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One Startup is Using Phone Calls and Other Inexpensive Means To Save TB Patients (microsoft.com)

Tuberculosis (TB) is one of most common causes of death globally. In 2016 alone, more than 10.4 million people fell sick to TB and 1.7 million TB-related deaths were reported. The WHO says India, in particular, and developing markets, in general, lead the count for the occurrence of TB in the world even as the local authorities provide free and effective medications to anyone who is ill. From a report: "One of the biggest barriers to recovery from TB is medication adherence," explains Microsoft Researcher Bill Thies, who is also the Chairman and Co-founder of Everwell Health Solutions, a Bangalore-based healthcare start-up. "Patients have to take daily drugs for a full six months, or else they do not fully recover, and are at risk of developing drug resistance. While medication adherence might sound like a simple problem, it turns out to be an enormously complex and heavily studied multi-disciplinary problem. If patients start feeling better after a few weeks, how can we convince them to take toxic drugs for another five months -- especially if patients have little or no understanding of germs and antibiotic resistance?"

The popular recommended practice to ensure medication adherence is Directly Observed Treatment or DOTS, which involves the patients going to a healthcare centre where they ingest the medication in front of a health worker. As it was implemented at the start of their work, patients needed to visit the centre three times per week for the first two months and once a week for the remaining four months. The system involves an unnecessary burden on the patients, who are typically from low-income groups -- every visit means travel expense and loss of work.
There are ways to ensure that a patient has taken medication on time -- we have things like smart pills, and you can send texts to people to remind them about the pills -- but in places like India, these solutions are beyond the reach of people. So in 2013, Thies and his colleagues, along with Microsoft Research Program Manager and TEM collaborator, started a project called 99DOTS to explore if any low-cost tech solution could be employed. They did find one, and it involves making a "missed call" to people. Here's the fascinating story of what happened next.

30 comments

  1. Patients made calls to verify by _Sharp'r_ · · Score: 4, Informative

    For those who read the summary and not TFA, the solution ultimately involves putting a toll-free phone number where you have to open each pill to read it and having the patients call that number for free to confirm they took their pill, otherwise someone follows-up with them. Cheaper than having the patients have to come somewhere to get their pills on a schedule from someone who records they took it.

    --
    The party of stupid and the party of evil get together and do something both stupid and evil, then call it bipartisan.
    1. Re:Patients made calls to verify by mentil · · Score: 1

      How about multiple choice quiz:

      Today's pill was laced with a
      a) stimulant
      b) depressant
      c) hallucinogen

      Not sure what to do about people in areas that don't have phone service, though.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    2. Re:Patients made calls to verify by mentil · · Score: 1

      Thies and his colleagues, along with Microsoft Research Program Manager and TEM collaborator, started a project called 99DOTS

      Bonus bad joke:
      I have 99DOTS and a barbiturate ain't one.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    3. Re:Patients made calls to verify by PolygamousRanchKid+ · · Score: 1

      the solution ultimately involves putting a toll-free phone number where you have to open each pill to read it and having the patients call that number for free to confirm they took their pill, otherwise someone follows-up with them.

      . . . so the patient:

      1) Opened the pill.
      2) Called the number.
      . . . then, either . . .
      3) Took the pill. No profit.
      . . . or . . .
      3) Sold it on the Black Market. Profit!

      If the patient is not convinced of the seriousness of the illness, and that taking the medication is absolutely necessary . . . no elaborate scheme of pill taking monitoring will help.

      --
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    4. Re:Patients made calls to verify by sonamchauhan · · Score: 3, Insightful

      "If the patient is not convinced of the seriousness of the illness, and that taking the medication is absolutely necessary . . . no elaborate scheme of pill taking monitoring will help."

      Not really. People procrastinate, change their mind, flip-flop, reverse decisions and revert again, on a second-by-second basis.

      There is a public health benefit to monitoring compliance with TB medication.

      And think of it from the individual's perspective. For whatever reason, you've already done the hard yards -- you made the time, located the drugs, opened the blister packing, texted the secret phone number. So now popping the pill is a trivial job - the hard work's already done.

