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Scientific Appeal to Community

dshatto writes "Help! This posting is to everyone who supports open source science: The California Institute for Regenerative Medicine (CIRM) will start taking shape in the next few months. This is the organization that will be spending $3 billion on stem cell and related research over the next 10 years. California has a chance to set a new model for scientific research. Models to consider for its intellectual property (IP) include open source models. I'm announcing a project that hopefully will:" Read more below... "
  1. 1) Demonstrate the power, speed, and effectiveness that open source principles and distributed collaboration offer.

    2) Produce a temporary community of advocates for open source science that links supporters together in a self-organized network aspiring to the common good.

    3) Develop information resources that the Committee setting up the CIRM can use in its consideration of open source models for intellectual property.

Please go here for details:
http://www.bol.ucla.edu/~dshatto/PROSODICOL.html

Slashdot gets the scoop on this - I won't post it anywhere else until I gauge your response. Why? Because, well, I think it's cool, and I think it's the right community to get this project going.

I believe that together we can make a lasting impact on science.
David"

27 comments

  1. Not for me.. by ThisNukes4u · · Score: 2, Interesting

    I don't support you because I don't believe that the state should be funding scientific research, and beyond that, that embryonic stem cells are not the wave of the future for regenerative science but rather, adult stem cells and DNA manipulation. Don't take it personally, but thats just my belief.

    --
    thisnukes4u.net
    1. Re:Not for me.. by Linuxathome · · Score: 2, Interesting

      What don't you support exactly? I respect that you don't support state funded research, nor embryonic stem cell science. However, the main issue of his "proposal" is to lay the groundwork for an "open source" science system whereby IP is open to build upon and to expand. Do you at least support that premise?

      Although I respect your opinions, I don't share your opinion on state funded science. At least with it coming into fray, we can make an impact now on how IP is handled--a bottom up approach that may be easier to implement. Whereas if we had to change the current funding system now, it would be much more difficult to supplant it with a new set of standards.

    2. Re:Not for me.. by sfjoe · · Score: 3, Insightful

      I don't support you because I don't believe that the state should be funding scientific research,...

      Interesting. From Da Vinci to Fermi and beyond, the state has supported and funded scientific research. In fact, I don't think there has ever been a scientific advance that wasn't either funded by or directly based on research funded by the state. Caves may be fine for some but I prefer many of the comforts of modern society.

      --
      It's simple: I demand prosecution for torture.
    3. Re:Not for me.. by dshatto · · Score: 1
      Thanks. Your second paragraph shows you get what I'm proposing, and why I think this project necessary. California is open to new standards right now - once it starts making real decisions in only a few months, protest would be futile.

      Save the sore throat and speak up before it's too late! Please support this project.

    4. Re:Not for me.. by the+gnat · · Score: 2, Insightful

      In fact, I don't think there has ever been a scientific advance that wasn't either funded by or directly based on research funded by the state.

      This is incorrect - there have been many of these. However, they usually fall into the category of "corporate engineering wizard", "lone genius", or "rich dude who can buy tons of laboratory equipment". The first is still quite common; the invention of PCR is a good example. The latter is occasionally found still (Craig Venter - although he got his start at the NIH, and also had a corporate sugar daddy that thought a genome sequence could make money) but more of those guys will just donate the money to scientists (thank you, Mr. Gates!). The second is the one that the libertarians praise the most, and I think it's the least common - because the lone genius can accomplish squat without a few hundred thousand dollars of equipment. (At least; I regularly use a $5 million facility at a $300 million accelerator. Thank you, American taxpayers!) Some rebel academic working out of his garage is never going to cure cancer unless he has access to a whole lot of money.

      Anyway, there was a time when quite a few advances were made privately, but I think the exponential progress in the hard sciences over the past century is due in part to increased funding. If we took all that away, I have no idea how progress would continue - most of basic research isn't driven by the commercial market because it's hard to predict whether something is going to be commercializable.

