I don't know about 7.10 (yet), but with 64-bit version of 7.04, there is some trouble with proprietary software, e.g. Flash and Java plug-ins for Firefox. You can get around (most of) the trouble but it takes some work. Open source software usually works just fine with the 64-bit software (YMMV). I haven't used Wine, so I don't know which version is better for that.
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I don't know about 7.10 (yet), but with 64-bit version of 7.04, there is some trouble with proprietary software, e.g. Flash and Java plug-ins for Firefox. You can get around (most of) the trouble but it takes some work. Open source software usually works just fine with the 64-bit software (YMMV). I haven't used Wine, so I don't know which version is better for that.