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Black Death's Genome Cracked

exceed writes: "This article on Wired, and this article on Yahoo! News states that scientists have decoded the genome of the bubonic plague bacterium. This will now (hopefully soon) lead to vaccinations and treatments for the disease it causes."

20 of 252 comments (clear)

  1. I can see it coming... by Anonymous Coward · · Score: 4, Funny

    Satan will sue these scientists under the DMCA for having cracked the protection of his copyrighted microscopic pupil. Will Congress learn to weigh all sides of an issue before passing random laws?

  2. Technology is a Double Edged Sword... by Ron+Bennett · · Score: 3, Insightful

    Sounds like a great advance, but sadly I fear such information will also be used by some to develop even more deadly biological weapons.

    1. Re:Technology is a Double Edged Sword... by leucadiadude · · Score: 3, Troll

      Smallpox won't "spread like crazy" because you need to be within close proximity to an infected person. Once it becomes known that there is a major smallpox outbreak, you can be sure people will severely limit their interpersonal contacts. And there is indeed a smallpox vaccine. See this article.

      An excerpt:
      "The possible use of smallpox virus as a weapon by terrorists has stimulated growing international concern and led to a recent review by the World Health Organization of the global availability of smallpox vaccine. This review found approximately 60 million doses worldwide, with little current vaccine manufacture, although limited vaccine seed remains available (1). Ongoing discussions in the United States suggest that the national stockpile should contain at least 40 million doses to be held in reserve for emergency use, including in case of a terrorist release of smallpox virus (O'Toole, this issue, pp. 540-6).

      The current U.S. stockpile contains approximately 15.4 million doses of vaccinia vaccine (Dryvax) made from the New York City Board of Health strain of vaccinia and was produced by Wyeth Laboratories in 13 separate lots. The vaccine is lyophylized in glass vials with rubber stoppers and sealed with a metal band. When rehydrated, each vial contains 100 doses and has a potency of at least 108 plaque-forming units (pfu)/ml. Some vials of the vaccine stockpile have shown elevated moisture levels and thus failed routine quality control testing; however, the vaccine in these vials remains potent, and the failed lots have not been discarded.
      "

    2. Re:Technology is a Double Edged Sword... by UserChrisCanter4 · · Score: 3, Insightful

      Let's consider something for the time being here: Most of slashdot is people in computing-related fields. We know computing. Most of us don't know much beyond the few college-level bio courses... this isn't our area of expertise.

      For a moment, let's just replace the words, 'publishing bubonic plague genome information' with "releasing source code for the 2.4 Kernel". Are we all of a sudden afraid that the script kiddies are going to root our box, or do we realize that the release of such information will allow the many skilled programmers of the Linux world to make fine adjustments to the security features of Linux?

      I'm talking out of my ass for this last bit here, but I'd have to figure that it takes a significantly skilled person to engineer a more dangerous strain of a given bacteria. I would also have to figure that the thousands of other people with roughly the same skill level could probably come up with a vaccine in a shorter time period. If I wanted something super-destructive, I'd probably stick with a nuke. They're a lot cheaper, and no one's come up with a personal nuke/radiation proof shield that can be injected into a toddler.

  3. Re:Wasteful by OmegaDan · · Score: 3, Insightful

    ummm, I care. They find squirrels carrying the disease all the time in southern california.

  4. Re:Wasteful by Alien54 · · Score: 4, Insightful
    It killed 200 million people in the 14th century and continues to kill about 3,000 people each year according to the World Health Organization. Some experts are newly worried that the bug could be used as a bio-weapon in light of the Sept. 11 terrorist attacks.

    Which is why you worry. People playing with bio engineering could come up with a new version that could be very nasty.

    --
    "It is a greater offense to steal men's labor, than their clothes"
  5. Black Death by Digitalia · · Score: 3, Funny

    Rest asssured, lowly peasants. Your fair and benevolent rulers have presented you with the ultimate cure for the vile scourge known as the black death. This, a lowly bar of soap, shall be your floral scented cure! Fear not any longer.

    --
    Pax Digitalia
  6. To clarify a couple points by alewando · · Score: 5, Insightful
    1. Antibiotics help a lot with treating bubonic plague, but they're only effective if the disease is first properly diagnosed. Because people are no longer used to contracting fatal diseases (which bubonic plague always is if left untreated), and because the symptoms are not all that different from symptoms of diseases people are used to shrugging off, the disease is often not diagnosed in time.
    2. Releasing the genome to the general public will help vaccination discoveries far more than it will help people who would use the plague for biological warfare. Frankly, you don't have to know the genetic sequence that underlies the organism in order to culture it and construct a suitable delivery device. In contrast, the benefits due to a vaccine discovery are obvious and numerous.
    3. A couple people do die of the bubonic plague every year, mostly in Asia and Africa. In addition to the importance of antibiotic treatment and a vaccine discovery, the importance of improving hygiene standards cannot be understated. It's a three-part chain involving rodents, fleas, and humans, so if you eliminate human contact with both, then you've effectively cut humans out of the loop and eliminated human infections.
    1. Re:To clarify a couple points by Metallic+Mongoose · · Score: 5, Informative

      "Because people are no longer used to contracting fatal diseases (which bubonic plague always is if left untreated"
      ----------------
      Actually, it isn't.

