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Chinese Experiment Creates Three-Parent Fetuses

what_the_frell writes "BBC News is reporting that a foetus has been created from the eggs of two women and the sperm of one man in China. Apparently, none of the three resulting foetuses survived, but it does raise some interesting questions about cloning, and more importantly, 'Who's your Mama?'"

51 comments

  1. sp by Rhinobird · · Score: 0, Offtopic

    so...who was cartman's mom?

    --
    If Mr. Edison had thought smarter he wouldn't sweat as much. --Nikola Tesla
    1. Re:sp by Anonymous Coward · · Score: 0

      A bitch. A big fat bitch.

    2. Re:sp by Anonymous Coward · · Score: 0

      The biggest bitch in the whole wide world.

    3. Re:sp by Anonymous Coward · · Score: 0

      She's a stupid bitch if there ever was a bitch, she's a bitch to all the boys and girls.

    4. Re:sp by Anonymous Coward · · Score: 0

      Kyle: Stop calling my mom a bitch!

  2. The impossible has been accomplished... by ksdd · · Score: 3, Funny

    ...a 2 woman/1 man threesome actually sounds unappealing in this context.

    1. Re:The impossible has been accomplished... by linzeal · · Score: 1

      Trust me, a threesome that goes beyond sex is always a conspiracy against someone.

  3. Congratulations Slashdot... by Anonymous Coward · · Score: 0

    ...for once again coming in DEAD LAST on the news.

    Go back to announcing Linux point releases, would you? I can get my news faster by telegram.

    1. Re:Congratulations Slashdot... by jafuser · · Score: 1

      I prefer RFC 1149 over the outdated technology referred to as "telegrams".

      --
      Please consider making an automatic monthly recurring donation to the EFF
  4. another article by tmtresh · · Score: 0

    Hmm. I submitted this story yesterday, but it was rejected. I'm a little upset that it was accepted when somebody else submitted it. Here was my source, from newsday.com.

    1. Re:another article by Anonymous Coward · · Score: 0

      Don't take it personally - it happens to everyone. Keep in mind, too, that some stories can take 2 weeks to post, and there is often quite a lag between submission and posting, so this poster may well have beaten you by hours or days and submitted first.

      We'll give you the benefit of the doubt and assume you're new here, so you didn't know. But don't complain again or you'll be flamed mercilessly.

    2. Re:another article by orthogonal · · Score: 1

      Hmm. I submitted this story yesterday, but it was rejected. I'm a little upset that it was accepted when somebody else submitted it. Here was my source, from newsday.com.

      The Slashdot editors wanted to mix your submission with submissions of the same story from two women, but unfortunately, the resulting article's HTML failed to pass W3C Standards, and spontaneously aborted all open-source browsers. (IE managed to load it, as it will load all HTML abominations, but immediately installed Gator, and redirected to goatse.cx.)

      Continued attempts to mix the article submissions of two women and one man were suspended when it was discovered that there are, in fact, only three Slashdot posters who are women, and in any case one of those is suspected of being a 14 year-old boy in real life.

    3. Re:another article by Anonymous Coward · · Score: 0

      Well I submitted it two days ago, linking to the original paper in the New Bejing Journal of Evil, *and* the blurb from the "What's New" section of Supervillain's Monthly.

  5. NOT cloning by tmtresh · · Score: 1

    This was not cloning. They are using similar technology here, but cloning is embedding the full DNA in an egg, whereas here they only embedded the mother's partial (egg) DNA, then fertilized the egg with the father's sperm.

  6. gotta love those commies by Anonymous Coward · · Score: 0

    I guess the next step is to create fetuses with the DNA of all citizens.

    Stamp out individuality!

    Encourage conformity!

    Bring honor to your family which is the entire Chinese population!

    1. Re:gotta love those commies by Orne · · Score: 1

      Perhaps it's time for everyone to re-read "Brave New World" so we can picture what happens when a society relies on artificially created children...

    2. Re:gotta love those commies by Blob+Pet · · Score: 1

      I don't think Brave New World applies here. This technology is meant to aid in fertilization for those with diffulties otherwise...not the sole method as we see in Huxley's book. Also, it's not like scientists are trying to create different classes of people (alphas, betas, etc). Brave New World wasn't really about creating offspring artifically anyway.