      The libertarian response to this is usually either "Not my problem!" (say that again when you're dying from cancer) or "Private donations will find a way!" (put down the bong, please). I agree with the libertarians on all sorts of issues (yay capitalism!) but I just don't see any replacement for our combination of public and commercial science. It seems to work pretty well. (Okay, it pays me, too.)

    5. Re:Not for me.. by node+3 · · Score: 1

      I don't support you because I don't believe that the state should be funding scientific research

      Then you don't really support science, because the state, in it's various forms, plays a critical role in science. The reason is that, if left to "free enterprise", no one wants to be the one to spend the money on research that will benefit everyone (including their competitors). Free enterprise is good for engineering and invention, but really bad for science.

      Or put another way, you don't get Fermilab and Hubble (or even the Internet) without the state.

  2. The 6th Day by AtariAmarok · · Score: 0

    It's pretty clear why Arnold is funding this. He's hoping to have clones of himself resume his movie career sometime by the middle of his 3rd term as governor.

    --
    Don't blame Durga. I voted for Centauri.
  3. The Boys from Sacramento? by Engineer-Poet · · Score: 1

    (Actually, it is the California voters who are funding this. You have to wonder what they know...)

  4. Australian Open source biology by Anonymous Coward · · Score: 2, Informative

    There's a similar approach being adopted in Australia, as reported in Wired.

  5. Published papers are akin to open source by infonography · · Score: 2, Interesting

    It's not exact but patents are pretty specific about bits of technology. However to get anywhere in hard science you need to publish. The techniques will be availible to the community. It is the primary benchmark for the research community.

    Open source works in the context of tech, however medical knowledge isn't so tightly defined by copyrights. The project is publicly funded, and like a university it will be availible to the public at a smaller price then a private research company's.

    --
    Sorry about the writing. Robot fingers, you know? Cliff Steele in DOOM PATROL #23
    1. Re:Published papers are akin to open source by the+gnat · · Score: 2, Interesting

      However to get anywhere in hard science you need to publish. The techniques will be availible to the community. It is the primary benchmark for the research community.

      This is true - but it's even more complicated.

      Among the many reasons why the US system of publically funded science continues to be such an incredible success is that within the confines of government funding, it's like an artificial free market. (All you Randians out there, shut the fuck up for a moment and listen.) Scientists compete for a limited amount of grant money - I believe about a fifth of NIH grant proposals actually get approved. Once you have money, you usually have hates to issue a retraction so they're pretty cautious most of the time.

      So, the incentive is to keep things secret until you're ready to publish. (Unfortunately, molecular biology is so competitive that it's gone too far and people will sometimes be ultra-secretive about their work.) Once you've published, virtually every journal requires you to make your data and materials publically available. If someone writes you saying "I'm working on the same protein - could we get that construct?", you're obligated to send it to them. And any "data not shown", or raw numerical data - that also needs to be shared on request. (The rules for this don't go far enough, in my opinion.)

      Patents only cover commercialization. Up to this point, you have a combination of ruthless competition and community-mandated sharing, plus some collaboration between investigators. This is probably the most efficient way to get science done under our current system. If we were to make commercializable discoveries "open-source", we'd end up with the same problem. No company would invest in the science; you could leave it to public investigators, but you'd have four or so competing with each other to make an actual product, which is more expensive and not as useful (from the public-funding perspective) than basic research. And let's say you do come up with a proven product - who's going to manufacture that when any competitor could potentially do it cheaper? Or do you want the government to pay for that too?

      Scoff all you want, but the current system has served us very well, and it's a bad idea to tamper with progress. Finding a happy medium between the free market and public science is exceedingly difficult but we've done it about as well as possible.

  6. Well, no by Otter · · Score: 2, Interesting
    I apologize for vaguely using the term "open source" to get my point across. I trust you will have an intuitive understanding of what I'm trying to communicate.

