The idea that a compact genome could be used to look for genes (or at least exons) in the human genome has already been put into practice. If you go to http://kicy.genoscope.cns.fr/cgi-bin/exofish_kicy. cgi you will get a short introduction on the topic as well as have access to the interface allowing you to look for exons in a sequence that you input.
EXOFISH (Exon Finding by Sequence Homology) uses DNA from another fish which is a cousin of Fugu (Tetraodon nigroviridis) in order to find highly conserved regions between it and human sequences. A method was developed to find these evolutionary conserved regions (ecores) efficiently as it is believed that they represent exons. More info here.
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The idea that a compact genome could be used to look for genes (or at least exons) in the human genome has already been put into practice. If you go to http://kicy.genoscope.cns.fr/cgi-bin/exofish_kicy. cgi you will get a short introduction on the topic as well as have access to the interface allowing you to look for exons in a sequence that you input.
EXOFISH (Exon Finding by Sequence Homology) uses DNA from another fish which is a cousin of Fugu (Tetraodon nigroviridis) in order to find highly conserved regions between it and human sequences. A method was developed to find these evolutionary conserved regions (ecores) efficiently as it is believed that they represent exons. More info here.