Dealing with the Unix Copy and Paste Paradigm?

MolecularBear asks: "I grew up on Windows machines, using the ol' ctrl-c to copy and ctrl-v to paste. For the past few years I've been a hardcore Linux user, running it almost exclusively at home and at work. As I am sure you are all aware, highlighting text in Linux automatically performs a copy while the middle mouse button performs a paste. The Ctrl-c, Ctrl-v standard works in many applications, but not all. Lately I have begun to find the automatic highlight-copy to be annoying. As in, I'll highlight text to copy it, then realize I want to highlight a block of text for the purpose of deleting it. Of course, the second highlighting overwrites the first highlighting. I am curious about how other people accomplish their copy/paste needs. Any special setups, applications, or words of wisdom?"