Posted by
timothy
on from the that-must-have-been-a-bitch dept.
Manwe's Herald writes "The first draft of the dog genome sequence has been deposited into free public databases for use by biomedical and veterinary researchers around the globe, the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), announced today."
Who would have known they would Open Source this stuff. I'm surprised someone didn't get a patent so you'd have to pay a royalty for every breath your dog takes.
-- If Darwin was right, you'd be dead by now.
Re:Open Source Pets
by
SB9876
·
· Score: 3, Informative
Actually, the vast majority of gemone sequences are in the public domain in whole or part. Even many of the proprietary genomes ended up being made availabe to the public after a year or two.
Open source is not a new idea for the academic sciences - they've been operating on that principle for a couple hundred years now.
Genealogy of a Mutt
by
crow
·
· Score: 3, Interesting
So how soon will I be able to take a DNA sample from my dog and find out what combination of breeds she is?
Re:Genealogy of a Mutt
by
Otter
·
· Score: 4, Informative
IIRC, the primary sequence was from a boxer and they did additional sequencing in 10 other breeds, including a greyhound and a Pomeranian (forget what else) plus coyotes and wolves. Celera, meanwhile, sequenced Craig Venter's poodle.
Much of the point of looking at dogs is to understand the differences between breeds, like why collies are born knowing how to herd sheep while Shih-Tzus are completely stupid all their lives. So, to the degree that your dog is related to breeds they've looked at, you can get started as soon as they clean the data enough to post it to dbSNP.
Re:Genealogy of a Mutt
by
SB9876
·
· Score: 4, Interesting
The issue of Science a few weeks back had a bg article devoted to the dog genome completion. They also reported results from initial studies that showed the relationships between various dog breeds. It turns out (as suspected) that dogs were domesticated in Asia as asian breeds are the most different from other domesticated breeds and most similar to wolves. They did an evolutionary tree for the rest of the dog breeds but the cladistics are still being worked out so most of the other breeds are still in a bit of limbo. They expect to work out the relationships of those breeds over time.
This study was significant because it was the first to be able to unambiguously identify dog DNA by breed reliably. Previous attempts using smaller numbers of SNPs tended to be very innacurate.
The biggest result of the dog genome is for human medicine. Geneticists have been pushing for dog genomes (they're already working on a second dog breed genome) for years. Purebreed dogs are a geneticists dream. Each breed has distintive features as well as characteristic diseases such as arthritis, nerve degeneration and cardiovascular disease. Purebreed dogs are also basically giant inbred families with meticulous documentation about their lineage. Having dog genomes actually has a great deal of potential to revolutionize human medicine as a result.
In case of slashdotting....
by
Hex4def6
·
· Score: 4, Funny
Please try to keep posts on topic. Try to reply to other people's comments instead of starting new threads. Read other people's messages before posting your own to avoid simply duplicating what has already been said. Use a clear subject that describes what your message is about. Offtopic, Inflammatory, Inappropriate, Illegal, or Offensive comments might be moderated. (You can read everything, even moderated posts, by adjusting your threshold on the User Preferences Page) Problems regarding accounts or comment posting should be sent to CowboyNeal.
Re:In case of slashdotting....
by
PateraSilk
·
· Score: 4, Funny
Tell NASA: now they can have cloned dogs to go with their robotic cats.
-- SJW: a person who perceives an injustice, and while correcting it, commits a greater injustice.
Massive number of chromosomes
by
RobertB-DC
·
· Score: 5, Interesting
I had heard that the biggest problem with either sequencing the dog's DNA or cloning a dog (the Missyplicity project) was the comparatively large number of chromosomes. In fact, a National Geographic article titled "Wolf to Woof" (tiny excerpt available here) notes the dog's 78 chromosomes (compared with our measly 46) as one of the reasons you can group a Great Dane and a Pomeranian as part of the same species.
I'm a cat person, myself. Cats, being contrary by nature, allowed themselves to be cloned, but then came out looking completely different because coat color and pattern is determined after conception.
-- Stressed? Me?
Of course not.
Stress is what a rubber band feels before it breaks, silly.
Re:Massive number of chromosomes
by
bcrowell
·
· Score: 4, Funny
Specifically, they found:
on chromosome 37: bringing home dead things.
on chromosome 16: sniffing other dogs' butts
on chromosome 19: rolling in the mud
on chromosome 62: peeing on fire hydrants
on chromosome 77: chasing cyclists and mail carriers
on chromosome 44: jerking your leg when you get your belly scratched
And in case any of this seems like irrelevant ivory-tower stuff, it has some very real applications, e.g., they may be able to modify the human genome to remove some of these same behaviors from the males of our own species.
Is allergy relief in sight?
by
boredman
·
· Score: 2, Insightful
Oh, I wish I could have a dog. I love 'em. The only problem is that I'm horribly allergic to them. I break out in hives, my throat closes up, the works.
