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Scientists Grow 'Mini-Brain On the Move' That Can Contract Muscle (theguardian.com)

An anonymous reader quotes a report from The Guardian: Scientists have grown a miniature brain in a dish with a spinal cord and muscles attached, an advance that promises to accelerate the study of conditions such as motor neurone disease. The lentil-sized grey blob of human brain cells were seen to spontaneously send out tendril-like connections to link up with the spinal cord and muscle tissue, which was taken from a mouse. The muscles were then seen to visibly contract under the control of the so-called brain organoid. The research is is the latest in a series of increasingly sophisticated approximations of the human brain grown in the laboratory -- this time with something approaching a central nervous system attached.

The scientists used a new method to grow the miniature brain from human stem cells, which allowed the organoid to reach a more sophisticated stage of development than previous experiments. The latest blob shows similarities, in terms of the variety of neurons and their organisation, to the human foetal brain at 12-16 weeks of pregnancy. However, the scientists said the structure was still too small and primitive to have anything approaching thoughts, feelings or consciousness. While a fully developed human brain has 80-90 billion neurons, the organoid has a couple of million, placing it somewhere between a cockroach and a zebrafish in terms of volume of grey matter.
After growing the organoid, the scientists "used a tiny vibrating blade to cut it into half millimeter-thick slices which were placed on a membrane, floating on a nutrient-rich liquid," reports The Guardian. "This meant the entire slice had access to energy and oxygen and it continued developing and forming new connections when it was kept in culture for a year. Alongside the organoid, the scientists added in a 1mm-long spinal cord, taken from a mouse embryo, and the surrounding back muscle. The brain cells automatically began to send out neuronal connections, linked up with the spinal cord and began sending electrical impulses, which caused the muscles to twitch."

The study has been published in the journal Nature Neuroscience.

84 comments

  1. Getting old by Anonymous Coward · · Score: 3, Funny

    This filled me more with terror than awe. Guess it's time to start yelling at clouds.

    1. Re:Getting old by AlanObject · · Score: 4, Interesting

      I found it scary as well. How long before they are able to culture a lizard's brain? A mouse? A dog's? Then ....

    2. Re:Getting old by Anonymous Coward · · Score: 0

      And then start calling it AI.

    3. Re:Getting old by Anonymous Coward · · Score: 0

      Move over, there's gonna be a crowd here with ya soon.

    4. Re:Getting old by Anonymous Coward · · Score: 0

      Once it starts licking its own junk, it will be considered intelligent.

    5. Re:Getting old by Anonymous Coward · · Score: 0

      the organoid has a couple of million [nerve cells], placing it somewhere between a cockroach and a zebrafish in terms of volume of grey matter.

      It's already past the neurological complexity of the average politician.

      How long before a [Beowulf] cluster of these can run a Drone carrying a tacical nuke?

      So what I guess I'm saying is that I welcome our new Organoid on a Dish Overlords.

    6. Re:Getting old by Anonymous Coward · · Score: 0

      or Mr President.

  2. So obviously it's a 1:1 model... by Gojira+Shipi-Taro · · Score: 0, Flamebait

    Of Trump's brain...

    --
    "Oh my God. This is terrible. This is the end of my Presidency. I'm fucked."; ~ Donald J. Trump
    1. Re: So obviously it's a 1:1 model... by Anonymous Coward · · Score: 2, Funny

      Consider that despite being a moron he still crushed Hillary in the election, best economy in modern times, knocked the Chinese off kilter, did not give billions of dollars to a terrorist state, say there are 57 states or refer to his tranny wife as Michael multiple times during interviews and speeches.

      I did not vote for him but compared to the alternative and previous office holders he is doing ok in my book.

    2. Re: So obviously it's a 1:1 model... by Anonymous Coward · · Score: 0

      Crushed?

  3. Look at this, more of a medical marvel by Anonymous Coward · · Score: 0

    https://regmedia.co.uk/2019/03...

    Babs is suing Nunes for some sort of theft of effect.

  4. The description is amazing - and unnerving by Anonymous Coward · · Score: 1

    I just hope they don't accidently create a face hugger ala Aliens, or some other malicous organism.

    1. Re:The description is amazing - and unnerving by Narcocide · · Score: 1

      Krang

    2. Re:The description is amazing - and unnerving by Anonymous Coward · · Score: 0

      I could tell you of atrocities that governments have done in this line of research.

