Slashdot Mirror
Cannabinoids Induce Brain Cell Growth?
Harlan writes "The Globe and Mail is reporting that researchers at the University of Saskatchewan are claiming that high doses of cannabinoids have induced new brain cell growth in the hippocampus, the part of the brain responsible for learning and memory, in rat subjects. There are some interesting potential implications in regards to high doses of cannabinoids found in substances like marijuana."
The authors are far more cautious in their interpretation than some of the /. readers...but then this is not that much of a surprise.
PDF (a few MBs) http://www.pubmedcentral.gov/picrender.fcgi?artid= 1253627&blobtype=pdf
If you read TFA you'd have read that the original publication is due to be released in JCI, a peer reviwed journal that is quite high impact. Not Nature or Science, but not the Ulan Bator Journal of Basket Weaving Medicine either.
Actual paper can be found here.
What a surprise to click on Slashdot and see news about cannabinoids - I feel like I'm reading my own site ...
... shortcut url http://cann.com/
t ml
I operate CANNABIS.COM
Some informative pages to check out:
Lots of cannabis Research information *with sources listed*
http://www.cannabis.com/research/
TR-446 Toxicology and Carcinogenesis Studies of 1-Trans-Delta9-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
http://www.cannabis.com/research/tr446study.shtml
(mirror of the study published by the U.S. National Toxicity Program)
Cannabis News
http://www.cannabisnews.com/
And finally, Erowid's Cannabis Vault...
http://www.erowid.org/plants/cannabis/cannabis.sh
Ron Bennett
Actually, the research talks about "cannabinoids." Cannabinoids are the primary psychoactive alkaloids contained in cannabis, of which, THC is the most concentrated in most strains, although each strain contains different levels of each. THC is a cannabinoid so it likely has very similar pharmacological effects as HU-210.
Ethanol and Methanol DO have roughly the same effect. You get the same intoxication from both of them. What kills you is not the methanol intoxication but the methanol hangover.
Methanol is metabolized by alcohol dehydrogenase (ADH) via formaldehyde to formic acid, being responsible for the metabolic acidosis in methanol poisoning.
That's why ethanol is given as a cure for methanol poisoning; by adding ethanol to the bloodstream the metabolization rate of methanol decreases as the body will also metabolize ethanol, and thus the level of toxic methanol byproducts in the blood will be kept at a non-lethal level.
Are you still sure that the only method they used was injecting cannabinoids and measuring how much they ate?
I guess that experiment is an accepted test for anxiety, and prozac cum suis scores very good on it. Science gets better if you use standard test where you can. Even though your 'munchies' hypothesis sounds plausible, it still cannot explain the neurogenesis bit.
This space is intentionally staring blankly at you
Happy now?
This space is intentionally staring blankly at you
Ever heard of a vaporizer?
It heats the herbs of your choice, to a point that releases the medicinal compounds, without creating pyrolytic compounds.
A very affordable Vaporizer can purchased here I have one and am VERY happy with it.
-Myke
From the conclusion of your first article:
Current marijuana use had a negative effect on global IQ score only in subjects who smoked 5 or more joints per week. A negative effect was not observed among subjects who had previously been heavy users but were no longer using the substance. We conclude that marijuana does not have a long-term negative impact on global intelligence. [emphasis added]
As for the hyperbole of your other claims, let's dispose of them by referring to the most-widely used medical textbook in the world, The Merck Manual of Diagnosis and Therapy entry on marijuana:
Critics of marijuana cite much scientific data regarding adverse effects, but most of the claims regarding severe biologic impact are unsubstantiated, even among relatively heavy users and in areas intensively investigated, such as immunologic and reproductive function. However, high-dose smokers of marijuana develop pulmonary symptoms (episodes of acute bronchitis, wheezing, coughing, and increased phlegm), and pulmonary function may be altered. This is manifested by large airway changes of unknown significance. Even daily smokers do not develop obstructive airway disease. Pulmonary carcinoma has not been reported in persons who smoke only marijuana, possibly because less smoke is inhaled than during cigarette smoking. However, biopsies of bronchial tissue sometimes show precancerous changes, so carcinoma may occur. In a few case-control studies, some tests detected diminished cognitive function in small samples of long-term high-dose users; this finding awaits confirmation. Studies in newborns have not found evidence of fetal harm due to maternal use of cannabis. Decreased fetal weight has been reported, but when all factors (eg, maternal alcohol and tobacco use) are accounted for, the effect on fetal weight disappears. delta-9-Tetrahydrocannabinol is secreted in breast milk. Although no harm to breastfed babies has been shown, breastfeeding mothers, like pregnant women, are advised to avoid using cannabis. [emphasis added]
Btw, I am not sure why you have to call the poster you are responding to names. Seems like your arguments should be able to stand on their own.