I hope we will eventually be able isolate the allergen, find the sequence that codes for it (assuming it is a protein), and alter it such that it doesn't adversely affect the dog's health and keeps people like me from having horrible reactions to them.
Re:Is allergy relief in sight?
by
amide_one
·
· Score: 4, Insightful
Not to sound unsympathetic, but why should dogs be changed (genetically modified, presumably) for the sake of your sinuses? Especially when the protein(s) that bother different people might be completely different?
I'd rather hope for the protein to be identified, as you said, and then for some sort of medicine created that specifically binds to that protein and blocks your immune response. Repeat for cats, plants, whatever else people are allergic to, you've got a nice allergy spray that really really works.
Degeneracies, IUPAC codes, etc.
by
dexter+riley
·
· Score: 4, Informative
To generate the sequence, all the chromosomes were cut into fragments, cloned, then sequenced. Dogs have two copies of each chromosome (and either an XX or XY pair). The DNA sequence of a region of one chromosome may be different than same region of the other chromosome. In this example, one sequence had a cytosine at that position, while the other sequence had a thymine. To make it easier to decsribe that difference, or polymorphism, the International Union of Pure and Applied Chemistry (IUPAC) created a nomenclature for describing degenerate sequences. The symbol Y represents either a C or a T at that position. To answer your question, Y (C or T) pairs with R (G or A).
But will this allow Poodles to fly?
by
jebiester
·
· Score: 3, Funny
From "The Vidiot from UHF"...
Ola! And welcome to Raul's Wild Kingdom! Today, we're teaching poodles how to fly! Are you ready Fifi? Are psyched? Here we gooooooo..... (Throws poodle out of window)
yipe yipe yipe yipe yipe yipe *thump*
You know, sometimes it takes 'em a leetle longer to get it right.
Slashdot Mirror
Who would have known they would Open Source this stuff. I'm surprised someone didn't get a patent so you'd have to pay a royalty for every breath your dog takes.
If Darwin was right, you'd be dead by now.
So how soon will I be able to take a DNA sample from my dog and find out what combination of breeds she is?
Heres the text in case of a slashdotting;
T CTACG ...
ATCTATCTC
TYGACTATA
ATCTATCTA
TGATCTACG
TGA
Please try to keep posts on topic.
Try to reply to other people's comments instead of starting new threads.
Read other people's messages before posting your own to avoid simply duplicating what has already been said.
Use a clear subject that describes what your message is about.
Offtopic, Inflammatory, Inappropriate, Illegal, or Offensive comments might be moderated. (You can read everything, even moderated posts, by adjusting your threshold on the User Preferences Page)
Problems regarding accounts or comment posting should be sent to CowboyNeal.
And open source geeks everywhere begin compiling their own version of Dog.
"Can of worms? The can is open... the worms are everywhere."
Tell NASA: now they can have cloned dogs to go with their robotic cats.
SJW: a person who perceives an injustice, and while correcting it, commits a greater injustice.
I had heard that the biggest problem with either sequencing the dog's DNA or cloning a dog (the Missyplicity project) was the comparatively large number of chromosomes. In fact, a National Geographic article titled "Wolf to Woof" (tiny excerpt available here) notes the dog's 78 chromosomes (compared with our measly 46) as one of the reasons you can group a Great Dane and a Pomeranian as part of the same species.
I'm a cat person, myself. Cats, being contrary by nature, allowed themselves to be cloned, but then came out looking completely different because coat color and pattern is determined after conception.
Stressed? Me? Of course not. Stress is what a rubber band feels before it breaks, silly.
Oh, I wish I could have a dog. I love 'em. The only problem is that I'm horribly allergic to them. I break out in hives, my throat closes up, the works.
I hope we will eventually be able isolate the allergen, find the sequence that codes for it (assuming it is a protein), and alter it such that it doesn't adversely affect the dog's health and keeps people like me from having horrible reactions to them.
To generate the sequence, all the chromosomes were cut into fragments, cloned, then sequenced. Dogs have two copies of each chromosome (and either an XX or XY pair). The DNA sequence of a region of one chromosome may be different than same region of the other chromosome. In this example, one sequence had a cytosine at that position, while the other sequence had a thymine. To make it easier to decsribe that difference, or polymorphism, the International Union of Pure and Applied Chemistry (IUPAC) created a nomenclature for describing degenerate sequences. The symbol Y represents either a C or a T at that position. To answer your question, Y (C or T) pairs with R (G or A).
A full listing of IUPAC codes may be found here.
From "The Vidiot from UHF"...
Ola! And welcome to Raul's Wild Kingdom! Today, we're teaching poodles how to fly! Are you ready Fifi? Are psyched? Here we gooooooo..... (Throws poodle out of window)
yipe yipe yipe yipe yipe yipe *thump*
You know, sometimes it takes 'em a leetle longer to get it right.