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Engineering An End to Aging

Reason writes "Biogerontologist Aubrey de Grey has put forward a biological engineering plan to end human aging and co-founded the Methuselah Mouse Prize in recent years. Now he is finally getting some of the public recognition he deserves in an excellent David Stipp article at Fortune Magazine. If you ever wondered exactly how to go about engineering away the 50 million deaths due to aging that occur each and every year - and how to bring about a sea change in the scientific establishment - then this is the place to start. As an added bonus, I don't think you'll find a more succinct (and utterly British) answer to overpopulation objections to life extension than the one at the end of this article!"

19 of 986 comments (clear)

  1. some one has to say (do) it. by mpost4 · · Score: 5, Funny

    If i lived forever I would get board, I probably join Wowbagger The Infinitely Prolonged in insulting the universe, we could insult everybody in it. Individually, personally, one by one, and in Alphabetical Order. I don't care if it is imposable I can dream can't I?

    http://hhgproject.org/entries/wowbagger.html

    1. Re:some one has to say (do) it. by fyngyrz · · Score: 5, Funny
      When someone gets up on a plank like this, it really goes against my grain. Same old saw, time after time. It lacks polish, not to mention finish. I mean, branch out a little, why don't you? If you're going to stump for puns, don't just seed one and hope someone will twig to it... get right in there and employ a little graft. Really, it's as easy as falling off a log.

      In Soviet Russia, YOU are the Knothead!

      --
      I've fallen off your lawn, and I can't get up.
  2. In response to the anticipated flood ... by Daniel+Dvorkin · · Score: 5, Interesting

    As to the question of life becoming so long that it loses its meaning, De Grey has a response that's truly guaranteed to silence critics: If you don't want to try it, you can simply reject rejuvenation therapy and fade away.

    Bingo. It seems like there are always people who whine every time the subject of immortality comes up -- overpopulation, interfering with the divine plan, or just, "I wouldn't want to live forever. I'd get bored." To which the proper answer is: you can always die. If you feel that you're selfishly using up too much of the planet's resources, or that God doesn't want you to live past a certain age, or the ennui of your endless existence is too much to bear (oh, the angst!), fine -- please kill yourself now.

    But of course people don't do this, because it is inherent in the nature of life to want to live. People who think a 200- or 1000- or 50000-year lifespan is nightmarish will still struggle, at the end of their lives, to hold on to whatever years or months or even days of life they have left. We rage against the dying of the light because the urge to live is part of our every cell.

    So, for those of you who think this kind of research is a terrible thing, an affront to God and man -- please go off somewhere to die quietly. And those of us who choose to live will drink a toast on your graves.

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
    1. Re:In response to the anticipated flood ... by awol · · Score: 5, Insightful

      Does this longevity include a increased period of fertility? If not then I wonder if the biological imperative to reproduce will produce a conflict that is not so easy to "cure" and I don't mean the incresing population, I mean the deep seated drive to make offspring being tempered by teh reality that 1100 years is a lot of offspring that one almost certainly cannot actually afford to raise. It might lead to some very complex problems. Even more weird if you live for 1100 years but can only produce offspring for the first 5% of them. Might make you go made. Might be very different for men and women. Might be _very_ scary.

      --
      "The first thing to do when you find yourself in a hole is stop digging."
  3. Job applications of the future by mccalli · · Score: 5, Funny
    Java/Swing developer required. Must have a minimum of 800 years of experience, with at least 600 of those having been gained in a financial environment.

    Cheers,
    Ian

    1. Re:Job applications of the future by Saige · · Score: 5, Insightful

      Amusing, but think about the effects of people not just working for 30-40 years, but hundreds. A person could become experienced and knowledgable in a subject to levels which we can't imagine, and who knows what they could come up with.

      Or a person could spend 50 years in a career, then take 5-10 off and learn something entirely new, then start a career there. Think about all the benefits that could come from that sort of inter-disciplinary work? What might someone who's been a chef, a writer, a materials engineer, and a chemist bring to a new job?

      --
      "You know your god is man-made when he hates all the same people you do."
    2. Re:Job applications of the future by period3 · · Score: 5, Funny

      If we're still using Java/Swing 800 years from now, then you can keep your immortality drugs!

    3. Re:Job applications of the future by Tablizer · · Score: 5, Funny

      If we're still using Java/Swing 800 years from now, then you can keep your immortality drugs!

      1964 Slashdot: "If we're still using COBOL 40 years from now, then you can keep your age-extension drugs!"

  4. I'm currently 58 years old and I'm not bored.. by the_rajah · · Score: 5, Interesting

    My mom is 81 and she's busier than she's ever been although physical constraints are starting to slow her down. My grandmother died very alert, aware and reasonable active at age 100 and said she was ready to go, but it had mostly to do with the fact that her friends had all been dead for a long time by then.

    Some people would look forward to a longer life because they find some meaning in their lives and others, I am sure, don't and probably would not partake of these treatments. I suggest that you folks who are not familiar with Robert A. Heinlein's novels several of which concern, among other things, longevity issues. Take a look at "Time Enough for Love"(1973).

    "Do the Right Thing. It will gratify some people and astound the rest." - Mark Twain

    --


    "Do the Right Thing. It will gratify some people and astound the rest." - Mark Twain
  5. Re:Off with their balls! by Tablizer · · Score: 5, Funny

    If people are going to stop dying they had best stop reproducing as well. There's already too many of you people breathing my air and eating my corn chips.

    That's the roaches and rats, dude. Time to get a maid I thinks.

