Technological Solutions for the Partially Sighted?

Jakeg asks: "My gran is currently losing her vision at a rapid rate and I'd desperately like to use technology to help her as best I can. She's used email on a computer before but is generally nervous of computers and technology. She's applied for talking books which come on tapes and CDs, some using DAISY . Can anyone here who is themselves partially sighted/blind, or knows someone who is, suggest what else I can do/buy for her? I was thinking perhaps of an DAP (MP3) jukebox loaded with her favourite music and audio books (which I could download from where?), which I could add more to every now and then. Solutions -must- be very easy to use, especially without good vision. I have a budget of around UKP500 (US$800)."