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Researchers Successfully Achieve Suspended Animation With Mouse Embryos (engadget.com)

"It was completely surprising. We were standing around in the tissue culture room, scratching our heads, and saying 'Wow, what do we make of this?'" An anonymous reader quotes Engadget's report on new research with "huge implications": A team of scientists from the University of California, San Francisco only wanted to slow down mice embryos' cell growth in the lab. Instead, they managed to completely pause their development, putting the blastocysts (very early embryos) in suspended animation for a month. What's more, they found that the process can put stem cells derived from the blastocysts in suspended animation as well, [and] the researchers were able to prove that the embryos can develop normally even after a pause in their growth. Team member Ramalho-Santos from the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research said... "To put it in perspective, mouse pregnancies only last about 20 days, so the 30-day-old 'paused' embryos we were seeing would have been pups approaching weaning already if they'd been allowed to develop normally."
The new research could lead to better treatments for damaged organs and even aging, according to the article. (Besides, of course, its science fiction-y implications for long-distance space travel...)

28 comments

  1. "long-distance space travel" by lobiusmoop · · Score: 2

    For that sort of thing, bacteria are a much better bet. Much more hardy than higher Earth-evolved species and proven to survive in suspended animation over the geological time-scales involved in interstellar travel.

    --
    "I bless every day that I continue to live, for every day is pure profit."
    1. Re:"long-distance space travel" by Anonymous Coward · · Score: 0

      I'll sleep until they develop a way to suspend multicellural organism with differentiated tissues.

    2. Re: "long-distance space travel" by Anonymous Coward · · Score: 0

      Yeah, but bacteria aren't human and defeat the primary purpose of space exploration, which is spreading human life to the stars.

    3. Re:"long-distance space travel" by Anonymous Coward · · Score: 0

      What could bacteria do for us on exoplanets? So far we've been careful not to pollute outer space with [micro] life, why should we change that?

    4. Re:"long-distance space travel" by dudpixel · · Score: 1

      Great, now you just need to explain what the point of sending bacteria on a long-distance space trip would be...

      --
      This seemed like a reasonable sig at the time.
    5. Re:"long-distance space travel" by Anonymous Coward · · Score: 0

      Great, now you just need to explain what the point of sending bacteria on a long-distance space trip would be...

      So they can eventually evolve into humans (and -oids), and thus Star Trek.

    6. Re:"long-distance space travel" by Vastad · · Score: 1

      To take a proactive role in Panspermia. I think our terrestrial bacteria, water bears and extremophiles should be seeded on as many suitable planets as possible. We're not going to be around forever so we should definitely get as much potential for new sapient life to evolve somewhere else. Or at least an eon or two of life on some previously uninteresting backwater planet that had no previous chance of having life evolve the "hard way" on it.

    7. Re:"long-distance space travel" by lucien86 · · Score: 1

      Your statement depends on an assumption that General Relativity is correct above the speed of light. An assumption for which there is less proof than .. astrology, geocentric solar system, hollow Earth theory, flat Earth theory, Biblical creationism, Barney the dinosaur... Above the speed of light general relativity defines a universe with no spatial stability, and that only makes sense in a universe that is a simulation or otherwise doesn't exist.. The only type of FTL theory that does work logically is an absolute frame model, and that requires an FTL simultaneity. An FTL simultaneity rules out general relativity categorically..

      In a universe like that FTL travel is possible. (or at least not categorically impossible)

      --
      Below the speed of light Special Relativity is one of the most accurate theories in physics - above the speed of light..
    8. Re:"long-distance space travel" by Anonymous Coward · · Score: 0

      Maybe it will adapt to an exoplanet and create entirely new forms of life. Why would you consider this to be polluting?

  2. stockpiled stemcells by wierd_w · · Score: 5, Insightful

    It also means that we can now inexpensively stockpile stemcells without appreciable loss. Freezing is expensive, and it is costly in time and other resources to store and retrieve tissues that way.

    Since this is a chemical doping technique, this would allow us to store regenerative stemcells much the way we store whole blood, or perhaps even longer, using simple refrigeration techniques.

    This could have wide reaching implications in stemcell based regenerative medicine, since humans could inexpensively bank the cultures now.

  3. Indeed, lots of implications. by Anonymous Coward · · Score: 0

    Depending on the length of 'viability' this could have lots of interesting implications.

    The abortion debate, for instance could become a debate in many nations over who pays for the billions/trillions of suspended embyos.