  6. Overpopulation isn't the problem by MythoBeast · · Score: 5, Insightful

    Well, ok, it could be a considerable problem if people stopped aging to death, but it wouldn't be the biggest problem.

    The biggest problem is that our society would collapse from corruption. It's a pretty simple formula. Powerful people maintain their power by maintaining the status quo. The more powerful a person is, the stronger their grip on the status quo. These people purposely manipulate the opinions of the less powerful people (via control of the media and other less well-publicised means) in order to do this, and we generally fall for it pretty readily.

    The only serious mechanism for social change is the death of the powerful. If death stopped being inevitable, then the rich and powerful would be the first ones to get that technology.

    At that point, the only means for social change would become bloody revolution. Finding and killing the methuselas would become an obscession for anyone who wanted to change things for the better (or even at all).

    I think that that world is inevitable, but I don't look forward to it.

    --
    Wake up - the future is arriving faster than you think.
  7. (Shamelessly ripped off from The Onion) by The-Bus · · Score: 5, Funny

    In other news:

    World Death Rate Remains Steady at 100%

    World Death Rate, Annual
    ------------------------
    2004 (est) 100.00%
    2003 100.00%
    2002 100.00%
    2001 100.00%
    2000 100.00%
    Source: USA Today

    --

    Small potatoes make the steak look bigger.

  8. What happens to 100+ year old memories by snooo53 · · Score: 5, Interesting
    The computer brain transfer bit aside, you brought up an interesting topic: What problems with the mind will crop up after the first hundred years or so? What happens to memories after such a long period of time? Will people forget their childhood after a couple hundred years? How much capacity does the brain have?

    With diseases like Alzheimers we at least have an idea of what causes it, and we know what changes happen to the brain as it progresses.... I think it's only a matter of time before it can be prevented. However, I daresay that theories about where and how exactly memories are formed and stored in the brain are mostly wild speculation. We know the roles that certain regions of the brain play in memory, and there are some good abstract models (such as the Phonological loop and the Visuospatial sketchpad) but we are a very long way away from knowing how these are done at the hardware level of the brain.

    --
    The sending of this message pretty much inconveniences everyone involved.
  9. Wow, that is hilarious! by gosand · · Score: 5, Funny
    As an added bonus, I don't think you'll find a more succinct (and utterly British) answer to overpopulation objections to life extension than the one at the end of this article!"

    FORTUNE is published biweekly and may also publish occasional extra issues. Cover price is $4.99. Rate good in U.S. only. In Canada, 6 issues/$6.95C, 14 issues/$13.90C, subject to GST, HST, and QST. Please allow 2-3 weeks for delivery of your first issue. Subscribers: If the Post Office alerts us that your magazine is undeliverable, we have no further obligation unless we receive a corrected address within two years.

    HAHAHAHAHAHA! Those crazy Brits!

    --

    My beliefs do not require that you agree with them.

  10. Re:Don't by gmack · · Score: 5, Interesting

    Actually strangely enough .. statistically the only way to reduce population growth is to lower the death rate.

    Check it in the poulation stats .. the only country to achieve a negative population growth with a high death rate is China. In every other case a high death rate results in an even higher birth rate.

    Low birth rates, on the other hand, make for low to negative population growth almost every time.

    It's counterintuitive and supprised the heck out of me the first time I noticed that.

  11. 5000 years? I think not by cruachan · · Score: 5, Insightful

    5000 years is won't happen without some major restructuring of society. As we currently have things set up you have a 50% chance of being involved in a fatal accident by the time you are 300.

  12. Re:We should not tamper with natural selection by jejones · · Score: 5, Insightful

    The anti-aging technology, if ever completed will stop the evolution of the species.

    We've been messing with natural selection ever since the beginning of medicine; it's a bit late to object now.

    Furthermore, this will probably only benefit the richest, not the fittest...

    Maybe at first, but there was a time when only the rich, or only governments, could afford computers. In the US today, poor people have TVs that the wealthy could only dream of in the 50s. Anti-aging technology will start out expensive, but it won't stay that way--and besides, doesn't the idea of the wealthy being the beta testers appeal to your little class-warfare soul?

  13. Re:This is cute, but... by prell · · Score: 5, Interesting

    I'd almost go as far as to posit that this article is an elaborate joke.

    Why, exactly, is death a problem? Just pause a moment and really think about why death is a problem, for you.

    Life doesn't work without death. In the end, that fact should be very life-affirming and comforting to you. Look around outside and realize that even horrible deaths contribute inifnitely to the natural world.

    People weren't meant to live in fear of death.

  14. Re:This is cute, but... by spincycle1953 · · Score: 5, Interesting

    "Why, exactly, is death a problem? Just pause a moment and really think about why death is a problem, for you. Life doesn't work without death. In the end, that fact should be very life-affirming and comforting to you."

    Maybe to you. Death is a problem for me because I enjoy life so very much. Death will put a very definite and wholly unwelcomed end to the fun. So far, my life is working just great without death, and I'd like to keep it that way. Do I fear death? NO. I resent it.

    I know full well that immortality is impossible, given entropy. That pisses me off. But if longevity is the best the universe has to offer, give me the maximum. I take first rate care of the equipment (at 51, I can still run a mile under 6 minutes, bench my body weight for reps, and cycle all day at 18 mph avg in rolling country), so I think it's perfectly reasonable for me to hold biomedical scientists responsible for doing their part to keep me alive and healthy at least long enough to get tired of it. "Accepting death" is a defeatist attitude that I just cannot abide.

    (uh-oh...I seem to have gotten a little worked up)

    --
    My other machine is a lever.