Removing Cross-Threaded Screws from Hardware?

TeaDaemon asks: "I currently have an expensive (dual CPU) motherboard mounted in a rack case. One of the mounting screws is cross-threaded, preventing me from removing the board. The case is designed to prevent access to the back of the risers, so that's not an option. Does anyone have experience with this sort of problem? Can anyone suggest a reliable way of removing said screw without damaging the board or any of it's components? The screw is next to the PCI slots, and has a couple of capacitors and ICs near by. Any help would be greatly appreciated."