OK, to be fair, I only know of one vaccine that poses a real threat, and that is only because it is misused. That would be the chicken pox vaccine. It should not be used on children. The data supplied by virtually every source shows this, even when the sources conclusion recommends the vaccine.
While I don't think that the mortality/morbidity rate is high enough for varicella to warrant worrying about a vaccine, (You are after all, more likely to die from a home cooked meal than chicken pox) it should be noted that the mortality rate of chicken pox is 10x higher in adults than it is in children. So, the herd immunity through universal vaccination that helps us with diseases like polio are likely dramatically increasing the risk of death from chicken pox.
Show me a vaccine against dying from a home cooked meal, and I'll take that too. It sounds like you don't understand herd immunity. When there is herd immunity, the disease can't propagate, so if everybody is vaccinated, chances are that you'll never come into contact with the virus. But if you are worried about declining immunity, get a booster. Notably, deaths from chicken pox have drastically declined since the vaccine was introduced. So the notion that it is simply postponing the disease to adulthood when it is more hazardous does not hold water.
You are more likely to die by being burned to death from a home cooked meal than you are from chicken pox. If your goal is to protect children, your efforts would be better spent having kitchens banned from homes, as well as the cooking that happens in them.
What an idiotic comparison. If I could be protected from getting burned in the kitchen by a simple vaccine, I'd take that too.
We don't know whether getting vaccinated against chicken pox protects against children, because the varicella vaccine was introduced in 1995, so nobody vaccinated against chicken pox as a child has yet reached the age of high risk to shingles.
Prior to vaccination, there were thousands of hospitalizations and over a hundred deaths yearly from chicken pox. There is not a single documented death from the vaccination, and serious reactions are extraordinarily rare.
There is no actual evidence to support the notion that vaccination pushes infection off to adulthood, when it is more severe. In fact, the statistics show a precipitous fall in hospitalizations and deaths from chicken pox since the vaccine's introduction.
If you are concerned about vaccine protection wearing off, the solution is give everybody a booster, not to skip vaccination. Boosters probably aren't necessary so long as the great mass of the population is vaccinated at birth, since herd immunity makes it unlikely that adults will ever encounter the virus.
Technically, being "struck off" the medical register means the loss of your license to practice medicine. It does not mean the loss of your medical degree.
App crashes used to be fairly frequent on the iPhone, while system crashes were much less frequent, but happened now and then. In recent years, system crashes have pretty much vanished, while app crashes have gotten a lot less common. I don't think I've seen a single system crash with iOS 7 on my 4s, which is unusual for a major OS revision. My new 5s does appear to crash a bit more. I see an app unexpectedly quit every day or two, and I've had 2 or 3 system crashes--more like the frequency of crashes I remember from the first year or two of the iPhone.
Smart Response Technology is a bit different, as it is a caching system. You generally find it used with small SSDs, because it is expensive to buy a big SSD to use it only as a cache. The Fusion Drive is a different type of system, because the SSD is not used as a cache--the SSD plus HD are combined into a virtual drive that is larger than both. The most recently written data is stored on the SSD. For example, I have a 240 GB SSD paired with a 1 TB HD. It appears to me as a single 1.23 TB drive. 240 GB is large enough hold pretty much all of the data that I use routinely, so I end up with near-SSD speed, but with large capacity at modest expense.
The Fusion drive does not use the SSD as a cache. Rather, it merges the SSD and the HD into one large virtual drive, keeping the most recently written data on the SSD and the old stuff on the HD. The advantage, of course, is that you can pair a reasonably sized SSD, which will hold most of the data that you or currently using, with a big HD, and get much of the speed benefit of a SSD at much lower cost than a SSD big enough to hold all your data, and without the need to "triage" your data to decide what should go on which drive. I currently have a 240 GB SSD paired with a 1 TB HD, and the speed increase is quite dramatic.
I've been using a conventional hard drive paired with a SSD in Apple's Fusion drive configuration. This is only for Macs, but it makes it possible to use whatever size SSD you want, and the system automatically keeps the most recently written data on the SSD, saving the user the trouble of having to decide what to keep on the SSD and what to keep on the HD. In practice, the speedup is quite dramatic.
