Pain-free mice
mccalli writes: "Not input devices, but real live squeaky things. Apparently, Canadian scientists are trying to breed mice that do not feel pain. The eventual goal is a better pain killer for humans, but this is said to be a long way off. More in the Nature article here."
I think one of the reasons we feel pain is so that we don't do stupid things...
Be very close to fire.
Touch very sharp things.
Drink/spill other people's pints, or look at their women
So if we now have painkillers that kill all pain, there are going to be a lot of mutillated people in future generations!