So they have the program look for the mention of human genes, then look at what other genes are mentioned in the article.
Maybe I'm missing something here, but isn't the fact that the other genes are being mentioned in the same article as the first gene already imply a relationship between the two? Why else would the authors mention them in the same article?
Another thing to consider is that scientist don't just go around randomly picking a gene and studying it. There are generally reasons why the gene is interesting, and those genes are studied more than others. There is a whole field of the sociology of science that deals with how the way scientists go about doing science influences the results that they find. It annoys the heck out of most scientists.
It is good that there were some relationships that the program found that had not been previously found, but essentially the program is an automated review article generator with a meta analysis component to organize and sort the data.
The idea posted above, that drug interaction would be a good thing to do as well, I can heartily agree with. Have the program go through not only the literature but also the PDR (Physician's Desk Reference), categorize pharmacological responses (e.g. what drugs cause blood pressure to rise by what mechanisms) and not only could we possibly avoid some nasty drug interactions, but perhaps we could find where some drugs act synergistically with each other to generate greater or new results that were not previously thought of.
We can increase the speed at which packets get switched and routed. We can increase the speed at which our computers can receive and process the information (which isn't addressed by this technology). But in the end, the bottleneck comes down to how quickly we, the users, can process and respond to the information.
Sure, there are situations that don't really require human intervention, at least not till a series of events have completed (say, FTP of a series of large files, or convergence of a network after a routing change). But for any interactive, the human in the slowest part, and always will be. Get a file in 63 seconds rather than 312 seconds? Nice, saves you four minutes of your life, but generally small compared to the time that you'll use manipulating or using the file.
...in Atlanta. WNNX (99X) is still 'casting on the Internet (listening to it right now). They're a commerical 'new rock' station.
In general, you have to imagine that AFTRA knew what the consequences of their action would be. I wonder if there hadn't been the precedent by the RIAA requiring royalties for web broadcasts, that AFTRA wouldn't have gotten the idea of supplemental payments.
The physical state and chemistry of the planet with the highly eccentric orbit would be fascinating. At furthest it is a little closer to its sun than the earth is to our sun. At closest it is about 17 lightseconds away from its sun. That must really kick up storms on the planet, if not outright distort it at times. The atmosphere gets really cooked then allowed to cool on a regular basis. You'd almost expect that the orbit would be unstable. Shades of Darkstar.
It looks like they replace the front portion, but the rest looks just like the black YY0221, which I also have.
FWIW, I eventually replace the power supply with a PC Power & Cooling 450W PS. I guess running five IDE drives, dual PIII 700's and a couple SCSI controllers (one of which was HVD) was too much for the stock PS.
1) Multicast lectures to students, particularly those on remote campuses. This can help with scheduling difficulties for the faculty and students.
2) Multicast campus events that have a limited capacity at the site, like sporting events, concerts and plays.
3) Multicast or unicast of a remote event to the campus, via point-to-point connection, which is then multicast to the students. Again, special lectures, sporting events and such could be covered.
That or you could just multicast parties at the local frats and sororities for entertainment value.
Sure, you can wait and try to implement something stronger into the standard. When that happens, it's going to be hacked anyway.
It's the same issue that the music industry is grappling with in developing SDMI - You can't make something unhackable if you expect an arbitrary number of people to be able to use it, and in a timely fashion. MAC addresses can be spoofed, encryption broken, watermarks remove, whatever.
The best thing to do is put it out there with the appropriate caveats, and work to secure it as best you can as you go along. If you are waiting until it is bulletproof, you'll never release it.
What the article is describing is the discovery of a factor that leads to apoptosis apart from the previously elucidated mechanism, which involves a protein (cytochrome c) leaking out from the mitochodria into the cytosol of the cell, where it shouldn't be. Essentially, if the cell detects that, it knows that the there is something terribly wrong, and it should suicide - which is essentially what apoptosis is.
Now, it had been arleady known that there was another mechanism, because if they knocked out the genes responsible for the known mechanism, they could still get apoptosis, though not as readily. This lead to the search of what was causing it. This article describes that discovery, which is AIF.
Interesting work. The reason that this is a more likely candidate that the previous method for fighting cancer is that cytochrome c is a very large, complex protein. Injecting it into cancer cells to initiate apoptosis would be difficult, to say the least. I didn't see enough of the article to see how large AIF is, but I bet it is smaller, and may be easier to get into cells that cystochrome c.
The thing that has me curious is if they could knock out the gene temporarily. They showed that cells were less likely to induce apoptosis under conditions of serum deprivation (starvation). Starving cells is one of the steps toward prepping the nucleus for use in cloning. If they keep more of the cells alive during that process, they might have a better success rate in cloning.