Government shutdown is not free--it increases costs, adding to the debt burden. It also creates business uncertainty, slowing the growth of the economy, which reduces tax receipts, further adding to the debt burden.
In fact, current projections (at least prior to this nonsense) showed that the debt was under control. And the demands that the Republicans are making as a price of funding the ongoing business would further increase the debt.
Not exactly. The Republican Bill does not just do partial funding of ongoing business of government--it bundles funding in with a delay in the Affordable Care Act and a repeal of a portion of the Act (the medical device tax). Neither of these have anything to do with funding the ongoing business of government.
Note that no Congressional action is necessary to fund Obamacare--it was previously funded by an Act of Congress, and its funding will continue.
Tetrodotoxin affinity is not all that high, just nanomolar. Same for LSD. And natural steroids have very high affinity for nuclear receptors, probably approaching the practical limits for small molecules. One possible mechanism of getting higher affinity is if a lipophilic compound acts in the membrane phase, since partitioning into the membrane could amplify the apparent potency by orders of magnitude. I have seen effects of a steroid down to low picomolar concentrations, perhaps by this mechanism (I think it's a membrane target), so I'm not excluding the possibility of ultra-high potency effects, but it does need to be explained.
The problem is that the concentrations of these agents in the environment tend to be extraordinarily low compared to the hormone levels that are normally present in the body, so it is hard to understand how they compete appreciably with the natural hormones. That doesn't mean it's impossible for these substances to have biological effects, but some explanation is needed beyond "they can mimic hormones."
Climate change might be happening. But who or what is responsible?
So we have a body of theory going back decades predicting global warming from increasing release of CO2. And we are observing warming very much like what was predicted. And other possible causes, like solar variation, have been extensively investigated and found unable to account for the observed changes.
So you really have to be grasping at straws to be suggesting that there is any real doubt over what is responsible.
If you look at the climate literature, you will find that the terms "climate change" and "global warming" have been used all along. The Intergovernmental Panel on Climate Change (IPCC) was established back in 1988. The two terms refer to different aspects of the same phenomenon: "global warming" refers to the global average temperature, "climate change" refers to the local impact.
Short term changes of under a decade or so are always weather. Modern climate science is able to predict trends, including such things how much weather variation around the trend to expect, but it cannot predict whether a particular year will be warm or cold (because it would be impractical to acquire the amount of data needed to predict such short term chaotic fluctuations more than a few days ahead).
It's not just a statistical trend. We have a well validated body of theory that predicts increased damage as a result of rising seas, as well as rising temperatures feeding more energy into storms. And the statistical trend agrees with those predictions. An insurance company would be foolhardy not to take this seriously.
Detractors tend to attribute Apples success to "hype," yet there are numerous products that have been heavily promoted and yet failed to sell. Consider Microsoft's "Surface" tablet/netbooks. Remember the ads with music and the acrobatic demonstrations of its clever (and brightly colored) keyboard covers. Brilliant ad, on a par with Apple's best. Yet the Surface tanked (Round two now coming up).
So what is it about Apple? At this point, it's not so much about the hype as about the brand. Most people who use Apple's products appreciate the attention that Apple gives to designing the user experience. It's subtle things like how fast Apple's phones and tablets respond to touch. Apple has built a reputation of only making premium products--no cheap, shoddily built stuff just to build market share. Other companies tend to have some good models and some not-so-good models. You buy Apple, and you know that you are getting a quality product that has been carefully tuned to optimize the user experience. You can trust Apple not to push specs at the expense of battery life, for example. So a lot of people probably ordered a new iPhone just because their old phone was two years old and out of contract, and based upon their previous experience with the company, and they trusted Apple to have something good. And judging from the early reviews, it appears that Apple has delivered once again.
Actually, there is no evidence of a trend of losing users. Apple's sales have increased with every iteration of the iPhone. Apple has lost marketshare to Samsung, which is something quite different--it means that Samsung is gaining users even faster than Apple is. But a lot of those phones are low-margin budget phones, sold to people who likely use few of their features, and, more importantly from Apple's perspective, don't buy much in the way of apps, music, books, or video for their phones. With the introduction of the 5c, Apple made its clearest declaration to date that it is not interested in the bottom end of the smartphone market
The iPhone 5 was competitive at introduction with the fastest phones available (a bit faster on some measures, a bit slower on others). There are some respects in which it is still faster; it's touchscreen response latency is still better than all phones except the iPhone 5s.
