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The Los Alamos Bug

Kannappan writes "'You somehow have to forget everything you know about life', says Steen Rasmussen, a colleague of Norman Packard. Packard and his team are working on creating life artificially, nicknamed The Los Alamos bug (pdf). It will be created out of a molecule called Peptide Nucleic Acid(PNA), with a blend of three different factors crucial to life, viz. containment, heredity and metabolism. The researchers believe that the synthetic lives so created will have an enormous practical value in producing clean fuels, healing injured bodies and acting as tiny diagnosticians roaming our bodies."

29 of 389 comments (clear)

  1. Only a matter of time by FlyByPC · · Score: 5, Insightful

    With our increasing knowledge of the mechanics of life, it's a matter of time until somebody succeeds in creating life from scratch. I don't think it's very controversial these days to say that if we don't already have the power to create life in vitro, we someday will.

    For my money, a much more interesting question is, can we create *intelligence* from scratch? Humor aside, I think creating something with recognizable intelligence (not just programming) will be much more difficult -- and have much more profound implications -- than "merely" creating life.

    Such experiments should help narrow down the various factors in the Drake Equation. Life, I suspect, is fairly commonplace. I have no idea if intelligence is.

    --
    Paleotechnologist and connoisseur of pretty shiny things.
    1. Re:Only a matter of time by MarkRose · · Score: 4, Insightful

      Our brains limit us to only create something less "intelligent" if we were to do it from scratch.

      I disagree. If we can determine the origin of intelligence and the mechanisms by which is works, we could improve upon those mechanisms. Also, it depends what kind of intelligence you a measuring. Math-wise, computers are far more intelligent than the average individual at computation. It's quite possible that we could create a device/organism that's better suited to other areas of intelligence.

      --
      Be relentless!
    2. Re:Only a matter of time by heinousjay · · Score: 5, Insightful

      Math-wise, computers are far more intelligent than the average individual at computation.

      Maybe you don't realize just how much calculus is involved in walking down stairs.

      The human brain is a computation engine of more power than people understand. It just doesn't happen at a conscious level, so we're not always aware of it. Our brains operate at a level far above raw computational power, which is really all our machines are good at right now.

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    3. Re:Only a matter of time by SeventyBang · · Score: 2, Insightful


      Math-wise, computers are far more intelligent than the average individual at computation.


      This is why non-technical people talk about "computer glitches" - as though the computer was dumb enough to screw up.

      Computers may have more speed than the human brain when it comes to math computations (savants aside), but I'd like to see where there's any useful intelligence in what a computer actually does. It's nothing more than a reflection of the coder(s).

      (and it's why I've generally maintained about 95% of the people who do it for a living shouldn't be allowed to)


    4. Re:Only a matter of time by shmlco · · Score: 2, Insightful
      "Maybe you don't realize just how much calculus is involved in walking down stairs."

      Yes, but we don't do "calculus" either. The brain's neural net has learned over the years, mostly by trail and error, which sets of neurons to fire, and in what order, to make walking down the stairs happen.

      Many seemingly complex actions can be created using a few simple rules.

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      Any sect, cult, or religion will legislate its creed into law if it acquires the political power to do so.
    5. Re:Only a matter of time by digitalunity · · Score: 2, Insightful

      There is one thing you are failing to see. Immortality has been sought after nearly as long as recorded history has existed. References to immortality occur as early as 2500 BC in the Gilgamesh Epic. Humans are unique in the respect that they have a conscious understanding of their own mortality. Although self-preservation can be observed in the majority of the animal kingdom, there is no evidence that any other species has self-awareness of their own mortality.

      Among humans, self-preservation is probably the strongest behavior. Yet your statements imply that it is unhealthy for society for individuals to live so long, and that a short lifespan is important? I disagree. The fact that couples today have so many children is a cultural problem, but not one that can be solved by preventing technology advancements that extend the time a person can live. If anything, longer lifespans may reduce overpopulation as people realize that they do not have to reproduce at such an early age so as to avoid their own demise before their children have grown to adulthood.