    Well, no. It's not at all clear to me what you have in mind, and your resume doesn't suggest that you know anything about biology or biomedical research.

    Guessing about what you might possibly mean:

    • Making data, conclusions and tools freely (by normal, non-Stallmanist usage of "free") available: this is easy enough to do, but you're talking about "public-domain" in that case.
    • Some sort of GPL-ish scheme: this would be an unmitigated freaking disaster. It would create precisely the sort of tangled web of encumbrance that you want to avoid.
    • Distributed collaboration: I'm always skeptical of these notions in biomedical research (and distributed and "open-source" aren't the same thing, anyway). If you have a workable scheme, I'd love to hear about it but as I said, it doesn't sound like you know the first thing about the subject.

    I wish you luck, and hopefully I'm underestimating your planning. (And if you get something promising going, I'll be glad to help.) But right now, with all due respect, this sounds like the equivalent of a new Sourceforge project from someone who expects volunteers to do all the work.

    1. Re:Well, no by dshatto · · Score: 1
      "If you have a workable scheme, I'd love to hear about it..."

      The point of this project is to get people together to pool their knowledge and experience to give the ICOC some choices to consider.

      And no, I'm not an expert about anything "open source," but what I've seen in its results and what I've read about some of its intentions makes me think there are people who believe some of its principles would bring benefits to other fields.

      This project isn't to do biomedical research; it's about getting people to explore the options for how it should be done here in California.

      The ICOC will decide on how to handle its IP with or without really understanding "open source" inspired possibilities. This project seeks to help demonstrate what those possibilities are.

  7. Playing devils advocate by tod_miller · · Score: 1

    If calif. fund this research, and a calif. company reaps rewards, and calif. based researchers get ace new jobs, and bring more brain power into calif. and more taxes get paid, then calif. can be the leading producer of stem cell based cosmetics, which, to be frank, will come about.

    Just a glance at reasoning for another model. Private investment in this area will lead to patents. If a state would fund it open source, then there would be no benefit for that state. (in terms of reaping back revenue to the fullest extent, through jobs etc)

    Other companies in cheaper states would benefit.

    Viola. Here we see a clear example where countries, states, people, neighbourhoods, all compete for a bigger piece of the pie.

    Of course, many things are gov funded. Space, until recently.

    THe rest of this message is OT (more like RT)

    [OT: Seeing a news report on 'cold' pollution and 'warm' pollution (particle versus CO2) and tsunamis and freak weather all this winter (el nino, other new patterns) and amazon and virgin galactic investing into new privitised space makes me think some people at the top know something we don't!

    The day after tomorrow is starting to be a more scarey and real film.]

    --
    #hostfile 0.0.0.0 primidi.com 0.0.0.0 www.primidi.com 0.0.0.0 radio.weblogs.com
    1. Re:Playing devils advocate by Young+Master+Ploppy · · Score: 1

      "Seeing a news report on 'cold' pollution and 'warm' pollution (particle versus CO2) and tsunamis and freak weather all this winter (el nino, other new patterns) and amazon and virgin galactic investing into new privitised space makes me think some people at the top know something we don't!"

      [OT too: you should read "Stark" and "This Other Eden" by Ben Elton. Then you'd REALLY worry...]

      --
      http://instantbadger.blogspot.com
    2. Re:Playing devils advocate by tod_miller · · Score: 1

      [OT too: you should read "Stark" and "This Other Eden" by Ben Elton. Then you'd REALLY worry...]

      This other eden was superb, I haven't read stark. Marketting the end of the world is not as worrying as having your steak and kidneys sewn back on, and flirting with the nurse who is doing it (WTF was that about?) the ending was crazy good.

      I might have a look at Stark. Wow, it was ages since I read TOE, I might re-read it! (do I dig in the attic, and inhale lots of dust, shortening my life for my paperback, or download a txt version and live with the OCR errors?)