    Same for insurance companies in several nations, who will have to 'consult' with patients about if suspended animation for a cure, or even if treatment is too expensive, and they will be put under until a viable generic is available.

    Basically, any time a group or company would find it cheaper to kill someone, but politically unpopular to actually kill them, this could be an option. Then, as time passes and pressure builds, change the debate to "should we dispose of all this material?"

    The plot kind of writes itself for this kind of story.

  4. Re:Consent by Anonymous Coward · · Score: 0

    Vivisectors don't care.

    They're primarily obese (from eating meat) white males like Dick Cheney. Do you think a person link this has the ability to empathize with animals? I highly doubt it.

  5. Take a closer look at macropods... by mi · · Score: 4, Interesting

    Instead, they managed to completely pause their development, putting the blastocysts (very early embryos) in suspended animation for a month.

    Depending on availability of water and food, mama roo (and mama wallaby) can suspend her regular four-week pregnancy by up to two years (see embyonic diapause — it is not unique to marsupials).

    This suggests two things:

    • the mechanisms used by the animals in nature, may also be applicable to us;
    • the suspension, however achieved, may not be infinite — there could be a point, after which the embryo, may not, in fact, resume normal development.
    --
    In Soviet Washington the swamp drains you.
  6. Cancer help by iplayfast · · Score: 2

    From the article "They used a drug that inhibited the activities of a protein called mTOR, which regulates different cellular processes. By inhibiting the protein, they also inhibit the cells' activities."

    I wonder if this might prove useful for stopping runaway tumors.

  7. Mice on ice. by denzacar · · Score: 1
    --
    Mit der Dummheit kämpfen Götter selbst vergebens
  8. Re:Consent by Anonymous Coward · · Score: 0

    They are just embryos - not real mice.

    Trust me, if they were doing anything untoward with mice, Disney would step in, pronto!

  9. Pfft by Anonymous Coward · · Score: 0

    Disney perfected this with their "vault" decades ago

  10. Who needs culture by petes_PoV · · Score: 5, Funny

    We were standing around in the tissue culture room, scratching our heads

    Well, I suppose that's one way to get samples.

    --
    politicians are like babies' nappies: they should both be changed regularly and for the same reasons
  11. Re: Consent by Anonymous Coward · · Score: 0

    Maybe your mother should have obtained consent from you before giving birth to you. No can do? Sorry, some births were a mistake.

  12. Am I missing something by Anonymous Coward · · Score: 0

    "Fertility Researchers Successfully Achieved Suspended Animation With Human Embryos - Decades Ago"

  13. Space travel by manu0601 · · Score: 1

    Ageing is not the only problem of space travel. When outside of Earth magnetic field, the space traveler is hit by high energy cosmic particle that damage DNA.

    And while you are in "animation suspension", things may get worse because cellular DNA repair mechanism are switched off.

    1. Re:Space travel by Anonymous Coward · · Score: 0

      Yes but if you have people stationary in suspension you can add all the protection they need because they are in a smaller area for the duration of the trip. Less food, less mass, faster transit, its pretty win win even if it isn't completely necessary.

      Who knows what the damage could be in the long term but there is a definite benefit to freezing people for space travel.

  14. Solution for critical illness during pregnancy? by Stonent1 · · Score: 1

    So lets say the Dr. finds something wrong with pregnant woman that requires treatment, but the treatment has to be completed before the baby is born because the stress of pregnancy along with her ailment might kill her. This might be just what they needed. Put the baby in a suspended state until the treatment has finished. Perhaps this could also be used in a situation where they baby might die as a result of its own body processing the treatment. If it could be suspended, it may survive.

  15. It must be Pinky and the Brain! by Required+Snark · · Score: 2
    This must be how the Brain is finally going to take over the eartht!

    They're Pinky and the Brain

    Yes, Pinky and the Brain

    One is a genius, the other's other insane

    They're laboratory mice

    Their genes have been spliced

    They're Pinky, they're Pinky and the Brain

    Brain, Brain, Brain, Brain, Brain, Brain, Brain, Brain

    -

    Before each night is done

    Their plan will be unfurled

    By the dawning of the sun

    They'll take over the world

    --
    Why is Snark Required?
  16. The song they were singing... by wikthemighty · · Score: 1
    --
    "There are people who do not love their fellow human being, and I _hate_ people like that!" - Tom Lehrer