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Nobel Prize in Chemistry Awarded

An anonymous reader writes "The Nobel Prize in Chemistry for 2005 has been jointly awarded to Robert H. Grubbs (California Institute of Technology), Richard R. Schrock (Massachusetts Institute of Technology), and Yves Chauvin (Institut Français du Pétrole) for the development of the metathesis method in organic synthesis." Advanced [PDF] and supplementary [PDF] information is also available from the Nobel Prize site.

28 of 114 comments (clear)

  1. Grubbs is great by rgmoore · · Score: 5, Interesting

    I took a class (Ch41, Chemistry of Covalent Compounds) from Professor Grubbs, and he is an excellent teacher as well as a great scientist. He can also take a joke. The following was published in Nothing, an unofficial humor paper published by a couple of bored Techers, and based by a standard lecture that Grubbs gave to every Organic Chemistry class before their first test.

    Caltech Professor Lashes Out Against High Energy Reaction

    In a remarkable demonstration of unbridled passion, Caltech professor Rober Brubbs yesterday lashed out against a high energy reaction--namely, one which includes the formation of a quintuply-bonded carbon. Provoked to a fever pitch by the prospect of dsp3 hybridization in a first period species, he opined: "This reaction doesn't have a chance in hell of happening." He proceeded to characterize quintuply-bonded carbons as "bad", "no good", "undesirable", and "a damned silly notion." After his oration Professor Gurbbs nonchalantly continued with the lecture.

    Earlier this mornin, students and other various members of the Caltech and Pasadena communities picketed Grubbs' office to demand retraction of his libelous comments. At the protest, Jennifer O'Leary, spokeswoman for the Quintuply-Bonded Carbon Anti-Defamation League, characterized Grubbs's statement as "shocking" and vowed, "He hasn't heard the last of us. High-energy reaction have just as much a chance of happening as any other. Grubbs's evil exergonocentrist demagoguery demands retraction." Nothing has also received reports from reliable sources that Grubbs has received death threats from both the Brotherhood for Hybridization Freedom and the Carbonic Liberation Front, left-wing propentavalent reactionist groups.

    In a response to the same event, the Coalition for Traditional Carbon Valence made public this statement: "We applaud Professor Grubbs for his courageous stand against the poison of quintuple bonds."

    Professor Grubbs was unavailable for comment after the lecture as his office refused to return phone calls.

    Caltech Security stated that in order to maintain a suitable atmosphere for study and research it would investigate the matter to the fullest extent of its capabilities.

    (Information in this story gathered by reporters on fat expense account.)

    --

    There's no point in questioning authority if you aren't going to listen to the answers.

    1. Re:Grubbs is great by Mr.+Underbridge · · Score: 2, Funny

      Pisses me off, I just left 7 months ago...I imagine I'm missing some great Chem department parties.

    2. Re:Grubbs is great by rgmoore · · Score: 4, Informative
      What is quintuply-bonded carbon? Is this one of those jokes like dihydrogen monoxide?

      Nope. Carbon can only form 4 bonds at a time. During the course of a reaction, there may be short-lived meta-stable carbon species with only 3 bonds, or reactive intermediates (i.e. unstable things that are a transition state between two more stable forms) that have 3 bonds plus one bond that's half made and one bond that's half broken, but there aren't any forms with a full 5 bonds. Undergraduates taking their first Organic test, though, are apt to draw such quintuply bonded carbons and thus get answers wrong on their tests.

      Prof. Grubbs always warns his students not to make that mistake before their first test, and even goes into a mini-rant on the topic much like the one in the article. I wouldn't be surprised if the "This reaction doesn't have a chance in hell of happening" were a direct quote. The rant is very memorable, and I'm sure that everyone who took Organic from him would remember it. Despite this, many students will go on to make exactly the mistake that he warned them against, which I assume is the reason that he's so vehement about it.

      --

      There's no point in questioning authority if you aren't going to listen to the answers.

  2. Re:Fuel? by thc69 · · Score: 4, Informative

    Well, we can already make diesel out of nearly any kind of oil extracted from nearly any biological material...

