboten.

    Now if you or someone you know is sick with Cancer or another one of those "incurable" diseases my advice is: do not be afraid to search for a cure yourself.

    They should - many of the so-called "cures" are dangerous in many ways. Some of them directly (as injecting poisons isn't healthy) and some indirectly (reducing effects of medical treatment). Some are "harmless", assuming the patient doesn't think they should replace real, proven effective treatment with whatever snake-oil they choose. Those in the third category can even have positive effects just as any other placebo.

    The very idea of a cancer cure is idiotic as it is a wide spectrum of different kinds of cellular malfunction. That's the reason there are a lot of different drugs and treatments as something effective for one of the cancers will not be effective for another kind.

    Yes, a cure. I'm sure it's a crazy concept for many people stuck with approved science but until you have direct, personal experience with an option you can't dismiss it anymore than you can dismiss mainstream-approved chemoterapy and radiotherapy, which by the way are bigger killers than the cancer itself.

    And that's bullshit spread by ignorant fools and people wanting to make money on peoples fears and hopes. How do I know? Science, medical science.
    Yes there are people that dies of the cancer treatment, most commonly by a fragile body overdosing on painkillers. It isn't talked about much but is a reality. But how should those deaths be avoided? Many terminal cancer cases are extremely painful and not giving them large amounts of painkillers would be torture of people not (even if they'd want to) capable of ending their own lives, even with the Hippocratic ideals in mind allowing the patients to be tortured by their own decaying bodies for a few extra days of "life" in agony isn't a realistic choice.

    Mind you I'm not saying there aren't charlatans out for desperate people.There are a lot... in the medical establishment as well as outside of it. Caveat emptor.

    I can count 6 people I know of (having read their sites, articles etc.) that thought they knew a cure for cancer. They all died of the cancer they were sure to be cured. Some of them just "knew" the cure(s), some of them left a huge pile of robbed corpses.

    There are people that claim to have been cured by something, the thing in common is that they either was self-diagnosed or diagnosed by quacks.

    If someone told me or anybody else I know that I/he/she have terminal cancer I'd seek a second opinion (not expecting any better news) and then just accept palliative care trying to make my/his/her last days as comfortable as possible.

    I'll end by noting that you didn't say what any of the "cures" are.

    Let's get something clear, ALL Cancer is terminal.
    It may go into remission, but the cells are ALWAYS in your body, waiting for the next chance to invade an organ or vascular system.
    As someone who recently lost a life partner after an 18 year battle, I have the chops to go with the statement. Anyone who tells you that you're 'cured' of cancer is blowing smoke up your behind.

  21. Yawn. Cancer cures abound, just not in big-pharma. by TheRealLifeboy · · Score: 2

    There are many spectacularly successful cures for cancers that simply enable the body to reverse the process that started the tumor in the first place.

    My father-in-law had a 10cm lung tumour last year and in 23 days the tumor shrank 50% and was gone in 60 days. The "magic"? The juice of 1.5kg of carrots daily.

    Oncologists just laugh and shake their heads because their information network doesn't have room for anything outside the feeds from their petro-chemical overlords. Yes, I said it. They're just being kept in the dark on purpose, minions in the war for the financial exploitation of the world's ignoramuses.

    Get started here... and many others.

  22. "Affordable" treatment in Russia is a croc of shit by burbilog · · Score: 1

    I guess you would have to get affordble treatment outsideof the USA (Europe,Israel, Russia, Canada, etc)

    "Affordable" in Russia? What a horrible joke. Treatment in Russia is not affordable. It was kinda affordable in USSR but you had to spend a lot of time proving that you need treatment, and even then it was matter of luck and bribing the "right" people. Today nothing real is available through "free" system except very basic paperwork and if you need real treatment you have to pay a lot of money. And commercial medical insurance is outrageously expensive, impossible to pay for average people.

    And if you've got cancer, you are done in Russia. They won't even provide painkillers because painkillers are "drugs" and to get daily dose your relatives have to stand in lines almost every day and still officials often refuse to give out painkillers! Medical personnel is afraid of being accused of drugs trade, cops are in constant search for easy prey to accuse somebody without real hard work.

    About two years ago a well known rear-admiral Vyacheslav Apanasenko commited suicide because medical personnel refused to give him painkillers. His suicide caused serious uproar in media -- and NOTHING changed. So if you've got cancer in Russia you'd better kill yourself, because you'll be left dying without aid and even without painkillers.