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Genetically-Modified 'Surrogate Hens' Could Lay Eggs of Rare Chicken Breeds, Scientists Say (theguardian.com)

In an effort to preserve rare varieties of chicken breeds and diversify the chicken gene pool, scientists at the University of Edinburgh's Roslin Institute have come up with a plan to breed genetically-modified chickens designed to act as surrogates that would be capable of laying eggs from any rare breed. Such rare breeds include the Nankin, Scots Dumpy and Sicilian Buttercup. The Guardian reports: The surrogacy technique, which places a new, mind-bending twist on the classic chicken or egg question, involves first genetically engineering hens to be sterile. This is done by deleting a gene, called DDX4, that is required for the development of primordial follicles (the precursors to eggs) meaning that the surrogate hens will never lay eggs that are biologically their own. The next step will be to transplant follicles from rare birds into the surrogate (this is done before the surrogate chick is hatched from its own egg), meaning it would go on to lay eggs belonging to entirely different breeds of chicken. Given that the hens would also need to be artificially inseminated with sperm from the same rare variety, the approach may appear unnecessarily convoluted. Why not just breed the rare birds the normal way? The scientists' ultimate goal is to create a gene bank of chicken breeds preserved for posterity, and since primordial follicles can be frozen efficiently, while eggs cannot, the surrogacy technique serves an essential work-around. Mike McGrew, who is leading the project and is the first author on a paper on the work published this week in the journal Development, predicts that the surrogates will be able to lay eggs from any breed, including chicken's wild predecessor, the red junglefowl, but he is doubtful about whether it will work efficiently across species -- it is not likely that the surrogate hens will be giving birth to eagle chicks, for instance. Richard Broad, a field officer for the Rare Breeds Survival Trust, agreed that rare chickens could be a source of valuable genetic variation, potentially carrying variants that would provide resistance against new forms of avian flu. At present, the team is focused on chicken breeds, but expects the technique to work to preserve rare varieties of ducks, geese and quail.

33 comments

  1. I knew it! by Kokuyo · · Score: 1

    I always said the egg came first!

    1. Re:I knew it! by nospam007 · · Score: 2

      "I always said the egg came first!"

      Everybody knows that dinosaurs laid eggs for millions of years before there was even a chicken.

    2. Re:I knew it! by Hognoxious · · Score: 1

      OK. So what came first - the dinosaur or the egg?

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
    3. Re:I knew it! by alvinrod · · Score: 3, Funny

      Actually, it was the rooster.

    4. Re:I knew it! by Mr+D+from+63 · · Score: 2

      Maybe in chronological order, but not in the pecking order.

  2. Surrogate chimps by Anonymous Coward · · Score: 0

    If a chicken can lay a surrogate egg, so can an indo-chimp on H1B. Called anchor chimp.

    1. Re:Surrogate chimps by Anonymous Coward · · Score: 0

      go kill ur self u racist piece of shit

  3. Hens giving birth? by twosat · · Score: 1

    "...it is not likely that the surrogate hens will be giving birth to eagle chicks..." - I know for a fact that this is impossible since birds do not give birth!

    1. Re: Hens giving birth? by Anonymous Coward · · Score: 0

      They do oviposit though.

      My question:

      How is this any different from any other chimera, aside from having a targeted organ system?

    2. Re: Hens giving birth? by rmdingler · · Score: 1
      Chimera? Unlikely... still just one zygote.

      While there is an infinitesimal possibility that some DNA could be transferred from the mother to the egg that she is carrying, this exchanged DNA will have no discernible effect. At most, it will be a few cells with DNA hiding out in the trillions of cells of the offspring. Too few cells of the surrogate mother are passed to the child for them to actually pass on any of her characteristics or affect the child in any significant way.

      --
      Happiness in intelligent people is the rarest thing I know.

      Ernest Hemingway

    3. Re: Hens giving birth? by Anonymous Coward · · Score: 0

      I was meaning this:

      The surrogate hen is itself a chimera. It contains germline cells from a rare chicken breed, but is otherwise some other, more common (or more prodigiously egg laying) breed of chicken. This is why it produces "foreign" eggs.

      As such, it has reproductive capacity as if it were the rare breed, but really is not phenotypically.

    4. Re: Hens giving birth? by rmdingler · · Score: 3, Informative
      In humans, at least, this phenomenon occurs in most pregnancies.