      While I can appreciate the dangers of unfetered technological development, limiting our research to development that falls into a specific and defined set of morals as given to us by religion is counter-productive.

      I guess my point is, it's easy to say longer lifespans aren't good when you are young. When you are older, your opinion may not be the same.

      Death and Immortality(long, philisophical, good history though)

      --
      You can't legislate goodness. Let each to his own destiny, by will of his freely made choices.
    6. Re:Only a matter of time by Shihar · · Score: 5, Insightful

      And the most insidious unintended consequence of our advance in medicine, most people don't appreciate, we have extended our life spans, if you have the money, to the point that we live much longer than we should, we have people living a poor quality of life for decades in their 80's and 90's draining societies resources, and worse we are producing an exploding population. I'm not sure near technology synthesized immortality is such a great thing. There is benefit in the renewal that comes with the old dieing and letting young, fresh people take over.

      I think you are looking at life expansion from entirely the wrong perspective. First, life expansion does NOT create a population boom. All of the rich western European nation are in a death cycle right now. Their populations are shrinking. Wealth and the ability to live a long time causes people to simply choose to not have as many children. This is an extremely well documented correlation. The US itself would be in a death cycle like Europe if it wasn't for its influx of immigrants.

      Life expansion does not result in a drastically lower standard of living. Being old isn't what makes being old suck. Having your organs fail, your bones become brittle, mental illness, and muscle loss are the reasons why being old is no fun. Fortunately, extending life requires dealing with all of the above. If you have ever watched a National Geographic on a tribe with low life expectancy, you will notice that a 35 year old man looks like an 80 year old American or European. That isn't to suggest that we keep people alive beyond what they would be able to be naturally in the same state, but it isn't right to assume that when people were dying at the age of 40 they were dying looking and feeling like a 40 year old of today.

      More importantly, life expansion these days almost entirely revolves around "solving" old age. If someone was to live to be 200 years old, you can bet that they have 'solved' old age and that 200 year old person probably looks about 30. You simply can't extend peoples' lives much longer without curing the natural degradation that your body suffers as you get older.

      Finally, I think you drastically overlook the social good that old age offers. In a society where people become older and older, you have people building up vast reservoirs of experience and knowledge. The only social ill old age brings is retirement, and as you see people living longer and healthier lives, you are going to see the retirement age kicked out further. I wouldn't be surprised in a decade or two when life expansion hits its next big surge that our way of thinking about retirement gets radically altered. I wouldn't be surprised if one day the normal mode of 'retirement' is to take a few years off from work every decade or two, but never permanently retire.

    7. Re:Only a matter of time by shmlco · · Score: 2, Insightful
      Let me rephrase that so we don't go off on another tangent.

      Yes, but we don't do calculus to walk down the stairs, even though those actions can be described using calculus.

      --
      Any sect, cult, or religion will legislate its creed into law if it acquires the political power to do so.
    8. Re:Only a matter of time by Famatra · · Score: 2, Insightful

      "Life, I suspect, is fairly commonplace. I have no idea if intelligence is."

      Of course we have an idea if intelligent life is common place out side of our solar system and the answer is: it is not. If it were very common then we would have likely picked up a signal by now if they were within a few hundred light years.

      Why isn't it common place? There are many possible answers, one of them which I think is that it is much easier to destroy then create so any intelligent civilization eventually reaches the point where it is both easy and capable of destroying itself. We are pretty much at that point right now with nuclear weapons, and with advances in life creation as this article suggests killer viruses will eventually be able to be made by anyone with $100 bucks in equipment in their home.

      Is everyone in the world sane enough not to create this virus shit and kill everyone? I dont think so in the long run ;).

    9. Re:Only a matter of time by localman · · Score: 5, Insightful

      We are certainly moving towards artificial intelligence. We actually have programs that can write themselves to a limited degree. And so we'll probably have artifical intelligence shortly.

