Nice idea, but phage are also very good at facilitating horizontal gene transfer, so there's a chance they could make the problem worse by conferring resistance to other strains of related bacteria.
Despite not having read TFA, the synopsis seems to imply that all Gram negative bugs are potentially superbugs because their cell walls are different to Gram +ve bacteriia. In fact, most Gram -ves are susceptible to penicillin (and other beta-lactams), just like their Gram +ve cousins, because their cell walls still contain peptidoglycans, albeit less than the average Gram +ve organism.
Sure LPS might be inflammatory but that doesn't make all (e.g.) E.coli pathogenic - it's the aquired attachment/invasion/toxin genes that confer pathogenicity. Similarly, it's the aquired antiobiotic resistance genes that are important in most cases of multiple resistance.
It has been said before and will be said again -- nothing to see here folks, move along.
Um, cloning genes into plasmids and propagating them in E.coli so that you can manipulate (mutate) the sequence invariably requires some kind of antibiotic selection. Letting people muck around in their garages with plasmids conferring antibiotics resistance in bugs that have the potential to become resident in your intestines and persist indefinitely in the environment is a horrendously bad idea.
It's why all labs that do this stuff routinely are required to adhere to physical containment guidelines.
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Woah! Easy there tiger, do you expect us to read the entire summary??
/.ers some credit, perhaps the title could have been a little more concise in anticipation of the usual knee-jerk comments.
Give
Maybe it's 98.01% (0.99 squared!).
Game devs FTW!
Aren't a lot of developers making a lot of money as a direct result of the tight controls apple has placed on iphone apps?
Isn't that a good thing for indy developers and small companies?
Shouldn't devs be applauding apple's approach instead of trashing it at every opportunity?
probably need a few hundred more links..
Nice idea, but phage are also very good at facilitating horizontal gene transfer, so there's a chance they could make the problem worse by conferring resistance to other strains of related bacteria.
Despite not having read TFA, the synopsis seems to imply that all Gram negative bugs are potentially superbugs because their cell walls are different to Gram +ve bacteriia. In fact, most Gram -ves are susceptible to penicillin (and other beta-lactams), just like their Gram +ve cousins, because their cell walls still contain peptidoglycans, albeit less than the average Gram +ve organism.
Sure LPS might be inflammatory but that doesn't make all (e.g.) E.coli pathogenic - it's the aquired attachment/invasion/toxin genes that confer pathogenicity. Similarly, it's the aquired antiobiotic resistance genes that are important in most cases of multiple resistance.
It has been said before and will be said again -- nothing to see here folks, move along.
Um, cloning genes into plasmids and propagating them in E.coli so that you can manipulate (mutate) the sequence invariably requires some kind of antibiotic selection. Letting people muck around in their garages with plasmids conferring antibiotics resistance in bugs that have the potential to become resident in your intestines and persist indefinitely in the environment is a horrendously bad idea.
It's why all labs that do this stuff routinely are required to adhere to physical containment guidelines.
Pretty fucking scary indeed.