Slashdot Mirror


Vitamin B3 Supplement Can Prevent Miscarriages and Birth Defects, Says Study (news.com.au)

brindafella writes: The landmark finding about vitamin B3, made by the Victor Chang Institute in Sydney, Australia, has been described as "the most important discovery for pregnant women since folate." The study has been published in the New England Journal of Medicine. From News.com.au: "The historic discovery, believed to be among Australia's greatest ever medical achievements, is expected to forever change the way pregnant women are cared for around the globe. Every year 7.9 million babies are born with a birth defect worldwide and one in four pregnant women suffer a miscarriage in Australia. In the vast majority of cases the cause of these problems has remained a mystery. Until now. Professor Sally Dunwoodie from the Victor Chang Institute has identified a major cause of miscarriages as well as heart, spinal, kidney and cleft palate problems in newborn babies. The landmark study found that a deficiency in a vital molecule, known as NAD, prevents a baby's organs from developing correctly in the womb. Nicotinamide adenine dinucleotide (NAD) is one of the most important molecules in all living cells. NAD synthesis is essential for energy production, DNA repair and cell communication. Disrupting its production causes a NAD deficiency. The Victor Chang researchers have found this deficiency is particularly harmful during a pregnancy as it cripples an embryo when it is forming. At the heart of the paramount discovery is the dietary supplement vitamin B3, also known as niacin. Scientists at the Victor Chang Institute have discovered how to prevent miscarriages and birth defects by simply boosting levels of the nutrient during pregnancy."

39 comments

  1. In Mice by Anonymous Coward · · Score: 5, Interesting

    This is massive overstatement and we need to wait for some human evidence.

    http://theconversation.com/pregnant-women-shouldnt-start-taking-vitamin-b3-just-yet-reports-it-prevents-miscarriage-and-birth-defects-are-overblown-82315

    1. Re:In Mice by redback · · Score: 2

      or just eat vegemite. delicious and high in all sorts of nutrients, including B3

    2. Re:In Mice by Anonymous Coward · · Score: 1

      Exactly this.
      The study relates to mice, with a specific gene mutation.
      It doesn't apply to all causes of miscarriage, and there were no human studies done.

    3. Re: In Mice by Anonymous Coward · · Score: 0

      I don't believe it's ethical to induce B3 deficiencies, to test if miscarriage will ensue. It's a great first step. Vitamin supplementation is already highly recommended, especially folate.

    4. Re:In Mice by Anonymous Coward · · Score: 0

      Good point. But I think it point out that health professionals TRIED THALIDOMIDE BEFORE THEY TRIED B3 SUPPLEMENTS.

    5. Re: In Mice by Anonymous Coward · · Score: 0

      There's only one true way to block miscarriages, and that's with my patented and USDA-approved HOSTS file!
      You thought I was crazy but my court-appointed psychiatrist says otherwise! I am a cow and I say moooooo! You Luddites will never app my appy apps! Apps!

      ~apk

  2. Nicotine by Anonymous Coward · · Score: 0

    Nicotine can be oxidised to nicotinic acid (niacin)

  3. Re:Expect the medical cartel to fight against this by Anonymous Coward · · Score: 0, Troll

    Planned Parenthood:

    https://en.wikipedia.org/wiki/Planned_Parenthood

    Was created by Margaret Sanger for the purpose of eugenics so of course they're willing to help you get rid of a genetically-inferior baby. That was the very reason they were created for.

  4. NAD by Waffle+Iron · · Score: 1

    Isn't that the outfit that pioneered selling stripped-down black electronic components to audiophiles for top dollar?

    1. Re:NAD by Anonymous Coward · · Score: 0

      Nah, NAD was one step above lowly consumer grade.
      Classé sells hyper-inflated junk to audiophiles.

    2. Re:NAD by Anonymous Coward · · Score: 0

      Isn't that the outfit that pioneered selling stripped-down black electronic components to audiophiles for top dollar?

      Actually their current gear is pretty good, especially for the price you pay. Not super-cheap, but it punches above its proverbial weight class by one or two levels.

  5. Huh... by Anonymous Coward · · Score: 0

    And for all these years, I thought smoking while pregnant was bad. The tobacco industry is going to love this study.

  6. Better Idea - Nuke the Norks! by Anonymous Coward · · Score: 0

    And end it nooooow!

    TRUMP powa!

  7. Correct by Anonymous Coward · · Score: 0

    Especially in math class with straight lines n curves, elliptical , Central point..n all disturbs all my wild calculations, resulting suppressed ejaculation..

  8. Elk Antler Spray by PopeRatzo · · Score: 1, Offtopic

    I guess we all knew it would eventually come to this: Slashdot hawking supplements.

    Meet the new Slashdot editor - Gorilla Mindset Juicebro & His Magic Jism.

    http://rationalwiki.org/wiki/M...

    --
    You are welcome on my lawn.
  9. Prevent? Prevent? by Anonymous Coward · · Score: 0

    Prevent !!? how is that suppose to help me now...

    1. Re:Prevent? Prevent? by Carewolf · · Score: 1

      Prevent !!? how is that suppose to help me now...

      It is too late to miscarry you at this point.

  10. Uhh, moderators? by Anonymous Coward · · Score: 0

    Why was this voted down for telling the truth?

    1. Re:Uhh, moderators? by alvinrod · · Score: 1

      Because that was 100 years ago and doesn't have a lot of bearing on the current goals or motivations of the organization. It's a bit like telling a black person that they're terrible for not voting Republican because they were the party that freed the slaves. You may have stated a perfectly true fact, but its one that is irrelevant at the current time.