    5. Re:Patients made calls to verify by Kjella · · Score: 2

      If the patient is not convinced of the seriousness of the illness, and that taking the medication is absolutely necessary . . . no elaborate scheme of pill taking monitoring will help.

      True, but most of those problems relate to taking a new drug. These people have been ill, taken the drugs and started feeling better like they beat it. They've just gotten a bit sloppy and lazy, not developed some deeper aversion against the drug. Just like they should have eaten healthier, exercised more, taken their vitamins, flossed properly and so on but never got around to it. This is just a small reminder that finishing your cure is kinda important so they don't relapse - at least that's what you should say is in it for them. That there's also a public benefit in reducing the spread of antibiotic resistant diseases is important to us, but maybe not so much to them. Easier to say you're doing it for your own health...

      --
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    6. Re:Patients made calls to verify by tomhath · · Score: 2

      Trying to get people to take the full regimen of drugs is good, and this idea seems like a reasonable approach.

      But what's missing from the article is how much impact it actually had. They didn't mention what percent of patients follow through by calling every day, how many start back up on the meds after they get the nag text message, etc. When the success rate isn't given you have to wonder why.

    7. Re:Patients made calls to verify by Anonymous Coward · · Score: 0

      That'll work even better for the low income group, that was unnecessarily burdened by loss of "work".

    8. Re:Patients made calls to verify by Immerman · · Score: 1

      Well, at least all the hard work except continuing to endure be mildly poisoned by toxic drugs.

      But yeah - laziness and procrastination is probably well into the top 10 fundamental motivating forces in human behavior. Overcome that and you're well on the way to letting enlightened self-interest do the rest.

      --
      --- Most topics have many sides worth arguing, allow me to take one opposite you.
    9. Re:Patients made calls to verify by Immerman · · Score: 1

      >That there's also a public benefit in reducing the spread of antibiotic resistant diseases is important to us, but maybe not so much to them.

      Pretty important to them too - if they become an incubator for antibiotic resistant TB then that relapse is going to be a lot more unpleasant.

      --
      --- Most topics have many sides worth arguing, allow me to take one opposite you.
    10. Re:Patients made calls to verify by Anonymous Coward · · Score: 0

      If the patient is not convinced of the seriousness of the illness, and that taking the medication is absolutely necessary . . . no elaborate scheme of pill taking monitoring will help.

      That statement has already been proven incorrect.

      One previous method was to have the medical staff contact and monitor ALL patients on such medications.
      This new method showed them who takes their meds as instructed and who does not.
      The medical staff then devotes their attention to those that need it, and doesn't waste their time (and money) reminding those who don't need such a reminder.

      That saves a lot of money and resources there alone.

      Another way it helps is that most people do end up taking their meds once reminded, and since it is a simple phone call to remind them, it keeps the slightly forgetful types on their meds which certainly helps the patient remain alive.

      The final way it helps is narrowing down the list of who refuses to take their medication due to "I'm fine" syndrome.
      Having the people who not only endanger themselves but everyone around them listed out with evidence of this, those patients can be put on one of the original medication monitoring systems.

      The article stated that this involves 2-3 trips per week to a medical facility while they are watched by a nurse to make sure they take the medication.
      This method can be a hardship to poorer people (travel time and time off work were given as common reasons) and this new method removes that burden and requirement for those that don't need it, certainly helping those patients.
      For the ones that do need it, it helps the patient remain alive while also helping everyone else around that patient from getting infected.

      Out-right refusal results in a forced hospitalization where the medications are administered.
      This is pretty invasive if someone doesn't need it so can certainly help someone to avoid it when not needed.
      When it is needed it is certainly a huge help to the many people who won't be infected by a stupid moron intent on carrying and spreading a deadly communicable infection.

      It can be argued either way for the patient themselves being force-hospitalized, but ultimately that person will live, which is a pretty highly scored item on the "helps" list IMHO.

  2. Re:Can't save Trump from prison though by negRo_slim · · Score: 0

    It was her turn! Also, use a fucking timer OP shit.