      FTA: A 2015 study suggested that this happens in almost all pregnant women, at least temporarily. The researchers tested tissue samples from the kidneys, livers, spleens, lungs, hearts, and brains of 26 women who tragically died while pregnant or within one month of giving birth. The study found that the women had fetal cells in all of these tissues. The researchers knew that the cells were from the fetus, and not from the mother, because the cells contained a Y chromosome (found only in males) and the women had all been carrying sons. In some cases, fetal cells may stay in a woman's body for years. In a 2012 study, researchers analyzed the brains of 59 women ages 32 to 101, after they had died. They found 63 percent of these women had traces of male DNA from fetal cells in their brains. The oldest woman to have fetal cells in her brain was 94 years old, suggesting that these cells can sometimes stay in the body for a lifetime.

      --
      Happiness in intelligent people is the rarest thing I know.

      Ernest Hemingway

    5. Re: Hens giving birth? by Anonymous Coward · · Score: 0

      I am aware of microchimerism. That is not what I am asking here.

      These hens are being genetically engineered to carry germline cells that are not their own. That makes them artificial chimeras, in the same vein as mouse/rat hybrids-- created by depositing embryonic stem cells from another genetically distinct individual into the blastocyst as the embryo develops.

      By manipulating either the genome of the host (to guide cell migration), or the timing and location at which the cells are introduced, the organs impacted by the introduction and integration of the foreign cell line can be controlled.

      In this case, you end up with a common chicken, which has an ovaduct and ovary that is composed of cells that came from a rare breed of chicken, resulting in that chicken producing eggs from that rare breed, instead of from its own germ line.

      I don't know how much more clearly I can state this.

      This kind of chimerism is how they get mice to produce rat sperm cells, and vice versa.

    6. Re: Hens giving birth? by Anonymous Coward · · Score: 0

      But maybe they could lay a dino egg? Jurassic chicken run

  4. That DOES explain where you came from. by mmell · · Score: 1

    Just sayin'.

  5. Alright then! by Anonymous Coward · · Score: 0

    Plan to exterminate all wildlife may proceed.

    Captcha: masonry

    1. Re:Alright then! by Dr.+Spork · · Score: 2

      That plan is in motion and will not be affected by research at some Scottish genetics lab. What they're trying to do is to make sure that wild chickens don't truly go extinct no matter how much wildlife we destroy: They can always be unfrozen and their population can reboot at some unspecified future time when we decide to be better stewards of nature.

    2. Re:Alright then! by slashrio · · Score: 1

      And may be very successful by just flipping the switch of the freezer to OFF.
      The possible variations to this theme include destroying the generator, stopping the access to diesel, etc., etc.

      --
      "Trump!!", the new Godwin.
  6. Hasn't this already been done? by realkiwi · · Score: 1
    --
    realkiwi
  7. Rare chicken by rossdee · · Score: 1

    I prefer my chicken well done

    1. Re:Rare chicken by Anonymous Coward · · Score: 0

      You shouldn't eat chicken. Factory farmed chickens are raised inhumanely and have as much cholesterol as beef. Don't be fooled by "free range" either. Look it up. It's a farce.

    2. Re:Rare chicken by tomhath · · Score: 1

      So long as it's cooked to an internal temperature of 160F chicken is okay to eat.

      Oh, and by the way, cholesterol isn't harmful in the amount you get from chicken or beef. But you should minimize the amount of processed sugar and flour in your diet.

    3. Re:Rare chicken by slashrio · · Score: 1

      I don't know how to categorise this fallacy, but it's an enormous one.
      Who said he doesn't eat real organically raised (real) free ranch chicken?

      --
      "Trump!!", the new Godwin.
  8. Chicken breeds preserved for posterity by jenningsthecat · · Score: 4, Interesting

    How about 'chicken breeds preserved so chicken actually tastes like chicken again'? I'm an old fart, and chicken tastes vastly more bland than it did when I was a kid. And no, it's not just the 'everything was better back then' syndrome. When I was in Guyana I ate meat from fully-grown chickens that weren't all that much bigger than just the breasts of the chickens we get here, and its flavour took me back to the chicken I used to eat as a kid.

    The chickens we buy in supermarkets have been bred to attain maximum weight in the minimum amount of time possible; they have also been bred to have a higher survival rate during transport, and to be more disease resistant. With these genetic alterations, they just taste bland - rather like most tomatoes today, and for much the same reasons.