      The most virulent & deadly version of plague (pneumatic) has a mortality rate of aprox. 90% if left untreated...

      ...if (untreated) bubonic plague had a 100% mortality rate, european history would look very diffrent.

  7. Re:I feel so much safer by Spootnik · · Score: 5, Informative

    Actually, while the destruction of the cats in the Middle ages may have contributed to (or even allowed) the huge increase in the rat population leading to the "Black Plague", I do feel a need to point out something regarding *current* problems with bubonic plague. One of the major problems with the plague is that the fleas that carry it do not live *exclusively* on rats. Domestic animals such as dogs and cats, can get them too.

    According to my source at the Coconino County Health Department in Flagstaff, Arizona, USA, there have been less than 60 cases state wide, since the first recorded one in 1950, of what we commonly refer to as "bubonic plague". Bubonic plague is actually descriptive of a symptom, not the disease itself which is caused by a bacterium called Yersinia pestis. Yersinia pestis is, as mentioned in the earlier post, carried by fleas.

    The fleas of rats, mice, prairie dogs, squirrels, chipmunks and even rabbits can all carry Y. pestis. If your dog or cat is out running around free and catches or picks up a dead animal with infected fleas, your dog or cat can get those fleas. Once your pet has those fleas on him or her, they can be brought into your home and you can get the plague. However, this is apparently a very rare happening.

    In 1995 there were 5 cases of Plague (Y. pestis) in Arizona. 2 of these were in Coconino county. One of these was in a woman who apparently was infected while visiting relatives in Maricopa County. The other was a man who had been out shooting prairie dogs and had handled several of the carcasses, getting fleas from them. The person at the Coconino County Health Dept. did say it was much more likely to get the aforementioned fleas from a carcass that a dog or cat brought home than directly from your dog or cat, though that was certainly possible and is believed to have happened in the past.

    The point being, that while in the 14th century the "Black Death" (which is only assumed to be the same disease as Y. pestis) may or may not have been triggered by the decimation of the cat populations in Europe, we aren't living in the 1300's anymore. Now days, if you let your cat or dog run free he/she is liable to bring you a present that could cost you your life.

    And don't even get me started about Hanta virus....

  8. All in the timing. by Chairboy · · Score: 4, Funny

    Great! This is excellent! This is something that could have been great about 400 YEARS AGO!

    Grr!

    What they REALLY need to decode is whatever virus it is that prompts record executives to pull together a group of 4-5 teenage boys and turn them into a 'boy band'. Cure THAT virus, and the world will thank you.

  9. vaccine availability by leucadiadude · · Score: 5, Interesting

    Smallpox:
    CDC is the only source of vaccinia vaccine and VIG for civilians. CDC will provide vaccinia vaccine to protect laboratory and other health-care personnel whose occupations place them at risk for exposure to vaccinia and other closely related Orthopoxviruses, including vaccinia recombinants. Vaccine should be administered under the supervision of a physician selected by the institution. Vaccine will be shipped to the responsible physician. Requests for vaccine and VIG, including the reason for the request, should be referred to

    Centers for Disease Control and Prevention
    Drug Services, National Center for Infectious Diseases
    Mailstop D-09
    Atlanta, GA 30333
    Telephone: (404) 639-3670
    Facsimile: (404) 639-3717


    Plague:
    Plague vaccine is available in the United States from Greer Labs. Plague vaccine USP is manufactured by Greer Laboratories, Inc., P.O. Box 800, Lenoir, NC, 28645-0800, telephone (800)438-0088 or (704)754-5327. The vaccine is shipped refrigerated in 20ml vials and should be stored at 2-8 degrees C (35-46 degrees F). It should not be frozen. The following groups of people should consider vaccination:

    Persons working with the plague bacterium in the laboratory or in the field. Persons working in plague-affected areas or with potentially infected animals where they have little control over their environments, particularly in developing countries.


    I don't know where you might find tularemia vaccine or some of the other lesser known organisms.

  10. Excellent! by stevarooski · · Score: 4, Informative

    Bubonic plague is nasty, nasty stuff. . .I've read a lot about the various fun ways it can kill you through history books. For those who have no idea of what it did to Europe, read a good summary of the Black Death here.