    --
    Procrastination -- because good things come to those who wait.
  3. Re:Fuel? by metternich · · Score: 3, Informative

    Synthetic Oil has been around for a long time. The Germans made oil from coal in WWII as did the South Africans under the Aparthaid Sanctions. (The Chinese are now starting to use this techlonogy as well.) I don't if this new method will help with this, but if it could be done at a large scale I imagine it would.

    --
    Facts do not cease to exist because they are ignored.
  4. Embarassed of a Nobel prize? by n01 · · Score: 5, Interesting
    1. Re:Embarassed of a Nobel prize? by gowen · · Score: 2, Funny

      He'll still mention it when chatting up women, though. That's the French for you.

      --
      Athletic Scholarships to universities make as much sense as academic scholarships to sports teams.
    2. Re:Embarassed of a Nobel prize? by DeeSnider · · Score: 3, Insightful

      That article was kind of sad to me. The guy seemed still in grief from his wife's death, and annoyed that 30 years after the fact tons of reporters started knocking on his door practically unannounced. Can't say I blame him. I wouldn't want that kind of sudden publicity now, much less at 74 for something I did half my life ago.

  5. But as Sideshow Bob says... by wernst · · Score: 5, Funny

    Yes, yes, that's very interesting and all, but what I want to know is who won the Nobel Prize this year for "Attempted Chemistry?"

    1. Re:But as Sideshow Bob says... by kbrosnan · · Score: 4, Funny

      You can find out tommorow when the IgNoble awards are released.
      http://www.improb.com/ig/2005/2005-details.html

      Last year the Chem Award went to Coca-Cola Co. of Great Britain for turning H20 into a cancer causing material.
      http://www.guardian.co.uk/business/story/0,3604,11 74127,00.html

      --
      These people look deep within my soul and assign me a number based upon the order I joined. -Homer Simpson
  6. Metathesis is like swinging by Dystopian+Rebel · · Score: 2, Funny

    "Metathesis can be compared to a dance in which the couples change partners."

    Whoo hoo! Grubbs, Shrock and Chauvin have done a great service to married SlashDotters.

    --
    Rich And Stupid is not so bad as Working For Rich And Stupid.
    1. Re:Metathesis is like swinging by Viper+Daimao · · Score: 2, Funny

      married SlashDotters.

      Who?

      --
      "In the game of life, someone always has to lose. To me, if life were fair, that someone would always be Oklahoma." -DKR
  7. Re:Fuel? by thebdj · · Score: 2, Informative

    this new method

    Remember this is the nobel prize we are talking about. These are not necessarily new methods, which is something people have repeatedly forgotten over the last few days of science award posts. Many of these discoveries have been done over time, and in fact started work in the '70s or earlier and may have been finalized in the late 80s or early 90s. Nobel Prizes do not have to be given to you the year you create some new and wonderful thing, and most often this is not the case. Think of the Nobel Prize more as a lifetime achievement award (I mean most the recipients are typically of advanced age) in your scientific field.

    --
    "Some days you just can't get rid of a bomb."
  8. No Theory, no equations?-I am disappointed! by Anonymous Coward · · Score: 5, Funny

    They used to have the good habit of giving Nobel Prizes in Chemistry for physical chemistry, clean spectroscopical experiments, nice theories with lots of equations, sophisticated mathematics, quantum theories etc. Many physicists, not olny chemists, magaged to receive the Nobel Prize in Chemistry. Not anymore, now smelly, organic chemistry and biochemistry grab everything! Think urine and meat and blood and saliva analyses and other gross things! I am VERY disappointed!

  9. Re:Fuel? by suchire · · Score: 4, Informative

    Not only is this a new method, but it isn't really all that practical for the synthesis of fuels. You can't run this reaction with just substrates and the Grubb's catalyst; you have to have solvents, which cost money. The catalysts have a finite lifetime and turnover, so you also have to replace those. That's not really very cost effective, in the end, compared to simply adapting technologies to use the substrates as fuel directly.

