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Do You Want to Live Forever?
Jamie McCarthy writes "In 1918, Gunnery Sergeant Daniel Daly inspired his weary men to attack by yelling, 'come on, you sons of bitches, do you want to live forever?' But how would the world change if we could? This month's Technology Review introduces us to the computer scientist, and self-taught biologist, Aubrey de Grey, who thinks immortality could be within our grasp by 2030. Thinking like an engineer, he's broken aging down into seven specific problems, like cell atrophy and mitochondrial mutation, which he believes can all, in principle, be solved. And he has good reason to think those seven are the only 'bugs' standing in the way of a thousand-year lifespan. De Grey is clearly both a genius and a little nuts, but I'm not sure in what proportion..."
The Social Security System will fail Shortly after 2031. Could you imagine getting paid to not work for 935 years? You would have to have a population growth 935 times what it is today to sustain that growth! This is one reason that SS is fundamentally flawed.
As he reviewed the possible reasons why so little progress had been made in spite of the remarkable molecular and cellular discoveries of recent decades, he came to the conclusion that the problem might be far less difficult to solve than some thought; it seemed to him related to a factor too often brushed under the table when the motivations of scientists are discussed, namely the small likelihood of achieving promising results within the period required for academic advancement--careerism, in a word. As he puts it, "High-risk fields are not the most conducive to getting promoted quickly."
The world needs more thinkers like him, even if he's a little nuts. Anyone willing to start his own international symposium after teaching himself micro biology is. Too many professional scholars are pinned into doing research that has immediate market viability and too many researchers are more interested in their own career advancement than the science they're supposed to be advancing. So they play it safe.
Daly dreams of being on the cover of Time magazine I'm sure, ego is almost certainly a factor for him as well, and no doubt a huge payday would follow and major advancement on any of his 7 problems. But it's the all-or-nothing mentality, the fact that he's willing to go for it even if it never pans out, that separates him.
I Want To Believe
3D High Def THX Surround Sound home entertainment (some brain surgery required)
The 100th season of the Simpsons
200 more years of Dick Clark in Times Square
Windows Cthulhu (C'mon, you know it was coming some day...)
Baseball players finally agree to seriously address the steroid issue after a homerun ball is driven through the skull of a guy two miles away from the stadium.
No matter how well you cared for your teeth, you'll eventually lose them.
Watching every public retirement system go into the stock market and then watch it really tank! (Alpo! Yum!)
Liver Spot removal pill spam
Survivor Krakatoa
Final Fantasy LXXVI: The ploy that isn't beaten to death, yet.
After about 20 presidents claiming to reduce spending you realize they're full of shit as the world runs out of money to finance the US debt. And those guys who said, "The debt doesn't matter", they died, so it didn't matter to them.
A feeling of having made the same mistake before: Deja Foobar
Oh great, in addition to the bigger penis spams, we'll start getting "Live Forever" messages.
AND...we'll be getting them much longer. Jeez!
Successfully condensing fact from the vapor of nuance since 1998.
I believe the proper question at this point isn't "can we" it's "Should we"
If you can't see the value in jet powered ants you should turn in your nerd card. - Dunbal (464142)
By the time you are in your 70's so much stuff pisses you off that you can barely deal with it. Things change so much from what it was even when you were growning up.
er em ... better post this AC
Who wants to live forever, when love must die?
Arch Obler addressed some of the realities of such a life span in one of the episodes of the old radio show "Lights Out".
There was a revolution. The younger generation was tired of being held down by the generation that was in power when immortality became possible. Bereft of political power for hundreds of years, there was a violent and bloody revolt, resulting in the massacre of the older generation.
Can you imagine the state of civil rights if the people running the country in the 1950s were still alive and well?
To an extent, society just doesn't change unless the older generation dies off.
"Live Free or Die." Don't like it? Then keep out of the USA
Is it because 2038 going to be just like 1970 all over again?
--- Jason Olshefsky
Karma: Poser (mostly affected by adding this line long after everyone else did)
If we "fix" this whole aging thing, won't we also need to put a stop to this giving birth thing?
I don't think the Catholics are gonna like this very much.
Duh! Of course!