      Just know that for any technology they permit the public to know about, they are tens or hundreds of years in advance in their secret weapons programs...

  5. cruel, just cruel by Anonymous Coward · · Score: 1, Insightful

    They're making some huge assumptions that it can't think and therefore justify to themselves and us that it's okay for them to slice and dice and torture this being they have created... They should at least have the guts to say "yeah we're being horrific but we're learning a lot".

    Sick cowards :-(

    1. Re:cruel, just cruel by Anonymous Coward · · Score: 0

      However, the scientists said the structure was still too small and primitive to have anything approaching thoughts, feelings or consciousness

      Scientists are an arrogant lot, acting as if they were experts on anything at all which can not be empirically tested.

      They assert feelings and thoughts aren't present despite motor movement. What is motor movement began in the brain if not a thought through the appropriate neurons? What are feelings but electrochemical stimulus and states?

      Worth remembering that once scientists thought aboriginal Australians were too small and primitive to be called human. Now they are doing the same to this "bundle of cells," as if we all could not be described with the same words.

    2. Re:cruel, just cruel by Nidi62 · · Score: 1

      They assert feelings and thoughts aren't present despite motor movement. What is motor movement began in the brain if not a thought through the appropriate neurons? What are feelings but electrochemical stimulus and states?

      I've seen a snake open and close it's mouth for 5 minutes straight after it's head was cut off. Cut the head off of a chicken far enough up that part of the brain stem remains and it will keep walking around. Mike the Headless chicken "lived" for almost 2 years after being beheaded. To quote the wikipedia article

      It was determined that the axe had missed the jugular vein and a clot had prevented Mike from bleeding to death. Although most of his head was severed, most of his brain stem and one ear were left on his body. Since basic functions (breathing, heart rate, etc.) as well as most of a chicken's reflex actions are controlled by the brain stem, Mike was able to remain quite healthy. This is a good example of central motor generators enabling basic homeostatic functions to be carried out in the absence of higher brain centres

      People in persistent vegetative states have reflexive movements as well. The body is amazing, and will continue to try to keep itself alive even in the absence of higher cognitive function or awareness.

      --
      The only thing necessary for evil to triumph is for it to be pitted against a slightly greater evil
    3. Re:cruel, just cruel by Anonymous Coward · · Score: 0

      Mike the Headless chicken "lived" for almost 2 years after being beheaded.

      Holy shit! How the fuck did it eat?!

    4. Re:cruel, just cruel by religionofpeas · · Score: 1

      What are feelings but electrochemical stimulus and states?

      Your computer also has electrical stimulus and states. Does it have feelings as well ?

    5. Re:cruel, just cruel by Anonymous Coward · · Score: 0

      It sounds like YOU are the one making huge assumptions. In particular, assumptions about what the scientists have and have not done to ensure that their experimentation remains within ethical boundaries.

    6. Re:cruel, just cruel by Anonymous Coward · · Score: 0

      The owner poured a nutrient slurry down its esophagus.

  6. Do we really need ... by sheramil · · Score: 1

    .... multi-core organisms? Why don't we just drink coffee and overclock the ones we have?

    1. Re:Do we really need ... by dissy · · Score: 1

      .... multi-core organisms? Why don't we just drink coffee and overclock the ones we have?

      Aww, but I wanna be both!

    2. Re:Do we really need ... by sheramil · · Score: 1

      Aww, but I wanna be both!

      You should probably strap a bunch of heat-sinks to the sides of your head first.

    3. Re:Do we really need ... by Anonymous Coward · · Score: 0

      https://bit.ly/2TiYkBb

  7. In other news.. by Anonymous Coward · · Score: 0

    ..a truck carrying a large consignment of vats was seen entering the premises of the Medical Research Councilâ(TM)s Laboratory of Molecular Biology.

  8. Interesting by Anonymous Coward · · Score: 0

    While a fully developed human brain has 80-90 billion neurons, the organoid has a couple of million, placing it somewhere between a cockroach and a zebrafish in terms of volume of grey matter.

    About on par with that knob end Caffinated Bacon then.

    1. Re: Interesting by Anonymous Coward · · Score: 1

      Sure but how many neurons are required for self awareness? We truly have no fucking clue. It could be a few hundred thousand in which case we have created life in a dish so we can torture it. (My degree is in neuroanatomy. We really dont know a whole lot.)

      The whole thing makes me feel vaguely ill.

