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Glowing Fish are First Genetically Engineered Pets

securitas writes "It was bound to happen. Texas-based biotechnology company Yorktown Technologies will start selling a 'genetically engineered aquarium fish that glows in the dark.' The trademarked GloFish -- 'a tropical zebra fish infused with the gene of a sea anemone that makes it glow fluorescent red' -- is first genetically engineered pet. The possible consequences of introducing a new trangenic species into the environment has touched off a debate that has critics such as the National Academies of Science and the Center for Food Safety calling for a ban on the sale of the fish unless the FDA regulates and approves it. The fish go on sale in January 2004. You can see photos of the GloFish here. Cool, but it's no Blinky." M : I think these guys are marketing the fish for a Taiwanese company.

19 of 361 comments (clear)

  1. Bummer by Durin_Deathless · · Score: 5, Funny

    From their FAQ:
    What if a fluorescent zebra fish is eaten? Eating a fluorescent zebra fish is the same as eating any other zebra fish. Their fluorescence is derived from a naturally occurring gene and is completely safe for the environment. Just as eating a blue fish would not turn a predator blue, eating a fluorescent fish would not make a predator fluoresce.

    Bummer, I was hoping to see fluorescent cats!

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    1. Re:Bummer by Daniel+Dvorkin · · Score: 4, Funny

      We breed fluorescent mice at my work. Cute little critters, have no idea that they glow. But they probably do wonder why people are always picking them up and sticking them under funny-colored lights and making "ooh, aah" noises. ;)

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  2. A Real Challenge by crass751 · · Score: 5, Funny
    Now if only someone could genetically engineer a fish that didn't die within a week.

    I've had about 5 fish, only one of them lived longer than a week.

    1. Re:A Real Challenge by richy+freeway · · Score: 5, Funny

      Or genetically modify people to look after fish better. :P

  3. Ultimate Case Mod by herulach · · Score: 5, Funny

    With a few of these and one of these you'd have a way cool case.

    Who needs cold cathodes?

  4. Novelty Item by KD5YPT · · Score: 5, Insightful

    You know, this has gone too far. Genetic engineering just for the heck of it? What purpose do a glowing fish have?

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    1. Re:Novelty Item by Richard_L_James · · Score: 5, Funny

      What purpose do a glowing fish have? 1) No need to install lights in fish tanks/ponds 2) Makes nightime fishing easier 3) You can actually see your food during the candle lit dinner with your girlfriend.... :-)

    2. Re:Novelty Item by Morgahastu · · Score: 4, Insightful

      The lessons learned in engineering a new breed of fish can be used in the future to say, engineer cancer fighting genes.

      This is just a side effect of a useful experiment, why not make some money from it and raise awareness for genetic engineering?

    3. Re:Novelty Item by Daniel+Dvorkin · · Score: 5, Informative

      Yep. Grandparent is a troll, but his question is common enough that it's worth answering.

      Genetic engineering is hard work. Just as mechanical engineers build prototypes to test their ideas before going into full-scale production, so do genetic engineers (and, actually, every other type of engineer I can think of.) As I mentioned in another post, we breed glowing mice at my work; it took about five years of basic research and another three years of trial and error to get a strain of true-breeding* GFP** mice.

      Are these mice useful for anything in themselves? Well, actually, they are; it turns out the GFP gene is a useful marker for other genes that don't express quite so dramatically. But that really wasn't the point. The point was to learn how to implant certain genes -- say, genes that are a risk factor for certain kinds of cancer, or genes for resistance to AIDS, or genes to produce useful drugs -- in a true-breeding strain of mice. Now that technology is understood, and it can usefully be applied to all the examples I gave and many more.

      No one gets upset when Ford builds a concept car, for God's sake.

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      * True-breeding means that the children of parents with these characteristics will reliably have the characteristics themselves.

      ** Green Fluorescent Protein. IIRC, originally found in jellyfish.

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    4. Re:Novelty Item by papasui · · Score: 4, Informative

      From glofish.com:

      Where do fluorescent zebra fish come from?

