If you are going to be format agnostic, the only one option is Kasenna MediaBase. It supports following formats: QuickTime, RealVideo, MPEG-1, MPEG-2 (!) and, possible, in future Windows Media. Server hardware may be driven by Linux or SGI IRIX.
Kasenna MediaBase is not free, but proven and stable.
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If you are going to be format agnostic, the only one option is Kasenna MediaBase. It supports following formats: QuickTime, RealVideo, MPEG-1, MPEG-2 (!) and, possible, in future Windows Media. Server hardware may be driven by Linux or SGI IRIX. Kasenna MediaBase is not free, but proven and stable.