Enterprise Grade Project Management Tools?

Gustavo asks: "My company is climbing the CMM ladder and the need for enterprise grade project management tools is growing. Currently we use a mix of MS-Project schedules and Excel spreadsheets, but this doesn't scale when one has a large pool of resources being used on several projects. Moreover, there being Project and Excel files are now scattered all around making it difficult to keep them up-to-date. One option is to go for the MS-Project Server but I was asked to find out if there is something free that we could use instead. Can you help me?"

"What I'm looking for is some web tool in which everyone involved in a project could make changes in their task's status. (Things like number of hours worked and percent completed.) Preferably, all data should be kept in a relational database for easy data gathering and reporting.

MrProject is a nice app but it's Linux only (so far) and doesn't seem to allow for resource sharing among projects.

ToutDoux, another Gnome app, promised much more, but its development stalled a while ago.

I looked at some of the project management tools I found at Freshmeat, like SiteScape, EPIWARE, ITMS, and A.C.E., but none of them satisfied my needs.

MimerDesk is a web-based groupware environment that has a very promising project management tool. It's not complete yet, but it's the best I could find so far.

So, what do your companies use for project management and how is it going?"