      Fluorescent zebra fish were specially bred to help detect environmental pollutants. By adding a natural fluorescence gene to the fish, scientists are able to quickly and easily determine when our waterways are contaminated. The first step in developing these pollution detecting fish was to create fish that would be fluorescent all the time. It was only recently that scientists realized the public's interest in sharing the benefits of this research. We call this the GloFish (TM) fluorescent fish.


  5. Old news by StrawberryFrog · · Score: 5, Informative

    This is old news. These may be other glowing fish, as they are from Taiwan, but you can get the details
    Here or here

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  6. Honolulu technique by Anonymous Coward · · Score: 5, Interesting

    This sounds a lot like what happened here at the Univeristy of Hawaii. They cloned mice and threw in a little jellyfish in the process to make the mice flourescent. "Four of the mice are fluorescent; they glow green under black light. The glow comes from modified gene protein from jellyfish, which "is a quick demonstration that they are transgenic," said researcher Istefo Moisyadi."

    http://starbulletin.com/2001/02/06/news/story11. ht ml

  7. Wrong. by Chess_the_cat · · Score: 4, Insightful
    The trademarked GloFish...is first genetically engineered pet[sic]

    The methods used may be different but just about every breed of dog known to Man has been 'genetically engineered.' For example, I have a Boston Terrier. The Boston was created in 1857 as a dog fighter by breeding English Bulldogs and English Terriers. Therefore, the Boston was engineered. Take any dog and you'll find that someone wanted a dog that could do this or that or was such a size so they went about selecting different existing species and breeding them to create their perfect dog. So many people think that genetic engineering is done with test tubes but any time two species are brought together artificially you are engineering genetics. Mendel was a genetic engineer and he lived in the 1100s.

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    1. Re:Wrong. by dgp · · Score: 5, Informative

      You make a good point but I believe the title refers to the fact that this is a "transgenic" engineering. That is a different ballpark that cross-breeding.

      From m-w.com:
      transgenic - Having chromosomes into which one or more heterologous genes have been incorporated either artificially or naturally

      heterologous - derived from a different species

      The article says: "a tropical zebra fish infused with the gene of a sea anemone that makes it glow fluorescent red." Im no fish expert but i dont think you can breed fish with sea anemones.

      For your analogy to work, you would have to say something like english bulldogs received genes from a silk spider and now has silky smooth dog turds and can walk up walls.

  8. Not "glow-in-the-dark" by Corgha · · Score: 4, Funny

    I'm a little disappointed. These aren't bioluminescent-type glow-in-the-dark fish like the ones that live in the deep sea. They're fluorescent glow-in-the-UV fish like the ones that live in the rave.

  9. Why we make glowing animals by corvi42 · · Score: 5, Informative

    My girlfriend is a molecular biologist who worked for a time in a lab where they made glowing animals like this ( mostly worms, but they had some rats also ). The reason, scientifically, for making these creatures is not just for the sake of seeing if you can make them glow. Rather, if you attach the genes for the glowing proteins adjacent to the genes for some other protein you'd like to monitor in the animal's DNA, then the glowing protein will become attached to the target protein, and you can get a snapshot of how active that protein is in the organism by simply turning on a UV light. This is a very useful tool for seeing how a particular gene is expressed in the active biology of the organism, because you can watch where, when and how the proteins which that gene codes for are expressed, and in what cells. The glowing pets is just some creepy Frankensteinian commercial spin-off of this research tool.

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  10. These DO NOT glow in the dark by banks · · Score: 4, Informative
    There seems to be this weird misconception going on here....


    These "GloFish" DO NOT glow in the dark. They fluoresce red under a black light (UV radiation, for those of us who care). But from everything I've read, they don't emit any light at all in the absence of external UV. None. So, that pretty much makes them "Glow-in-the-LIGHT fish."


    Now, I'm not entirely suprised that the NYTimes doesn't understand that difference, but slashdotters should be able to.

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  11. I can assure the world by Glowing+Fish · · Score: 4, Funny

    I can assure the world that I am Mostly Harmless.

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  12. Happy fish have baby fish by jhines · · Score: 5, Interesting

    Zebra fish are difficult, but not impossible for the hobbyist to breed, what happens then?

    Since the fish is covered by patent, what happens to the next generations? Are aquarists going to fall into the same trap as farmers, where they can't replant patented products?