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The Lazarus Zoo: Resurrecting Extinct Species

An anonymous reader writes "The Australian Museum is attempting to resurrect the extinct Tasmanian tiger, using pup cells harvested from storage jars in alcohol from 70 years ago. The tiger was hunted to extinction, and has the ironic distinction of receiving legal protection the same year that the last of its kind (named Benjamin) died at the Hobart Zoo on September 7, 1936. Other cloning attempts at conserving endangered species include the South Asian banteng on an Ohio farm, the world's last burcado (a Spanish mountain goat), a wild Asian ox called the gaur, and even a woolly mammoth." They're hoping for a live birth in 2010.

46 comments

  1. Oh great by Anonymous Coward · · Score: 2, Funny

    Mention "Woolly Mammoth" and "Goat" in the same story. They are just asking for it. :)

  2. Hey! by Andy_R · · Score: 2, Funny

    I just had this GREAT idea for a movie! We could get Jeff Goldblum, and have this sort of theme park on an island somewhere, and... oh, DAMNIT!

    --
    A pizza of radius z and thickness a has a volume of pi z z a
  3. Telomere damage by PD · · Score: 3, Insightful

    Clones have short telomeres. But, do the offspring of clones have normal telomeres? Dolly had some lambs, so the answer should be known. If the offspring's telomeres are normal, that's good news because even if the clone has problems, the offspring might not have those problems.

    1. Re:Telomere damage by tsa · · Score: 2, Insightful

      I was wondering about that too. The telomeres must be restored in the genitals somehow or the offspring would live shorter than their parents...
      By the way, I saw a tidbit about resurrecting the Tasmanian devil on TV last night, and there were some people that claimed they had seen live ones and are not convinced that it's really extinct. That would be great because if they are resurrected from the puppy cells from the jars you can bet that a live one comes wandering out of the forest just then. And then you can compare the DNA of the 'real' tiger with the cloned one to see how much it differs!

      --

      -- Cheers!

    2. Re:Telomere damage by tsa · · Score: 1

      Oops, there's a devil in my post somewhere, of course I meant tiger...

      --

      -- Cheers!

    3. Re:Telomere damage by Anonymous Coward · · Score: 0
      The telomeres must be restored in the genitals somehow or the offspring would live shorter than their parents..

      Or they don't shorten in an embrio and in genitals, which I think that's more likely, but I'm just talking out my, um, hat. I hope someone with some facts answers your question.

    4. Re:Telomere damage by Radical+Rad · · Score: 1

      I have heard about this too but even though people have claimed to see them, no one has produced a shred of evidence that they still survive. Not a photograph, not a carcass, nothing. Even Sasquatch has more evidence for it and that is obviously a load of Malarky. But who knows? Other supposedly extinct species have been found again.

    5. Re:Telomere damage by Anonymous Coward · · Score: 0

      Of course, how can it have any offspring if it is the ONLY ONE of its kind?

    6. Re:Telomere damage by PD · · Score: 1

      They'd clone more than one of them.

    7. Re:Telomere damage by RedCard · · Score: 1


      >The telomeres must be restored in the genitals
      >somehow or the offspring would live shorter than
      >their parents..

      Or they don't shorten in an embrio and in genitals, which I think that's more likely, but I'm just talking out my, um, hat. I hope someone with some facts answers your question.


      I would like to qualify this by saying that I am not a human phys person. I am a CS/Ecology person, so I expecte to be corrected if I'm too far off base. That said, I do believe that yes, you are talking out of your, erm, 'hat'.

      If telomeres can never be restored, and can only be maintained as you say, it would then imply that if telomeres in an egg cell suffered any damage that shortened them, they could never be repaired.

      Logically, over millions of generations, a great deal of telomere-shortening damage must have happened.

      Therefore, with no way to re-lengthen telomeres in egg cells, our lives would be shorter than our predecessors by orders of magnitude!

