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Experimental Spit Test Could Identify Men Most At Risk of Prostate Cancer (gizmodo.com)
An anonymous reader quotes a report from Gizmodo: A test developed by scientists in the U.K. and U.S. might someday be able to pinpoint the men most likely to get prostate cancer. A new study published Monday in Nature Genetics suggests the test can detect the one percent of men who are genetically most vulnerable to developing prostate cancer, a leading cause of cancer deaths among American men. The international research team used a new DNA analysis technique to peer into the genes of more than 70,000 people enrolled in previous studies. Some 45,000 of the subjects had already developed prostate cancer, while 25,000 hadn't. So the researchers compared the two groups, singling out any inherited genetic variations that might have contributed to their cancer risk. According to the authors, they managed to find 63 new variants never before associated with prostate cancer.
These results were then integrated with nearly a hundred genetic variants linked to prostate cancer previously found among 60,000 people to create a total genetic risk score. And finally, the researchers devised a test that uses a person's saliva to detect these more than 150 variants. In the U.S., people over the age of 50 are generally screened for prostate cancer via the prostate-specific antigen (PSA) blood test. Those with a certain high level of PSA should be screened annually, while everyone else is advised to be screened every two years. But the saliva test could reveal especially high-risk people who need annual screening regardless of their PSA level, while ruling out low-risk people who don't need annual screening based on their genetic risk and PSA scores. Those people would only need screenings every two, five, and maybe even 10 years.
These results were then integrated with nearly a hundred genetic variants linked to prostate cancer previously found among 60,000 people to create a total genetic risk score. And finally, the researchers devised a test that uses a person's saliva to detect these more than 150 variants. In the U.S., people over the age of 50 are generally screened for prostate cancer via the prostate-specific antigen (PSA) blood test. Those with a certain high level of PSA should be screened annually, while everyone else is advised to be screened every two years. But the saliva test could reveal especially high-risk people who need annual screening regardless of their PSA level, while ruling out low-risk people who don't need annual screening based on their genetic risk and PSA scores. Those people would only need screenings every two, five, and maybe even 10 years.
Elizabeth Holmes...is that you?
First post!!
On a two-wheel flyer, risking everything
V-twin take him higher
And the danger it will bring
Tempting fate, time and time again
Bones break and crumble
Grim Reaper in the wind
Grim Reaper
One man of his word
Not afraid to lose it all
A single shot of whiskey – ready to take a fall
One American, with honor with pride
And a burning desire to fly fuckin’ high
Clutch Nixon – Riding through the storm
Clutch Nixon – In hell you were born
Clutch Nixon – Death he did defy
Clutch Nixon – Psycho in heaven, angel in hell
The greatest man to ever set foot on two wheels
Possibly, the greatest man to ever live
A man that brought the world together
Not through song or dance
Not with the act of love
Not through violence or tyranny - No!
Just one man, two wheels
Two wheels strapped to a Harley v-twin
Feel the engine roar!
Feel the engine roar!
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Feel the engine roar!
Feel the engine roar!
Feel the engine roar!
Clutch Nixon – Riding through the storm
Clutch Nixon – In hell you were born
Clutch Nixon – Death he did defy
Clutch Nixon – Psycho in heaven, angel in hell
Psycho in heaven, angel in hell!
Cryptofeces Lepidoptera Creimerus infestation is a serious problem. Not only are they capable of reproducing asexually like amoebas, they can also lay eggs hermaphroditically in unexpected places. They can disguise eggs as something useful to fool the unaware, sometimes pretending to be a haiku author, blogger, vlogger, or IT closet cleaner.
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Only a concerted, targeted downmodding campaign has been shown effective in controlling this dangerous pest.
Experience shows that stopping such a campaign leads to C. Lepidoptera Creimerus returning within days.
Don't let it happen again!
Or, someone could just poke a finger up your butt. Either way works.
More men die of that than anal cancer, it's just easier to test for and doctors don't look for it. oh it's been 3 min in a dfferent threat well clearly am abusing AC and not giving slashdot enough resellable information
It distracts from breast cancer.
A simple spit test can determine your HLA markers and all sorts of stuff. The fact that you can also test for genetic vulnerabilities is pretty mundane. The consumer genetic testing services already do a great deal of this including much more obscure stuff.
This isn't news. This is the dull side of a butter knife.
A Pirate and a Puritan look the same on a balance sheet.
This test is only for men who get prostate cancer? What about all those poor women who get prostate cancer? This is what is wrong with America.
I thought the consensus was that screening for prostate cancer was not recommended for ANYONE because detection and treatment rarely leads to overall better outcomes.
Maybe once they get the weaponized-immune-system thing down it will be a different story.
Agreed, you're not a fucking doctor and have no business giving any kind of medical advice.
The problem often is not the PSA screening per se, it's the prostate snatcher urologist eager to sell his "services" - old fashioned biopsies and surgery. There are many flavors of PSA related tests that can less invasively help enumerate your prostate cancer odds.
We are at the threshold of diagnostic technologies that are less invasive, and early treatments that are not well recieved by all urologists.
and ne'er worry about said appendage already.
You get it from lying down.
Here... Spit on my finger before I insert it.
Experimental spit test identifies men that just gave me a blow job.
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You're going to get it. So what good is a test if it can't tell you if you're going to get it early on?
There's one problem with the PSA test. It doesn't actually lengthen anyones life. It seems to detect a lot of very slow growing cancers. So slow growing that by the time the prostate cancer kills you, you'd be far more likely to do of something else.
https://www.medscape.com/viewarticle/893458
'people over the age of 50 are generally screened for prostate cancer'
Are we so PC that we can't specify the gender that actually has prostate glands, but have to be inclusive and all, and avoid excluding those genders that do not?
deleting the extra space after periods so i can stay relevant, yeah.
OP says " one percent of men ..., a leading cause of cancer deaths"
So the 1% is a "leading" cause?! What about the 99%?
That specific cancer has mostly 2 variants, the one that kills you quickly, no matter how many dangerous operations you do and one that won't be a problem, since it grows so slowly that you can ignore it, because you'll be dead from old age before it can possibly kill you.
But nonetheless, the medical industry wants to radiate, operate and make you piss your pants the rest of your life.