But no phone remains the fastest for the full two years of a typical contract...
On contract, the cheapest 5c is half the price of the cheapest 5s (or other new generation phones), and while other phones have surpassed it in some respects, it still delivers the full Apple iOS experience. In fact, a recent study found that the iPhone 5 has half the touch screen delay (which is probably the main factor determining the perception of touchphone responsiveness) of the Samsung Galaxy S4 (in fact, even the two-year old iPhone 4s, available free with a contract, beats the Galaxy S4).
Probably the same kind of people who buy Macs, even though Dell computers do the same thing for a fraction of the cost Or the people who buy a Mercedes Benz, even though a Hyundai does the same thing for a fraction of the cost.
Of course, while all of these products do generally the same thing, the user experience can be quite different for people who notice this sort of thing. For example, Apple is very concerned about conveying a touch experience that creates the illusion that the user is interacting directly with elements of the display, so Apple puts a lot of effort into minimizing the lag between touch input and response. For example, the previous generation, the iPhone 5, has half the latency of the fastest Android device. And the iPhone 5s is benchmarking twice as fast as the iPhone 5 for some functions.
For some people, this sort of thing makes a big difference. They may not be able to put their finger on it, but they know that Apple's devices are more enjoyable to use than other devices that do the "same thing," just as a Mercedes is more enjoyable to drive than a Hyundai.
But while you'll spend a great deal more for a Mercedes, you can buy the iPhone 5s at nearly the same price as top-of-the-line competitors. This Apple's big achievement with the iPhone, and Apple continues to reap these huge sales numbers year after year--the ability to deliver a premium quality product at a price that is competitive with the knock-offs.
My phone is covered with overlapping, often smeared, fingerprints. I'm sure than an expert could isolate a good copy, but it wouldn't be a trivial task.
I'd certainly like some more security on my iPhone, but not so much that I'm willing to type in a code every time I pull it out. I'll certainly use the fingerprint sensor.
Yes, I currently don't use a passcode at all, because it is too inconvenient. So I'm not particularly concerned with whether the fingerprint sensor can be broken by somebody who has managed to get hold of my fingerprint and go through the rather elaborate process described--it's still going to be better than no security at all.
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Utter nonsense. Chicken pox hospitalizations and deaths have drastically declined since introduction of the vaccine. And despite huge numbers of people receiving the vaccine, adverse reactions have remained extraordinarily rare.
Show me a vaccine against dying from a home cooked meal, and I'll take that too.
It sounds like you don't understand herd immunity. When there is herd immunity, the disease can't propagate, so if everybody is vaccinated, chances are that you'll never come into contact with the virus. But if you are worried about declining immunity, get a booster.
Notably, deaths from chicken pox have drastically declined since the vaccine was introduced. So the notion that it is simply postponing the disease to adulthood when it is more hazardous does not hold water.
What an idiotic comparison. If I could be protected from getting burned in the kitchen by a simple vaccine, I'd take that too.
We don't know whether getting vaccinated against chicken pox protects against children, because the varicella vaccine was introduced in 1995, so nobody vaccinated against chicken pox as a child has yet reached the age of high risk to shingles.
Prior to vaccination, there were thousands of hospitalizations and over a hundred deaths yearly from chicken pox. There is not a single documented death from the vaccination, and serious reactions are extraordinarily rare.
There is no actual evidence to support the notion that vaccination pushes infection off to adulthood, when it is more severe. In fact, the statistics show a precipitous fall in hospitalizations and deaths from chicken pox since the vaccine's introduction.
If you are concerned about vaccine protection wearing off, the solution is give everybody a booster, not to skip vaccination. Boosters probably aren't necessary so long as the great mass of the population is vaccinated at birth, since herd immunity makes it unlikely that adults will ever encounter the virus.
Technically, being "struck off" the medical register means the loss of your license to practice medicine. It does not mean the loss of your medical degree.