      So egg cells must be able to restore their telomere length, at least before they fuse with a sperm cell.

    8. Re:Telomere damage by Dahan · · Score: 1
      Um, while I'm sure gay sex is fun and all that, it's not going to produce offspring.

      You do realize that all clones will have the same gender... right?

    9. Re:Telomere damage by Psion · · Score: 1

      You don't suppose that someone might consider cloning other samples, do you?

    10. Re:Telomere damage by Fuzzy+Sasquatch · · Score: 1

      "Even Sasquatch has more evidence for it and that is obviously a load of Malarky."

      Hrrrk?

      GRRRRRRR!!

    11. Re:Telomere damage by PD · · Score: 1

      You mean that they'll all be female? What's the reason for that?

    12. Re:Telomere damage by Dahan · · Score: 1

      Ah, I got the impression from the article that there was only one preserved pup... but last year's article has more details and does say that they have DNA from three individuals.

  4. Its a dupe (n/t) by bofkentucky · · Score: 1

    Cenozoic Park: Cloning the Tasmanian Tiger, nearly a year old, much better than the 2 hour gap we were seeing.

    --
    09f911029d74e35bd84156c5635688c0
    1. Re:Its a dupe (n/t) by Anonymous Coward · · Score: 2, Funny

      The earlier story is already linked into the post, so your dupe is a dupe.

  5. Ok, ok, ok. All species are equal, yadda yadda... by HaloZero · · Score: 1, Interesting

    'A Spanish mountain goat.'

    Right, but do we REALLYneed more goats? I mean, a goat is a goat is a goat.

    --
    Informatus Technologicus
  6. Live birth in 2010 by Caractacus+Potts · · Score: 4, Funny

    Wow, with a seven-year gestation period, it's no wonder they went extinct.

  7. Re:Ok, ok, ok. All species are equal, yadda yadda. by Anonymous Coward · · Score: 0
    Tell that to a goat!

    Actually, some of these animals might be vary useful to agriculture. Especially if they can be bread with current stock in some way. I'm not sure how this list was selected. It sounds more like a zoo list than a useful one, but I have no real knowledge here.

  8. Good News by Anonymous Coward · · Score: 2, Funny
    I was wondering about that too. The telomeres must be restored in the genitals somehow or the offspring would live shorter than their parents...

    I recently received an email from someone who has discovered a way to lengthen genitals. I'll forward it to the Australian Museum.

  9. On UK TV next week by amcguinn · · Score: 2, Informative

    Discovery Channel, 9p.m. 1st April in the UK.

    Cloning the Tasmanian Tiger

    (It's been shown before).

    1. Re:On UK TV next week by Anonymous Coward · · Score: 0

      You do know that /. is getting paid to post stories that are realted to upcoming tv shows don't you?

  10. That's OK, but... by bunseki+suru · · Score: 1

    Couldn't they have found something better to resurrect? Like unicorns? Or maybe that one female computer engineer that I keep hearing about... I've got this nagging feeling that one o'them is just mythical, though.

    --
    Integrated application integration with synergistic synergized synergy
    1. Re:That's OK, but... by Anonymous Coward · · Score: 0

      Unicorns would be useful. They could be used to point out all the male computer engineers...

    2. Re:That's OK, but... by Randolpho · · Score: 1

      Heh... The problem with all those female computer engineers is that they're either married or gay. ;)

      --
      "Times have not become more violent. They have just become more televised."
      -Marilyn Manson
  11. Don't count your _______ until they've hatched by barakn · · Score: 1

    Embryonic growth involves a complicated, precisely timed, and crucial exchange of regulatory signals between embryo and mother. The chances of accomplishing this without any living relatives (same genus) are vanishingly small. Even getting the right regulatory proteins to kick the process off in the "egg" sounds impossible. I don't believe this will work.