Just think how well my meager investments will be doing after they've had the chance to grow for 100 years! I'll be loaded!
Seriously, I think the money and class issues are the interesting side of this. If it happened there would be a clear class division between those that could afford it and those that couldn't. And for those that could, their wealth could grow without bounds. Our (in the US and most other western countries) society depends on inheritance and the associated taxes, dividing of estates, etc, to redistribute wealth, and this would immediately negate that effect. Anyone with an estate worth much could afford the technology to extend their life, and therefore not pass on the estate.
While it raises all kinds of social issues, on a personal level it means each of us has to try to accumulate enough wealth to get into the category of people that can afford it before the end of our natural lifespan. It's a race against time.
"I don't know half of you half as well as I should like, and I like less than half of you half as well as you deserve."
All us middle-aged geeks want to be well retired by 2038 so we don't have to deal with the *nix/Linux 32-bit date problem - or at least semi-retired so we can be called back on consultancy basis and hefty fee.
AT&ROFLMAO
The problem isn't that life expectancy could be raised to 1000 years or more.
The problem is that it would only be available to relatively few people. People who could afford multimillion dollar fees (which might exist solely to keep out the riffraff) or people with key political connections.
Working slaves can forget about it. Banks can always repossess a multimillion dollar house, but what do you do here when somebody declares bankruptcy after treatment?
The bottom line is that assets and power will quickly become (even more) concentrated in the top 1% or so of the population. Imagine what the average working person could do with a second lifetime where they own their own home from the beginning -- but they would start with much more real world experience and street smarts. Now imagine the same thing with people will millions of dollars in assets and dozens of lifetimes of experience.
The result would not be unlike the Go'uld in Stargate. The "immortals" might even put on the cloak of divinity. A few hundred years ago monarchs claimed they ruled by divine right, but they died just like us. How hard would it be for people with a centuries-long lifetime to manipulate society so the emphemerals believe that the immortals are graced by god. How long would it take for the emphemerals to forget that these medical treatments even forget or that everyone naturally dies within a century or so.
For every complex problem there is an answer that is clear, simple, and wrong. -- H L Mencken
I want to see what the year 2505 will be like just as much as the next Slashdotter, but it is not meant to be.
And as much as I am seriously a religious person I don't let it stand in the way of the rights of others to choose. Man will play out his destiny and if God has a problem with it I'm sure he can take care of it on his own. I doubt that a group of scientists can stand in the way of God's plan.
Who knows... We of faith may be dead wrong too and that in itself should be reason enough for us to let others "do unto themselves". Instead of bashing people with Bibles (or Korans or Gitas or Necronomicons) we should be tolerant and guide those who desire our guidance.
Dedicated Cthulhu Cultist since 4523 BC.
Even if you replace every damaged cell, there are still supercellular structures (tissues, organs) that have to be maintained. You are probably going to need a lot of wholesale organ replacement. Living things have elvolved to grow their organs from small or large by multiplying cells in a certain pattern. I'm not sure that cell replacement can adequately maintain that pattern. If you have an old house and you replace each piece of wood as it rots out, small inacuracies will build up over time, and the whole structure will become misshapen, and you will have to replace the whole wall.
I guess the point is that living things were designed to grow, and by that I mean go from small to large, into adult form, and then die. Can maintenance really work? If you look at, say, the spiral pattern on a flower, I think it's fairly easy to get one cell to multiply into that pattern, but then to replace a single petal? A lot of our organs have that branching tree structure. I think it's easier to grow that than to maintain. I don't know if our DNA has a program to replace a section of artery, but it certainly has a program to grow it.
I remember from a radio interview a museum curator said "It's easier to destroy than to create, and it's easier to create than to maintain". I think it will be cheaper to make new people and let the old ones die than it will be to maintain everyone.
Computers are useless. They can only give you answers.
-- Pablo Picasso
Just like the much hyped social security collapse of the early 1980s?
The level of "fix" needed to make social security solvent past 2031 is tiny. Besides, the reason we had (past tense, unfortunately) a social security "surplus" was due to the fact that lifespans *weren't* increasing as expected (among other things). Should they start to change, social security will clearly change to adapt - most likely with a later retirement age. A mere 2 year age boost in the retirement age made most of the difference in the 1980s - if you're living 50, or even 500 years longer, a longer work period should be a given.