      Care to take a bet on that? :)

      I don't believe there is anything magical about the brain, and I believe it can be reproduced in a man-made form. But I think it is far far more complex than we yet realize. Even the most advanced neural nets of today are nowheres near the level of complexity of even a rodent brain. And I'm not just talking about the number of neurons. I'm talking about the secondary effects -- the self-organizing nature of the brain, and how different parts, with slightly different layouts are used for vastly different processing tasks. We're still a long ways off. If I had to guess I'd say not within the next 50 years. Perhaps much longer.

      And I don't believe that we'll achieve intelligence through direct programming, even through self modifying programs. If you can look at the low level and tell what's happening at the top level (like with a program) then it's far to simple to encode intelligence. Intelligence requires layers of meaning.

      Nonetheless, an interesting topic.

      Cheers.

    10. Re:Only a matter of time by FireFury03 · · Score: 2, Insightful

      it is not. If it were very common then we would have likely picked up a signal by now if they were within a few hundred light years.

      First of all you should remember that you can't use the absence of evidence to disprove something (only to show that it may be less likely). Second, you hit it right on the head when you said "we would have likely picked up a signal.

      Whether we're going to pick up a signal depends on a lot of factors. For example: how common is common? the universe is a *big* place, even if there are a reasonable number of civilisations in our galaxy they could be spaced quite thinly. What makes us so sure a civilisation is going to use radio (at the moment)? We have only been transmitting radio signals capable of being detected at interstellar distances for a very short time when compared to the scale of evolution and there's no guarantees how long we will keep using radio - if we find a better method of communication we'll ditch radio in favor of it. Even assuming we stick with radio signalling for 1000 years, that's still a _really_ short window of opportunity.

    11. Re:Only a matter of time by vikks · · Score: 2, Insightful
      Note to grandparent: resource drain is created by uncontrolled growth of human greed, not by growth of human race. With today's technologies it is possible to feed all humans on earth. Resources are not enough however for everyone to own SUV and a house.


      More importantly, life expansion these days almost entirely revolves around "solving" old age.


      It had always been that way, not just these days. Yogis are doing just that for many thousand years. And without any technology whatsoever. It's all in one's mind.

      In a society where people become older and older, you have people building up vast reservoirs of experience and knowledge.


      Well, it should be like this - in theory. Now imagine a slashdotter 50 years from now. He's been reading slashdot since teen years, his main source of information is TV, of which he prefers simpsons (or something like this), and from national geographic channel he finds out, that leaves of tree in autumn are supposed to be yellow. [It is known fact that many people who live their whole lives in big cities (New York, etc.) have never seen stars - smog covers sky at all times.] Now tell me - just how much wisdom and what kind of experience you could get from such person? Pop-culture is named like this because it is popular, not because it brings wisdom.


      So my statement is - people are misusing their lives and wasting time for nonsense. As long as this is true, letting them do it for longer will only make matters worse. And yes - wisdom is more important than knowledge.

      --
      Digital is an exercise in precision, while analog was an exercise in controlled chaos.
      [ digitalFAQ.com ]
  2. Re:constructed.... by whogben · · Score: 2, Insightful

    well, yes, creationists - when we have constructed life - will point out that we have failed to conjure forth mass from nothing. When we have constructed mass - they will point out that we have only converted some other energy into mass. The difference between creation and construction is entirely political and insubstantial - if we believe first life arose on its own, in the primordial ooze, we still believe that that it was constructed of smaller particles....

  3. Re:Focus on Artificial life by audacity242 · · Score: 5, Insightful

    Lots of seemingly meaningless scientific pursuits have led to things that have had huge impacts on human life.

    I seem to recall a silly woman, who specialized in x-ray crystallography, taking a picture of a molecule she wasn't supposed to be wasting her time on. If it weren't for Rosalind Franklin doing that, the discovery of the structure of DNA would have been delayed for god only knows how long.