  11. NAD deficiency? by cyber-vandal · · Score: 1

    Isn't the just a politically incorrect way of describing a female baby?

    1. Re:NAD deficiency? by mentil · · Score: 1

      Ovaries also count as gonads.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
  12. Re:Expect the medical cartel to fight against this by Anonymous Coward · · Score: 0

    All babies are genetically inferior to adults. Lamarckism proves this!

  13. Vitamin B3 Supplement Can Prevent Miscarriages and by rickyslashdot · · Score: 0

    For all the newly pregnant mothers-to-be - - - pre-natal vitamins are NOT a joke - they are a vital necessity for your child's health and welfare ! ! !

    --
    redneck geek
  14. Medicine by Anonymous Coward · · Score: 0

    Hey there, if something as complex as miscarriage has a "simple" solution of adding B3 in your diet, it's probably not properly researched and verified. Not saying that B3 may or may not have some benefit, but it is EXTREMELY likely that it does not prevent miscarriage as a whole.

    -Dr. in Slashdot

    Still take your pre-natal vitamins please, even while you're trying to conceive :)

  15. (B3) nicotinamide has worked wontders by Anonymous Coward · · Score: 0

    My personal experience with nicotinamide (A form of B3) has being amazing, saved my father from arthritis (his 90)
    he could only work 50ft and barely close his hands, and was in constant pain, after 4 months on nicotinamide, his back walking 1.2 Miles every day
    and can close his hand's.. I have a number of other friends who are now on nicotinamide, arfter seeing the his results. And there are all showing benefits too.
    It may be only Anecdotal evidence, but at the end of the day, what else matter's ?

    So if would not surprise me at lest if there was a drop in birth defects.

  16. NIACIN NOT NIACINAMIDE by Anonymous Coward · · Score: 0

    Niacin can give a great buzz when combined with your drug of choice.
    Of course, you don't have to combine it with any drug.
    It dilates the capillaries giving an all-over warm flush. And I do mean WARM.
    If you've never done it before, it can scare the crap out of you.
    You need at least 100mg of niacin NOT niacinamide.
    It's cheap, no prescription required and available at any drug store.
    Also great if you can't warm up on a cold day.
    Try it - you can thank me later.

    AMA Disclaimer: I don't know jack shit, and you shouldn't listen to anything I say.

  17. So, as per ussual, a balanced diet... by Veilex · · Score: 1

    This isn't news. It isn't ground breaking. We've heard this before. In fact, discussions on this topic shifted long ago from if niacin is good to take during pregnancy... to how much is safe. We all know eating right is important. We all know a balanced diet is key... niacin is in a LOT of foods... and you really only need trace amounts, as with most vitamins and minerals... even during pregnancy. Here's a quick breakdown of some foods with niacin --- (1) Turkey. 1 breast: 101 mg (over 100% DV), (2) Chicken breast. 3 oz: 8.9 mg (44% DV), (3) Peanuts. 1 cup: 21.9 mg (over 100% DV), (4) Mushrooms. 1 cup: 7.6 mg (34% DV), (5) Liver. 1 slice: 11.9 mg (60% DV), (6) Tuna. 3 oz: 11.3 mg (56% DV), (7) Green peas. 1 cup: 3 mg (15% DV), (8) Grass-fed Beef. For additional information, go here: https://www.nutrition.gov/

  18. Re:Vitamin B3 Supplement Can Prevent Miscarriages by rickyslashdot · · Score: 1

    hmmmm - - - downgraded as 'REDUNDANT'
    So be it.

    There can NEVER be enough warnings and sound medical advice to give to ANY expectant mother.
    I'll take the hit gracefully.
    I just hope it gets to at least ONE more new mother-to-be and gets her to take the proper nutritional care of her developing child.

    cheers

    --
    redneck geek
  19. Re:Vitamin B3 Supplement Can Prevent Miscarriages by Anonymous Coward · · Score: 0

    Vitamin supplements are not nutrition.

  20. whoa, not so fast by jds91md · · Score: 2

    It is a massive overstatement to say that birth defects are going to be prevented. Did anyone here read the article? I did. This is still in the realm of science and optimism and hypothesis. 1. researchers looked at genes in human family members of those with multiple congenital anomalies, found some genetic stuff, speculated genetic issues could have caused birth defects (and maybe miscarriages) and could be fixed by increased NAD (Niacin, Vit B3) 2. researches put the speculated problematic genes with CRISPR technology into mice. 3. supplementing mice with NAD (Niacin, a.k.a. B3) reduced birth defects That's it. There are a lot of hypotheses and assumptions here, and not a single human miscarriage or birth defect has been prevented yet. This article is great for forming hypotheses like "we oughtta test women/couples for these genes" or "we oughtta give pregnant women vit B3 supplements". But until we actually do these medical studies testing these ideas, we know nothing and have not advanced human health. -- Josh (yes, I am a doctor and I practice obstetrics and I'm not recommending any additional supplementation with Vit B3 until we have outcomes evidence in humans)

    1. Re: whoa, not so fast by Anonymous Coward · · Score: 0

      What if you have a patient in the middle of miscarriage number three, whose mother also had three or four miscarriages, and whose biological clock is ticking? Family history of recurrent miscarriage suggests at least the possibility of a genetic issue. Or a woman who has given birth to more than one child with type of birth defects described in the study? Another indicator of a possible genetic cause. I think under those circumstances, a moderate increase in prenatal niacin supplementation likely won't do any harm. And it might help. They build a factor of safety into supplement guidelines anyway.

  21. Proof that eating meat is essential by Anonymous Coward · · Score: 0

    Vitamin B3 is found in Meat.