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Embryonic Stem Cells Emit Healing Molecules

gim_alelen writes "The Associated Press (found here on Salon.com) is reporting that a new study finds that embryonic stem cells, even if they may not grow new limbs and organs may have other healing properties. The study reports that embryonic stem cells emitted molecules that reversed a lethal birth defect in mice."

14 of 58 comments (clear)

  1. Would this work on humans? by mind21_98 · · Score: 2, Insightful

    Mice and humans are different. Would this be easily extended to human embryonic stem cells? And could they emit other molecules to reverse other diseases? If so, this is a great step in the right direction.

  2. Not that surprising by FiReaNGeL · · Score: 4, Interesting

    Many cells express extracellular factors involved in regulation, growth, etc. These can be cytokines (protein-based molecules) or chemokines (small non-proteic molecules). So this discovery is not that surprising, but cool nonetheless. The 'article' (4 lines?) don't give much details, and Science magazine is subscription only... I wonder if they identified the said molecule. Would be interesting to see if it's something we already knew but involved in a process we didn't suspect, or something new altogether. Will have to go to my University library to get details I guess :(

    1. Re:Not that surprising by Rikurzhen · · Score: 4, Interesting

      They did find the molecules involved. They are IGF-1 and WNT5a. The interesting twist was that the ES cells partially corrected the defect even if they were injected into the mother during pregnancy. The cells don't cross the placenta, rather it is the IGF-1 that does.

    2. Re:Not that surprising by reverseengineer · · Score: 2, Informative
      It should be noted that the mice used in this experiment were knockouts for the Id1, Id2, and Id3 genes, which causes underproliferation of myocardial cells- the walls of the heart are too thin, and the mice generally die about 13.5 days into gestation (mentioned in the Science article, but not the Salon writeup). IGF-1 (insulin-like growth factor-1) and WNT5a (wingless-type, a carryover from Drosophila studies) are both relatively small proteins that act as signaling molecules which act to spur cells to grow and proliferate. As the Science article notes, it would be interesting to know how much "rescue" of tissues comes from the stem cells themselves, and how much from the potent growth and proliferation factors they secrete. This is especially important in light of "the potential of ES cells to induce the formation of teratomas (fetal tissue tumors)." Which, by the way, are among the most awful things you could ever see.

      Could IGF-1 and/or WNT5a be used in human therapies? Perhaps- after all they are already produced by healthy humans- and IGF-1 is already in use to treat some kinds of dwarfism- and by athletes, illegally, for its anabolic effects which are similar to growth hormone. IGF-1 does have the drawback of being structually similar to insulin (duh), so an overabundance can cause glucose intolerance, and since both are regulators of cell proliferation, both may increase the risks of certain cancers themselves.

      --
      "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
  3. Adult Stemcells work just as fine by genrader · · Score: 3, Insightful

    If we could allowocate all the money going to embryonic stem cells to adult stem cells, bam, problem solved and no ethic problems with lots of people.

    They found out you can extract adult stemcells from fat recently, and god knows we have plenty of that in America.

    1. Re:Adult Stemcells work just as fine by NanoGator · · Score: 4, Funny

      "If we could allowocate all the money going to embryonic stem cells to adult stem cells"

      That's unpossible!

      --
      "Derp de derp."
    2. Re:Adult Stemcells work just as fine by EnronHaliburton2004 · · Score: 3, Informative

      http://www.stemcellresearch.org/

      Look at you try and slip in that propogandist website. "Oh, hopefully nobody will notice if I sneak this in real quiet like".

      At least have the decency to let people know that the site sponsors are against embryonic stem-cell research.

  4. more info by v1x · · Score: 3, Informative

    NewScientist has some more info on this.

  5. Health Packs by St.+Arbirix · · Score: 4, Funny

    In wars of the future soldiers will have to wander around the battlefield picking up increasingly more devastating weapons and ammo left lying around and collecting packs of emryonic cells to bring their life back up to 100.

    --
    Direct away from face when opening.
  6. Re:How Handy... by Gorath99 · · Score: 4, Insightful
    If you're an atheist (as I am) how can you defend any view other than "as soon as it's a zygote (a DNA pattern separate from the mother's and the father's) it's a person"? If you're the final arbiter of morality (as an atheist is to himself) how can you fudge this one?

    I'm an atheist (well, agnostic to be precise, but the end effect is pretty much the same) and a zygote is not a person to me. In fact, DNA really doesn't figure into my definition of a person. (What about clones? They have the same DNA as someone else, but they are persons in their own right.)