Much of the SS calculations, by the way, is rather pessimistic. They assume pretty poor economic growth and population figures.
Jesus: "Son of a
Welfare is for lazy trailer trash who can't get off their fat ass to find a job.
Trailer trash such as my mother, who after the divorce was a single mother of five. Trailer trash that worked her ass off, lived in a "house" in the "city." Eventually she got off Welfare, but thank God it was there for us when we needed it. It was not for lack of work ethic that we were on it, it was poor planning on my mother's part.
Social Security is for old people who worked hard and want to retire.
Socialist Security is not for people who want to retire, the benefits are so tiny that all it does is supplement the typically small income our elderly are able to procure. Think about it -- who wants to hire a 70 year old to a six figure job when that person is bordering on senility and has very few productive years left? Age discrimination may be illegal, but it happens. I see a lot of old people working at Wal-Mart and McDonald's. Social Insecurity will barely pay their rent or house insurance, whichever is applicable.
Lots of people are in favor of cutting welfare benefits in the name of forcing these people to get a job and quit being leeches, while very few people want to be seen as "cutting" SS in the eyes of the older voters.
Not everyone on Welfare, Food Stamps, or whatever other public assistance programs are out there are leeches. Some are just in a shitty part of life and need a boost. I have no problem cutting Social Security as long as everyone gets their dues if they want. I plan on denying my Social Security benefits even after paying into the system all my life. Hopefully I won't need them, because I will plan better than my parents did. It may be a drop in the bucket, and more symbolic than anything, but that is doing my part to keep the system from fucking some poor Joe who gets the short end of the stick in 40-60 years.
24 beers in a case, 24 hours in a day. Coincidence? I think not!
I have a degree in Biochemistry, Cellular and Molecular Biology. I used to work in a Genetics research lab as well. Now, I'm no Cambridge Scholar, but I'm not stupid. But unless I'm missing something, this guy has basic points wrong in most of his 7 points.
Eliminating telomerase is not bad, and a way to reduce/eliminate cancer. Telomoerase is essential for Germ Cells, i.e. sperm and egg cells. It seems unlikely to be able to eliminate it in all cells but these.
Cancer cells don't need telomerase. There are countless avenues to cancerous cell growth.
Stimulation cell growth is good and necessary. Cell growth in the brain could be extremely problematic. The brain is a living, connected system. The connections are what make the brain what it is. Unlike computeres with fixed hardware and variable software, the brain is variable in both. The electrical patterns can change as well as the paths the patterns take. Essentially, they are insepearable. The addition of new cells, with no way to control their connectedness would not aleveate the problems of cellular degredation and loss.
Extrecellular protein linkages are unique. Biology is extremely effecient at its use of chemical compounds, structurally. Our knowledge of protein strcuture is limited, due to the limitiations we have of computational modeling due to limited computational abilities. That he should think that extracellular proteins show unique linkages seems hubristic. It is possible we don't understand all protein interactions yet.
Cell growth can be stimulated naturally. Here, even a passing comment has errors. Muscle cells are stimulated to divide by excercise. No! Excercise increases the size of muscles by stimulating an increase in production of muscle fiber proteins. More proteins cause a cell to be larger, and thus the overall muscle to be bigger. Thus excercise increases the size of muscles, not the number of cells. This is basic biology.
Mitochondrial proteins will work in the nucleus.While most cells in the world use a universal genetic code, some vary specific cells do not fully share the code's universality. Some non-eukaryotic cells and mitochondria. (It is interesting to note that mitochondria are thought to be descendended from symbiotic non-eukaryotics cells themselves.) I don't know off the top of my head if these proteins will work with both codes, but it seems likely that even if the nucleus can produce the raw protein, the proper folding, transport, and ultimate use of the proteins might not occurt since they are not where they need to be, namely inside the mitochondria. Only native proteins might be functional.
Again, I might have too simple an outlook or be completely incorrect, but it seems that there are basic concepts of biology that conflict with de Grey's ideas.