App crashes used to be fairly frequent on the iPhone, while system crashes were much less frequent, but happened now and then. In recent years, system crashes have pretty much vanished, while app crashes have gotten a lot less common. I don't think I've seen a single system crash with iOS 7 on my 4s, which is unusual for a major OS revision. My new 5s does appear to crash a bit more. I see an app unexpectedly quit every day or two, and I've had 2 or 3 system crashes--more like the frequency of crashes I remember from the first year or two of the iPhone.
Not available in my Boston neighborhood of Jamaica Plain.
Smart Response Technology is a bit different, as it is a caching system. You generally find it used with small SSDs, because it is expensive to buy a big SSD to use it only as a cache. The Fusion Drive is a different type of system, because the SSD is not used as a cache--the SSD plus HD are combined into a virtual drive that is larger than both. The most recently written data is stored on the SSD. For example, I have a 240 GB SSD paired with a 1 TB HD. It appears to me as a single 1.23 TB drive. 240 GB is large enough hold pretty much all of the data that I use routinely, so I end up with near-SSD speed, but with large capacity at modest expense.
The Fusion drive does not use the SSD as a cache. Rather, it merges the SSD and the HD into one large virtual drive, keeping the most recently written data on the SSD and the old stuff on the HD. The advantage, of course, is that you can pair a reasonably sized SSD, which will hold most of the data that you or currently using, with a big HD, and get much of the speed benefit of a SSD at much lower cost than a SSD big enough to hold all your data, and without the need to "triage" your data to decide what should go on which drive. I currently have a 240 GB SSD paired with a 1 TB HD, and the speed increase is quite dramatic.
I've been using a conventional hard drive paired with a SSD in Apple's Fusion drive configuration. This is only for Macs, but it makes it possible to use whatever size SSD you want, and the system automatically keeps the most recently written data on the SSD, saving the user the trouble of having to decide what to keep on the SSD and what to keep on the HD. In practice, the speedup is quite dramatic.
Government shutdown is not free--it increases costs, adding to the debt burden. It also creates business uncertainty, slowing the growth of the economy, which reduces tax receipts, further adding to the debt burden.
In fact, current projections (at least prior to this nonsense) showed that the debt was under control. And the demands that the Republicans are making as a price of funding the ongoing business would further increase the debt.
Not exactly. The Republican Bill does not just do partial funding of ongoing business of government--it bundles funding in with a delay in the Affordable Care Act and a repeal of a portion of the Act (the medical device tax). Neither of these have anything to do with funding the ongoing business of government.
Note that no Congressional action is necessary to fund Obamacare--it was previously funded by an Act of Congress, and its funding will continue.
Tetrodotoxin affinity is not all that high, just nanomolar. Same for LSD. And natural steroids have very high affinity for nuclear receptors, probably approaching the practical limits for small molecules. One possible mechanism of getting higher affinity is if a lipophilic compound acts in the membrane phase, since partitioning into the membrane could amplify the apparent potency by orders of magnitude. I have seen effects of a steroid down to low picomolar concentrations, perhaps by this mechanism (I think it's a membrane target), so I'm not excluding the possibility of ultra-high potency effects, but it does need to be explained.
The problem is that the concentrations of these agents in the environment tend to be extraordinarily low compared to the hormone levels that are normally present in the body, so it is hard to understand how they compete appreciably with the natural hormones. That doesn't mean it's impossible for these substances to have biological effects, but some explanation is needed beyond "they can mimic hormones."
So we have a body of theory going back decades predicting global warming from increasing release of CO2. And we are observing warming very much like what was predicted. And other possible causes, like solar variation, have been extensively investigated and found unable to account for the observed changes.
So you really have to be grasping at straws to be suggesting that there is any real doubt over what is responsible.
If you look at the climate literature, you will find that the terms "climate change" and "global warming" have been used all along. The Intergovernmental Panel on Climate Change (IPCC) was established back in 1988. The two terms refer to different aspects of the same phenomenon: "global warming" refers to the global average temperature, "climate change" refers to the local impact.
Short term changes of under a decade or so are always weather. Modern climate science is able to predict trends, including such things how much weather variation around the trend to expect, but it cannot predict whether a particular year will be warm or cold (because it would be impractical to acquire the amount of data needed to predict such short term chaotic fluctuations more than a few days ahead).
