Stubborn Spyware Removal Advice?

onedobb asks: "I'm sure all of us are familiar with Lavasoft's Ad-Adware and Spybot Search and Destroy, however there always seems to be that particular piece of spyware, or malware that seems to slip past both of those programs (even with the most recent definition updates, and virus definitions). What program combinations, or websites do you use to uproot that last bit of unwanted software intrusion?"