    2. Re: Interesting by Anonymous Coward · · Score: 0

      It's why he can't drink. Buffalo theory doesn't work with only one.

    3. Re: Interesting by Anonymous Coward · · Score: 0

      To be fair the main issue is we don't actually have a definition for "self awareness".

      Also it's probable you don't actually need any neurons for self awareness. There are plants that comunicate chemically and respond to predation by increasing their toxicity, not to mention all the weird shit corals and anemones do. For some common usages of the term 'self aware' both would qualify if the definition were applied rigorously even though neither have any nerve tissue at all.

      What we actually base our behavior on when we talk about self awareness is "does this entity trigger my empathy enough that I feel bad hurting it".

    4. Re: Interesting by Anonymous Coward · · Score: 0

      Exactly, this stem neuron blob needs to let us know if we should feel bad about hurting it. They should definitely hook up some vocals cords so we can hear if it's screaming.

  9. somewhere between a cockroach and a zebrafish.. by Anonymous Coward · · Score: 0

    How about some local metrics we can point to, like somewhere between a Kendall and a Luckyo...

    1. Re:somewhere between a cockroach and a zebrafish.. by Micah+NC · · Score: 1

      Just because these scientists lack ethics doesn't mean they have cockroach brains

      But I sympathize with your comparison

  10. Brain!!! by Anonymous Coward · · Score: 0

    These brains spontaneously grew retinas. Sensory input please! https://bigthink.com/surprisin...

  11. Do you want Skaven? by Anonymous Coward · · Score: 0

    Because that's how you get Skaven....
    I for one, welcome our new human-mouse hybrid overlords?

  12. Re:Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 0

    Shut up fag.

  13. Suck it bitch traitor. Prison is a-comin on YOU by Anonymous Coward · · Score: 0

    https://www.reuters.com/article/us-usa-trump-russia-tower-explainer/why-an-unbuilt-moscow-trump-tower-caught-muellers-attention-idUSKCN1QZ159

  14. Hey /. ~ In Relation To Trump by Anonymous Coward · · Score: 1

    Hey Slashdot,

    Do us all a favor, instill a way to curb these chuckleheads who have nothing on their mind but posting pathetic political figure jokes, over the likes of Trump or anyone else for that matter, to an unrelated story such as this. It's a real turn off to even want to get involved in any discussion here. Talk about mini brains.

    Seriously you guys need to get a life. Only you care about Trump.
    Never have I seen such a mental obsession over someone go so far.

    1. Re:Hey /. ~ In Relation To Trump by dpidcoe · · Score: 1

      So make yourself an account and mod down the political posts.

  15. Re: Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 1

    Against him, losing by 0.01% is sill utter humiliation.

    But you can keep the "popular vote" participation medal.

  16. Brain AND muscle ? by Laxator2 · · Score: 1

    Now that is a powerful combination ! I wish more humans were like that, "loaded with both".
    Still I would not like to have to chase after that thing when the brain will figure out that the experiment will be finished and command the muscle to jump out of the dish.

  17. Empowered ignorance by fygment · · Score: 0

    A case of technological prowess in the hands of the ill informed. Specifically:

      "... the scientists said the structure was still too small and primitive to have anything approaching thoughts, feelings or consciousness."

    But they do not know that for a fact. This isn't about foetal rights, this is about accuracy and honesty in research. The scientists are being duplicitous in order to be able to continue their research. And that is the unnerving part about all of this. Why not be honest and say "we do not know ..."

    --
    "Consensus" in science is _always_ a political construct.
    1. Re:Empowered ignorance by Anonymous Coward · · Score: 3, Insightful

      The scientists are being duplicitous in order to be able to continue their research.

      Of course they are, they're trying to cure motor neuron disease! Ethical constraints could really throw a monkey wrench in their plans to develop a cure for a debilitating group of disorders; they're beating around the bush for a damn good reason. At least they're growing a brain in a lab rather than cutting apart living human volunteers. This isn't the kind of biological research that can be performed on cadavers, after all.

      Also, consider this: Yes, the brain they grew *MIGHT* have feelings. However, we already know that people afflicted with motor neuron diseases *DO* have feelings. By my measurement, I've got a lot more shits to give about a person with ALS than a quivering grey blob in a petri dish by comparison.

    2. Re:Empowered ignorance by kackle · · Score: 1

      +1 Informative.