      --
      #hostfile 0.0.0.0 primidi.com 0.0.0.0 www.primidi.com 0.0.0.0 radio.weblogs.com
  8. Re:Not for me..or is it? by clonan · · Score: 2, Insightful

    You are correct when you say that "embryonic" stem cells are not the wave of the future for regenerative medicine...but they ARE a critical first step.

    The goal is to take adult stem cells and give them the abilities of embryonic stem cells and THEN use them for medicinal purposes.

    Just taking adult stem cells will not give you much...but by understanding embryonic stem cells we can in effect Have our cake and eat it too.

    Get all the real benifits of embryonic stem cells without the problems of rejection and ethical problems.

  9. FUD DETECTED! ACTIVATING EDUCATION! by Anonymous Coward · · Score: 0

    by normal, non-Stallmanist usage of "free"

    First, some brief background: "Stallmanist" refers to Richard Stallman, founder of the GNU project and the Free Software Foundation. He has defined "software freedom" as follows:

    • The freedom to run the program, for any purpose (freedom 0).
    • The freedom to study how the program works, and adapt it to your needs (freedom 1). Access to the source code is a precondition for this.
    • The freedom to redistribute copies so you can help your neighbor (freedom 2).
    • The freedom to improve the program, and release your improvements to the public, so that the whole community benefits (freedom 3). Access to the source code is a precondition for this.

    For non-computer code such as books, facts, or music, the work itself could be considered the source code, as there is no "compilation" or "conversion" step from a human-understandable form to a computer-understandable form.

    Note that these requirements are met by the GPL, the LGPL, the BSD license (in its current form), as well as the public domain. For whatever reason, the slashdot user above would like you to believe otherwise. However he does not get to specify what Stallman thinks, only Stallman does.

    This message has been a public service of FDE (the FUD Detection and Education Service), committed to "setting the record straight" in online discussions.

    1. Re:FUD DETECTED! ACTIVATING EDUCATION! by Otter · · Score: 1
      FUD DETECTED! ACTIVATING EDUCATION!

      Dear Mr. Smarmypants,

      Your objections, while correct, are irrelevant. My point is not that public domain does not meet Stallman's definition of "free"; it is that constructs like the GPL do not meet the scientific community's definition of "free", particularly when applied to ideas or facts, rather than to lines of code.

      Thank you for your concern.

  10. Ripping off the taxpayers by Anonymous Coward · · Score: 0

    Time for a handful of biotech companies to rip off the California taxpayers. Whoo! BONANZA!!!

    1. Re:Ripping off the taxpayers by dshatto · · Score: 1

      That's what I want to prevent!

  11. why here? by Goldsmith · · Score: 1

    You work at UCLA... one of the centers for this kind of research. Get off your butt, go across campus and talk to one of the stem cell researchers if you have an idea for them. What do you want us to do?

    For all the talk of corporations getting money for this thing, most of the people in charge are going to be academics who have a big interest in seeing all the research in public domain (published in a journal).

  12. Scientist? Now? No thanks! by ic0wb0y · · Score: 1
    Missing / Dead Scientists

    1. Dr. Steven Mostow, 63, was one of the country's leading infectious disease experts and was associate dean at the University of Colorado Health Sciences Center. He died in a plane crash near Centennial Airport.

    2. A man of boundless physical as well as intellectual energy, Wynn-Williams generated a constant flow of ideas, which entranced both his contemporaries and the young. He was killed in a road accident while out jogging near his Cambridge home.

    3. Dr. Tanya Holzmayer, a pioneering scientist, was surprised Wednesday night to find a Domino's Pizza deliveryman at the front door of her Mountain View home.

    Moments later, a former colleague appeared out of the dark, shot her dead and ran off, police said.

    4. Ian Langford, 40, a senior Fellow at the University of East Anglia's Centre for Social and Economic Research on the Global Environment, was discovered on Monday night by police and ambulancemen. The body was naked from the waist down and partly wedged under a chair.