    --
    Such irE
  10. awesome potential by smellsofbikes · · Score: 5, Interesting
    These are spectacular reactions: they allow for all sorts of neat syntheses if you can just form terminal alkenes, which isn't too hard. The systems aren't horribly abusive to most side-chains so you don't have to spend lots of time (and reduce your yield) protecting everything in sight.

    I think it's interesting how many nobel prizes have been given for work on the C=C bond: Diels-Alder, Wittig, reduction, oxidation... I think that more nobels have been given for x-ray techniques than anything else, but this must be well up there. (Of course that depends on how broadly you classify your groupings.)

    But this particular synthesis is already producing some amazing results in bioactive materials, and it should be a strong industrial technique, given its apparent robustness. Back when I was doing organic chemistry, I was trying to make a weird cyclopropene using a synthesis that was multi-step and very low yield. I wish I'd read about this.

    --
    Nostalgia's not what it used to be.
    1. Re:awesome potential by k98sven · · Score: 3, Informative

      Ironic, isn't it, that so many Nobel winners are Americans?

      Surely you're joking?

      The USA has about 200 (give or take) laureates (counted as ones at US universities). And a population of 295 million. 0.67 per million.

      Switzerland: 28 and 7.5 million population : 3.7 per million.
      Sweden: 29 and 9 million. 3.2 per million.
      Norway: 11 and 4.5 million. 2.4 per million.
      Austria: 21 and 8 million. 2.6 per million.
      Denmark: 13 and 5.5 million. 2.3 per million.
      Germany: 89 and 82 million 1.1 per million.
      Netherlands: 16 and 16. One in a million.
      France: 49 and 60 million. 0.8 per million.
      Belgium: 8 and 10.5 million. 0.76 per million.
      Italy: 19 and 58 million. 0.3 per million.
      Japan: 12 and 127 million. 0.1 per million.

      Call it bias or whatever you want. But the US certainly isn't overrepresented.
      All figures from doing a simple laureate-search, so they're all approximate, and refer to country of residence, not birth.

    2. Re:awesome potential by smellsofbikes · · Score: 2, Interesting
      A lot of strain, yeah.

      I was in an advanced organic synthesis class. The project was "make something new. Preferably by an unusual synthesis." My first project is not discussable these days, given the current political climate, but my second project was making a cyclopropene, turning it into a cyclohexene (!), and then turning THAT into a spiro compound with one six and one seven membered ring. (!!!) It was way out there on the weirdness scale, but the problem was that the cyclopropene was, as one might expect, very suseptible to polymerization, so I mostly ended up making round-bottom flasks full of solid brown tar. I could dig up the papers from which I was working, but this was, uh, 15 years ago (eeeek!) and I can't remember all the details off the top of my head. I can't imagine what one could do with a metathesis reaction, although I suspect you'd spend most of your time just synthesizing the catalyst. Most of those look like boogers to make, and not very many were/are commercially available (and those that are probably cost hundreds of dollars a gram.)

      --
      Nostalgia's not what it used to be.
    3. Re:awesome potential by frozenraisin · · Score: 3, Interesting

      I'm pretty sure you can't make cyclopropenes with metathesis. The thermodynamics of that particular reaction are against you. The 1,4 diene starting material is often unreactive for transition metal catalyzed processes due to catalyst inhibition. Cyclopropenes, at least these days, are best prepared using rhodium(II) catalyzed cyclopropenation of alkynes.

  11. Good Show by Jim_Callahan · · Score: 2, Interesting

    I like Nobel Prizes in Chem. They're usually actually important discoveries, as evidenced by the fact that chemists use them constantly two decades after their formulation. The literature-type prizes, I'm still not so sure about.

    --
    ...it's really a sad day for America when we require a goddamn ACT OF CONGRESS to make our DVD players work properly. ~
  12. Re:dupe by MagikSlinger · · Score: 3, Insightful
    for [frak]'s sake, do we have to read this twice? it was dull the first time round!

    <sarcasm style="dripping">
    I'm sorry today's omelette wasn't to your taste. Maybe tomorrow they'll talk about Halo and Doom 3 instead! That'd be more interesting, right?
    </sarcasm>

    --
    The bitter lessons of a veteran coder: http://bitterprogrammer.blogspot.com
  13. A Chem Nobel Prize that actually goes to chemists! by Jonathan · · Score: 5, Interesting

    It's interesting that this year the chemistry nobel prize actually goes to chemists this year -- the last two years it went to molecular biologists...