    To me, a person at the very least needs to be capable of independent cognitive processing of some sort. Unfortunately, what exactly constitutes independent cognitive processing is something that I don't have a clear answer on yet, but it's something that a zygote, being only a single cell, isn't yet capable of, while an advanced foetus is.
  7. Re:How Handy... by Xybot · · Score: 4, Insightful

    Why not leave it up to the individual to decide? According to your argument any cell capable of growing into an autonomous human being is designated as a seperate life. How do you differentiate this from lost blood from a cut finger, I'm sure that each of these cells could be used to create a new life (albeit a cloned life). Why does the DNA Sequence necessarily have to be different in order to qualify a cell as a seperate life?

    This whole area elicits so much controversy, I really doubt it will ever be possible to find a a solution that will keep everyone happy.

    Personally I feel that as an adult and a responsible individual the choices I make regarding my bio-chemistry should be mine and mine alone. It should be my decision as to what I do with my Biology and the Biology of any potentially autonomous lifeforms I may be responsible for, and when there is a decision concerning a second person, then a consensus should be reached with this person.

    The key to this type of decision making for individuals lies in education and rationalism. These are the types of choices that need to be taught in schools. If people want to make a moral choice for themselves based on these viewpoints, that's fine. But their ideas should not be forced upon others.

    --
    God was my co-pilot, but then we crashed and I was forced to eat him.
  8. Re:Embryonic? by VenTatsu · · Score: 2, Informative
    Embryonic stem cells (along with other pieces) has the capability to grow into a new life.

    "Do you have scientific proof of this? Or are you just repeating [insert political figure in the news] rhetoric?"

    Last I heard you could not make a clone or a twin just by sticking an Embryonic stem cell in a womb.

    Embryonic stem cell != Embryo

    The research isn't being done on sticking a fetus in another person, so it's a bit untruthful to try to include that with a parenthetical comment.

    Each time I see a vague article on embryonic stem cells I can't help but think it sounds a lot like 'free energy' (a.k.a. perpetual motion) announcements.

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  10. Re:How Handy... by LordLucless · · Score: 3, Insightful

    Why not leave it up to the individual to decide? According to your argument any cell capable of growing into an autonomous human being is designated as a seperate life. How do you differentiate this from lost blood from a cut finger, I'm sure that each of these cells could be used to create a new life (albeit a cloned life). Why does the DNA Sequence necessarily have to be different in order to qualify a cell as a seperate life?

    Actually, a blood cell cannot grow into an autonomous human - it is already differentiated, it can't grow into anything apart from a blood cell. It is possible, however, that scientists could take that cell, extract its DNA, stick it into an undifferentiated cell, and grow a genetically identical human being - but that hardly qualifies as a "cell capable of growing into an autonomous human being" does it?

    The DNA sequence doesn't have to be different in order for it to be a distinct human life - I don't think you could find many people who would claim identical twins are really one entity.

    It's a distinct consciousness that diferentiates two entities, but unfortunately, we haven't found a way to measure the soul yet (Feel free to insert scientific nomenclature - "locus of awareness" maybe - if you don't like soul).

    Personally I feel that as an adult and a responsible individual the choices I make regarding my bio-chemistry should be mine and mine alone. It should be my decision as to what I do with my Biology and the Biology of any potentially autonomous lifeforms I may be responsible for, and when there is a decision concerning a second person, then a consensus should be reached with this person.

    You say you can make decisions for the biology of any potential autonomous lifeforms you are responsible for. But when does "potential" become "actual"? That's what the whole debate hinges on. Many people believe that a foetus *is* an actual lifeform, not merely one in potential. And, as there is little evidence on either side, it is a perfectly valid belief.

    It's not really a choice for the individual, any more than the decision on the morality of murder is. The morality of the situation is contingent upon one question - "Is a foetus a human being?" If the answer is yes, then it is morally equivelant to murder. If the answer is no, then it is not. So far, rationalism has yet to provide an answer to that question, which is why debate still rages.

    The key to this type of decision making for individuals lies in education and rationalism. These are the types of choices that need to be taught in schools. If people want to make a moral choice for themselves based on these viewpoints, that's fine. But their ideas should not be forced upon others.

    Sorry, but that's just wrong. It's fine for individuals to make decisions regarding actions which directly affect only them. But if an action would harm another, that's when law intervenes and forces its morals upon the individual. And that's as it should be.

    --
    Just because you're paranoid doesn't mean there isn't an invisible demon about to eat your face