Moving from Corporate IT to Science?

EdinBear asks: "I've been working as a SysAdmin in an increasingly corporate internet services company, which has been hit hard by the fallout from the .com bust. When I started some years ago, I felt I was helping small and interesting companies get benefit from the burgeoning Internet through useful and attractive web services. However, since the Internet became 'normal', the focus has been purely commercial - and instead of helping an enterprise get exposure in an interesting way, it's all about money and finance. I now feel I want to move into Science to use my skills in a productive, 'big picture' kind of way, rather than just helping a client get more rich through financial services. I'm interested to hear if other people have found themselves in a similar position; is the transfer to Science/Research/Academia difficult? Is the grass greener on the other side? The money is less, but is the job satisfaction more?"