    How many microbiologists does it take to change a light bulb? Whatever you think the answer may be, change

    5. The body of a Harvard scientist missing for more than a month since his rental car was left parked on a bridge over the Mississippi River has been found downstream, police said

    Workers at a hydroelectric plant in Louisiana found the body of Don Wiley on Thursday, about 300 miles south of where the molecular biologist was last seen on Nov. 18 at a medical meeting in Memphis

    6. Schwartz, who worked at Virginia's Center for Innovative Technology, was found dead Monday afternoon in his secluded farmhouse southwest of Leesburg. Sources said Schwartz was stabbed several times in what they described as a ritualistic slaying. One source said his body was found facedown and an "X" was carved into the back of his neck. The killing had "cult overtones,"

    7. Israeli biological and nuclear scientists are being knocked off one by one and this covert war is going unnoticed. A plane carrying scientists to Russia's biological warfare center at Novosibirsk was blown up over the Black Sea and no one questions that the Ukrainian missile that supposedly did the job was a hundred miles out of range. Then a Swissair Corsair crashes killing the head of Ichilov Hospital's Hematology department, as well as directors of the Hebrew University School Of Medicine and the Tel Aviv Public Health Department and not a word of suspicion is raised. After that, one of the country's most prominent nuclear scientists, Baruch Zinger is assassinated and still, no one is putting the pieces together. Your front line against nuclear and biological attacks is being picked off in a covert murder campaign and your government is taking no security precautions to stop the intellectual slaughter. Or if it is, your public is totally unaware of the daily danger to its most educated citizens."

    "Something big happening. I am getting very close. I think that biotech and govt. needed massive funding for this genetic bioweapon project and that is why anthrax was mailed. I think we now have a "target" weapon, i.e. ethnic or racial target weapon.

    Something BIG is happening. My guess is that this has to do with Dr. Wiley. Quite possibly both scientists stumbled onto something. Does the US have a "genetic" bioweapon?? My guess is these researchers have stumbled upon a bioweapons black ops project and were killed.

    It would appear that we have a "simple" case of burglary victim coming home and catching burglars in the act. As a result Dr. Robert M. Schwartz, age 57 was killed. ...OR, was Dr. Schwartz death made to look like a simple burglary/murder case?

    Robert M. Schwartz, 57, was found by neighbors Monday after co-workers called them to say Schwartz had uncharacteristically skipped work and missed a meeting 8. A microbiologist killed at CSIRO's animal diseases facility in Geelong had logged 15 years' experience with the unit, police said today. Victoria Pol

  13. Very confusing. by DerekLyons · · Score: 1
    I apologize for vaguely using the term "open source" to get my point across. I trust you will have an intuitive understanding of what I'm trying to communicate.

    Frankly, I don't understand in the least what you are trying to communicate. "Open Source" is a wide variety of different licensing models, philosophies, etc... You sound (from the tone of your website) like a /.zealot who firmly believes that open source is the cure for everything... Even if you aren't to clear on exactly what 'open source' is, and with only a (handwave) idea of how it will help in this situation.
  14. C'mon people, this is important... by node+3 · · Score: 1

    Where's the support and discussion? We're being granted the chance to act now for once. If we pass this up, we'll just ensure more frustrating stories on yro.slashdot.org.

  15. Wrong audience. by Ransak · · Score: 1
    I hope you pull off everything you envision, and even some things you (nor anyone) currently can. However, you've just asked the Internet equiv. of a schoolbus of bored 12 year olds to give thoughtful input to a project that most of them have no realistic knowledge of, aside from a left/right wing article they read on someones blog.

    The best you're going to get is 'Mike Hunt' signatures and moral elitists who think that they emit some kind of 'morality field' and as such their posts have some kind of an effect on the reader.

    --
    "Powers. I have them."
    1. Re:Wrong audience. by dshatto · · Score: 1

      Ha! Thanks for your comment. I figured this out after seeing the first day's responses. Oh well, lesson learned.