Precision Gene Editing

mpthompson writes "NewScientist.com is reporting that scientists at Sangamo Biosciences have developed a method of editing DNA mutations with unprecedented precision without weaving in potentially harmful foreign genetic material. Different combinations of amino acids are designed to latch on and cut the DNA at exactly the place where the mutated gene lies. This triggers the body's natural repair process which corrects the gene where the DNA was cut. The technique will be used to target diseases caused by single-gene mutations such as combined immune deficiency (X-SCID) - or bubble boy disease - and sickle cell anaemia."

Comments

Re:I don't care what they say..

[thanasakis]

If sick people can get cured by something like this, we can't afford not to exploit it.

Let's just not forget that there is not such thing as evil knowledge. The way we use it makes good or evil.

I only agree partially...

[bennomatic]

There are indeed dangers, but we've been doing this sort of thing for thousands of years; breeding of animals and plants is an old, old practice.

I know people who are geneticists, and who work in a lab where they are able to essentially make a mouse to order. You want one that grooms obsessively, here you go! Want one that glows in the dark? You got it. Just because they do it through genetic manipulation rather than breeding doesn't make it any more evil than other means.

What it does do is accelerate our ability to learn about life. Should we take things in measured steps? Absolutely! We should also have been more careful about asbestos, lead based paint, DDT, agent orange and more. But should we ignore these amazing advances? Absolutely not!

Re:I don't care what they say..

[ciroknight]

Forgive me for not believing in your esoteric views of this "God" character nobody has any proof of, but I feel genetic manipulation is going to be one of the few things that allow us (the human race) to continue existing.

As time goes on, we defeat simple diseases such as the bubonic plague, then upgrade to tougher ones like smallpox. We're now at the point where the only communicable diseases that are seriously fatal are biologically engineered bacteria, and viruses. On top of that, we've still got Cancer to worry about, which is kicking our asses.

While it may be cheaper to produce drugs for everyone alive and distribute them to everyone, no company in their right minds would do this. But if we could figure out genetically how to teach our immune systems to deal with cancer, and certain foreign invaders, we could save millions simply by changing our children's genes.

I think the biggest paranoia attributed to genetic engineering is the fear of change; just because we know how something works now, and we assume that it'll continue working the same way into the future, we give up the notion that we can change things for the better or for the worse. Yes, we are foulable creatures, but at the same time, we now know how to clean up our mistakes. It's far past time we take our fates into our own hands. Why use medicines that can screw up other things in our bodies when we can simply prevent the problem from occuring naturally?

Mutations...

[John Seminal]

That is how nature changes people, that is how humans evolved to what we are today. I dunno how smart it is messing with mother nature. So far, mother nature has been able to keep things going well for thousands and thousands of years. But for some human to say, I am not happy living to 80 years old, I want to live to 90 years old, that is a risky proposition considering they are not using standard medicine, but messing with DNA. Maybe what would have happened naturally now won't.

I think there is a natural equilibrium between nature and gene mutations. When the hand of man starts changing one side of the equation, can the consequences on the otherside be foreseen? For example, who is to say that some form of cancer today won't mutate to something 1,000 years from now that will save humanity from some enviormental change?