What is needed in many of the present search engines is a way to specify pages that are no more that x days/months/years old.
Some of the search engines have this, but Google in particular does not. Having this feature would allow one to potentially cull out a lot of dead links, given the half-life of the average link
BGP and OSPF actually aren't covered in CCNA. They are part of the CCNP exam series.
I suspect that when he was refering to LSD he was talking about the OSPF database.
He's incorrect on a number of points anyway. Evidently he has never heard of route summarization, which helps not having to run the SPF algorithm every time a route changes somewhere.
I can imagine a scenario where OSPF would be useful. Say the ISP has a fiber out to a subdivision. The ISP sets up a GSR running BGP and OSPF to handle the local network of routers at individual homes. The routers at each home runs OSPF. Using something like RIP in an area with 500-1000 routers would flood the local network. You'd want something that can handle VLSM's, and of the candidates, OSPF is the more widely used.
The pay wasn't the issue. The problem is that when there is a lack of permanent positions, all that are left are post-docs. Going from post-doc to post-doc keeps you in science, but it doesn't make for a stable life.
There is such a view in the popular press that with the inital mapping of the human genome done, that genetic engineering will bring in a new age. They don't realize how this is scratching the surface - or perhaps don't want to report it that way to the public.
Given all the manipulation that occurs with the DNA in the present cloning strategies, there is bound to be some damage. This is likely why the success rate is so low - so few of the trials result in a nucleus that is viable enough to develope into a living animal.
The present technique has demonstrated that cloning can be done. But for the technique to be used more widely, it will definitely need to be improved. You don't see us still flying in the Wrights Brother's flyer.
If I was 21 and wanted to get into genetic engineering, in order to do anyting above being a tech that follows other people's directions, I would need a Ph.D.
Five years later, I would have my Ph.D., and would find that I need to do a two or three year post-doc before anyone will consider me seriously.
Once that was done, I might find that Genetic Engineering was no longer hot, and I have no job prospects. Or that so many other people had the same idea, and there are only so many Ph.D.'s needed, that there aren't a lot of job prospects.
Unlikely? It's what happened to me, but replace "Genetic Engineering" with "Toxicology". What happened (and is still happening) was a lot of mergers in the pharmaceutical industry. It dumped a lot of skilled toxicologists on the market, and it doesn't take a lot to saturate that segment of the market. I can see the same thing happening in Biotech in the future, where Amgen and others by buying up smaller firms first, then merge with peers in order to stay competative.
Besides, anyone who thinks being a gene jock is exciting has never done it.
But could you build a larger screen by using an array of smaller screens? Sort of like a wall of monitors that you see in some stores. I suppose the question becomes how close can you mount one TFT screen next to another, and issues of power/heat/logic come into play, but at least that would work around the duff pixel part.
Carefully reread the title of the post 'Other statistics on site'. Does that give you an idea as to where the information is from? In fact, I give the title of the area on the site where the statistics come from.
What more do you need?
I was stating that their statistics show that. I didn't say that this was gospel. Sheesh - this is *marketing* research, which is virtually an oxymoron.
One of the other summaries was server market share theft/upgrades - or how many servers were switched from one type of web server to another.
The interesting thing was that while Apache still has the lion's share of web servers in the survey, it has been losing ground to IIS. Given all the hacks on IIS-based servers recently, this is an unsettling trend.
Water absorbs in the microwave part of the spectrum, which is how this weapon works in the first place. So what will the range be like in a downpour? Heavy enough rain, it may not be able to have much effect at all.
Another defence might be shredded metal foil. Fill the air with it, like confetti, and the beams will be reflecting all over the place.
I think people are taking this question far too seriously.
What the question is really striving for is, if you had to design a computing system from the ground up, knowing what you know now, what changes would you make? What mistakes would you avoid?
It's given that you would need to build some elementary systems before you could start getting close to the goal systems, and that would take time. But what would you aim for?
You have a container that is toroidal - like a circular particle accelerator - a cyclotron. Like the accelerator, the toroid is ringed with magnets.
The sample, comprised of a mix of proteins from the bacteria, is subjected to a process that ionizes the proteins. I'm not going into Fast Atom Bombardment (FAB) here. Just take my word for it that it is a routine practice to be able to ionize molecules the size of proteins.
The ionized sample speeds into the toroid and begins to travel around the circle. However, molecules of differing weights will have different periodicities. Since they are ionized, they are a moving charge, which generates a magnetic field. The field will be a composite of the individual fields generated by the different weight ions. Take a snapshot of the field, and apply Fourier Transform to generate the individual frequencies.