  4. Synthetic Extremophiles by PresidentEnder · · Score: 2, Insightful

    We've known for a long time that extremophiles (organisms capable of surviving in extreme conditions, often incapable of surviving under human-friendly conditions) exist, and speculated that such life is the kind we'd find on other planets. However, this type of thinking (not necessarily PNA life; I think the slower diffusion inherent to fatty acids relative to water will mean that this new life-form is only useful as a test) allows us to produce extremophiles more exotic than what we see on Earth. All known life is DNA-based, and cannot survive in situations where DNA is for some reason broken up (hostile chemicals, high-evergy environments, low-energy environments, and the like). Imagine, however, life based on elements solid at room temperature and liquid at higher temperatures living on Mercury, where water can't be liquid; or life based on liquid oxygen or hydrogen, living far from any star, surviving distances between star systems without life support. This also challenges (traditional) creationism. If we can make life to exist anywhere, that means that the argument about Earth's specialization as a life-bearing planet is meaningless. This doesn't mean that God doesn't exist or that he is dead, merely that he doesn't have to exist. However, it gets rid of the creationism Trump Card so often played by precocious high-school students in Biology class. Conversely, if we find that we can't make life at all, or can only create PNA life, and can't manage artificial DNA life, it could turn evolutionary theory on its head. If we can't make life in a lab, how could we expect it to happen outside a lab? This would get rid of the Trump Card so often played by precocious devout atheists in High School biology classes.

    --
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  5. Re:constructed.... by Vellmont · · Score: 2, Insightful

    Beyond some undefinable religious aspect I suspect you're hinting at, what's the difference between the two words?

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    AccountKiller
  6. Re:Scientists need to stop playing God! by AbraCadaver · · Score: 4, Insightful

    I'm hoping the parent was trying to be funny (the sasser worm??) but may inflame people who actually think like this, so I'll bite. And yes, this is relevant.

    In all the "we are playing god" arguments that I've heard, I ask "where in the Bible/Talmud/Torah/Qur'an does it say 'Ye shall not create life'?". No one can ever give me a direct quote where it says we are forbidden from doing so. So, with that in mind, and given that we are given, the parent would say, from our devine creator, the gifts of intelligence AND curiosity, who is to say that we are not expressly ALLOWED to do this because we were granted the abilities. Now I'm sure I'll get replys that say "well, I'm given the ability to kill or steal, but it doesn't mean that I'm ALLOWED to do so..." and for the asshat that comes up with this argument, I'll counter with: Taking Life or Doing Harm (TM), in that intent, is usually a direct, willful act of agression. Creating, whether it be life, or a painting, or a controversial book, is not intended to be directly harmful in most cases, especially if the intent is to learn, or open a discourse, etc. Sure, some science has yielded results that might be harmful to someone in some circumstance, but I, driving my car to work, might be harmful to someone, in some circumstance, whether it be hitting them or poisoning the air of their great grand children and causing global warming, the seas to melt, and all of us end up doing bad Kevin Costner impersonations. My point is, and this is my own opinion, that the intent of most of the religious texts of the world seem to be "don't be evil bastards." How can creation be evil, when it's A) not intended to be evil, and B) Not even expressly forbidden? (that I know of)

    Flame away!

  7. Re:Source of creation, or evolution? by The+Master+Control+P · · Score: 2, Insightful

    Simple - the first life wasn't a cell. It was a bit of DNA or RNA floating in a sea rich in organic chemicals. Eventually the bits of what we'd call genes which created proteins that formed a crude shell were more likely to survive (some insulation against changing conditions). Then this little viruslike thingy got in and started making ATP and the cell ended up using that for fuel; The virus-thingy became a mitochondria. Then these simple cells competed and started adding dongles to help them compete. And then the perpetual arms race began, all the cells trying to 1-up each other with the newest addition or minor tweak.

    But for each 'stage' I described I probably left out 20 or 30 others...

  8. Re:Oh dear by Dan+Farina · · Score: 2, Insightful

    It just proves that life COULD be made through intelligent deisign (although it would short circuit the notion that only a 'higher power' has such capability.

    It doesn't disprove the notion that life could be a product of stochastic processes.

  9. Re:Source of creation, or evolution? by Vellmont · · Score: 3, Insightful


    While I am not a creationist, I did see the point of their argument - how simple amino acids and organic chemicals were first formed into cells, I have no idea.