    --
    On the Oregon Cost born and raised, On the beach is where I spent most of my days
  3. Re:Can't save Trump from prison though by Anonymous Coward · · Score: 0

    And yet Trump will die in prison. Sad? Sad! :D

  4. developing markets by Anonymous Coward · · Score: 0

    "developing markets, in general, lead the count for the occurrence of TV."
    I am disgusted by the thought of developing TV

  5. What you’ll read here will baffle you by Anonymous Coward · · Score: 0

    Don’t you dare to use that type of bait links *ever* again!

    1. Re: What you’ll read here will baffle you by Anonymous Coward · · Score: 0

      It was shocking

  6. Medication Adherence by mentil · · Score: 3, Funny

    This is a solved problem. Just add a little Morphine into their pills, and they'll be SURE to finish every single one. In fact, they'll be begging for more!
    Seriously though, the pills can come in daily blister packs (like contraceptive pills), and the Morphine dosage can gradually reduce so they'll no longer be addicted by the end.

    --
    Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    1. Re:Medication Adherence by dcw3 · · Score: 2

      At first, I thought you were trying to be funny...sigh. This is a serious problem, and by the way, morphine doesn't work the same on everyone...it's a DNA thing. One I had to go through with my ex-wife for nearly a year because she got several months into the first round of treatment, and hated the medication. When you screw up, you have to move to a different med, and start all over.

      --
      Just another day in Paradise
  7. Maybe fix the society too by Anonymous Coward · · Score: 0

    "..especially if patients have little or no understanding of germs and antibiotic resistance" - surely this is the biggest problem that needs solved. prevention being better than a cure, after all.

  8. Re:Can't save Hillary from KKK presidency though by Anonymous Coward · · Score: 0

    "Hillary for KKK President!"

    Trump will win that too.

  9. To Save TB patients by hcs_$reboot · · Score: 2

    At first I read Tera Bytes... and I thought these phones are not iPhones...

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  10. Make them feel sick by bussdriver · · Score: 1

    Why not have pills INCLUDE something to make people feel back. Chemotherapy is not as bad today but it used to be a horrible experience people just suffered thru because they had to do so to possibly get better. People did it despite it not being a sure thing.

    I see nothing wrong with having the treatment cost in some suffering and not tell the general public... even if they find out, you will also find out that you will not be cured if you stop taking the drugs early.

    Addiction drugs actually make the most sense but only if you have a better way to avoid a serious addiction than we have today. Less extreme drugs exist which could be used. Caffeine is pretty harmless and quite addicting... the users are likely stuck on coffee already. (combine it with advice you can't drink coffee with the medication.)

  11. Missed call technique by Registered+Coward+v2 · · Score: 1

    For /. Users of a certain age who remember payphones will remember this way of making free calls that transmitted information. Need a ride home from the movies? Call home, hang up after two rings. Get dime back from pay phone and ride shows up. An older variant was, IIRC, to send a postcard with postage due since you could read the card and then mark return to sender, who would know you got it. People were hacking messaging long before cell phones.

    --
    I'm a consultant - I convert gibberish into cash-flow.
  12. TB or not TB by RogueWarrior65 · · Score: 2

    Consumption be done about it? Of cough, of cough.
    It's not the cough that carries you off. It's the coffin they carry you off in.

  13. Phone Calls Are Cheap? by Thelasko · · Score: 1

    I'm surprised to hear phone calls are cheap. Every doctor's office I've been to lately has replaced their phone system with an automated one. Usually I get reminders via text message, and am rarely able to talk to a person. Apparently receptionists are too expensive.

    I've been looking for a new doctor with a real receptionist, apparently they are going extinct.

    --
    One of our competitors trademarked the term "hypothesis". From now on, we will call them "boneheaded ideas".
  14. Telling turn of phrase by jenningsthecat · · Score: 1

    India, in particular, and developing markets, in general ...

    When the phrase "developing markets" is used to describe the context for a story about a health crisis, then you know the corporatists are winning. Yeah, I know, it's 'just a turn of phrase' - but consider the implications, then ask yourself if you even stopped to question the wording while you were reading TFS.

    --
    'The Economy' is a giant Ponzi scheme whose most pitiable suckers are the youngest among us and the yet-unborn.