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Self-Assembling DNA Pyramids

Posted by ScuttleMonkey on from the new-and-improved-building-blocks dept.

FleaPlus writes "Physicists in England and the Netherlands have unveiled a technique for constructing rigid DNA pyramids. With the technique, trillions of d4's can rapidly self-assemble from a solution of single-stranded DNA. The scientists also showed that single DNA strands called linkers could be used to attach the tetrahedra to each other, acting as a possible building block for 3D nanofabrication."

2 of 108 comments (clear)

  1. In lay-man's terms this means... by MLopat · · Score: 5, Informative

    Since the article summary doesn't even begin to explain why this is significant, I'll attempt to.

    First of all, the DNA pyramids are useful because they have some attractive properties, namely they are about 10 nanometers wide and are rigid. They are also tetrahedral in shapre (3 faces and a base) which makes them good building blocks. This all lends itself rather nicely to developing things like three dimensional electronic circuits.

    Today's announcement is simply to say that scientists have fonud a way to do this all in a single step by mixing trillions of the base strands in a mixture to produce the mini-pyramids. However, what is really needed moving forward, is a way to bind all of these pyramids into more complex structures. For more information, check out the article on PhysicsWeb

  2. Re:old non news by RussG146 · · Score: 5, Informative
    ned seeman at nyu has been doing this for years

    That's certainly true - Ned Seeman is definitely the 'founding father' of the field, and has lab continues to be a driving force in this sort of research. However, while I'm not exactly an objective observer, I believe this paper offers a number of practical advances in the field, such as yield, ease of synthesis, rigidity, and adaptability.

    it has little if any practical value; dna is VERY $$, and a delicate molecule that is destroyed by normal shipping temperatures (at least in tuscon)

    This simply isn't true. DNA is shipped all over the place at room T (we ordered the DNA for this experiment from America), and in lyophilised form is very stable. It's less stable in solution, but you can make modifications to increase its stability. DNA tetrahedra in my experience are very stable. As for cost, you can buy the DNA for this kind of synthesis relatively cheaply, and DNA gets cheaper every year.