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Synthetic Life In The Lab

niktesla writes "Scientific American is carrying a story about sythetic life - genetic engineered "machines" made from DNA building blocks called "BioBricks". The goal is to produce a library of building blocks that can be assembled to give predictable results. Reminds me of the technology behind Blade Runner's replicants."

9 of 284 comments (clear)

  1. MIT Database by cTbone · · Score: 5, Informative

    MIT Registry of Standard Biological Parts:

    http://parts.mit.edu/

    As mentioned in the article.

  2. Re:Guess it depends on the definition of "life" by Wudbaer · · Score: 2, Informative

    IIRC the definition of life depends on an organism being able to reproduce in some way without having to depend on another species. By that definition viruses are not alive, as they depend on some kind of host.

  3. Re:Blade runner's replicants are part of a *story* by Biotech9 · · Score: 3, Informative

    Tell that to Arthur C. Clarke.

    His 'satellites' were part of a story, as was radar.

  4. Re:Micromachines by meanroy · · Score: 2, Informative
    Very interesting! This is fantastic science and may lead to great advances in many fields. As some other posters note, however, I see potential serious problems on the horizon however. Here are some specifics:
    We already have problems with Genetically engineered crops, now it appears we have custom bacteria on the way. (here already, actually)
    An earlier Slashdot topic addressed this, though without many supporting links. Here are a few:
    "Toxic pollen from widely planted, genetically modified corn can kill monarch butterflies, Cornell study shows"

    Genetically Engineered Corn Appears in One-Tenth of Grain Tests"

    Nebraska soybeans were contaminated with engineered corn grown by ProdiGene in 2001"

    These links only scratch the surface of the problems with G.E crops but serve to illustrate the point.

    As far as I can see no 'special' precautions are being taken to isolate these experiments from the biosphere. Indeed, the work is being performed in ordinary university labs and *some* of the work at least is being done with common human bacteria.

    The article claims "self policing" has worked for recombinant-DNA technology and calls for an Asilomar Conference to address the issue of safety.
    I refer you to this article
    "The parts for a DNA synthesizer can now be purchased for approximately $10,000. By 2010 a single person will be able to sequence or synthesize 10^10 bases a day. Within a decade a single person could sequence or synthesize all the DNA describing all the people on the planet many times over in an eight-hour day or sequence his or her own DNA within seconds. Given the power and threat of biological technologies, the only way to ensure safety in the long run is to push research and development as fast as possible. Open and distributed networks of researchers would provide an intelligence gathering capability and a flexible and robust workforce for developing technology."
    Sounds like bio-hackers are on the way. I remind you, once the geni is out of the bottle it's damn hard (impossible) to put it back!
  5. Problems with GM foods by frankie · · Score: 2, Informative
    What the hell are you talking about

    He might be talking about things like GM pollen escaping into other crops. Aside from political/legal stupidities of farmers getting sued, there is a serious danger in contamination of wild species. If we end up with a GM monoculture of food a century from now, that puts us one virus away from global famine.

  6. a copy of you by dpilot · · Score: 2, Informative

    Any science fiction matter transporter really works by scanning the original, making a copy at the destination, and destroying the original. Usually they squeamishly avoid the potential paradoxen by making the scanning process itself destructive.

    But any number of Star Trek 'transporter accident' episodes devolve from the separation of these steps. Including the fact that *there is a pattern buffer* and only the readily-available matter supply prevents you from marching an army of yourself out of the transporter.

    In "The Saga of Cuckoo" (author's name forgotten) their transporter clearly works by copying, and they touch on what happens when copies meet, including copies taken at different times and copies of friends you hadn't met, yet.

    --
    The living have better things to do than to continue hating the dead.
  7. Re:Saviour for people in need in of transplants? by Jagasian · · Score: 2, Informative

    Depending on the branch of mathematics (classical, intuitionism, etc) true is not necessarily the opposite of false. This is referred to as the law of the excluded middle, and its status as a law has been debated time and again.

  8. Re:End of death by Sgt+York · · Score: 4, Informative
    The corpus callosum is not the only conection between the two sides of the brain. There are also connections in the fornix, peduncles, and other portions of the basal ganglia. The callosum connects the cortical regions to each other, but not the basal ganglia*.

    Moreover, the parts of the brain that control life support (heart=beating, vasculature=functioning, etc) are not so easily divided into hemishperes as is are the lobes. These are also the regions in which a good deal of the left-right crossover in the central nervous system takes place. I doubt you would be able to remove one side without seriously disrupting the other.

    *For the anatomists : yes, I know that the ganglia are also hemispheric. They do, however, have communicating white matter going between the hemispheres.

    --

    There is a reason for everything. Sometimes that reason just sucks.

  9. Re:Saviour for people in need in of transplants? by Sgt+York · · Score: 2, Informative
    think $1,000,000 to set up a lab to do some low-moderate work.

    It's expensive, but that's a little over the top. Unless, of course, you're talkng about building a lab from "open field" to "research building", in which case you're a bit low. We started up our lab with $500k startup funds. We've grown a LOT since then, and put a lot more money into it, but I remember not even using all the startup grant. I also recall that during the budgeting phase, we figured on a cost of $20k/yr/person in reagents. So yeas, it gets really expensive.

    Anyway, you're in bioinformatics, so you probably work with chips & arrays. I recall that equipment is quite expensive. We normally farm out the data collection part of that.

    --

    There is a reason for everything. Sometimes that reason just sucks.