Mail User Agent Comparisons?

tjgoodwin asks: "I'm the SysAdmin in an astronomy department. Our currently supported mail user agent is pine ^[?] , but I'm looking at alternatives. I'm particularly interested in strong support for qmail's maildirs. I need to support at least one text-based UA: mutt ^[?] does what I need with maildirs, but is it really suitable for a user base, many of whom are new to Unix? I'm also considering graphical UAs, preferably gnome-based. I've failed to find any useful comparison information (the UNIX Email Software Survey FAQ is seriously out of date). Any pointers?"