    3. Re:Empowered ignorance by sconeu · · Score: 1

      As someone whose wife died from ALS, thank you for saying this.

      --
      General Relativity: Space-time tells matter where to go; Matter tells space-time what shape to be.
  18. Pickle Rick! by Anonymous Coward · · Score: 1

    Obviously they watch Rick and Morty too. I doubt they where able to turn themselves in to pickles though.

  19. Re: Crushing in Elections by Anonymous Coward · · Score: 1, Interesting

    I'm not rich and my taxes are dramatically less.

    In fact, it was a tax increase on the rich. Not allowing you champaign socialists to keep bilking the rest of America with local and state tax write-offs was brilliant, and obviously the real reason you're angry.

    Sorry. We won't subsidize your outrageous tax schemes anymore. Welcome to reality.

  20. A greater advance than AI has achieved in decades by Anonymous Coward · · Score: 0

    This is the (ethically disturbing) future of AI. Reverse Engineering the functioning of the human brain, from the earliest developing stages - so that we can actually have a proper understanding of how it works. We can't advance AI until we do this first, and then try to replicate what we learn in artificial neural networks.

    If you want an accurate gauge on when the current stages of rudimentary AI will become 'Strong AI', look to the field of biology and neuroscience - as it is the advances in our understanding of the human brain there, which will determine what we can replicate artificially.

  21. Re:Ye Olde Politizzianze, Trump Anyone? by Applehu+Akbar · · Score: 1

    Now think of how early in pregnancy a human fetus would have that stage of brain development. Kind of illuminates the abortion debate in a whole new way, doesn't it.

  22. Another step closer ... by Compulawyer · · Score: 1
    --

    Laws affecting technology will always be bad until enough techies become lawyers.

  23. Coming to an AI system by shayd2 · · Score: 1

    So far, I don't see comments about using this as part of artificial intelligence system. The connection to muscles would be the output path. The researchers should work on connecting a "retina" so that we'd have (admittedly small) computer

    1. Re:Coming to an AI system by Anonymous Coward · · Score: 0

      We could give them Mechanoid bodies send them into space!

  24. It begins (1656) by DontBeAMoran · · Score: 1

    So that's how Mother Brain gets born. Someone call Samus Aran, NOW!

    --
    #DeleteFacebook
  25. Awesome, but... by beep54 · · Score: 1

    reminds me a lot of bad '50's sci-fi flicks. 'The Brain That Wouldn't Die' comes to mind.Hum, that one was '62, eh, close enough.

  26. Re: Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 0

    Is "1 citizen = 1 vote" is too complicated for you?

  27. Re:Ye Olde Politizzianze, Trump Anyone? by iggymanz · · Score: 0, Troll

    Not an argument for the gung-ho pro-abortion crowd, which even wants to kill babies after birth, they don't care how developed the mind and brain of a baby is. They claim it's a woman's right but don't care about other humans' rights. They want to use murder to keep people from properly dealing with the consequences of their actions.

  28. They grew a human baby missing organs by Anonymous Coward · · Score: 0

    They grew a human baby missing organs and they call it a success. This is disgusting.

  29. Re:Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 1

    47% is "crushed" lol?

    Yeah, according to the rules of the game they were playing. Not my fault Queen Hillary and her fans are too stupid to even not bring a basketball to a game of football.

  30. Re:Ye Olde Politizzianze, Trump Anyone? by religionofpeas · · Score: 0

    Most of the people against abortion don't care how developed the mind and brain of a cow or pig is. It's all rather arbitrary.

  31. Re: Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 0

    Ok. So when trump was going to lose and blamed the electoral college pre emptively, Clinton supporters mocked him for not knowing how the system worked.

    When Obama was pres running a huge deficit was a good thing and the right "no deficit " crowd was stupid.

    Anyone on either side has such a fucked up view of "facts" it is appalling. If you identify with either party at this point, do us all a favor and don't vote next election.

  32. Re: Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 1

    The formula involves dividing by the number of electoral votes to gauge the relative value of any particular voter. Some votes are worth more than others due to population differences. It's too bad math is too hard for liberals or this whole thing could be explained to them, but as it is, we're stuck with ignorant people whining about the same thing forever. LOL

  33. Re:Ye Olde Politizzianze, Trump Anyone? by Anonymous Coward · · Score: 0

    I am in awe of your nuanced and careful consideration of the often polarizing issues in this ongoing debate.

