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Accelerated Aging Gene Identified
bradbury writes "A host of news sources are carrying news that the gene responsible for Progeria, otherwise known as Hutchinson-Gilford Syndrome, has been identified as Lamin A (LMNA). Sources include a Eureka Alert article, a Science Daily article and a Nature Science Update article. Of interest is the fact that the gene causes at least 6 other genetic diseases. For the hard core science people, an extended discussion of LMNA can be found in the OMIM database here."
Okay they think they have the gene isolated, but now what? How many more years will it take to use this information effectively? It seems like these discoveries are happening faster, but when you are dealing with accelerated aging the people do not have much time to wait.
Spelled: "Children". Having just one is enough to accelerate anyone's aging. Results are directly proportional to the number of kids. Your rate of acceleration may vary.
... means establishing a roadmap to develop treatments. Many beancounters are wondering how mapping genes is every going to benefit anyone - well, it's like drawing a map, over time you discover relationships which were previously unknown... Once you understand the mechanisms behind those relationships, you are able to design treatments and establish a better understanding of the genesis of genetic deseases.
And when will we see the cure for old?
Progeria is genetic disorder, patients have defective gene that messes up the nuclear membrane. Hence DNA deffects acumulate fast, cells apoptose and the whole picture is similar to accelerated aging. Understanding the problem will help with the affliction diagnosis, but the underlying mechanism of the damage will probably turn out to be something common, even banal - like oxidative stress that does not get repaired quickly enough.
This may emulate aging, but not explain how to prevent aging.
I doubt that we will ever figure out - and I suspect that even if we did figure out we couldn't do much about it
Regarding the statements:
Accelerated Aging Gene Identified
and
the fact that the gene causes at least 6 other genetic diseases
Genes do not exist to "cause disease". Genes have a function and genes which have mutations or inherited flaws can cause disease by not performing their intended function properly.
The gene LMNA codes for Lamin A which is a protein that is a component of the nuclear membrane. When the gene is flawed, the protein is flawed and so are the cells' nuclear membranes. This leads to poor tissue strength and widespread cell death.
Also, I contend that the disease "Progeria" is misnamed. Afflicted persons have symptoms that mimic some symptoms of ageing, but are marginally related. I further believe that while many bio-medical insights may be found in the pursuit of a cure or treatment for Progeria, the results will have little or no impact on treatments for true ageing.
Still, any new knowledge about our genetic makeup and processes is good.