From the frequencies and the external magnetic field, one can deduce the weight of the ions, which is what mass spectroscopy is all about.
That was my point - that there shouldn't be different levels of access just because the medium is different. You can copy a tape, but you can't copy a DVD. I think that's wrong. The MPAA would say that the tape is analog, and a copy is less than the original, but the DVD is digital, so an exact copy can be made.
Of course, the argument is BS. Even when copying from CD to hard drive, errors can occur, and when going to CDR, yet more errors do occur. Same for going to tape.
Oddly, Hatch has been quite Napster-friendly. One of his aides left to join Napster.
While Hatch co-authored the DMCA, the view of many is that he didn't realize what the entertainment industry would do with how it was worded, and has since been keeping a close eye on anything coming from that corner of the cesspool.
Slashdot Mirror
Maybe I'm missing something here, but isn't the fact that the other genes are being mentioned in the same article as the first gene already imply a relationship between the two? Why else would the authors mention them in the same article?
Another thing to consider is that scientist don't just go around randomly picking a gene and studying it. There are generally reasons why the gene is interesting, and those genes are studied more than others. There is a whole field of the sociology of science that deals with how the way scientists go about doing science influences the results that they find. It annoys the heck out of most scientists.
It is good that there were some relationships that the program found that had not been previously found, but essentially the program is an automated review article generator with a meta analysis component to organize and sort the data.
The idea posted above, that drug interaction would be a good thing to do as well, I can heartily agree with. Have the program go through not only the literature but also the PDR (Physician's Desk Reference), categorize pharmacological responses (e.g. what drugs cause blood pressure to rise by what mechanisms) and not only could we possibly avoid some nasty drug interactions, but perhaps we could find where some drugs act synergistically with each other to generate greater or new results that were not previously thought of.
Sure, there are situations that don't really require human intervention, at least not till a series of events have completed (say, FTP of a series of large files, or convergence of a network after a routing change). But for any interactive, the human in the slowest part, and always will be. Get a file in 63 seconds rather than 312 seconds? Nice, saves you four minutes of your life, but generally small compared to the time that you'll use manipulating or using the file.
In general, you have to imagine that AFTRA knew what the consequences of their action would be. I wonder if there hadn't been the precedent by the RIAA requiring royalties for web broadcasts, that AFTRA wouldn't have gotten the idea of supplemental payments.
The physical state and chemistry of the planet with the highly eccentric orbit would be fascinating. At furthest it is a little closer to its sun than the earth is to our sun. At closest it is about 17 lightseconds away from its sun. That must really kick up storms on the planet, if not outright distort it at times. The atmosphere gets really cooked then allowed to cool on a regular basis. You'd almost expect that the orbit would be unstable. Shades of Darkstar.
FWIW, I eventually replace the power supply with a PC Power & Cooling 450W PS. I guess running five IDE drives, dual PIII 700's and a couple SCSI controllers (one of which was HVD) was too much for the stock PS.
2) Multicast campus events that have a limited capacity at the site, like sporting events, concerts and plays.
3) Multicast or unicast of a remote event to the campus, via point-to-point connection, which is then multicast to the students. Again, special lectures, sporting events and such could be covered.
That or you could just multicast parties at the local frats and sororities for entertainment value.
The best thing to do is put it out there with the appropriate caveats, and work to secure it as best you can as you go along. If you are waiting until it is bulletproof, you'll never release it.
The short period in question is 1978 - 1993. Fifteen years can be a substantial protion of a freelance writer's career.
What the article is describing is the discovery of a factor that leads to apoptosis apart from the previously elucidated mechanism, which involves a protein (cytochrome c) leaking out from the mitochodria into the cytosol of the cell, where it shouldn't be. Essentially, if the cell detects that, it knows that the there is something terribly wrong, and it should suicide - which is essentially what apoptosis is.
Now, it had been arleady known that there was another mechanism, because if they knocked out the genes responsible for the known mechanism, they could still get apoptosis, though not as readily. This lead to the search of what was causing it. This article describes that discovery, which is AIF.
Interesting work. The reason that this is a more likely candidate that the previous method for fighting cancer is that cytochrome c is a very large, complex protein. Injecting it into cancer cells to initiate apoptosis would be difficult, to say the least. I didn't see enough of the article to see how large AIF is, but I bet it is smaller, and may be easier to get into cells that cystochrome c.