    I think this is an important question in biology, and I'm sure no biologist would deny it. The problem comes when the creationists merely assume god must have done anything we can't explain. It's the "god in the gaps" argument that's been popular probbably since we first learned to communicate. The problem of course is that science marches on and when you try to find your god in the gaps of science, science eventually closes those gaps. Religion always fights like mad because they've invested much of their belief structure in the argument. The gaps used to be in evolution. Those gaps have closed and now the gaps have moved to the creation of life itself.

    The point that people like you were talking to seem to miss is that assuming the existence of a god to explain current lack of scientific understanding of scientific questions has always been a losing proposition. Where religion always fails is when it gets mixed up with scientific questions. Science adapts, and religion tries to cling to dogma. Religion changes too perhaps.. no one is seriously pissed off about heliocentrism anymore, it just takes about 100 times longer.

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    AccountKiller
  10. Re:Source of creation, or evolution? by demachina · · Score: 2, Insightful

    You really need to look no further than the virus. It is little more than a small bit of DNA or RNA and a protective coating. They generally are parasites on cells since they don't have some of the machinery to reproduce on their own, but as you can tell from the epidemics and pandemics they cause they are a quite successful form of life at its most elemental level.

    One things people who fall for intelligent design refuse to appreciate is that life has had hundreds of millions of years to evolve and perfect itself. We can't get our heads around that but that is an enormous number of cycles of mutation and natural selection that would inevitably lead to great diversity and complexity over time. Living organisms have to work because if they don't they die. All the failed mutations are dead, we only see the ones that worked so we are amazed life works but if it didn't we wouldn't be here to judge.

    You would be really hard pressed to explain why an intelligent omnipotent being would have made all the design mistakes that we carry with. For example why would an intelligent designer give us an appendix that frequently threatens to kill us.

    "and they dispute that such a thing could have evolved out of less complex parts."

    So where did their creator and intelligent designer come from then? I think I could visualize random interactions of molecules leading to life better than I could that there is some omnipotent intelligence that has existed for eternity or whom just popped in to existence one day. That is at least as far fetched as amino acids randomly assembling themselves in to a virus or proto cell.

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    @de_machina
  11. Re:Source of creation, or evolution? by QuantumG · · Score: 2, Insightful

    Ok, then obviously talking about cells isn't going to get us anywhere. So let's talk about the analogy that ID makes: the mouse trap.

    The modern mouse trap has four parts. A base, a spring, a crushing wire and a trigger lever. If you take away any of the parts it doesn't work. The ID argument is that it must have been designed as any small change that removed one of these critical components would render the mouse trap ineffective.

    This is a powerful argument, and it is what gets most people suckered into ID. Not because it is a good argument, but simply because you believe the mouse trap was intelligently designed and by drawing analogies to structures seen in nature you fall into the same kind of thinking.

    There's one more thing most people are ignorant of that makes the argument powerful: how the modern mouse trap came about. People largely think the modern mouse trap came into the world fully formed without any evolution. Much like Edison's light bulbs, however, the mouse trap actually did evolve. The addition and removal of superfluous parts continues to this day. Designs compete much like genetic variations and the market selects which designs are improved upon.

    To suggest that a flagellum or ATP-syntase must have been intelligently designed because it is irreducibly complex is to ask us to believe that no superfluous parts could possibly have been removed from the currently "perfect" design and that the parts which make up the current design could not have served any other purpose (even though I've just mentioned two biochemical systems which have similar components).

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  12. Time is a factor by WindBourne · · Score: 2, Insightful

    The fact that it took about the planets lifetime to form the first cells (BILLIONS of years) smacks of evolution rather than creationism. or did god simply take billions of years to think that he might like life here?

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  13. Re:constructed.... by m50d · · Score: 2, Insightful

    That's not the way the word is normally used. We say a chef has created a wonderful desert, an artist has created a sculpture, etc.