    --
    "I'm so moist I'm sticking to the leather." -Kermit the Frog on The Late Late Show
  12. Re:Hey! [Obligatory Simpsons reference] by RedCard · · Score: 1

    Principal Skinner: "I'm not sad about losing my job, Bart. I'm working on a movie about a magical park where dinosaurs are brought back to life by genetic engineering. We'll call it 'Billy and the Clone-a-saurus'"

    Apu: "What? First you take a concept that's already been done, then you give it a name that nobody could possibly ever like..." "... biggest movie ever! ... best seller list for six months!..." "...HAVE YOU BEEN LIVING UNDER A ROCK, SIR?....uh...I mean, thank you, come again."

  13. What other extinct animals will they bring back? by Anonymous Coward · · Score: 0

    I'm hoping they'll bring the DoDo back!

  14. Re:Ok, ok, ok. All species are equal, yadda yadda. by RedCard · · Score: 1

    Actually, some of these animals might be vary useful to agriculture. Especially if they can be bread with current stock in some way. I'm not sure how this list was selected. It sounds more like a zoo list than a useful one, but I have no real knowledge here.

    Actually, it's probably FAR more important to look at the species we're using for agriculture NOW, instead of trying to bring back extinct species.

    We would do a LOT better to introduce at least some measure of diversity into our farms, and our diets, and we would probably profit far more from this than from bringing back some strange-ass species which might one day possibly maybe have some value.

  15. Big F*cking Deal - Here's why this is not smart. by RedCard · · Score: 2, Interesting

    Here are the facts.

    1) Most species are rare. Very few species can be considered to be common.
    2) Most species have ALWAYS been and will ALWAYS be rare.
    3) Rarity is not something that is special in and of itself.
    4) Extinctions have been happening since the dawn of time.
    5) If a species is extinct, there's most always a reason for it. What has changed that would allow them to survive now?

    Conservation is VERY important, but our time and effort would be much better served by preserving what we have, not trying to undo what we have done. What's done is done. Concentrate on the present.

    WE MUST SOLVE THE PROBLEMS THAT CAUSE HUMANS TO DRIVE SPECIES TO EXTINCTION, THEN AND ONLY THEN SHOULD WE WORRY ABOUT SPECIES THAT WE HAVE LOST.

    Rabid conservationists, please flame away. I'll reply, don't you worry.

  16. Megatherium by texchanchan · · Score: 2, Interesting

    I want the giant sloth back.

    1. Re:Megatherium by StaticLimit · · Score: 1

      I want the giant sloth back

      Dude, you should see me after a big lunch on a Wednesday... only coffee can change me back to a productive worker.

      - StaticLimit

    2. Re:Megatherium by panthro · · Score: 1

      The giant sloth is cool, as with pretty much any animal with the word 'giant' in its name, but personally I've always wanted a pet glyptodon...

      --
      If you're not part of the solution, you're part of the precipitate.
  17. Re:Big F*cking Deal - Here's why this is not smart by Tardigrade · · Score: 1

    Think of the technique and other knowledge that will be garnered from this. It's far more than just resurrecting species.

  18. Re:Big F*cking Deal - Here's why this is not smart by mtstump · · Score: 1

    the difference is that this was an unnatural exticntion. it was the result of the actions taken by man.

  19. False dilemna by jensend · · Score: 1

    You seem to assume that any efforts at resurrecting extinct species will either prevent the success of or take resources away from efforts to minimize human contributions to future species loss. This is probably not the case.

    It's true enough that it is no substitute for working to prevent further human-caused extinction, but I doubt anyone seriously thought it would be.

    1. Re:False dilemna by RedCard · · Score: 1
      No, they do not prevent the success of efforts to prevent species loss via human contribution, but (and this is a big but) they do the following:
      1. Divert monetary flow from said studies/programs
      2. Divert scientific/intellectual participation in said studies/programs
      3. Give firepower to those who view preservation-in-a-jar as a viable way of keeping species 'present'
      4. Ignore or discard the fact that once an animal is removed from a habitat to an artificial setting, neither the animal nor the habitat can ever be truly the same again

      And the list goes on and on and on.