The thing that has me curious is if they could knock out the gene temporarily. They showed that cells were less likely to induce apoptosis under conditions of serum deprivation (starvation). Starving cells is one of the steps toward prepping the nucleus for use in cloning. If they keep more of the cells alive during that process, they might have a better success rate in cloning.
Chew on that one for a while.
Some of the search engines have this, but Google in particular does not. Having this feature would allow one to potentially cull out a lot of dead links, given the half-life of the average link
I suspect that when he was refering to LSD he was talking about the OSPF database.
He's incorrect on a number of points anyway. Evidently he has never heard of route summarization, which helps not having to run the SPF algorithm every time a route changes somewhere.
I can imagine a scenario where OSPF would be useful. Say the ISP has a fiber out to a subdivision. The ISP sets up a GSR running BGP and OSPF to handle the local network of routers at individual homes. The routers at each home runs OSPF. Using something like RIP in an area with 500-1000 routers would flood the local network. You'd want something that can handle VLSM's, and of the candidates, OSPF is the more widely used.
The pay wasn't the issue. The problem is that when there is a lack of permanent positions, all that are left are post-docs. Going from post-doc to post-doc keeps you in science, but it doesn't make for a stable life.
There is such a view in the popular press that with the inital mapping of the human genome done, that genetic engineering will bring in a new age. They don't realize how this is scratching the surface - or perhaps don't want to report it that way to the public.
The present technique has demonstrated that cloning can be done. But for the technique to be used more widely, it will definitely need to be improved. You don't see us still flying in the Wrights Brother's flyer.
Five years later, I would have my Ph.D., and would find that I need to do a two or three year post-doc before anyone will consider me seriously.
Once that was done, I might find that Genetic Engineering was no longer hot, and I have no job prospects. Or that so many other people had the same idea, and there are only so many Ph.D.'s needed, that there aren't a lot of job prospects.
Unlikely? It's what happened to me, but replace "Genetic Engineering" with "Toxicology". What happened (and is still happening) was a lot of mergers in the pharmaceutical industry. It dumped a lot of skilled toxicologists on the market, and it doesn't take a lot to saturate that segment of the market. I can see the same thing happening in Biotech in the future, where Amgen and others by buying up smaller firms first, then merge with peers in order to stay competative.
Besides, anyone who thinks being a gene jock is exciting has never done it.
But could you build a larger screen by using an array of smaller screens? Sort of like a wall of monitors that you see in some stores. I suppose the question becomes how close can you mount one TFT screen next to another, and issues of power/heat/logic come into play, but at least that would work around the duff pixel part.
What more do you need?
I was stating that their statistics show that. I didn't say that this was gospel. Sheesh - this is *marketing* research, which is virtually an oxymoron.
The interesting thing was that while Apache still has the lion's share of web servers in the survey, it has been losing ground to IIS. Given all the hacks on IIS-based servers recently, this is an unsettling trend.
Another defence might be shredded metal foil. Fill the air with it, like confetti, and the beams will be reflecting all over the place.
I think people are taking this question far too seriously.
What the question is really striving for is, if you had to design a computing system from the ground up, knowing what you know now, what changes would you make? What mistakes would you avoid?
It's given that you would need to build some elementary systems before you could start getting close to the goal systems, and that would take time. But what would you aim for?
In any event, check out this for the earliest still-live registration of 'windows' by MS at the USPTO.
You mean like 'windows'?
All they need to do is use that legal equivalent of a spiked basball bat, called DMCA, and sue anyone who publishes the crack, at least in the U.S.
You have a container that is toroidal - like a circular particle accelerator - a cyclotron. Like the accelerator, the toroid is ringed with magnets.
The sample, comprised of a mix of proteins from the bacteria, is subjected to a process that ionizes the proteins. I'm not going into Fast Atom Bombardment (FAB) here. Just take my word for it that it is a routine practice to be able to ionize molecules the size of proteins.
The ionized sample speeds into the toroid and begins to travel around the circle. However, molecules of differing weights will have different periodicities. Since they are ionized, they are a moving charge, which generates a magnetic field. The field will be a composite of the individual fields generated by the different weight ions. Take a snapshot of the field, and apply Fourier Transform to generate the individual frequencies.
From the frequencies and the external magnetic field, one can deduce the weight of the ions, which is what mass spectroscopy is all about.
Of course, the argument is BS. Even when copying from CD to hard drive, errors can occur, and when going to CDR, yet more errors do occur. Same for going to tape.
While Hatch co-authored the DMCA, the view of many is that he didn't realize what the entertainment industry would do with how it was worded, and has since been keeping a close eye on anything coming from that corner of the cesspool.