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Researchers Reconstruct 1918 Flu Virus
Gnpatton writes "CNN is running a story on how researchers have recreated the gene sequence for the 1918 virus which claimed 50 million lives. The mapping for the gene sequence was found on a victim frozen in Alaskan permafrost. From the article: 'Using a technique called reverse genetics, the Mount Sinai researchers used the genetic coding to create microscopic, virus-like strings of genes, called plasmids.'" Researchers are hoping that reconstructing a virus like this will help them to better understand similar problems. The structure was originally determined earlier this year.
What the fuck is wrong with you?
What if this secured facility gets compromised, an accident happens that leads to the infection of one of the staff, testtubes are improperly sterilized. I could name hundreds of things that could go wrong, and will not even start wildly speculating what would happen if 5HN1 somehow mutates with this virus.
You can make this argument about any virus. Your argument, taken to its logical conclusion, implies that we should not do any research on any harmful micro-organism for fear of it getting out. Ignoring harmful things and hoping they go away is not an intelligent strategy.
Toronto-area transit rider? Rate your ride.
I understand your intuition that reviving a killed off deadly strain of the flu could be dangerous, but given the mutability of flu viruses, the potential for new deadly strains is very much real and we have to study our epidemiological history to avoid them.
Studying viruses is very difficult, as you can only tell so much from examining the raw sequence information or using simulations. Everything from the exact mechanism of transmission to how this flu caused so many deaths to (and this is probably the most important) how this bug made it from animals to humans is still not precisely known. In order to learn such things, you'd have to directly infect some test organisms or cells and observe the effects and do other lab studies using a live viruses. There is just no substitute. (Another controversial approach involves deliberately crossing human and avian and porcine flus to try and generate one that will cross between the species)
The justification for doing so is clear, and goes beyond a desire for Nobel glory, many scientists agree that we are just a day away from another deadly and widespread flu epidemic. If we are going to predict and prevent such an epidemic, we need to really understand the kinds of features that made the "Spanish" flu possible and so potent. Another massive problem we have is the utter lack of real epidemiological surveillance in large domesticated animal populations (on chicken and pig farms, for example). Not only do we need to do this, but we need to understand the viral features that we need to look for.
-- "Sucks to your ass-mar"
I am sure someone who actually knows about biology will correct me if I'm wrong... but surely the reason we are alive today is because we are descended from the people who were immune to the original strain of the virus?
More likely because our parents/grandparents/great-grandparents were either not infected or lived after becoming infected. Doing a quick search find that the mortality rate was 2.5%. That means that 2.5% of all those who became infected died. Given that 50 million people died, that's 2 billion people that were infected. Chances are you foreparents had it.
So are we immune? No. Did we descend from the lucky ones? Yes.
Fly me to the moon Let me sing among those stars Let me see what spring is like On jupiter and mars