It's not just a statistical trend. We have a well validated body of theory that predicts increased damage as a result of rising seas, as well as rising temperatures feeding more energy into storms. And the statistical trend agrees with those predictions. An insurance company would be foolhardy not to take this seriously.
Detractors tend to attribute Apples success to "hype," yet there are numerous products that have been heavily promoted and yet failed to sell. Consider Microsoft's "Surface" tablet/netbooks. Remember the ads with music and the acrobatic demonstrations of its clever (and brightly colored) keyboard covers. Brilliant ad, on a par with Apple's best. Yet the Surface tanked (Round two now coming up).
So what is it about Apple? At this point, it's not so much about the hype as about the brand. Most people who use Apple's products appreciate the attention that Apple gives to designing the user experience. It's subtle things like how fast Apple's phones and tablets respond to touch. Apple has built a reputation of only making premium products--no cheap, shoddily built stuff just to build market share. Other companies tend to have some good models and some not-so-good models. You buy Apple, and you know that you are getting a quality product that has been carefully tuned to optimize the user experience. You can trust Apple not to push specs at the expense of battery life, for example. So a lot of people probably ordered a new iPhone just because their old phone was two years old and out of contract, and based upon their previous experience with the company, and they trusted Apple to have something good. And judging from the early reviews, it appears that Apple has delivered once again.
Actually, there is no evidence of a trend of losing users. Apple's sales have increased with every iteration of the iPhone. Apple has lost marketshare to Samsung, which is something quite different--it means that Samsung is gaining users even faster than Apple is. But a lot of those phones are low-margin budget phones, sold to people who likely use few of their features, and, more importantly from Apple's perspective, don't buy much in the way of apps, music, books, or video for their phones. With the introduction of the 5c, Apple made its clearest declaration to date that it is not interested in the bottom end of the smartphone market
The iPhone 5 was competitive at introduction with the fastest phones available (a bit faster on some measures, a bit slower on others). There are some respects in which it is still faster; it's touchscreen response latency is still better than all phones except the iPhone 5s.
But no phone remains the fastest for the full two years of a typical contract...
On contract, the cheapest 5c is half the price of the cheapest 5s (or other new generation phones), and while other phones have surpassed it in some respects, it still delivers the full Apple iOS experience. In fact, a recent study found that the iPhone 5 has half the touch screen delay (which is probably the main factor determining the perception of touchphone responsiveness) of the Samsung Galaxy S4 (in fact, even the two-year old iPhone 4s, available free with a contract, beats the Galaxy S4).
Probably the same kind of people who buy Macs, even though Dell computers do the same thing for a fraction of the cost
Or the people who buy a Mercedes Benz, even though a Hyundai does the same thing for a fraction of the cost.
Of course, while all of these products do generally the same thing, the user experience can be quite different for people who notice this sort of thing.
For example, Apple is very concerned about conveying a touch experience that creates the illusion that the user is interacting directly with elements of the display, so Apple puts a lot of effort into minimizing the lag between touch input and response. For example, the previous generation, the iPhone 5, has half the latency of the fastest Android device. And the iPhone 5s is benchmarking twice as fast as the iPhone 5 for some functions.
For some people, this sort of thing makes a big difference. They may not be able to put their finger on it, but they know that Apple's devices are more enjoyable to use than other devices that do the "same thing," just as a Mercedes is more enjoyable to drive than a Hyundai.
But while you'll spend a great deal more for a Mercedes, you can buy the iPhone 5s at nearly the same price as top-of-the-line competitors. This Apple's big achievement with the iPhone, and Apple continues to reap these huge sales numbers year after year--the ability to deliver a premium quality product at a price that is competitive with the knock-offs.
My phone is covered with overlapping, often smeared, fingerprints. I'm sure than an expert could isolate a good copy, but it wouldn't be a trivial task.
I'd certainly like some more security on my iPhone, but not so much that I'm willing to type in a code every time I pull it out. I'll certainly use the fingerprint sensor.
Yes, I currently don't use a passcode at all, because it is too inconvenient. So I'm not particularly concerned with whether the fingerprint sensor can be broken by somebody who has managed to get hold of my fingerprint and go through the rather elaborate process described--it's still going to be better than no security at all.
But has he previously trained it to recognize his middle finger?