      --
      "...today consumers have been conditioned to think of beer when they see a bullfrog..."
    3. Re:gotta love those commies by linzeal · · Score: 1

      So, what is wrong with creating superiour human beings? You know eventually we may have to inhabit places radically different from any place on earth and getting a headstart on such a technology is not only prudent and sane but just and necessary. We simply do not have the time anymore to allow "nature to take it's course" here we are in the 21st century; let the wellspring of progress flow over all the simple notions of good and evil who would betray it.

    4. Re:gotta love those commies by Anonymous Coward · · Score: 0

      The people who lived in the Brave New World system were happy. It was only the outsider, who wasn't conditioned, that caused problems.

  7. Re:I for one by Jeremiah+Cornelius · · Score: 0, Offtopic

    It has two heads! And... tentacles!!!!

    --
    "Flyin' in just a sweet place,
    Never been known to fail..."
  8. What is the big deal? by XBL · · Score: 1

    How is this any worse than using egg/sperm donor for fertilization?

    1. Re:What is the big deal? by WolfWithoutAClause · · Score: 2, Informative
      The difference is that the nuclear DNA of the donor egg is that of the infertile couple, not the egg donor.

      The only genetic material from the donor is in the mitochondria; but that doesn't affect the appearance or personality of the baby, so the baby would be for all intents and purposes, that of the infertile couple.

      --

      -WolfWithoutAClause

      "Gravity is only a theory, not a fact!"
  9. eggs of two women and the sperm of one man by Anonymous Coward · · Score: 2, Funny

    eggs of two women and the sperm of one man

    This is also known as a "continental breakfast" at the Marriott.

  10. Greg Evigan and that chimp, right? by AtariAmarok · · Score: 1

    There was a TV show about this: "My Two Dads". It starred Greg Evigan and that ape, or was it Paul Reiser?

    --
    Don't blame Durga. I voted for Centauri.
    1. Re:Greg Evigan and that chimp, right? by Anonymous Coward · · Score: 0

      You stupid shit.

  11. WHO'S YOUR DADDY?! by Anonymous Coward · · Score: 0

    Last post, beatches!

  12. This is the coolest thing ever! by L.+VeGas · · Score: 1

    Oh wait, I thought you said 3 headed fetus.

  13. gotta love those capitalists by Anonymous Coward · · Score: 0

    Give a false sense of individuality!

    Encourage moral conformity to an arbitrary religion, despite your individual beliefs!

    Bring profit to your company which buys off the entire Amerikan government!

    Buy! Consume! Spend! and then (and only then) will you be happy!

  14. Just get over it by exp(pi*sqrt(163)) · · Score: 0, Troll

    DNA is a chemical like any other. THere's nothing magical about it. We can do what we like with it. I don't see the big deal about combining the DNA from three people. We are all already complex recombinations of the DNA of millions of ancestors.

    --
    Doesn't it make you feel good to know that our freedoms are protected by politicans, lawyers and journalists.
    1. Re:Just get over it by Abraxis · · Score: 1

      Actually, there was no DNA from the "second mother" involved in the process.

      The problem was that something wrong with the egg of the first mother that resulted in the zygote failing to continue growing after the first cell division.

      Their solution here was to fertalize the egg, then remove it's DNA and transplant it into the donor's egg cell that had it's original DNA removed.

      I'd very much hesitate to call the donor of the DNA-less egg cell a "mother". She's more of just an "egg cell donor", as none of her DNA would be passed on to a resulting offspring.

    2. Re:Just get over it by stanmann · · Score: 1

      Actually, the Cell membrane contains the "mitochindrial(sp) DNA" so... in a way it is all 3...Gooogle mitochondrial dna...

      --
      Food not Bombs is a nice platitude but it breaks down when you notice that the Bombees are usually well fed
    3. Re:Just get over it by payslee · · Score: 1
      I hesitate even to call regular egg-donors mothers. I've thought about this a lot, as I have been an egg donor for two different couples. I don't consider myself the mother of anybody, although there may well be three or four genetically-related-to-me children out there by now.

      I always rather enjoyed considering myself a "father" since it seems more applicable to the one-time genetic material donation role that many fathers have. Plus it amuses me, since I'm a girl.

      Because of egg donation I got to play the heredity game, even without any desire to be a parent, and I think it's a cool option. As for the actual parents using donor eggs, I'm sure they'd be overjoyed to be able to have their "own" child, related to both of them. That's why most of them are seeking fertility treatments and donor eggs instead of adoption in the first place, they desperately want to either experience pregnancy and birth or have genetically related children. I find this urge very strange, but I respect the intensity of it, as what the mother has to go through is even more painful than what I did, and more expensive than you might believe.
      I'm sure they'll keep trying until they get decent odds with this technique. They'll make a fortune, some parents will get what they hope for, and some won't.
      Pretty much just like conception the old fashioned way, except, of course, for all the money.

