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Domain: nottingham.ac.uk
Stories and comments across the archive that link to nottingham.ac.uk.
Stories · 6
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'Sister Clones' Of Dolly The Sheep Have Aged Like Any Other Sheep, Study Says (npr.org)
An anonymous reader quotes a report from NPR: About four years ago, Kevin Sinclair inherited an army of clones. "Daisy, Debbie, Denise and Diana," says Sinclair, a developmental biologist at the University of Nottingham in England. "'Sister clones' probably best describes them," Sinclair says. "They actually come from the exactly the same batch of cells that Dolly came from." In an article out Tuesday in the journal Nature Communications, Sinclair and his colleagues write that the ewes' age, along with their strapping health, might be a reason for people to start feeling more optimistic about what cloning can do. Dolly's life did not turn out as scientists in the cloning field hoped it would. She died young -- 6 1/2 -- with a nasty lung virus. "That was really just bad luck," Sinclair says, and had "nothing to do" with the fact that Dolly was a clone. It was a daunting concept for those in the cloning field, because, says Sinclair, "If you're going to create these animals, they should be normal in every respect. They should be just as healthy as any other animal that's conceived naturally. If that is not the case, then it raises serious ethical and welfare concerns about creating these animals in the first place." But, the good health of the 13 clones in the Nottingham herd suggest better prospects for the procedure. Sinclair and his colleagues evaluated the animals' blood pressure, metabolism, heart function, muscles and joints, looking for signs of premature aging. They even fattened them up (since obesity is a risk factor for metabolic problems including diabetes) and gave them the standard tests to gauge how their bodies would handle glucose and insulin. The results? Normal, normal, normal. "There is nothing to suggest that these animals were anything other than perfectly normal," says Sinclair. They had slight signs of arthritis (Debbie in particular), but not enough to cause problems. "If I put them in with a bunch of other sheep, you would never be able to identify them," he says. -
Space Worms Live Long and Prosper
astroengine writes "A microscopic worm used in experiments on the space station not only seems to enjoy living in a microgravity environment, it also appears to get a lifespan boost. This intriguing discovery was made by University of Nottingham scientists who have flown experiments carrying thousands of tiny Caenorhabditis elegans (C. elegans) to low-Earth orbit over the years. It turns out that this little worm has genes that resemble human genes and of particular interest are the ones that govern muscle aging. Seven C. elegans genes usually associated with muscle aging were suppressed when the worms were exposed to a microgravity environment. Also, it appears spaceflight suppresses the accumulation of toxic proteins that normally gets stored inside aging muscle. Could this have implications for understanding how human physiology adapts to space?" -
Flatworms Defy Aging Through Cell Division Tricks
An anonymous reader writes "Researchers from The University of Nottingham have demonstrated how a species of flatworm overcomes the aging process to be potentially immortal. The discovery, published (abstract; full text PDF) in the Proceedings of the National Academy of Sciences, is part of a project funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council and may shed light on the possibilities of alleviating aging and age-related characteristics in human cells." After finding the gene for telomerase synthesis in the worms, the researchers were able to observe that the worms "...dramatically increase the activity of this gene when they regenerate, allowing stem cells to maintain their telomeres as they divide to replace missing tissues." -
Programming Cells, With CellOS
First time accepted submitter JoeMerchant writes "An international team of synthetic biologists, led by professor of computer science Natalio Krasnogor at the University of Nottingham, hopes to revolutionize synthetic biology with what they call CellOS, a 'bottom-up approach to cellular computing, in which computational chemical processes are encapsulated within liposomes.' The bold project is aptly named AUdACiOuS." -
Oldest Submerged City Visualized With CGI
Stirling Newberry writes "Nottingham University's Pavlopetri project spent months measuring a city that sank beneath the waves 3,000 years ago, perhaps in a tsunami. The result is a BBC documentary that features a detailed CGI reconstruction. 'The entire city – covering 20 acres – has been surveyed in ultra-high definition, with error margins of less than three centimeters. ... [T]he survey team has so far located scores of buildings, half a dozen major streets and even religious shrines and tombs.' eScience News chimes in about the oldest known submerged city, first inhabited 5,000 years ago and rediscovered in 1967. Of course, Slashdot readers will probably want to dig into the details of how stereo-vision mapping was used (PDF) to create the map in the first place." -
Nobel Prize for Medicine For MRI
andy1307 writes "American Paul C. Lauterbur and Briton Sir Peter Mansfield have won the Nobel prize for medicine for discoveries leading to MRI. Worldwide, more than 60 million investigations with MRI are performed each year, and the technique is ``a breakthrough in medical diagnostics and research,'' the Assembly said. The work was done on the 1970s. Lauterbur is at the Biomedical Magnetic Resonance Laboratory at the University of Illinois in Urbana and Mansfield is at the University of Nottingham in Britain. "