  14. Re:Who got 50% and which of them get 25% ??? by Anonymous Coward · · Score: 2, Informative

    I don't know about the rules, but according to the nobel foundation, they will indeed receive one third of the prize.

  15. Not meant to be a lifetime achievement award by 200_success · · Score: 4, Insightful

    Actually, according to Alfred Nobel's will and the statutes of the Nobel Foundation, the prizes are meant to be awarded rather promptly:

    The interest... shall be annually distributed in the form of prizes to those who, during the preceding year, shall have conferred the greatest benefit to mankind.

    Granted, the passage of time is often necessary for the relative importance of a work to become apparent, since bold new ideas tend to be controversial and cannot be appreciated without hindsight.

  16. Re:A Chem Nobel Prize that actually goes to chemis by Dionysus · · Score: 2, Informative

    Well, that's OK. 2004 Peace prize went to the an environmentalist who thinks AIDS is a bio-weapon created by bad western white scientists.

    --
    Je ne parle pas francais.
  17. Re:Who got 50% and which of them get 25% ??? by reverseengineer · · Score: 3, Informative
    Are you sure about that? The laureates for the Chemistry prize for this year are listed here; each is noted as receiving 1/3 of the prize. I think you may be confused by the fact that a single prize can be split to honor two (and no more) different achievements in the same year.

    An example of that is here. Notice that one guy got half the prize, while two others split the remaining half. It was like half a prize was awarded for the soft-ionization MS work, which one person received, and half a prize for the NMR work, which was split between two people. No more than three persons total may split a prize though- you can't have a prize split 4x25% or 1x50%+3x16.7%. As science has become more of a team effort and an international enterprise, virtually every science Nobel given out recently has honored the maximum of three. The Nobel Foundation statute for shared prizes may be found here.

    --
    "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
  18. Dumbing a complicated subject down by aphexbrett · · Score: 5, Interesting

    "Metathesis can be compared to a dance in which the couples change partners."

    This has to be the worst quote I've ever heard describing Grubbs' catalyst. When I woke up this morning and heard that Grubbs had won the Nobel I wondered what the brief description of his work was going to be, and I honestly have to say I was amazingly disappointed with it. However this is part of a larger problem that I've encountered often especially on this webpage, how do you explain complicated subjects to the uninformed masses? How do you explain detailed chemistry to computer geeks? In some cases a pretty simplistic idea is transferred successfully, but this is the exception rather than the rule. IMO, the comments left about the story tend to further complicate the matter.

    Having use chemistry developed by Grubbs I'll provide a brief description of his remarkable achievements in the field of organic synthesis (one of the serveral fields Grubbs has impacted [Grubbs is however an organometallic / inorganic chemist]). Organic synthesis is the study of building complext molecules from simple starting materials. The "goal" of organic synthesis is to make compounds with biological activity, e.g. new drugs. Many of the target compounds are initially isolated from nature, chemist then try to replicate them in the lab environment. One of the catalysts Grubbs developed allowed for synthesis of a particularly common structural feature (I'm thinking of cyclic structures, there are more, I know) and it opened whole new doors in terms of synthetic routes that one could take to complete a molecule. It was fairly evident in the mid 90s that his work had a huge impact on the synthetic community and it was apparent he would win the nobel, it was just a matter of time.

  19. Re:Fuel? by twiddlingbits · · Score: 3, Interesting

    That's the Fischer-Tropsch process to take coal and convert/refine into high octane gasoline. It was invented in Germany in the 1920's. Fischer was awarded the Nobel in Chemistry (1902) but not for for this idea. South Afica makes most of thier gasoline this way still since they adopted the process when embargoed in the 1980s for Apartheid. SA has lots of coal but not much oil. Sasol and Shell are using the process today to make gasoline from coal in SA and from natural gas in Malaysia. It's quite a good process, very scalable to industrial use. Why we don't use it in the USA I don't know as we also have plenty of coal.