      Plus, what about loss of genetic information? Without a large enough number of animals of any species, genetic stochastic effects will tend to drive a population to extinction. Several dozen (or even several hundred, depending on the species) animals would have to be cloned for the species to avoid extinction. Sure, we can clone up a couple animals now, but what about 100 years from now? Will the population that we resurrect be a viable, continuing one that far in the future? How about 500 years from now?

      And THAT is why the resurrection of animals is a pointless and largely stupid exercise. We should conserve what we have, so that it exists in the wild a thousand years from now.

      The problem here is that people think ecology is simple. It's not, at least not when it's done right.
    2. Re:False dilemna by jensend · · Score: 1
      Divert monetary flow from said studies/programs
      Divert scientific/intellectual participation in said studies/programs
      How about some specific examples of money or mindshare which was going to go into preservation of existing species but went into resurrecting extinct species instead? I don't think you have any. The two issues are not connected in those ways. It's like saying "Open source software should not be developed because there are people starving in Africa, and open source efforts are draining money and mindshare from efforts to feed the hungry."

      Of course nobody expects this to bring back stable populations of the animals concerned. You'd have to resurrect a whole bunch of different specimens with enough genetic variation to prevent the typical inbred expression of all sorts of harmful recessive genes. You're attacking a position which to the best of my knowledge nobody holds, and which those involved in the project certainly do not hold. The same applies to your argument that it "Gives firepower to those who view preservation-in-a-jar as a viable way of keeping species 'present'" - who really thinks that? Nobody.
  20. An awesome option by Evil+Pete · · Score: 1

    Yeah. Definitely a "dont fuck with me" creature. Able to snap trees in half simply because it couldn't be bothered walking around them. Yep ... want one!

    --
    Bitter and proud of it.
  21. Re:Big F*cking Deal - Here's why this is not smart by RedCard · · Score: 1

    And what would you say to those that want to clone the wooly mammoth?

    Ressurrecting animals species is a whiz-bang tech demo, but nothing else.

    This is a futile exercise. Genetic stochastic effects would drive a small population to extinction.
    See my response "Re:False dilemna" to jensend's post "False dilemna" below for a further explanation.

  22. Re:Big F*cking Deal - Here's why this is not smart by RedCard · · Score: 1

    That indeed is the only valid argument that I see for researching these techniques. From a conservation/preservation point of view, however, they are sorely lacking.

  23. Re:What other extinct animals will they bring back by KewlPC · · Score: 1

    "Doom on you! Doom on you! Doom on you!"

  24. Re: Shortened Telomeres by holy+zarquon's+singi · · Score: 1
    The deal is that most cells in the body lack telomerase which is an enzyme that replicates the ends of chromosomes properly (the usual DNA polymerases are 'built' to process circular molecules, so have difficulty with the linear ends of chromosomes.

    Cells that are very active / replicate a lot through an organisms lifetime (eg in the small intestine, the uterus) do contain telomerase. I don't know whether anyone has tried cloning cells from one of these areas of the body.

    --
    "...we should just trust our president in every decision that he makes and we should just support that." B.Spears 2003
  25. It's not all about what WE need.. by jonskerr · · Score: 1

    Slashdotters are always opening their yaps without a second thought. If we wipe out a species due to habitat loss, hunting, whatever, its up to US to clean up our own mess. Biodiversity is valuable for its own sake, not just so some asshole can make a buck off it or create a new drug from a creature's ground up eyeballs.

    --
    O~ Him that studies revenge keeps his own wounds green. -- Francis Bacon
  26. Re: Shortened Telomeres by Amousha · · Score: 1

    they have.
    cells from the intestine are one of the prime area for harvesting. Also less nuclear damage...
    omard-out