    --
    'The Economy' is a giant Ponzi scheme whose most pitiable suckers are the youngest among us and the yet-unborn.
    1. Re:Chicken breeds preserved for posterity by drinkypoo · · Score: 2

      The chickens we buy in supermarkets have been bred to attain maximum weight in the minimum amount of time possible; they have also been bred to have a higher survival rate during transport, and to be more disease resistant. With these genetic alterations, they just taste bland - rather like most tomatoes today, and for much the same reasons.

      Are you sure that the difference you're detecting isn't down to what they're eating? Gallena de patio commonly consumes a far more varied diet than a factory-farmed, never-sees-the-sun-but-we-can-still-call-it-cage-free bird.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    2. Re:Chicken breeds preserved for posterity by jenningsthecat · · Score: 1

      Are you sure that the difference you're detecting isn't down to what they're eating? Gallena de patio commonly consumes a far more varied diet than a factory-farmed, never-sees-the-sun-but-we-can-still-call-it-cage-free bird.

      Good point - hadn't thought of it. Thanks.

      --
      'The Economy' is a giant Ponzi scheme whose most pitiable suckers are the youngest among us and the yet-unborn.
    3. Re:Chicken breeds preserved for posterity by chiefmojorising · · Score: 3, Informative

      That's part of it. The chicken you get from a store is almost certainly a Cornish Cross, which reaches market weight in something like 5 weeks for a fryer and 8 weeks for a broiler. Heritage breeds (read: "real" chickens) take 20-22 weeks to reach maturity. The meat is very, very different -- dark meat is *dark*, far more flavorful, and requires more time / different methods to cook since the muscles have actually been used. CC's mostly do two things: eat and shit. They really don't move around a whole lot.

      Anyway, CC's don't really forage a whole lot anyway, so even if they're raised in a manner that they can eat grass, bugs, etc. they usually don't -- they plop down in front of a feeder and just gorge. They're *amazing* birds, but their quality of life is horrible. It's impossible to beat them on feed conversion ratio, though, which is why that's pretty much all you see. There are some other breeds making their way into the market that take 3-4 more weeks to reach maturity but they're still very, very much in the minority.

    4. Re:Chicken breeds preserved for posterity by Anonymous Coward · · Score: 0

      ... they just taste bland ...

      Freshly killed chickens taste better. I don't know if it's the freezing process or if the chickens are raised differently. Try your butcher, or a supermarket since some chains also sell them.

  9. AWESOME! by Gravis+Zero · · Score: 1

    This is going to do wonders to prevent the extinction of the chocobos! I can't wait to up the population and finally breed a black chocobo! ;)

    --
    Anons need not reply. Questions end with a question mark.
  10. Uh-huh by Anonymous Coward · · Score: 0

    I intentionally avoid headlines that contain the word 'could'. Other people aren't nearly as fascinated with your speculative work as you grad students are or seem to think others should be. We are sorta past all that at this point in our lives. I know it's 'new to you', but we discovered our belly buttons many, many years ago. Staring at them gets real boring after awhile, and yours aren't so unique we are going to waste our time on them, either. NEWSFLASH: There are real problems to be tackled in life.

  11. I still don't get it by nospam007 · · Score: 1

    I can't make head or tail of this 'convoluted workaround'

    1. Take an expensive sterile chicken. (since they're sterile, you can't breed them, you have to buy them)
    2. Kill an expensive, rare chicken to get the follicles.
    3. Put those follicles into the expensive sterile chicken.
    4. Get rare chicks to kill and take follicles to freeze.

    The only thing that i can think of is that the expensive, sterile chicken can lay 400 eggs a year and the rare chicken only a dozen or so.

    1. Re:I still don't get it by Hognoxious · · Score: 1

      Maybe you should RTFA? The follicles survive freezing, so they're a good long-term backup medium. A genetic thumb drive that you keep at your friend's house, if you like. If the breed goes extinct defrost the follicles, implant in a mother hen, and you're good to go.

      --
      Confucius say, "Find worm in apple - bad. Find half a worm - worse."
  12. hens-a-poppin' by Anonymous Coward · · Score: 0

    Can they lay progressive eggs directly into boiling water ? Count to 3-min and remove them ?? Eat the yoke ???