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  14. Re:Sai Dorsai! by hitmark · · Score: 4, Insightful

    i guess thats where evolution outperforms us. it gives randomness a chance and therefor can discover a better brain by chance.

    thing is realy, how to put evolution into effect when creating a microchip or a computer program. and then how to test against parameters so that the program becomes self aware.

    ie, the moment we can set down the requirements for selfawareness then we can build something thats selfaware. atleast in theory.

    and yes, i have not read the book or whatever it is your refering to. maybe ill have to look it up sometime.

    still, i belive one could build a more intelligent "being", that is if one fully understood what it is that make up intelligence. understanding what makes it stronger or faster is simple. understanding intelligence is hard.

    but it seems that current research shows that the brain is a neural net in a chemical bath. drop the right amounts of the right chemicals and the neural net pathways are changed or disabled.

    so, stacking a bayesian system of values on top of a neural net so that they interact and one should get some interesting results if one pipe the raw data of video and audio into the same setup and let it run for any number of years.

    but as of now we dont fully understand how the brain works, and therefor can not yet build a better one. but if we manage to figure out how it works then we should allso be able to design a better one. atleast in theory.

    so yes, the monkeys would not be able to build a smarter monkey as they dont have the knowhow about how smartness is designed. but if they understood that then they may well have been able to build a smarter monkey.

    thing is tho that to fully understand a brain we may well have to put in into a jar and play around with it while its still "alive". but that flys in the face of medical ethics. maybe its time we have another round of nazi medical research? we may not like what they did, but the results where used to help medical science move forward...

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  15. Re:Source of creation, or evolution? by MichaelSmith · · Score: 2, Insightful
    While I am not a creationist, I did see the point of their argument - how simple amino acids and organic chemicals were first formed into cells, I have no idea.

    Maybe so, but it doesn't address the issue of where their creator came from. Unless the creator is inherently less complex than the system it created, you need to explain how this earlier step came into being.

    These people seem to take their existance of their god as a given, not requiring explanation.

  16. Re:Source of creation, or evolution? by ColaMan · · Score: 2, Insightful

    Don't forget, it happened with quantities and timescales that you cannot easily (let alone physically) comprehend.

    *the following are numbers pulled from nowhere, but help to convey the idea*

    So, it takes a billion (1,000,000,000) years for single-celled organisms to evolve. On planet with at least a billion-billion (1,000,000,000,000,000,000) bits of organic building blocks in it's oceans, randomly and constantly thrown together. So if it's a one in a million chance to do a particular step on the road to life, it'll probably happen a million times a second worldwide for a billion years.

      When you look at the numbers like *that*, the odds are pretty good you'll get something like life out the other end.

    --

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  17. Re:Scientists need to stop playing God! by getwhipped · · Score: 2, Insightful
    who is to say that we are not expressly ALLOWED to do this
    Intead of thinking from an authoritative (religious) standpoint, think from something more broad: Ethics. Stealing and killing, under Kantianism, would be unethical; if everyone stole, we'd have no belongings, and if everyone killed, there'd be no life. Similarly, under a utilitarian view, most stealing and killing would produce far more bad than good. If we created new life, we could possibly mess with the integrity of our own; similarly, creating our own life *may* produce more bad than good. Finally, under the social contract that we call the Constitution, doing either would violate our own foundations as a society. Whether or not religious texts say not to is beside the point; if we all want to live together, there are some things that we should and shouldn't do.
    How can creation be evil
    Well... who says we can create life? Just because we are physically able to, do we have a forum that will support both the current life and the new life? How do we know the life we create will not greatly alter the life now? If we create life, what will be it's predators? Us? Why can't we bring animals, fruit or plants from one country to the next? Is it because of plague/sickness, or could that animal/fruit/plant run rampant in a habitat that has no predators? Does Australia ring a bell? If we can't answer all of these (and most likely more) questions, then we are probably not suited for creating life. If we are not suited for creating life, then any life we do create will probably -- however inadvertantly -- become something dubbed as "evil".
    --
    get whipped (you know you like it)
  18. Re:Source of creation, or evolution? by JonathanBoyd · · Score: 2, Insightful

    Has it occurred to you that the problem lies with some practishoners of said religions, rather than the religions themselves?