Slashdot Mirror
Seaweed Antibiotics?
Dan Gaffney writes "A new treatment for cholera and perhaps a new type of antibiotic medicine may emerge from compounds discovered in an Australian seaweed. University of New South Wales researchers have found that furanones - isolated from the seaweed Delisea pulchra - can prevent the bacteria that cause cholera from switching on their disease-causing mechanisms. Furanones don't kill such microbes but simply "jam" their ability to signal each other, meaning their use less likely to create the drug-resistance problems."
small note. Next time you want to pimp your findings on slashdot, proofread. It'll make people take you more seriously. "their [IS] use less likely"
stuff
As in adapting to our frequencies?
If the Doctors would stop handing out antibiotics like it were candy (and the people would take them correctly! No more "I feel better so I'll SAVE the last three doses" crap) we wouldn't have a drug resistance problem in the first place.
The discovery of a new type of antibiotics is always welcome. The overuse of the common goups such as cephalosporins, and penicillins have contributed to bacterial resistance with the resulting appearance of bacteria such as MRSA.
It will be interesting to see how broad a spectrum these furanones will turn out to have or how well they are in combination with other drugs, as well as their pharmacokinetics and tolerance. This research looks positive but it's early days.
One point though, the poster should state their involvement in the study and also that of Biosignal.
I misread the poster, apologies to Michael.
Jesus christ, it's "ancient news day" on slashdot.. I don't know how much more of this I can take, and I'm only two articles in so far today.
"Champagne for my real friends - and real pain for my sham friends!" http://ericblade.postalboard.com/
Wouldn't it be nice if its commercial value led to the preservation of the world's oceans and responsible use thereof rather than the currect practice of exploitation?
Well, I can dream.
While any new antimicrobial drug would be very welcome in this time of increase resistance and decreased antibiotic innovation, this research has just started the animal testing phase and as such there are no live trials yet. If furanones disable the ability of microbes to send signals to each other this could have a very detrimental effect on our health. Our bodies are partialy controled by the symbiotic relationship we have with certain benevolent bacteria that we carry around with us. The human intestinal microbiota plays an important role in maintaining human health by preventing colonization by pathogens and increased nutrient uptake by the body. While antibiotics are somewhat targeted toward a specific type of bacteria, furanones disrupt basic microbial communication. I'm not saying this wont work, just that without live testing this is way too early to be news.
What can be asserted without evidence, can be dismissed without evidence.
Bacteria detect this critical density by sensing molecular emissions from other bacteria. If you make a molecular antagonist for the receptor site that is used to sense these molecules (a molecule which binds to the receptor but does not activate it, like Naloxone binds to opiate receptor sites without activating them) you can shut down the molecular signalling and stop the problematic bacterial behavior. This doesn't kill the bacteria so much as it leaves them with their defenses down.
For a bit more information on this, see this Wired article.
Incidentally, molecular jamming appears to be able to defeat certain antibiotic resistance mechanisms. One can imagine a triple-threat treatment for resistant infections: antibiotic, biofilm and antibiotic resistance jammers and viral bacteriophages. The staphyllococci wouldn't know what hit them.
Sustainability and energy independence essay
You are right. You are so right, in fact, that it verges on a straw man argument. Or maybe I see this more than the average person.
From the doctor's perspective, I see patients all the time who complain of infectious symptoms. I have a choice: the slow way or the fast way. The slow way is: I explain to them why it is important to finish the full course of antibiotics. More likely, though, I spend the time to tell them why it is more likely that they have a viral illness where they don't need antibiotics. If I do that, then I need to make sure that they really don't have a bacterial infection (or at least one that should be treated). Even if I am confident that they don't need antibiotics, I need to show to the patient that I took their concern seriously, or else they will simply ignore my medical advice and go to another doctor, who might do it the fast way.
The fast way is: I write a prescription for "amoxicillin 875mg PO bid; mit: #20". Done! Boy, that was fast. Zip in, zip out. I could see 10 patients an hour this way, and make so much money that I could afford to buy Windows XP. In this day and age, you add a disclaimer to the patient: "It's mostly likely a virus where the antibiotic doesn't work, but just in case ... I want to make sure you get better, you know." There, now you can't be classified as "doctor who tells patients that antibiotics will treat viruses."
I almost invariably choose the slow way, but the choice is not always that black & white. Not only is there time pressure to do it the fast way (think about this the next time you complain about waiting room times), but there is pressure from the patients who demand the antibiotic. Even for these demanding patients, I try to explain why the antibiotic is probably not effective, hoping to wear away at their resistance to conservative (non-medical) treatment, knowing full well that I will end up writing a prescription, at least this time.
It's not all the patient's fault either. Suppose you are a coder working for EA Games or something. You need to be at work, but you have infectious symptoms. You want something to make it go away, quickly and reliably. Can you be blamed for wanting an antibiotic? You know, *just in case* it's bacterial. And, geez, it's been 7 days of sore throat already --surely a visit to the doctor is justified? And surely you don't want to walk out of there with the doctor merely patting you saying, "There there, there there"? Besides, what good are drug benefits if you don't take advantage of them?
Maybe you decide to get the antibiotic, but you won't take them if your symptoms improve --that way you don't overuse antibiotics, right? Two months down the road, George in the next cubicle goes home sick with strep throat during one of those Death March sessions, and you can't afford to go home sick either! Hey, didn't you have some antibiotics from last time that you never used? You'd go to a doctor and all, but, geez, you're already behind schedule with 12-hour days. Might as well use the antibiotics before they expire.
You see, even with an educated populace it's difficult to do the right thing, simply because the acute problem is so much more overwhelming than the abstract concept of "population epidemiology". Surely if you pop that one antibiotic, it wouldn't cause spiraling Medicare costs ten years down the road? If this is so, what can you expect of citizens of impoverished countries who get these magical pills that make things all better?
404555974007725459910684486621289147856453481154 in hex is "You sank my Battleship?"
[GPG key in journal]
Careful though, it'll only be 5 or 6 shots before they adapt to our phaser frequency modulation.
The friendliest digital photography forums on the net!
OK... now on
Yes Doc, I did not take the medicine. But it was on the expert advise of my medical transcriptionists office manager... And I got a second opinion from his GF, but that's OK, cuz she's a college student. And it is common knowledge that antibiotics are over perscribed. So I decided to ignore the advise of a professional and take the advise of some poseur.
Yes, I did train as an EMT several years ago, but decided I hated working with losers (drunks, druggies, etc). BUT I don't use that little bit of training as a claim to ahem... "Medical Expert".
- High Tech workers, please say NO to Union Carpenters, their Union sees fit to control our compensation.
what about this stuff? Some people swear by it
Colloidal silver (note the spelling) is just another snake-oil cure, and it can turn your skin permanently gray (think about what B&W film is made from, why doncha).
i cannot see why this approach would make the development of resistance impossible. it is still a form of evolutionary pressure, and mutations which are less affected by furanones will still have an advantage
I think you'll find the use of anti-biotics as growth promoters in meat production is more of a problem.