Best Antivirus Options for a Mailserver?

CSIP asks: "I am setting up a small mailserver, with ~500 users, across 80 domains. I'm planning to use qmail-scanner and an antivirus scanner to block incoming viruses. I would prefer to use ClamAV, however I've read conflicting reports on its effectiveness. The commercial scanners appear to detect 99.X% however they are licensed per-user, which at 500+ users becomes quite the annual bill. What is everyone's experience with ClamAV? Are their other commercial scanners that allow you to license on a per-server basis?" The best indicator of quality for a virus scanner is the information in its virus database. How do ClamAV's virus definitions compare to commercial scanners, like McAfee's?