    Also, before people go off on biological weapons, etc, consider that there have been several recent breakouts of this disease, particularly in the southwest US(where I'm from). Don't know what I'm talking about? Check out this as an example. I remember reading in the paper in AZ about outbreaks occasionally and shuddering. A cure would be a godsend--even though there are only about 10-15 cases in the US a year, its a painful way to go.

    --

    - - - - - - - -
    Don't worry, being eaten by a crocodile is just like going to sleep in a giant blender.
  11. A couple questions by Z4rd0Z · · Score: 3, Interesting
    Since the article mentions there is already a vaccine for this, why is there talk that this could be used to create a vaccine? Why would we need another?

    The scientists were saying they knew that the bacteria modified itself and they even knew that it did it 1500 years ago. How do they know that? Would anyone with some knowledge of this care to speculate?

    --
    You had me at "dicks fuck assholes".
    1. Re:A couple questions by Lars+Arvestad · · Score: 3
      Since the article mentions there is already a vaccine for this, why is there talk that this could be used to create a vaccine? Why would we need another?

      The press release from the Sanger Center actually says that they have a vaccine undergoing trials and that the sequencing efforts from this project helped the research for the vaccine. You don't need a full genome to do sequence analysis. Indeed, if you have some idea for what you are looking for, you can find fairly efficiently. The scientists were saying they knew that the bacteria modified itself and they even knew that it did it 1500 years ago. How do they know that? Would anyone with some knowledge of this care to speculate?

      Here is a speculation, because I have not read the actual Nature paper: They recognize some genomic material in the bacteria coming from some other bacteria. By analysing the amount of mutations in the incorporated material, they can get an estimate of how long ago it was incorporated.

      Speculation 2: They computed evolutionary tree for different strains of plague bacteria and its relatives based on some genomic region with nice properties. This tree could give you estimates for when the strains started to deviate. Then, by studying for what bacteria the new modified material is common, you can decide the earliest point of inclusion.

      --
      Reality or nothing.
  12. Karma-whoring: Some info links by Lars+Arvestad · · Score: 5, Informative
    Instead of reading fluffy sources such as Wired and Yahoo!, why don't you check out some real informational sites? This can be seen as blatant karma-whoring, but I would really appreciate if submitters of science stories dug out links like these before posting. Gives much better credibility, IMHO.
    --
    Reality or nothing.
  13. Not far from AIDS by manon · · Score: 3, Insightful

    This is geat news, but scientists also dicovered something else. In the years when the plague was still making thousands die in Europe, some people develloped an immunity, based on their genes. Call it a mutation.
    Now the chances are VERY big that this same immunity is causing some people that are HIV possitive never to get AIDS.
    Now we can only hope that the two discoveries can work together in ending both AIDS and the plague.

    --
    42 + 1 = 42
    1. Re:Not far from AIDS by koekepeer · · Score: 3, Informative

      Interesting observations, but how sure are we that the "Black Death" is caused by Y. pestis, and not by a viral agent (as pointed out in a previous post)? Without that presumption, the whole argument of Y. pestis, and HIV using the same cells to attack the host (human macrophages) is invalid.

      But let's stay positive and hope this little far-fetched theory turns out to be true. Tell me, how are you going to cure AIDS with it? Targeted gene replacement of CCR5 in macrophages? That's SciFi, and won't happen in the next 10 yrs IM-not-so-HO. Also, it's not very cost-effective: it only works as a defence when you get infected by someone in the earlier stages of HIV infection, so the use is to limited. Plus, I don't see how the genome of Y.pestis would help to understand the HIV-macrophage virus-host interaction better, but maybe I'm prejudiced towards the use of genomics. I wouldn't bet my money on this being the cure for aids.

      Okay let's stop here. I've lost the average /. user already, so there's no karma in this one, unless the moderator is a molecular biologist or something ;-)

      Regards,

      Meneer de Koekepeer

  14. From the article: by PD · · Score: 5, Funny

    In their study, published in the Oct. 4 issue of Nature, the researchers mapped a strain of plague that killed a veterinarian in the United States in 1992. He contracted the disease after an infected cat sneezed on him.

    Oh my god I would hate to die that way. Please just let me drown or get consumed by rats. Anything, but please don't let them print an obituary about me that admits that I was killed by a sneezing cat.

  15. Further Correction... by Talisman · · Score: 4, Informative

    "The most virulent & deadly version of plague (pneumatic)..."

    Actually, there were three types:

    Bubonic (lymph nodes)
    Pneumonic (lungs)
    Septicemic (blood)

    The deadliest was Septicemic, killing 100% of the people that contracted it. However, there had to be a very specific set of circumstances (temerature, etc.) for a person to get this type.

    Just FYI, Pneumonic killed about 90% of the people that got it and Bubonic killed about 75%.

    --

    "Study your math, kids. Key to the universe." -The Archangel Gabriel