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Domain: embl-heidelberg.de

Stories and comments across the archive that link to embl-heidelberg.de.

Comments · 6

  1. Link to Nature article by JuliusSu · · Score: 5, Informative · on Creating Artificial Proteins

    Full text of article, institutional/personal subscription required.

    Abstract: Classical studies show that for many proteins, the information required for specifying the tertiary structure is contained in the amino acid sequence. Here, we attempt to define the sequence rules for specifying a protein fold by computationally creating artificial protein sequences using only statistical information encoded in a multiple sequence alignment and no tertiary structure information. Experimental testing of libraries of artificial WW domain sequences shows that a simple statistical energy function capturing coevolution between amino acid residues is necessary and sufficient to specify sequences that fold into native structures. The artificial proteins show thermodynamic stabilities similar to natural WW domains, and structure determination of one artificial protein shows excellent agreement with the WW fold at atomic resolution. The relative simplicity of the information used for creating sequences suggests a marked reduction to the potential complexity of the protein-folding problem.

    From this page : a WW domain is the smallest, monomeric, triple-stranded, anti-parallel beta-sheet protein domain that is stable in the absence of disulfide bonds, cofactors or ligands.

  2. Re:Genetic Mouse code unveiled by Mercaptan · · Score: 2 · on Mouse Genetic Code Published

    It's open source and then some. You'll be able to pick it up from the NIH and a number of other places, on government tabs no less.

    Good luck compiling it though.

    By the way, here's a more official press release.

  3. Re:Genetic Mouse code unveiled by Mercaptan · · Score: 2 · on Mouse Genetic Code Published

    It's open source and then some. You'll be able to pick it up from the NIH and a number of other places, on government tabs no less.

    Good luck compiling it though.

    By the way, here's a more official press release.

  4. Recalling Wrong by Christopher+B.+Brown · · Score: 2 · on Distributed Operating Systems?
    NeXTStep was based on an early version of Mach, back before Mach was a "seriously distributed system." It parallels Digital's OSF/1 aka "Digital Unix," which also was implemented atop "early Mach."

    Both NeXTStep and Digital Unix were monolithic OSes, despite the association with Mach.

    What you may be thinking of is that NeXTStep included a "distributed objects" scheme, lately being "cloned" as GDO (GNU Distributed Objects).

  5. Macintosh Servers and CGI by superdan2k · · Score: 3 · on Which CGI Language For Which Purpose?

    In the case of a Mac server, you have two rather esoteric options:

    1. Applescript CGI. There's a good tutorial on this here. And I recommend Applescript for Dummies, which, despite its title, is a pretty good foundation in the language. (And about the only thing still in print on the subject, which is odd.)

    2. RealBasic CGI. RealBasic is a version of VB for the Mac, produced by a company in Texas (IIRC). It's a solid little package, and someone out there has written module for RB to allow CGI functions...

  6. Mirror by otuz · · Score: 2 · on GNUstep 0.6.0

    Here's the german gnustep mirror:

    http://www.nmr.embl-heidelberg.de/GNUste p/

    It's [still] not slashdotted :)