  34. Re: Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 0

    The opposite, it's far too simple and only appeals to simpletons.

  35. "Organoid" by cyberchondriac · · Score: 1

    That term just hits my funny bone for some odd reason. That'd be an awesome name for a monster from a sci-fi horror movie, sounds a little better than just, "The Thing" I suppose.

    --

    Look back up at my post, now look back down, you're on the Internet. Now look back up. I'm a signature.
  36. Re:Ye Olde Politizzianze, Trump Anyone? by Anonymous Coward · · Score: 0

    Can we at least agree that chickens are stupid, mean creatures deserving of little sympathy?

    It's telling that chickens (and turkey) aren't prohibited by any of the major religions. Beautifully delicious birds.

  37. Re:Lol you didn't vote for him, suuure Bubba. by Anonymous Coward · · Score: 0

    47% is "crushed" lol? She won by 3 million votes

    That's like saying Captain Marvel lost by tens of thousands of pre-release "I don't want to see it" votes on Rotten Tomatoes. The movie actually did quite well when the votes that meant something (opening weekend box office) were tallied.
    Direct votes by citizens for the Presidency mean diddly squat because it's the states which vote for the President of their Union via their electors in the electoral college. The United States of America is a union of states. The states should never have ceded federal senate appointments to be local citizenry votes; that would have served as a constant reminder that states actually have power in the union. At least the number of senators per state still reminds people that Rhode Island is an equal partner in the union with the likes of California, Texas, and Alaska.

    Oh, and Trump had 304 actual votes and Hillary had 227. Trump won by 77 votes out of 531, so he had roughly 57.3% of the votes.

  38. Re: Ye Olde Politizzianze, Trump Anyone? by Anonymous Coward · · Score: 2, Insightful

    A pregnant woman knows how developed the thing inside her is, and it's her right to choose, not you, and not a "gung ho abortionist" that supposedly doesn't know better than you about fetal development.

    This is the truth, everybody has seen "your baby at X weeks is the size of a Y" in magazines, online, doctor's office, everywhere. Suggesting the people actually having the procedure done to themselves don't know, or that it's an easy decision to make, goes to show you don't have any skin in the game at all, you don't understand why people seek the procedure, at all, you care about imposing your will on others more than the women faced with making difficult decisions.

  39. Supersoldiers by ghoul · · Score: 1

    We can use this tech to create supersoldiers with embedded mini brains in their arms (faster reaction times for operating weapons,ships) as well as a backup brain in the gut to keep fighting if headshot.

    --
    **Life is too short to be serious**
  40. Dun dun duh DAAA! by Hallux-F-Sinister · · Score: 1

    Once a mere cluster of human brain cells from mild-mannered Richard A. Torrence cultured in a lab, when mated to the spinal cord and peripheral nervous system of a mouse and grown into a complete organism, he can now successfully navigate incredibly complex, labyrinthine mazes to find a bit of cheese or peanut butter! Able to run on a hamster wheel for several seconds on end before becoming bored and losing interest, able to leap from one artificial plastic rock to another nearby while caged, in a single bound, Richard A. Torrence has become... Mouse Man!

    However, he is too lazy to bother finding the cheese until he is nearly starving to death, and he spends most of his time watching the TV mounted to the ceiling of the office adjacent to the lab.

    --
    Our reign has gone on long enough. Indeed. Summon the meteors.
  41. Re:Ye Olde Politizzianze, Trump Anyone? by Anonymous Coward · · Score: 0

    Our planet is overpopulated. The more abortions the better.

  42. Re:Ye Olde Politizzianze, Trump Anyone? by GLMDesigns · · Score: 1

    They don't care about individual rights. There isn't any "women's" right that isn't also a "man's" right. You either own your own body or you do not.

    And, very few liberals - and close to no progressives - believe that we own our own bodies.

    After all - individual ownership of owns body is antithetical to the nanny state.

    --
    If you're scared of your govt then you need to further restrict its powers
    Vote 3rd Party in 2016 and beyond
  43. Re:Ye Olde Politizzianze, Trump Anyone? by iggymanz · · Score: 1

    those are not human life, and our ancestors were cooking meat 250,000 years ago if not 1.8 million years ago, it's natural.

  44. Re:Ye Olde Politizzianze, Trump Anyone? by Anonymous Coward · · Score: 0

    Offtopic?!

    Fucking moderator is a moron!

    Cunt!