      --
      Doing my part to piss off the religious right.
  15. An entirely new kind of mama jokes! by elliotj · · Score: 1

    Yo Mamas are so ugly that when they look at each other they both turn to stone!

    Yo Mamas are so fat that when they have a threesome everybody thinks is a foursome!

    Ba dum dum!

  16. having a biological child is so important by emilymildew · · Score: 1

    There are so many children in the world who have no parents, and these are the lengths to which people are willing to go to have their own biological children?

    It's not enough that she can carry a baby to term, it has to be with her own genetic material?

    I just don't understand why this is such a great thing. Creating more children for the people who are wealthy enough to pay for this instead of adopting the children that already exist, woo. Pardon me if I'm not excited.

  17. This can lead to... by cmdrwhitewolf · · Score: 1

    Conversations like:
    "Your mama wears Combat boots!"

    "Which One - My biological mother #1 or #2? Or the one who raised me?"

    ----
    Angry Wife: "Your Mother is a slut!"

    husband: "Which one?"

    Angry Wife: "They both are!"
    ----

    Lawyer reading dead wife's will: "Your Wife left everything to your Mother-in-Law."

    Greiving husband: "Which one? Her biological mother #1 or #2, the mother who raised her or her step-mother through her fathers divorce last year?"

    -----
    Dr {reading off of a questionare}: "Has either your mother's or father's side of the family had a history of Diabetes, heart disease, or infertility?"

    Ailing Patient {with head in hands}: "Oh god, wouldn't I like to know..."
    -----

    Besides, just think of what this will do to maternity suits alone!

    --
    [Now, I'm off to lift my le... Um, visit... at another place.]
    1. Re:This can lead to... by ckaminski · · Score: 1

      Really? Just how many maternity suits do you think there are? It's a little hard to deny that big fat kid coming out of your uterus...

      </sarcasm>

  18. Re:I for one by linzeal · · Score: 1

    Welcome to a world where they can have tentacle rape scenes in live japanase porn. That is unless the japanese find someway of eating the creature first, they are pretty good about that.

  19. Similarity to cloning... by X-rated+Ouroboros · · Score: 1

    In cloning they'll take the genetic material (full set, diploid) from a somatic cell and inject it into an egg (having removed the egg's own genetic material [half set, haploid]). They then do some interestingstuff to convince the egg it's been fertilized so it will start dividing.

    In this case they're just removing the haploid DNA from a donor egg and replacing it with the haploid DNA from another egg. Then it's pretty much standard IVF techniques

    I'm not sure why this is outlawed. On the one hand it could be the reason many (large mammal) clones die prematurely is because of the nuclear transfer process and all the speculation about telomere erosion and the like are red herring. No one much likes the scenario of some parents having to clean up Junior with a sponge mop due to macroscale apoptosis when he reaches puberty.

    I haven't heard much about these kind of trials being conducted in other animals, though. It would be useful, as it would allow you to control for a number of things (aforementioned telomere erosion, for example). I'd assume either the results weren't that interesting (I.E. no significant effect on development or mortality) or the laws banning it were worded broadly enough to ban non-human animal testing as well.

    Anyone know whether anyone is doing this in animals besides humans?

    --
    Simple Machines in Higher Dimensions
    1. Re:Similarity to cloning... by mik · · Score: 1
      According to the NPR story I heard, this process actually involved replacing the diploid DNA from the (fertilized) doner egg with the diploid DNA from the original (fertilized) egg.

      The origin mother's eggs apparently could be fertilized alright but tended to fail after a relatively small number of divisions. I'd expect the theory was that the origin mother's obvious defect could be left behind with the original mitochondria. Seems a stretch to me, but what do I know?

      It is worth noting that the putative child would, in fact, be genetically related to three parents (one via mtDNA).

  20. 'Who's your Mama?' by NanoGator · · Score: 1

    Cowboy Neal!

    --
    "Derp de derp."
  21. Last of the Mildews. by Anonymous Coward · · Score: 0

    Presumably your non existant children will hold simmilar values and from your line an entire race will be borne that sees it your way. oops, maybe not.

  22. The answer to the mama question doesn't change by Artifex · · Score: 1

    The woman who raised you lovingly is your mama. That means, of course, that some people have housekeepers for mamas, but it also includes all grandmas who've taken over parenting, or adoptive mothers. Unfortunately, that also means that many people with genetic mothers don't have mamas.

    --
    Get off my launchpad!
    1. Re:The answer to the mama question doesn't change by Anonymous Coward · · Score: 0

      Which one of your dads do you call mama? I am guessing it would be the one that is the more flaming of the two.

  23. Hehe... by Bob+Vila's+Hammer · · Score: 1

    I think they may be taking their overpopulation problem's solution in the wrong direction.

    --


    --"The perfect example of the man of action is the suicide." - William Carlos Williams
  24. Even if they survived... by Anonymous Coward · · Score: 0

    ...there would still a 50/50 chance that once born it would be killed because it was born a girl.

  25. This is misleading... by mOoZik · · Score: 1

    I didn't read the BBC version, but here's what New Scientist said. Note the importance of the following:

    * None were born, but the researchers say this was due to obstetric complications rather than the fertility technique used, and that it would work in future.

    *Some children have already been born with three genetic parents, but the new research has prompted additional controversy because the method used shares a technical step, called nuclear transfer, with cloning procedures. However, the US scientist who developed in animals the technique used by the Chinese researchers says: "It's nothing to do with human cloning."

    Just thought these would help clarify, so people don't yell "human cloning should be banned!" as a result.

    1. Re:This is misleading... by geoswan · · Score: 1
      The BBC article said that the eggs had the egg donor's genetic material cleaned out before the host mother's Nucleus was implanted. So, it seems to me, that it is a mistake to talk about these fetuses (feti?) as having three genetic parents.

      Also worth noting -- I believe the mitochondria are the only cell organelles that have their own DNA. So, children born using this technique may inherit a genotype that impairs their own fertility. Unless it was mom's mitochondria that was at fault in the first place.

      Robert Heinlein fans would say this would make this technique a mistake not from the ethical point of view but from the long-term survivability of humanity point of view.

    2. Re:This is misleading... by rangek · · Score: 1
      The BBC article said that the eggs had the egg donor's genetic material cleaned out before the host mother's Nucleus was implanted. So, it seems to me, that it is a mistake to talk about these fetuses (feti?) as having three genetic parents.

      But what about the mitochondria? These beings would have genetic information (nucleic acids) from three other beings, chromosomes from the sperm and the transfered egg nucleus and mitochondrial DNA from the original egg.

      My understanding is that this won't really work anyway. Nuclear transfer techniques fail to produce viable cells in higher animals due to destruction of spindles or some such structures during the process. These structures are associated with the nucleus in higher animals, but are more homogeneously distributed in the cytoplasm of animals like sheep and cats.

    3. Re:This is misleading... by geoswan · · Score: 1
      But what about the mitochondria?

      OK, what about the mitochondrial DNA? Is it significant?

      My understanding is that this won't really work anyway... Nuclear transfer techniques fail ... due to destruction of spindles ... associated with the nucleus in higher animals, but are more homogeneously distributed in the cytoplasm of animals like sheep and cats.

      I presume you mention sheep and cats because they have already been cloned. I am sorry, but what definition of "higher animals" includes humans but doesn't include sheep and cats?

    4. Re:This is misleading... by rangek · · Score: 1
      OK, what about the mitochondrial DNA? Is it significant?

      I refer you to this link for starters.

      what definition of "higher animals" includes humans but doesn't include sheep and cats

      I don't have the reference in front of me, so I can't give you the exact break down of where things seem to be going arwy. I will give you an example of a definition of "higher animals" that does not include sheep and cats: Kingdom - Animala, Phylum - Craniata, Order - Primates. There may be a few other mammilian orders for which nuclear transfer in its current incarnation is almost certainly doomed to failure (cetacea perhaps?). Pehaps the old kpofgs is not the best way to group things as it does not follow exact evolutionary lines but I think it works good enough for ths discussion.

      Needless to say, it appears that certain animals (primates for sure), have structures relating to cell division actually attached to or in close proximity to their nuclei, such that these essential components are almost always severely damaged or destroyed during nuclear transfer. In "lower animals", these structures are apparently not so closly affiliated with the nucleus and nuclear transfer is a viable technique. Some people even suggest that the high failure rate of nuclear transfer even in those species where it is considered viable may be related to the damaging or destruction of cell division machinery during the process.